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Q99P75

- RAB9A_RAT

UniProt

Q99P75 - RAB9A_RAT

Protein

Ras-related protein Rab-9A

Gene

Rab9a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Involved in the transport of proteins between the endosomes and the trans-Golgi network.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 229GTPBy similarity
    Nucleotide bindingi62 – 665GTPBy similarity
    Nucleotide bindingi124 – 1274GTPBy similarity
    Nucleotide bindingi154 – 1563GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTPase activity Source: UniProtKB
    3. GTP binding Source: UniProtKB

    GO - Biological processi

    1. bone resorption Source: RGD
    2. positive regulation of exocytosis Source: Ensembl
    3. protein transport Source: UniProtKB-KW
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-9A
    Gene namesi
    Name:Rab9a
    Synonyms:Rab9
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi619740. Rab9a.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated. Late endosome By similarity. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
    Note: Colocalizes with OSBPL1A at the late endosome. Recruited to phagosomes containing S.aureus or Mycobacterium By similarity.By similarity

    GO - Cellular componenti

    1. late endosome Source: UniProtKB-SubCell
    2. lysosome Source: Ensembl
    3. phagocytic vesicle Source: UniProtKB
    4. phagocytic vesicle membrane Source: UniProtKB-SubCell
    5. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 201200Ras-related protein Rab-9APRO_0000121141Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei179 – 1791PhosphoserineBy similarity
    Lipidationi200 – 2001S-geranylgeranyl cysteineBy similarity
    Lipidationi201 – 2011S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Phosphoprotein, Prenylation

    Proteomic databases

    PaxDbiQ99P75.
    PRIDEiQ99P75.

    Expressioni

    Gene expression databases

    GenevestigatoriQ99P75.

    Interactioni

    Subunit structurei

    Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain).1 Publication

    Protein-protein interaction databases

    MINTiMINT-4569971.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99P75.
    SMRiQ99P75. Positions 4-175.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi36 – 449Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00700000104345.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ99P75.
    KOiK07899.
    OMAiAHLFHTI.
    OrthoDBiEOG7G4QG8.
    PhylomeDBiQ99P75.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99P75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGKSSLFKI ILLGDGGVGK SSLMNRYVTN KFDSQLFHTI GVEFLNKDLE    50
    VDGHFVTMQI WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN 100
    WKKEFIYYAD VKEPESFPFV ILGNKTDIKE RQVSTEEAQA WCKDNGDYPY 150
    FETSAKDSTN VAAAFEEAVR RILATEDRSD HLIQTDTVNL HRKPKPNSSC 200
    C 201
    Length:201
    Mass (Da):22,896
    Last modified:April 26, 2005 - v2
    Checksum:i43F490EAA67CF7EA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291T → A in AAG49586. (PubMed:12051767)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325692 mRNA. Translation: AAG49586.1.
    BC070502 mRNA. Translation: AAH70502.1.
    RefSeqiNP_445910.1. NM_053458.1.
    UniGeneiRn.35289.

    Genome annotation databases

    EnsembliENSRNOT00000050018; ENSRNOP00000050986; ENSRNOG00000030443.
    GeneIDi84589.
    KEGGirno:84589.
    UCSCiRGD:619740. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325692 mRNA. Translation: AAG49586.1 .
    BC070502 mRNA. Translation: AAH70502.1 .
    RefSeqi NP_445910.1. NM_053458.1.
    UniGenei Rn.35289.

    3D structure databases

    ProteinModelPortali Q99P75.
    SMRi Q99P75. Positions 4-175.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4569971.

    Proteomic databases

    PaxDbi Q99P75.
    PRIDEi Q99P75.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000050018 ; ENSRNOP00000050986 ; ENSRNOG00000030443 .
    GeneIDi 84589.
    KEGGi rno:84589.
    UCSCi RGD:619740. rat.

    Organism-specific databases

    CTDi 9367.
    RGDi 619740. Rab9a.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00700000104345.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q99P75.
    KOi K07899.
    OMAi AHLFHTI.
    OrthoDBi EOG7G4QG8.
    PhylomeDBi Q99P75.

    Miscellaneous databases

    NextBioi 617185.
    PROi Q99P75.

    Gene expression databases

    Genevestigatori Q99P75.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins."
      Zhao H., Ettala O., Vaananen H.K.
      Biochem. Biophys. Res. Commun. 293:1060-1065(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Bone.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    3. "A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling."
      Reddy J.V., Burguete A.S., Sridevi K., Ganley I.G., Nottingham R.M., Pfeffer S.R.
      Mol. Biol. Cell 17:4353-4363(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GCC2.

    Entry informationi

    Entry nameiRAB9A_RAT
    AccessioniPrimary (citable) accession number: Q99P75
    Secondary accession number(s): Q6NS34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3