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Protein

Sclerostin

Gene

Sost

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-RNO-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Names & Taxonomyi

Protein namesi
Recommended name:
Sclerostin
Gene namesi
Name:Sost
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi69358 Sost

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000003317929 – 213SclerostinAdd BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi80 ↔ 134By similarity
Disulfide bondi94 ↔ 148By similarity
Disulfide bondi105 ↔ 165By similarity
Disulfide bondi109 ↔ 167By similarity
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99P67

Expressioni

Inductioni

Down-regulated by parathyroid hormone (PTH).

Gene expression databases

BgeeiENSRNOG00000020805
GenevisibleiQ99P67 RN

Interactioni

Subunit structurei

Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028238

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 172CTCKAdd BLAST91

Sequence similaritiesi

Belongs to the sclerostin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVV4 Eukaryota
ENOG4111KFN LUCA
GeneTreeiENSGT00390000014900
HOGENOMiHOG000252934
HOVERGENiHBG003729
InParanoidiQ99P67
KOiK16834
OMAiDVSEYSC
OrthoDBiEOG091G13DX
PhylomeDBiQ99P67
TreeFamiTF353019

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR008835 Sclerostin/SOSTDC1
IPR015665 SOST
PANTHERiPTHR14903 PTHR14903, 1 hit
PTHR14903:SF4 PTHR14903:SF4, 1 hit
PfamiView protein in Pfam
PF05463 Sclerostin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLSLAPCLA CLLVHAAFVA VESQGWQAFK NDATEIIPGL REYPEPPQEL
60 70 80 90 100
ENNQTMNRAE NGGRPPHHPY DTKDVSEYSC RELHYTRFVT DGPCRSAKPV
110 120 130 140 150
TELVCSGQCG PARLLPNAIG RVKWWRPNGP DFRCIPDRYR AQRVQLLCPG
160 170 180 190 200
GAAPRSRKVR LVASCKCKRL TRFHNQSELK DFGPETARPQ KGRKPRPRAR
210
GAKANQAELE NAY
Length:213
Mass (Da):23,974
Last modified:June 1, 2001 - v1
Checksum:i6C56C878CBCD684B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326741 mRNA Translation: AAK13456.1
RefSeqiNP_085073.1, NM_030584.1
UniGeneiRn.95369

Genome annotation databases

EnsembliENSRNOT00000028238; ENSRNOP00000028238; ENSRNOG00000020805
GeneIDi80722
KEGGirno:80722
UCSCiRGD:69358 rat

Similar proteinsi

Entry informationi

Entry nameiSOST_RAT
AccessioniPrimary (citable) accession number: Q99P67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health