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Protein

Sclerostin

Gene

Sost

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiR-RNO-3772470. Negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Names & Taxonomyi

Protein namesi
Recommended name:
Sclerostin
Gene namesi
Name:Sost
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi69358. Sost.

Subcellular locationi

GO - Cellular componenti

  • extracellular matrix Source: Ensembl
  • extracellular space Source: RGD
  • Golgi apparatus Source: UniProtKB
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 213185SclerostinPRO_0000033179Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence analysis
Disulfide bondi80 ↔ 134By similarity
Disulfide bondi94 ↔ 148By similarity
Disulfide bondi105 ↔ 165By similarity
Disulfide bondi109 ↔ 167By similarity
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99P67.

Expressioni

Inductioni

Down-regulated by parathyroid hormone (PTH).

Gene expression databases

GenevisibleiQ99P67. RN.

Interactioni

Subunit structurei

Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028238.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17291CTCKAdd
BLAST

Sequence similaritiesi

Belongs to the sclerostin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVV4. Eukaryota.
ENOG4111KFN. LUCA.
GeneTreeiENSGT00390000014900.
HOGENOMiHOG000252934.
HOVERGENiHBG003729.
InParanoidiQ99P67.
KOiK16834.
OMAiDVSEYSC.
OrthoDBiEOG7CVPZN.
PhylomeDBiQ99P67.
TreeFamiTF353019.

Family and domain databases

InterProiIPR008835. Sclerostin/SOSTDC1.
IPR015665. SOST.
[Graphical view]
PANTHERiPTHR14903. PTHR14903. 1 hit.
PTHR14903:SF4. PTHR14903:SF4. 1 hit.
PfamiPF05463. Sclerostin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLSLAPCLA CLLVHAAFVA VESQGWQAFK NDATEIIPGL REYPEPPQEL
60 70 80 90 100
ENNQTMNRAE NGGRPPHHPY DTKDVSEYSC RELHYTRFVT DGPCRSAKPV
110 120 130 140 150
TELVCSGQCG PARLLPNAIG RVKWWRPNGP DFRCIPDRYR AQRVQLLCPG
160 170 180 190 200
GAAPRSRKVR LVASCKCKRL TRFHNQSELK DFGPETARPQ KGRKPRPRAR
210
GAKANQAELE NAY
Length:213
Mass (Da):23,974
Last modified:June 1, 2001 - v1
Checksum:i6C56C878CBCD684B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326741 mRNA. Translation: AAK13456.1.
RefSeqiNP_085073.1. NM_030584.1.
UniGeneiRn.95369.

Genome annotation databases

EnsembliENSRNOT00000028238; ENSRNOP00000028238; ENSRNOG00000020805.
GeneIDi80722.
KEGGirno:80722.
UCSCiRGD:69358. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326741 mRNA. Translation: AAK13456.1.
RefSeqiNP_085073.1. NM_030584.1.
UniGeneiRn.95369.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028238.

Proteomic databases

PaxDbiQ99P67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028238; ENSRNOP00000028238; ENSRNOG00000020805.
GeneIDi80722.
KEGGirno:80722.
UCSCiRGD:69358. rat.

Organism-specific databases

CTDi50964.
RGDi69358. Sost.

Phylogenomic databases

eggNOGiENOG410IVV4. Eukaryota.
ENOG4111KFN. LUCA.
GeneTreeiENSGT00390000014900.
HOGENOMiHOG000252934.
HOVERGENiHBG003729.
InParanoidiQ99P67.
KOiK16834.
OMAiDVSEYSC.
OrthoDBiEOG7CVPZN.
PhylomeDBiQ99P67.
TreeFamiTF353019.

Enzyme and pathway databases

ReactomeiR-RNO-3772470. Negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Miscellaneous databases

NextBioi614858.
PROiQ99P67.

Gene expression databases

GenevisibleiQ99P67. RN.

Family and domain databases

InterProiIPR008835. Sclerostin/SOSTDC1.
IPR015665. SOST.
[Graphical view]
PANTHERiPTHR14903. PTHR14903. 1 hit.
PTHR14903:SF4. PTHR14903:SF4. 1 hit.
PfamiPF05463. Sclerostin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "SOST is a target gene for PTH in bone."
    Keller H., Kneissel M.
    Bone 37:148-158(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOWN-REGULATION BY PTH.

Entry informationi

Entry nameiSOST_RAT
AccessioniPrimary (citable) accession number: Q99P67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.