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Q99P75

- RAB9A_RAT

UniProt

Q99P75 - RAB9A_RAT

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Protein
Ras-related protein Rab-9A
Gene
Rab9a, Rab9
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the transport of proteins between the endosomes and the trans-Golgi network By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229GTP By similarity
Nucleotide bindingi62 – 665GTP By similarity
Nucleotide bindingi124 – 1274GTP By similarity
Nucleotide bindingi154 – 1563GTP By similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTP binding Source: UniProtKB
  3. GTPase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. bone resorption Source: RGD
  2. positive regulation of exocytosis Source: Ensembl
  3. protein transport Source: UniProtKB-KW
  4. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-9A
Gene namesi
Name:Rab9a
Synonyms:Rab9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi619740. Rab9a.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side Reviewed prediction. Late endosome By similarity. Cytoplasmic vesiclephagosome membrane; Lipid-anchor; Cytoplasmic side By similarity
Note: Colocalizes with OSBPL1A at the late endosome. Recruited to phagosomes containing S.aureus or Mycobacterium By similarity.

GO - Cellular componenti

  1. late endosome Source: UniProtKB-SubCell
  2. lysosome Source: Ensembl
  3. phagocytic vesicle Source: UniProtKB
  4. phagocytic vesicle membrane Source: UniProtKB-SubCell
  5. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 201200Ras-related protein Rab-9A
PRO_0000121141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei179 – 1791Phosphoserine By similarity
Lipidationi200 – 2001S-geranylgeranyl cysteine By similarity
Lipidationi201 – 2011S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ99P75.
PRIDEiQ99P75.

Expressioni

Gene expression databases

GenevestigatoriQ99P75.

Interactioni

Subunit structurei

Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain).1 Publication

Protein-protein interaction databases

MINTiMINT-4569971.

Structurei

3D structure databases

ProteinModelPortaliQ99P75.
SMRiQ99P75. Positions 4-175.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 449Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00700000104345.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ99P75.
KOiK07899.
OMAiAHLFHTI.
OrthoDBiEOG7G4QG8.
PhylomeDBiQ99P75.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P75-1 [UniParc]FASTAAdd to Basket

« Hide

MAGKSSLFKI ILLGDGGVGK SSLMNRYVTN KFDSQLFHTI GVEFLNKDLE    50
VDGHFVTMQI WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN 100
WKKEFIYYAD VKEPESFPFV ILGNKTDIKE RQVSTEEAQA WCKDNGDYPY 150
FETSAKDSTN VAAAFEEAVR RILATEDRSD HLIQTDTVNL HRKPKPNSSC 200
C 201
Length:201
Mass (Da):22,896
Last modified:April 26, 2005 - v2
Checksum:i43F490EAA67CF7EA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291T → A in AAG49586. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325692 mRNA. Translation: AAG49586.1.
BC070502 mRNA. Translation: AAH70502.1.
RefSeqiNP_445910.1. NM_053458.1.
UniGeneiRn.35289.

Genome annotation databases

EnsembliENSRNOT00000050018; ENSRNOP00000050986; ENSRNOG00000030443.
GeneIDi84589.
KEGGirno:84589.
UCSCiRGD:619740. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325692 mRNA. Translation: AAG49586.1 .
BC070502 mRNA. Translation: AAH70502.1 .
RefSeqi NP_445910.1. NM_053458.1.
UniGenei Rn.35289.

3D structure databases

ProteinModelPortali Q99P75.
SMRi Q99P75. Positions 4-175.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-4569971.

Proteomic databases

PaxDbi Q99P75.
PRIDEi Q99P75.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000050018 ; ENSRNOP00000050986 ; ENSRNOG00000030443 .
GeneIDi 84589.
KEGGi rno:84589.
UCSCi RGD:619740. rat.

Organism-specific databases

CTDi 9367.
RGDi 619740. Rab9a.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00700000104345.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi Q99P75.
KOi K07899.
OMAi AHLFHTI.
OrthoDBi EOG7G4QG8.
PhylomeDBi Q99P75.

Miscellaneous databases

NextBioi 617185.
PROi Q99P75.

Gene expression databases

Genevestigatori Q99P75.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins."
    Zhao H., Ettala O., Vaananen H.K.
    Biochem. Biophys. Res. Commun. 293:1060-1065(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Bone.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling."
    Reddy J.V., Burguete A.S., Sridevi K., Ganley I.G., Nottingham R.M., Pfeffer S.R.
    Mol. Biol. Cell 17:4353-4363(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GCC2.

Entry informationi

Entry nameiRAB9A_RAT
AccessioniPrimary (citable) accession number: Q99P75
Secondary accession number(s): Q6NS34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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