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Protein

Ras-related protein Rab-27B

Gene

Rab27b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in targeting uroplakins to urothelial apical membranes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 249GTPBy similarity
Nucleotide bindingi74 – 785GTPBy similarity
Nucleotide bindingi133 – 1364GTPBy similarity
Nucleotide bindingi163 – 1653GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTPase activity Source: UniProtKB
  3. GTP binding Source: UniProtKB

GO - Biological processi

  1. GTP catabolic process Source: GO_Central
  2. intracellular protein transport Source: GO_Central
  3. melanosome transport Source: GO_Central
  4. multivesicular body sorting pathway Source: Ensembl
  5. positive regulation of exocytosis Source: GO_Central
  6. protein secretion Source: GO_Central
  7. Rab protein signal transduction Source: GO_Central
  8. regulation of exocytosis Source: RGD
  9. vesicle docking involved in exocytosis Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-27B
Gene namesi
Name:Rab27b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 18

Organism-specific databases

RGDi620114. Rab27b.

Subcellular locationi

Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

  1. apical plasma membrane Source: RGD
  2. extracellular vesicular exosome Source: Ensembl
  3. Golgi apparatus Source: GO_Central
  4. Golgi stack Source: Ensembl
  5. melanosome Source: GO_Central
  6. multivesicular body membrane Source: Ensembl
  7. secretory granule membrane Source: RGD
  8. trans-Golgi network transport vesicle Source: Ensembl
  9. zymogen granule membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 218217Ras-related protein Rab-27BPRO_0000121226Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity
Disulfide bondi123 ↔ 188By similarity
Lipidationi216 – 2161S-geranylgeranyl cysteineBy similarity
Modified residuei218 – 2181Cysteine methyl esterBy similarity
Lipidationi218 – 2181S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ99P74.
PRIDEiQ99P74.

Expressioni

Gene expression databases

GenevestigatoriQ99P74.

Interactioni

Subunit structurei

Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016369.

Structurei

3D structure databases

ProteinModelPortaliQ99P74.
SMRiQ99P74. Positions 6-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 469Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00770000120510.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ99P74.
KOiK07886.
OMAiQNVEKSV.
OrthoDBiEOG7FFMSC.
PhylomeDBiQ99P74.
TreeFamiTF312895.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P74-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDGDYDYLI KLLALGDSGV GKTTFLYRYT DNKFNPKFIT TVGIDFREKR
60 70 80 90 100
VVYDTQGADG SSGKAFKVHL QLWDTAGQER FRSLTTAFFR DAMGFLLMFD
110 120 130 140 150
LTSQQSFLNV RNWMSQLQAN AYCENPDIVL IGNKADLLDQ REVNERQARE
160 170 180 190 200
LAEKYGIPYF ETSAATGQNV EKSVETLLDL IMKRMEKCVE KTQVPDTVNG
210
VNSGKVDGEK PAEKKCAC
Length:218
Mass (Da):24,620
Last modified:January 23, 2007 - v3
Checksum:i784C894F9B935FEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325693 mRNA. Translation: AAG49587.1.
RefSeqiNP_445911.1. NM_053459.1.
XP_006254992.1. XM_006254930.2.
UniGeneiRn.112603.

Genome annotation databases

EnsembliENSRNOT00000016369; ENSRNOP00000016369; ENSRNOG00000012176.
GeneIDi84590.
KEGGirno:84590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325693 mRNA. Translation: AAG49587.1.
RefSeqiNP_445911.1. NM_053459.1.
XP_006254992.1. XM_006254930.2.
UniGeneiRn.112603.

3D structure databases

ProteinModelPortaliQ99P74.
SMRiQ99P74. Positions 6-190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016369.

Proteomic databases

PaxDbiQ99P74.
PRIDEiQ99P74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016369; ENSRNOP00000016369; ENSRNOG00000012176.
GeneIDi84590.
KEGGirno:84590.

Organism-specific databases

CTDi5874.
RGDi620114. Rab27b.

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00770000120510.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ99P74.
KOiK07886.
OMAiQNVEKSV.
OrthoDBiEOG7FFMSC.
PhylomeDBiQ99P74.
TreeFamiTF312895.

Miscellaneous databases

NextBioi617189.
PROiQ99P74.

Gene expression databases

GenevestigatoriQ99P74.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of small GTP binding rab proteins in rat long bones."
    Zhao H., Vaananen K.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Bone.

Entry informationi

Entry nameiRB27B_RAT
AccessioniPrimary (citable) accession number: Q99P74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.