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Q99P50

- GHSR_MOUSE

UniProt

Q99P50 - GHSR_MOUSE

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Protein

Growth hormone secretagogue receptor type 1

Gene

Ghsr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine) (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB
  2. growth hormone-releasing hormone receptor activity Source: HGNC
  3. growth hormone secretagogue receptor activity Source: HGNC
  4. peptide hormone binding Source: Ensembl

GO - Biological processi

  1. actin polymerization or depolymerization Source: UniProtKB
  2. adult feeding behavior Source: HGNC
  3. cellular response to insulin stimulus Source: MGI
  4. decidualization Source: UniProtKB
  5. G-protein coupled receptor signaling pathway Source: HGNC
  6. growth hormone secretion Source: MGI
  7. hormone-mediated signaling pathway Source: HGNC
  8. negative regulation of inflammatory response Source: UniProtKB
  9. negative regulation of insulin secretion Source: MGI
  10. negative regulation of interleukin-1 beta production Source: UniProtKB
  11. negative regulation of interleukin-6 biosynthetic process Source: UniProtKB
  12. negative regulation of tumor necrosis factor biosynthetic process Source: UniProtKB
  13. positive regulation of appetite Source: HGNC
  14. positive regulation of fatty acid metabolic process Source: Ensembl
  15. positive regulation of insulin-like growth factor receptor signaling pathway Source: MGI
  16. positive regulation of multicellular organism growth Source: HGNC
  17. regulation of hindgut contraction Source: Ensembl
  18. regulation of synapse assembly Source: MGI
  19. response to food Source: MGI
  20. response to hormone Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_235286. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth hormone secretagogue receptor type 1
Short name:
GHS-R
Alternative name(s):
GH-releasing peptide receptor
Short name:
GHRP
Ghrelin receptor
Gene namesi
Name:Ghsr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:2441906. Ghsr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040ExtracellularSequence AnalysisAdd
BLAST
Transmembranei41 – 6626Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini67 – 726CytoplasmicSequence Analysis
Transmembranei73 – 9624Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini97 – 11721ExtracellularSequence AnalysisAdd
BLAST
Transmembranei118 – 13922Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini140 – 16223CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei163 – 18321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini184 – 21128ExtracellularSequence AnalysisAdd
BLAST
Transmembranei212 – 23524Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini236 – 26328CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei264 – 28522Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini286 – 30217ExtracellularSequence AnalysisAdd
BLAST
Transmembranei303 – 32624Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini327 – 36438CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: HGNC
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: UniProtKB
  4. neuron projection Source: UniProtKB
  5. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Growth hormone secretagogue receptor type 1PRO_0000069480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi115 ↔ 197PROSITE-ProRule annotation
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ99P50.

Expressioni

Gene expression databases

BgeeiQ99P50.
CleanExiMM_GHSR.
GenevestigatoriQ99P50.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061153.

Structurei

3D structure databases

ProteinModelPortaliQ99P50.
SMRiQ99P50. Positions 22-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303294.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000272571.
HOVERGENiHBG006538.
InParanoidiQ99P50.
KOiK04284.
OMAiMVWVSSV.
OrthoDBiEOG7992QV.
PhylomeDBiQ99P50.
TreeFamiTF332184.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR003905. GHS-R.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01417. GHSRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99P50-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWNATPSEEP EPNVTLDLDW DASPGNDSLS DELLPLFPAP LLAGVTATCV
60 70 80 90 100
ALFVVGISGN LLTMLVVSRF RELRTTTNLY LSSMAFSDLL IFLCMPLDLV
110 120 130 140 150
RLWQYRPWNF GDLLCKLFQF VSESCTYATV LTITALSVER YFAICFPLRA
160 170 180 190 200
KVVVTKGRVK LVILVIWAVA FCSAGPIFVL VGVEHENGTD PRDTNECRAT
210 220 230 240 250
EFAVRSGLLT VMVWVSSVFF FLPVFCLTVL YSLIGRKLWR RRGDAAVGSS
260 270 280 290 300
LRDQNHKQTV KMLAVVVFAF ILCWLPFHVG RYLFSKSFEP GSLEIAQISQ
310 320 330 340 350
YCNLVSFVLF YLSAAINPIL YNIMSKKYRV AVFKLLGFES FSQRKLSTLK
360
DESSRAWTKS SINT
Length:364
Mass (Da):40,969
Last modified:May 10, 2004 - v3
Checksum:i8F1214E58EF3B2E8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591G → S in AAL13336. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049671 mRNA. Translation: BAC33866.1.
AY056474 mRNA. Translation: AAL13336.1.
AF332997 mRNA. Translation: AAG61141.1.
CCDSiCCDS17273.1.
RefSeqiNP_796304.1. NM_177330.4.
UniGeneiMm.194721.

Genome annotation databases

EnsembliENSMUST00000057186; ENSMUSP00000061153; ENSMUSG00000051136.
GeneIDi208188.
KEGGimmu:208188.
UCSCiuc008oto.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049671 mRNA. Translation: BAC33866.1 .
AY056474 mRNA. Translation: AAL13336.1 .
AF332997 mRNA. Translation: AAG61141.1 .
CCDSi CCDS17273.1.
RefSeqi NP_796304.1. NM_177330.4.
UniGenei Mm.194721.

3D structure databases

ProteinModelPortali Q99P50.
SMRi Q99P50. Positions 22-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000061153.

Chemistry

BindingDBi Q99P50.
ChEMBLi CHEMBL3428.
GuidetoPHARMACOLOGYi 246.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q99P50.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000057186 ; ENSMUSP00000061153 ; ENSMUSG00000051136 .
GeneIDi 208188.
KEGGi mmu:208188.
UCSCi uc008oto.1. mouse.

Organism-specific databases

CTDi 2693.
MGIi MGI:2441906. Ghsr.

Phylogenomic databases

eggNOGi NOG303294.
GeneTreei ENSGT00700000104070.
HOGENOMi HOG000272571.
HOVERGENi HBG006538.
InParanoidi Q99P50.
KOi K04284.
OMAi MVWVSSV.
OrthoDBi EOG7992QV.
PhylomeDBi Q99P50.
TreeFami TF332184.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.
REACT_235286. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi 372206.
PROi Q99P50.
SOURCEi Search...

Gene expression databases

Bgeei Q99P50.
CleanExi MM_GHSR.
Genevestigatori Q99P50.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR003905. GHS-R.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01417. GHSRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spinal cord.
  2. "Cloning of mouse ghrelin/growth hormone secretagogue receptor cDNA by rapid amplification of cDNA ends (RACE)."
    Kacsoh B.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-183.
    Strain: C57BL/6J.
    Tissue: Hypothalamus.
  3. Peng X., Frohman L.A., Kineman R.D.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-257.
    Strain: 129S3/SvImJ.

Entry informationi

Entry nameiGHSR_MOUSE
AccessioniPrimary (citable) accession number: Q99P50
Secondary accession number(s): Q8BWX8, Q91Z82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 10, 2004
Last modified: November 26, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3