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Q99P77

- NOG1_RAT

UniProt

Q99P77 - NOG1_RAT

Protein

Nucleolar GTP-binding protein 1

Gene

Gtpbp4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Involved in the biogenesis of the 60S ribosomal subunit.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi175 – 1828GTPPROSITE-ProRule annotation
    Nucleotide bindingi221 – 2255GTPPROSITE-ProRule annotation
    Nucleotide bindingi289 – 2924GTPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: HGNC
    2. GTP binding Source: HGNC

    GO - Biological processi

    1. GTP catabolic process Source: GOC
    2. negative regulation of cell-cell adhesion Source: HGNC
    3. negative regulation of cell migration Source: HGNC
    4. negative regulation of cell proliferation Source: HGNC
    5. negative regulation of collagen binding Source: HGNC
    6. negative regulation of DNA replication Source: HGNC
    7. negative regulation of protein ubiquitination Source: HGNC
    8. protein stabilization Source: HGNC
    9. regulation of cyclin-dependent protein serine/threonine kinase activity Source: HGNC
    10. ribosome biogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Ribosome biogenesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleolar GTP-binding protein 1
    Alternative name(s):
    Chronic renal failure gene protein
    Gene namesi
    Name:Gtpbp4
    Synonyms:Crfg, Nog1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620783. Gtpbp4.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: HGNC
    2. nucleolus Source: UniProtKB-SubCell
    3. nucleus Source: HGNC
    4. perinuclear region of cytoplasm Source: HGNC

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 637636Nucleolar GTP-binding protein 1PRO_0000195025Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei103 – 1031N6-acetyllysineBy similarity
    Modified residuei559 – 5591PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ99P77.
    PRIDEiQ99P77.

    Expressioni

    Gene expression databases

    GenevestigatoriQ99P77.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000041057.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99P77.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini169 – 340172OBG-type GPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.PROSITE-ProRule annotation
    Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1084.
    HOGENOMiHOG000164071.
    HOVERGENiHBG052642.
    PhylomeDBiQ99P77.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR006073. GTP_binding_domain.
    IPR024926. NOG1.
    IPR010674. NOG1_Rossman_fold_dom.
    IPR012973. NOG_C.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF06858. NOG1. 1 hit.
    PF08155. NOGCT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038919. NOG1. 1 hit.
    PRINTSiPR00326. GTP1OBG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51710. G_OBG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99P77-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHYNFKKIT VVPSAKDFID LTLSKTQRKT PTVIHKHYQI HRIRHFYMRK    50
    VKFTQQNYHD RLSQILSDFP KLDDIHPFYA DLMNILYDKD HYKLALGQIN 100
    IAKNLVDNVA KDYVRLMKYG DSLYRCKQLK RAALGRMCTI IKRQRQSLEY 150
    LEQVRQHLSR LPTIDPNTRT LLLCGYPNVG KSSFINKVTR ADVDVQPYAF 200
    TTKSLFVGHV DYKYLRWQVV DTPGILDHPL EDRNTIEMQA ITALAHLRAA 250
    VLYVMDLSEQ CGHGLKEQLG LFQNIRPLFI NKPLIVVASK CEVKRIAELS 300
    EEDQKIFLDL QAEGFPVIET STLTEEGVIQ VKTEACDRLL AHRVETKMKG 350
    NKVNEVLNRL HLAVPNKRDD KERPPFIPEG VVARRKRMEI AEPKKKRERD 400
    LELEMGDDYI LDLQKYWDLM NSSEKYDKIP EIWEGHNAAD YIDPAIMKKL 450
    EELEKGKKSS EQLLGSMPVS LRVKTRKWWK IRQLAKQIRE KKKLKILQSK 500
    EKNTQGPRMP RTAKKVQRAD LENEMRSLGV DMDDKDNAHY AVRARRSRSV 550
    TRKRKREESV PPSSIARSRS RSCSKTPRDV SGLRDVKMVK KAKTMMKKAQ 600
    KKMNRLGKKG EADRHVFDMK PKHLLSGKRK AGKKERR 637
    Length:637
    Mass (Da):74,288
    Last modified:January 23, 2007 - v3
    Checksum:i5CBF5FA48140F702
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325355 mRNA. Translation: AAK13446.1.
    UniGeneiRn.96111.

    Genome annotation databases

    UCSCiRGD:620783. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325355 mRNA. Translation: AAK13446.1 .
    UniGenei Rn.96111.

    3D structure databases

    ProteinModelPortali Q99P77.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000041057.

    Proteomic databases

    PaxDbi Q99P77.
    PRIDEi Q99P77.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:620783. rat.

    Organism-specific databases

    RGDi 620783. Gtpbp4.

    Phylogenomic databases

    eggNOGi COG1084.
    HOGENOMi HOG000164071.
    HOVERGENi HBG052642.
    PhylomeDBi Q99P77.

    Miscellaneous databases

    NextBioi 13959829.

    Gene expression databases

    Genevestigatori Q99P77.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR006073. GTP_binding_domain.
    IPR024926. NOG1.
    IPR010674. NOG1_Rossman_fold_dom.
    IPR012973. NOG_C.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF06858. NOG1. 1 hit.
    PF08155. NOGCT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038919. NOG1. 1 hit.
    PRINTSi PR00326. GTP1OBG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51710. G_OBG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease."
      Laping N.J., Olson B.A., Zhu Y.
      J. Am. Soc. Nephrol. 12:883-890(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Kidney.

    Entry informationi

    Entry nameiNOG1_RAT
    AccessioniPrimary (citable) accession number: Q99P77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 24, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 94 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3