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Protein

Ras-related protein Rab-9A

Gene

Rab9a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of proteins between the endosomes and the trans-Golgi network.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229GTPBy similarity
Nucleotide bindingi62 – 665GTPBy similarity
Nucleotide bindingi124 – 1274GTPBy similarity
Nucleotide bindingi154 – 1563GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-9A
Gene namesi
Name:Rab9a
Synonyms:Rab9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi619740. Rab9a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 201200Ras-related protein Rab-9APRO_0000121141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei179 – 1791PhosphoserineBy similarity
Modified residuei187 – 1871PhosphothreonineBy similarity
Lipidationi200 – 2001S-geranylgeranyl cysteineBy similarity
Lipidationi201 – 2011S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ99P75.
PRIDEiQ99P75.

Expressioni

Gene expression databases

GenevestigatoriQ99P75.

Interactioni

Subunit structurei

Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain).1 Publication

Protein-protein interaction databases

MINTiMINT-4569971.

Structurei

3D structure databases

ProteinModelPortaliQ99P75.
SMRiQ99P75. Positions 4-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 449Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119125.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ99P75.
KOiK07899.
OMAiFQNLGNW.
OrthoDBiEOG7G4QG8.
PhylomeDBiQ99P75.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKSSLFKI ILLGDGGVGK SSLMNRYVTN KFDSQLFHTI GVEFLNKDLE
60 70 80 90 100
VDGHFVTMQI WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN
110 120 130 140 150
WKKEFIYYAD VKEPESFPFV ILGNKTDIKE RQVSTEEAQA WCKDNGDYPY
160 170 180 190 200
FETSAKDSTN VAAAFEEAVR RILATEDRSD HLIQTDTVNL HRKPKPNSSC

C
Length:201
Mass (Da):22,896
Last modified:April 26, 2005 - v2
Checksum:i43F490EAA67CF7EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291T → A in AAG49586 (PubMed:12051767).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325692 mRNA. Translation: AAG49586.1.
BC070502 mRNA. Translation: AAH70502.1.
RefSeqiNP_445910.1. NM_053458.1.
UniGeneiRn.35289.

Genome annotation databases

EnsembliENSRNOT00000050018; ENSRNOP00000050986; ENSRNOG00000030443.
GeneIDi84589.
KEGGirno:84589.
UCSCiRGD:619740. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325692 mRNA. Translation: AAG49586.1.
BC070502 mRNA. Translation: AAH70502.1.
RefSeqiNP_445910.1. NM_053458.1.
UniGeneiRn.35289.

3D structure databases

ProteinModelPortaliQ99P75.
SMRiQ99P75. Positions 4-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4569971.

Proteomic databases

PaxDbiQ99P75.
PRIDEiQ99P75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000050018; ENSRNOP00000050986; ENSRNOG00000030443.
GeneIDi84589.
KEGGirno:84589.
UCSCiRGD:619740. rat.

Organism-specific databases

CTDi9367.
RGDi619740. Rab9a.

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119125.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ99P75.
KOiK07899.
OMAiFQNLGNW.
OrthoDBiEOG7G4QG8.
PhylomeDBiQ99P75.

Miscellaneous databases

NextBioi617185.
PROiQ99P75.

Gene expression databases

GenevestigatoriQ99P75.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins."
    Zhao H., Ettala O., Vaananen H.K.
    Biochem. Biophys. Res. Commun. 293:1060-1065(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Bone.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling."
    Reddy J.V., Burguete A.S., Sridevi K., Ganley I.G., Nottingham R.M., Pfeffer S.R.
    Mol. Biol. Cell 17:4353-4363(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GCC2.

Entry informationi

Entry nameiRAB9A_RAT
AccessioniPrimary (citable) accession number: Q99P75
Secondary accession number(s): Q6NS34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: April 26, 2005
Last modified: May 27, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.