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Protein

Ras-related protein Rab-27B

Gene

Rab27b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in targeting uroplakins to urothelial apical membranes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 24GTPBy similarity9
Nucleotide bindingi74 – 78GTPBy similarity5
Nucleotide bindingi133 – 136GTPBy similarity4
Nucleotide bindingi163 – 165GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-27B
Gene namesi
Name:Rab27b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi620114. Rab27b.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • extracellular exosome Source: Ensembl
  • Golgi apparatus Source: GO_Central
  • Golgi stack Source: Ensembl
  • melanosome Source: GO_Central
  • multivesicular body membrane Source: Ensembl
  • secretory granule membrane Source: RGD
  • trans-Golgi network transport vesicle Source: Ensembl
  • zymogen granule membrane Source: RGD

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001212262 – 218Ras-related protein Rab-27BAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Disulfide bondi123 ↔ 188By similarity
Lipidationi216S-geranylgeranyl cysteineBy similarity1
Modified residuei218Cysteine methyl esterBy similarity1
Lipidationi218S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ99P74.
PRIDEiQ99P74.

PTM databases

iPTMnetiQ99P74.
PhosphoSitePlusiQ99P74.

Expressioni

Gene expression databases

BgeeiENSRNOG00000012176.
GenevisibleiQ99P74. RN.

Interactioni

Subunit structurei

Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016369.

Structurei

3D structure databases

ProteinModelPortaliQ99P74.
SMRiQ99P74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 46Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0081. Eukaryota.
ENOG410XQ3T. LUCA.
GeneTreeiENSGT00890000139417.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ99P74.
KOiK07886.
OMAiQCVDKTQ.
OrthoDBiEOG091G0I51.
PhylomeDBiQ99P74.
TreeFamiTF312895.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDGDYDYLI KLLALGDSGV GKTTFLYRYT DNKFNPKFIT TVGIDFREKR
60 70 80 90 100
VVYDTQGADG SSGKAFKVHL QLWDTAGQER FRSLTTAFFR DAMGFLLMFD
110 120 130 140 150
LTSQQSFLNV RNWMSQLQAN AYCENPDIVL IGNKADLLDQ REVNERQARE
160 170 180 190 200
LAEKYGIPYF ETSAATGQNV EKSVETLLDL IMKRMEKCVE KTQVPDTVNG
210
VNSGKVDGEK PAEKKCAC
Length:218
Mass (Da):24,620
Last modified:January 23, 2007 - v3
Checksum:i784C894F9B935FEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325693 mRNA. Translation: AAG49587.1.
RefSeqiNP_445911.1. NM_053459.1.
XP_006254992.1. XM_006254930.3.
UniGeneiRn.112603.

Genome annotation databases

EnsembliENSRNOT00000016369; ENSRNOP00000016369; ENSRNOG00000012176.
GeneIDi84590.
KEGGirno:84590.

Similar proteinsi

Entry informationi

Entry nameiRB27B_RAT
AccessioniPrimary (citable) accession number: Q99P74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families