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Q99P77 (NOG1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleolar GTP-binding protein 1
Alternative name(s):
Chronic renal failure gene protein
Gene names
Name:Gtpbp4
Synonyms:Crfg, Nog1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length637 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the biogenesis of the 60S ribosomal subunit By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.

Contains 1 OBG-type G (guanine nucleotide-binding) domain.

Ontologies

Keywords
   Biological processRibosome biogenesis
   Cellular componentNucleus
   LigandGTP-binding
Nucleotide-binding
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGTP catabolic process

Inferred from sequence or structural similarity. Source: GOC

negative regulation of DNA replication

Inferred from sequence or structural similarity. Source: HGNC

negative regulation of cell migration

Inferred from sequence or structural similarity. Source: HGNC

negative regulation of cell proliferation

Inferred from sequence or structural similarity. Source: HGNC

negative regulation of cell-cell adhesion

Inferred from sequence or structural similarity. Source: HGNC

negative regulation of collagen binding

Inferred from sequence or structural similarity. Source: HGNC

negative regulation of protein ubiquitination

Inferred from sequence or structural similarity. Source: HGNC

protein stabilization

Inferred from sequence or structural similarity. Source: HGNC

regulation of cyclin-dependent protein serine/threonine kinase activity

Inferred from sequence or structural similarity. Source: HGNC

ribosome biogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: HGNC

nucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from sequence or structural similarity. Source: HGNC

perinuclear region of cytoplasm

Inferred from sequence or structural similarity. Source: HGNC

   Molecular_functionGTP binding

Inferred from sequence or structural similarity. Source: HGNC

GTPase activity

Inferred from sequence or structural similarity. Source: HGNC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 637636Nucleolar GTP-binding protein 1
PRO_0000195025

Regions

Domain169 – 340172OBG-type G
Nucleotide binding175 – 1828GTP Potential
Nucleotide binding221 – 2255GTP Potential
Nucleotide binding289 – 2924GTP Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1031N6-acetyllysine By similarity
Modified residue5591Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99P77 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 5CBF5FA48140F702

FASTA63774,288
        10         20         30         40         50         60 
MAHYNFKKIT VVPSAKDFID LTLSKTQRKT PTVIHKHYQI HRIRHFYMRK VKFTQQNYHD 

        70         80         90        100        110        120 
RLSQILSDFP KLDDIHPFYA DLMNILYDKD HYKLALGQIN IAKNLVDNVA KDYVRLMKYG 

       130        140        150        160        170        180 
DSLYRCKQLK RAALGRMCTI IKRQRQSLEY LEQVRQHLSR LPTIDPNTRT LLLCGYPNVG 

       190        200        210        220        230        240 
KSSFINKVTR ADVDVQPYAF TTKSLFVGHV DYKYLRWQVV DTPGILDHPL EDRNTIEMQA 

       250        260        270        280        290        300 
ITALAHLRAA VLYVMDLSEQ CGHGLKEQLG LFQNIRPLFI NKPLIVVASK CEVKRIAELS 

       310        320        330        340        350        360 
EEDQKIFLDL QAEGFPVIET STLTEEGVIQ VKTEACDRLL AHRVETKMKG NKVNEVLNRL 

       370        380        390        400        410        420 
HLAVPNKRDD KERPPFIPEG VVARRKRMEI AEPKKKRERD LELEMGDDYI LDLQKYWDLM 

       430        440        450        460        470        480 
NSSEKYDKIP EIWEGHNAAD YIDPAIMKKL EELEKGKKSS EQLLGSMPVS LRVKTRKWWK 

       490        500        510        520        530        540 
IRQLAKQIRE KKKLKILQSK EKNTQGPRMP RTAKKVQRAD LENEMRSLGV DMDDKDNAHY 

       550        560        570        580        590        600 
AVRARRSRSV TRKRKREESV PPSSIARSRS RSCSKTPRDV SGLRDVKMVK KAKTMMKKAQ 

       610        620        630 
KKMNRLGKKG EADRHVFDMK PKHLLSGKRK AGKKERR 

« Hide

References

[1]"Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease."
Laping N.J., Olson B.A., Zhu Y.
J. Am. Soc. Nephrol. 12:883-890(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF325355 mRNA. Translation: AAK13446.1.
UniGeneRn.96111.

3D structure databases

ProteinModelPortalQ99P77.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000041057.

Proteomic databases

PaxDbQ99P77.
PRIDEQ99P77.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:620783. rat.

Organism-specific databases

RGD620783. Gtpbp4.

Phylogenomic databases

eggNOGCOG1084.
HOGENOMHOG000164071.
HOVERGENHBG052642.
PhylomeDBQ99P77.

Gene expression databases

GenevestigatorQ99P77.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR006073. GTP_binding_domain.
IPR024926. NOG1.
IPR010674. NOG1_Rossman_fold_dom.
IPR012973. NOG_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF06858. NOG1. 1 hit.
PF08155. NOGCT. 1 hit.
[Graphical view]
PIRSFPIRSF038919. NOG1. 1 hit.
PRINTSPR00326. GTP1OBG.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS51710. G_OBG. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio13959829.

Entry information

Entry nameNOG1_RAT
AccessionPrimary (citable) accession number: Q99P77
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families