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Q99P74

- RB27B_RAT

UniProt

Q99P74 - RB27B_RAT

Protein

Ras-related protein Rab-27B

Gene

Rab27b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    May be involved in targeting uroplakins to urothelial apical membranes.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 249GTPBy similarity
    Nucleotide bindingi74 – 785GTPBy similarity
    Nucleotide bindingi133 – 1364GTPBy similarity
    Nucleotide bindingi163 – 1653GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTPase activity Source: UniProtKB
    3. GTP binding Source: UniProtKB
    4. protein binding Source: RGD

    GO - Biological processi

    1. multivesicular body sorting pathway Source: Ensembl
    2. positive regulation of exocytosis Source: Ensembl
    3. protein transport Source: InterPro
    4. regulation of exocytosis Source: RGD
    5. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-27B
    Gene namesi
    Name:Rab27b
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 18

    Organism-specific databases

    RGDi620114. Rab27b.

    Subcellular locationi

    Membrane By similarity; Lipid-anchor By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: RGD
    2. Golgi stack Source: Ensembl
    3. multivesicular body membrane Source: Ensembl
    4. secretory granule membrane Source: RGD
    5. trans-Golgi network transport vesicle Source: Ensembl
    6. zymogen granule membrane Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 218217Ras-related protein Rab-27BPRO_0000121226Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylthreonineBy similarity
    Disulfide bondi123 ↔ 188By similarity
    Lipidationi216 – 2161S-geranylgeranyl cysteineBy similarity
    Modified residuei218 – 2181Cysteine methyl esterBy similarity
    Lipidationi218 – 2181S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Disulfide bond, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiQ99P74.
    PRIDEiQ99P74.

    Expressioni

    Gene expression databases

    GenevestigatoriQ99P74.

    Interactioni

    Subunit structurei

    Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000016369.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99P74.
    SMRiQ99P74. Positions 6-190.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi38 – 469Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00740000114962.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ99P74.
    KOiK07886.
    OMAiQNVEKSV.
    OrthoDBiEOG7FFMSC.
    PhylomeDBiQ99P74.
    TreeFamiTF312895.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99P74-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDGDYDYLI KLLALGDSGV GKTTFLYRYT DNKFNPKFIT TVGIDFREKR    50
    VVYDTQGADG SSGKAFKVHL QLWDTAGQER FRSLTTAFFR DAMGFLLMFD 100
    LTSQQSFLNV RNWMSQLQAN AYCENPDIVL IGNKADLLDQ REVNERQARE 150
    LAEKYGIPYF ETSAATGQNV EKSVETLLDL IMKRMEKCVE KTQVPDTVNG 200
    VNSGKVDGEK PAEKKCAC 218
    Length:218
    Mass (Da):24,620
    Last modified:January 23, 2007 - v3
    Checksum:i784C894F9B935FEA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325693 mRNA. Translation: AAG49587.1.
    RefSeqiNP_445911.1. NM_053459.1.
    XP_006254992.1. XM_006254930.1.
    UniGeneiRn.112603.

    Genome annotation databases

    EnsembliENSRNOT00000016369; ENSRNOP00000016369; ENSRNOG00000012176.
    GeneIDi84590.
    KEGGirno:84590.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325693 mRNA. Translation: AAG49587.1 .
    RefSeqi NP_445911.1. NM_053459.1.
    XP_006254992.1. XM_006254930.1.
    UniGenei Rn.112603.

    3D structure databases

    ProteinModelPortali Q99P74.
    SMRi Q99P74. Positions 6-190.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000016369.

    Proteomic databases

    PaxDbi Q99P74.
    PRIDEi Q99P74.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000016369 ; ENSRNOP00000016369 ; ENSRNOG00000012176 .
    GeneIDi 84590.
    KEGGi rno:84590.

    Organism-specific databases

    CTDi 5874.
    RGDi 620114. Rab27b.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00740000114962.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q99P74.
    KOi K07886.
    OMAi QNVEKSV.
    OrthoDBi EOG7FFMSC.
    PhylomeDBi Q99P74.
    TreeFami TF312895.

    Miscellaneous databases

    NextBioi 617189.
    PROi Q99P74.

    Gene expression databases

    Genevestigatori Q99P74.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of small GTP binding rab proteins in rat long bones."
      Zhao H., Vaananen K.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Bone.

    Entry informationi

    Entry nameiRB27B_RAT
    AccessioniPrimary (citable) accession number: Q99P74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3