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Q99P74

- RB27B_RAT

UniProt

Q99P74 - RB27B_RAT

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Protein
Ras-related protein Rab-27B
Gene
Rab27b
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in targeting uroplakins to urothelial apical membranes By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 249GTP By similarity
Nucleotide bindingi74 – 785GTP By similarity
Nucleotide bindingi133 – 1364GTP By similarity
Nucleotide bindingi163 – 1653GTP By similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTP binding Source: UniProtKB
  3. GTPase activity Source: UniProtKB
  4. protein binding Source: RGD
Complete GO annotation...

GO - Biological processi

  1. multivesicular body sorting pathway Source: Ensembl
  2. positive regulation of exocytosis Source: Ensembl
  3. protein transport Source: InterPro
  4. regulation of exocytosis Source: RGD
  5. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-27B
Gene namesi
Name:Rab27b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 18

Organism-specific databases

RGDi620114. Rab27b.

Subcellular locationi

Membrane; Lipid-anchor By similarity

GO - Cellular componenti

  1. Golgi stack Source: Ensembl
  2. apical plasma membrane Source: RGD
  3. multivesicular body membrane Source: Ensembl
  4. secretory granule membrane Source: RGD
  5. trans-Golgi network transport vesicle Source: Ensembl
  6. zymogen granule membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 218217Ras-related protein Rab-27B
PRO_0000121226Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonine By similarity
Disulfide bondi123 ↔ 188 By similarity
Lipidationi216 – 2161S-geranylgeranyl cysteine By similarity
Modified residuei218 – 2181Cysteine methyl ester By similarity
Lipidationi218 – 2181S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ99P74.
PRIDEiQ99P74.

Expressioni

Gene expression databases

GenevestigatoriQ99P74.

Interactioni

Subunit structurei

Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016369.

Structurei

3D structure databases

ProteinModelPortaliQ99P74.
SMRiQ99P74. Positions 6-190.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 469Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00740000114962.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ99P74.
KOiK07886.
OMAiQNVEKSV.
OrthoDBiEOG7FFMSC.
PhylomeDBiQ99P74.
TreeFamiTF312895.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P74-1 [UniParc]FASTAAdd to Basket

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MTDGDYDYLI KLLALGDSGV GKTTFLYRYT DNKFNPKFIT TVGIDFREKR    50
VVYDTQGADG SSGKAFKVHL QLWDTAGQER FRSLTTAFFR DAMGFLLMFD 100
LTSQQSFLNV RNWMSQLQAN AYCENPDIVL IGNKADLLDQ REVNERQARE 150
LAEKYGIPYF ETSAATGQNV EKSVETLLDL IMKRMEKCVE KTQVPDTVNG 200
VNSGKVDGEK PAEKKCAC 218
Length:218
Mass (Da):24,620
Last modified:January 23, 2007 - v3
Checksum:i784C894F9B935FEA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325693 mRNA. Translation: AAG49587.1.
RefSeqiNP_445911.1. NM_053459.1.
XP_006254992.1. XM_006254930.1.
UniGeneiRn.112603.

Genome annotation databases

EnsembliENSRNOT00000016369; ENSRNOP00000016369; ENSRNOG00000012176.
GeneIDi84590.
KEGGirno:84590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325693 mRNA. Translation: AAG49587.1 .
RefSeqi NP_445911.1. NM_053459.1.
XP_006254992.1. XM_006254930.1.
UniGenei Rn.112603.

3D structure databases

ProteinModelPortali Q99P74.
SMRi Q99P74. Positions 6-190.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016369.

Proteomic databases

PaxDbi Q99P74.
PRIDEi Q99P74.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000016369 ; ENSRNOP00000016369 ; ENSRNOG00000012176 .
GeneIDi 84590.
KEGGi rno:84590.

Organism-specific databases

CTDi 5874.
RGDi 620114. Rab27b.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00740000114962.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi Q99P74.
KOi K07886.
OMAi QNVEKSV.
OrthoDBi EOG7FFMSC.
PhylomeDBi Q99P74.
TreeFami TF312895.

Miscellaneous databases

NextBioi 617189.
PROi Q99P74.

Gene expression databases

Genevestigatori Q99P74.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of small GTP binding rab proteins in rat long bones."
    Zhao H., Vaananen K.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Bone.

Entry informationi

Entry nameiRB27B_RAT
AccessioniPrimary (citable) accession number: Q99P74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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