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Q99P75 (RAB9A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ras-related protein Rab-9A
Gene names
Name:Rab9a
Synonyms:Rab9
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the transport of proteins between the endosomes and the trans-Golgi network By similarity.

Subunit structure

Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain). Ref.3

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Late endosome By similarity. Cytoplasmic vesicle › phagosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Co-localizes with OSBPL1A at the late endosome. Recruited to phagosomes containing S.aureus or Mycobacterium By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201Ras-related protein Rab-9A
PRO_0000121141

Regions

Nucleotide binding14 – 229GTP By similarity
Nucleotide binding62 – 665GTP By similarity
Nucleotide binding124 – 1274GTP By similarity
Nucleotide binding154 – 1563GTP By similarity
Motif36 – 449Effector region By similarity

Amino acid modifications

Modified residue1791Phosphoserine By similarity
Lipidation2001S-geranylgeranyl cysteine By similarity
Lipidation2011S-geranylgeranyl cysteine By similarity

Experimental info

Sequence conflict291T → A in AAG49586. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q99P75 [UniParc].

Last modified April 26, 2005. Version 2.
Checksum: 43F490EAA67CF7EA

FASTA20122,896
        10         20         30         40         50         60 
MAGKSSLFKI ILLGDGGVGK SSLMNRYVTN KFDSQLFHTI GVEFLNKDLE VDGHFVTMQI 

        70         80         90        100        110        120 
WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN WKKEFIYYAD VKEPESFPFV 

       130        140        150        160        170        180 
ILGNKTDIKE RQVSTEEAQA WCKDNGDYPY FETSAKDSTN VAAAFEEAVR RILATEDRSD 

       190        200 
HLIQTDTVNL HRKPKPNSSC C

« Hide

References

« Hide 'large scale' references
[1]"Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins."
Zhao H., Ettala O., Vaananen H.K.
Biochem. Biophys. Res. Commun. 293:1060-1065(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Bone.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[3]"A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling."
Reddy J.V., Burguete A.S., Sridevi K., Ganley I.G., Nottingham R.M., Pfeffer S.R.
Mol. Biol. Cell 17:4353-4363(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GCC2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF325692 mRNA. Translation: AAG49586.1.
BC070502 mRNA. Translation: AAH70502.1.
IPIIPI00200427.
RefSeqNP_445910.1. NM_053458.1.
UniGeneRn.35289.

3D structure databases

ProteinModelPortalQ99P75.
SMRQ99P75. Positions 4-175.
ModBaseSearch...

Proteomic databases

PaxDbQ99P75.
PRIDEQ99P75.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000050018; ENSRNOP00000050986; ENSRNOG00000030443.
GeneID84589.
KEGGrno:84589.
UCSCRGD:619740. rat.

Organism-specific databases

CTD9367.
RGD619740. Rab9a.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00700000104345.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidQ99P75.
KOK07899.
OMALIPTDTV.
OrthoDBEOG4R7VBS.

Gene expression databases

GenevestigatorQ99P75.
GermOnlineENSRNOG00000030443. Rattus norvegicus.

Family and domain databases

InterProIPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio617185.

Entry information

Entry nameRAB9A_RAT
AccessionPrimary (citable) accession number: Q99P75
Secondary accession number(s): Q6NS34
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: April 26, 2005
Last modified: May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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