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Protein

Ras association domain-containing protein 3

Gene

Rassf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 3
Gene namesi
Name:Rassf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2179722. Rassf3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 232231Ras association domain-containing protein 3PRO_0000240397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99P51.
MaxQBiQ99P51.
PaxDbiQ99P51.
PRIDEiQ99P51.

PTM databases

PhosphoSiteiQ99P51.

Expressioni

Gene expression databases

BgeeiQ99P51.
GenevisibleiQ99P51. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026902.

Structurei

3D structure databases

ProteinModelPortaliQ99P51.
SMRiQ99P51. Positions 51-179, 183-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 180103Ras-associatingPROSITE-ProRule annotationAdd
BLAST
Domaini181 – 22848SARAHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 SARAH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4239. Eukaryota.
ENOG410Y2N1. LUCA.
GeneTreeiENSGT00390000003367.
HOGENOMiHOG000013025.
HOVERGENiHBG054362.
InParanoidiQ99P51.
KOiK09852.
OMAiKRCHKED.
OrthoDBiEOG7TF796.
PhylomeDBiQ99P51.
TreeFamiTF319243.

Family and domain databases

InterProiIPR000159. RA_dom.
IPR011524. SARAH_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF16517. Nore1-SARAH. 1 hit.
PF00788. RA. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS50951. SARAH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGYSSLEE DEDFFFTART SFFRRAPPGK SRSGQPDVEK EKETHNYLSK
60 70 80 90 100
EEIKEKVHKY NSAVTDKLKM TLNSNGIYTG FIKVQMELCK PAQPSPEPSS
110 120 130 140 150
GGCMNTLHIS STNTVGEVIE ALLRKFLVTE SPTKFALYKR CHREDQVYAC
160 170 180 190 200
KLSDREHPLY LRLVAGPRTD TLSFVLREHE IGEWEAFSLP ELQNFLRILD
210 220 230
KEEDEQLQSL KRRYTAYRQK LEEALGEVWK PG
Length:232
Mass (Da):26,749
Last modified:June 1, 2001 - v1
Checksum:iEA3E671259412CA2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131N → D in BAE39678 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332864 mRNA. Translation: AAK06849.1.
AK155495 mRNA. Translation: BAE33293.1.
AK167627 mRNA. Translation: BAE39678.1.
BC011511 mRNA. Translation: AAH11511.1.
BC055023 mRNA. Translation: AAH55023.1.
BC071204 mRNA. Translation: AAH71204.1.
CCDSiCCDS24211.1.
RefSeqiNP_620406.1. NM_138956.3.
UniGeneiMm.41265.

Genome annotation databases

EnsembliENSMUST00000026902; ENSMUSP00000026902; ENSMUSG00000025795.
GeneIDi192678.
KEGGimmu:192678.
UCSCiuc007hfs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332864 mRNA. Translation: AAK06849.1.
AK155495 mRNA. Translation: BAE33293.1.
AK167627 mRNA. Translation: BAE39678.1.
BC011511 mRNA. Translation: AAH11511.1.
BC055023 mRNA. Translation: AAH55023.1.
BC071204 mRNA. Translation: AAH71204.1.
CCDSiCCDS24211.1.
RefSeqiNP_620406.1. NM_138956.3.
UniGeneiMm.41265.

3D structure databases

ProteinModelPortaliQ99P51.
SMRiQ99P51. Positions 51-179, 183-227.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026902.

PTM databases

PhosphoSiteiQ99P51.

Proteomic databases

EPDiQ99P51.
MaxQBiQ99P51.
PaxDbiQ99P51.
PRIDEiQ99P51.

Protocols and materials databases

DNASUi192678.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026902; ENSMUSP00000026902; ENSMUSG00000025795.
GeneIDi192678.
KEGGimmu:192678.
UCSCiuc007hfs.1. mouse.

Organism-specific databases

CTDi283349.
MGIiMGI:2179722. Rassf3.

Phylogenomic databases

eggNOGiKOG4239. Eukaryota.
ENOG410Y2N1. LUCA.
GeneTreeiENSGT00390000003367.
HOGENOMiHOG000013025.
HOVERGENiHBG054362.
InParanoidiQ99P51.
KOiK09852.
OMAiKRCHKED.
OrthoDBiEOG7TF796.
PhylomeDBiQ99P51.
TreeFamiTF319243.

Miscellaneous databases

NextBioi371346.
PROiQ99P51.
SOURCEiSearch...

Gene expression databases

BgeeiQ99P51.
GenevisibleiQ99P51. MM.

Family and domain databases

InterProiIPR000159. RA_dom.
IPR011524. SARAH_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF16517. Nore1-SARAH. 1 hit.
PF00788. RA. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS50951. SARAH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1."
    Tommasi S., Dammann R., Jin S.-G., Zhang X.-F., Avruch J., Pfeifer G.P.
    Oncogene 21:2713-2720(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiRASF3_MOUSE
AccessioniPrimary (citable) accession number: Q99P51
Secondary accession number(s): Q3TJ17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.