Q99P77 (NOG1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleolar GTP-binding protein 1

Alternative name(s):
Chronic renal failure gene protein

Gene names

Name:	Gtpbp4
Synonyms:	Crfg, Nog1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	637 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the biogenesis of the 60S ribosomal subunit By similarity.
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the GTP1/OBG family. NOG subfamily.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Cellular component	Nucleus
Ligand	GTP-binding Nucleotide-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of DNA replication Inferred from sequence or structural similarity. Source: HGNC negative regulation of cell migration Inferred from sequence or structural similarity. Source: HGNC negative regulation of cell proliferation Inferred from sequence or structural similarity. Source: HGNC negative regulation of cell-cell adhesion Inferred from sequence or structural similarity. Source: HGNC negative regulation of collagen binding Inferred from sequence or structural similarity. Source: HGNC negative regulation of protein ubiquitination Inferred from sequence or structural similarity. Source: HGNC protein stabilization Inferred from sequence or structural similarity. Source: HGNC regulation of cyclin-dependent protein serine/threonine kinase activity Inferred from sequence or structural similarity. Source: HGNC ribosome biogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from sequence or structural similarity. Source: HGNC perinuclear region of cytoplasm Inferred from sequence or structural similarity. Source: HGNC
Molecular_function	GTP binding Inferred from sequence or structural similarity. Source: HGNC GTPase activity Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 637	636	Nucleolar GTP-binding protein 1		PRO_0000195025
Regions
	Nucleotide binding	175 – 182	8	GTP Potential
	Nucleotide binding	221 – 225	5	GTP Potential
	Nucleotide binding	289 – 292	4	GTP Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	103	1	N6-acetyllysine By similarity
	Modified residue	559	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q99P77 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 5CBF5FA48140F702	FASTA	637	74,288
	10 20 30 40 50 60 MAHYNFKKIT VVPSAKDFID LTLSKTQRKT PTVIHKHYQI HRIRHFYMRK VKFTQQNYHD 70 80 90 100 110 120 RLSQILSDFP KLDDIHPFYA DLMNILYDKD HYKLALGQIN IAKNLVDNVA KDYVRLMKYG 130 140 150 160 170 180 DSLYRCKQLK RAALGRMCTI IKRQRQSLEY LEQVRQHLSR LPTIDPNTRT LLLCGYPNVG 190 200 210 220 230 240 KSSFINKVTR ADVDVQPYAF TTKSLFVGHV DYKYLRWQVV DTPGILDHPL EDRNTIEMQA 250 260 270 280 290 300 ITALAHLRAA VLYVMDLSEQ CGHGLKEQLG LFQNIRPLFI NKPLIVVASK CEVKRIAELS 310 320 330 340 350 360 EEDQKIFLDL QAEGFPVIET STLTEEGVIQ VKTEACDRLL AHRVETKMKG NKVNEVLNRL 370 380 390 400 410 420 HLAVPNKRDD KERPPFIPEG VVARRKRMEI AEPKKKRERD LELEMGDDYI LDLQKYWDLM 430 440 450 460 470 480 NSSEKYDKIP EIWEGHNAAD YIDPAIMKKL EELEKGKKSS EQLLGSMPVS LRVKTRKWWK 490 500 510 520 530 540 IRQLAKQIRE KKKLKILQSK EKNTQGPRMP RTAKKVQRAD LENEMRSLGV DMDDKDNAHY 550 560 570 580 590 600 AVRARRSRSV TRKRKREESV PPSSIARSRS RSCSKTPRDV SGLRDVKMVK KAKTMMKKAQ 610 620 630 KKMNRLGKKG EADRHVFDMK PKHLLSGKRK AGKKERR

References

[1]	"Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease." Laping N.J., Olson B.A., Zhu Y. J. Am. Soc. Nephrol. 12:883-890(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF325355 mRNA. Translation: AAK13446.1.
IPI	IPI00200431.
UniGene	Rn.96111.
3D structure databases
ProteinModelPortal	Q99P77.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000041057.
Proteomic databases
PaxDb	Q99P77.
PRIDE	Q99P77.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:620783. rat.
Organism-specific databases
RGD	620783. Gtpbp4.
Phylogenomic databases
eggNOG	COG1084.
HOGENOM	HOG000164071.
HOVERGEN	HBG052642.
OrthoDB	EOG48WC1N.
Gene expression databases
ArrayExpress	Q99P77.
Genevestigator	Q99P77.
GermOnline	ENSRNOG00000016217. Rattus norvegicus.
Family and domain databases
InterPro	IPR006073. GTP_binding_domain. IPR024926. NOG1. IPR010674. NOG1_Rossman_fold_dom. IPR012973. NOG_C. [Graphical view]
Pfam	PF06858. NOG1. 1 hit. PF08155. NOGCT. 1 hit. [Graphical view]
PIRSF	PIRSF038919. NOG1. 1 hit.
PRINTS	PR00326. GTP1OBG.
ProtoNet	Search...
Other
NextBio	13959829.

Entry information

Entry name

NOG1_RAT

Accession

Primary (citable) accession number: Q99P77

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2001
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program