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Q99P77

- NOG1_RAT

UniProt

Q99P77 - NOG1_RAT

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Protein

Nucleolar GTP-binding protein 1

Gene

Gtpbp4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the biogenesis of the 60S ribosomal subunit.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi175 – 1828GTPPROSITE-ProRule annotation
Nucleotide bindingi221 – 2255GTPPROSITE-ProRule annotation
Nucleotide bindingi289 – 2924GTPPROSITE-ProRule annotation

GO - Molecular functioni

  1. GTPase activity Source: HGNC
  2. GTP binding Source: HGNC

GO - Biological processi

  1. GTP catabolic process Source: GOC
  2. negative regulation of cell-cell adhesion Source: HGNC
  3. negative regulation of cell migration Source: HGNC
  4. negative regulation of cell proliferation Source: HGNC
  5. negative regulation of collagen binding Source: HGNC
  6. negative regulation of DNA replication Source: HGNC
  7. negative regulation of protein ubiquitination Source: HGNC
  8. protein stabilization Source: HGNC
  9. regulation of cyclin-dependent protein serine/threonine kinase activity Source: HGNC
  10. ribosome biogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar GTP-binding protein 1
Alternative name(s):
Chronic renal failure gene protein
Gene namesi
Name:Gtpbp4
Synonyms:Crfg, Nog1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620783. Gtpbp4.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. cytoplasm Source: HGNC
  2. nucleolus Source: InterPro
  3. nucleus Source: HGNC
  4. perinuclear region of cytoplasm Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 637636Nucleolar GTP-binding protein 1PRO_0000195025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei103 – 1031N6-acetyllysineBy similarity
Modified residuei559 – 5591PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ99P77.
PRIDEiQ99P77.

Expressioni

Gene expression databases

GenevestigatoriQ99P77.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041057.

Structurei

3D structure databases

ProteinModelPortaliQ99P77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini169 – 340172OBG-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1084.
HOGENOMiHOG000164071.
HOVERGENiHBG052642.
InParanoidiQ99P77.
PhylomeDBiQ99P77.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006073. GTP_binding_domain.
IPR024926. NOG1.
IPR010674. NOG1_Rossman_fold_dom.
IPR012973. NOG_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06858. NOG1. 1 hit.
PF08155. NOGCT. 1 hit.
[Graphical view]
PIRSFiPIRSF038919. NOG1. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P77-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHYNFKKIT VVPSAKDFID LTLSKTQRKT PTVIHKHYQI HRIRHFYMRK
60 70 80 90 100
VKFTQQNYHD RLSQILSDFP KLDDIHPFYA DLMNILYDKD HYKLALGQIN
110 120 130 140 150
IAKNLVDNVA KDYVRLMKYG DSLYRCKQLK RAALGRMCTI IKRQRQSLEY
160 170 180 190 200
LEQVRQHLSR LPTIDPNTRT LLLCGYPNVG KSSFINKVTR ADVDVQPYAF
210 220 230 240 250
TTKSLFVGHV DYKYLRWQVV DTPGILDHPL EDRNTIEMQA ITALAHLRAA
260 270 280 290 300
VLYVMDLSEQ CGHGLKEQLG LFQNIRPLFI NKPLIVVASK CEVKRIAELS
310 320 330 340 350
EEDQKIFLDL QAEGFPVIET STLTEEGVIQ VKTEACDRLL AHRVETKMKG
360 370 380 390 400
NKVNEVLNRL HLAVPNKRDD KERPPFIPEG VVARRKRMEI AEPKKKRERD
410 420 430 440 450
LELEMGDDYI LDLQKYWDLM NSSEKYDKIP EIWEGHNAAD YIDPAIMKKL
460 470 480 490 500
EELEKGKKSS EQLLGSMPVS LRVKTRKWWK IRQLAKQIRE KKKLKILQSK
510 520 530 540 550
EKNTQGPRMP RTAKKVQRAD LENEMRSLGV DMDDKDNAHY AVRARRSRSV
560 570 580 590 600
TRKRKREESV PPSSIARSRS RSCSKTPRDV SGLRDVKMVK KAKTMMKKAQ
610 620 630
KKMNRLGKKG EADRHVFDMK PKHLLSGKRK AGKKERR
Length:637
Mass (Da):74,288
Last modified:January 23, 2007 - v3
Checksum:i5CBF5FA48140F702
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325355 mRNA. Translation: AAK13446.1.
UniGeneiRn.96111.

Genome annotation databases

UCSCiRGD:620783. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325355 mRNA. Translation: AAK13446.1 .
UniGenei Rn.96111.

3D structure databases

ProteinModelPortali Q99P77.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000041057.

Proteomic databases

PaxDbi Q99P77.
PRIDEi Q99P77.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:620783. rat.

Organism-specific databases

RGDi 620783. Gtpbp4.

Phylogenomic databases

eggNOGi COG1084.
HOGENOMi HOG000164071.
HOVERGENi HBG052642.
InParanoidi Q99P77.
PhylomeDBi Q99P77.

Miscellaneous databases

NextBioi 13959829.

Gene expression databases

Genevestigatori Q99P77.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR006073. GTP_binding_domain.
IPR024926. NOG1.
IPR010674. NOG1_Rossman_fold_dom.
IPR012973. NOG_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF06858. NOG1. 1 hit.
PF08155. NOGCT. 1 hit.
[Graphical view ]
PIRSFi PIRSF038919. NOG1. 1 hit.
PRINTSi PR00326. GTP1OBG.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51710. G_OBG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease."
    Laping N.J., Olson B.A., Zhu Y.
    J. Am. Soc. Nephrol. 12:883-890(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Kidney.

Entry informationi

Entry nameiNOG1_RAT
AccessioniPrimary (citable) accession number: Q99P77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3