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Q99P50

- GHSR_MOUSE

UniProt

Q99P50 - GHSR_MOUSE

Protein

Growth hormone secretagogue receptor type 1

Gene

Ghsr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 3 (10 May 2004)
      Previous versions | rss
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    Functioni

    Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine) By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB
    2. growth hormone-releasing hormone receptor activity Source: HGNC
    3. growth hormone secretagogue receptor activity Source: HGNC
    4. peptide hormone binding Source: Ensembl

    GO - Biological processi

    1. actin polymerization or depolymerization Source: UniProtKB
    2. adult feeding behavior Source: HGNC
    3. cellular response to insulin stimulus Source: MGI
    4. decidualization Source: UniProtKB
    5. G-protein coupled receptor signaling pathway Source: HGNC
    6. growth hormone secretion Source: MGI
    7. hormone-mediated signaling pathway Source: HGNC
    8. negative regulation of inflammatory response Source: UniProtKB
    9. negative regulation of insulin secretion Source: MGI
    10. negative regulation of interleukin-1 beta production Source: UniProtKB
    11. negative regulation of interleukin-6 biosynthetic process Source: UniProtKB
    12. negative regulation of tumor necrosis factor biosynthetic process Source: UniProtKB
    13. positive regulation of appetite Source: HGNC
    14. positive regulation of fatty acid metabolic process Source: Ensembl
    15. positive regulation of insulin-like growth factor receptor signaling pathway Source: MGI
    16. positive regulation of multicellular organism growth Source: HGNC
    17. regulation of hindgut contraction Source: Ensembl
    18. regulation of synapse assembly Source: MGI
    19. response to food Source: MGI
    20. response to hormone Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth hormone secretagogue receptor type 1
    Short name:
    GHS-R
    Alternative name(s):
    GH-releasing peptide receptor
    Short name:
    GHRP
    Ghrelin receptor
    Gene namesi
    Name:Ghsr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:2441906. Ghsr.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: HGNC
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane raft Source: UniProtKB
    4. neuron projection Source: UniProtKB
    5. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Growth hormone secretagogue receptor type 1PRO_0000069480Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi115 ↔ 197PROSITE-ProRule annotation
    Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ99P50.

    Expressioni

    Gene expression databases

    BgeeiQ99P50.
    CleanExiMM_GHSR.
    GenevestigatoriQ99P50.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000061153.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99P50.
    SMRiQ99P50. Positions 45-329.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4040ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini67 – 726CytoplasmicSequence Analysis
    Topological domaini97 – 11721ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini140 – 16223CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini184 – 21128ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 26328CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini286 – 30217ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini327 – 36438CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6626Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei73 – 9624Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei118 – 13922Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei212 – 23524Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei264 – 28522Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei303 – 32624Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG303294.
    GeneTreeiENSGT00700000104070.
    HOGENOMiHOG000272571.
    HOVERGENiHBG006538.
    InParanoidiQ99P50.
    KOiK04284.
    OMAiMVWVSSV.
    OrthoDBiEOG7992QV.
    PhylomeDBiQ99P50.
    TreeFamiTF332184.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR003905. GHS-R.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01417. GHSRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99P50-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWNATPSEEP EPNVTLDLDW DASPGNDSLS DELLPLFPAP LLAGVTATCV    50
    ALFVVGISGN LLTMLVVSRF RELRTTTNLY LSSMAFSDLL IFLCMPLDLV 100
    RLWQYRPWNF GDLLCKLFQF VSESCTYATV LTITALSVER YFAICFPLRA 150
    KVVVTKGRVK LVILVIWAVA FCSAGPIFVL VGVEHENGTD PRDTNECRAT 200
    EFAVRSGLLT VMVWVSSVFF FLPVFCLTVL YSLIGRKLWR RRGDAAVGSS 250
    LRDQNHKQTV KMLAVVVFAF ILCWLPFHVG RYLFSKSFEP GSLEIAQISQ 300
    YCNLVSFVLF YLSAAINPIL YNIMSKKYRV AVFKLLGFES FSQRKLSTLK 350
    DESSRAWTKS SINT 364
    Length:364
    Mass (Da):40,969
    Last modified:May 10, 2004 - v3
    Checksum:i8F1214E58EF3B2E8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti59 – 591G → S in AAL13336. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK049671 mRNA. Translation: BAC33866.1.
    AY056474 mRNA. Translation: AAL13336.1.
    AF332997 mRNA. Translation: AAG61141.1.
    CCDSiCCDS17273.1.
    RefSeqiNP_796304.1. NM_177330.4.
    UniGeneiMm.194721.

    Genome annotation databases

    EnsembliENSMUST00000057186; ENSMUSP00000061153; ENSMUSG00000051136.
    GeneIDi208188.
    KEGGimmu:208188.
    UCSCiuc008oto.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK049671 mRNA. Translation: BAC33866.1 .
    AY056474 mRNA. Translation: AAL13336.1 .
    AF332997 mRNA. Translation: AAG61141.1 .
    CCDSi CCDS17273.1.
    RefSeqi NP_796304.1. NM_177330.4.
    UniGenei Mm.194721.

    3D structure databases

    ProteinModelPortali Q99P50.
    SMRi Q99P50. Positions 45-329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000061153.

    Chemistry

    BindingDBi Q99P50.
    ChEMBLi CHEMBL3428.
    GuidetoPHARMACOLOGYi 246.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q99P50.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057186 ; ENSMUSP00000061153 ; ENSMUSG00000051136 .
    GeneIDi 208188.
    KEGGi mmu:208188.
    UCSCi uc008oto.1. mouse.

    Organism-specific databases

    CTDi 2693.
    MGIi MGI:2441906. Ghsr.

    Phylogenomic databases

    eggNOGi NOG303294.
    GeneTreei ENSGT00700000104070.
    HOGENOMi HOG000272571.
    HOVERGENi HBG006538.
    InParanoidi Q99P50.
    KOi K04284.
    OMAi MVWVSSV.
    OrthoDBi EOG7992QV.
    PhylomeDBi Q99P50.
    TreeFami TF332184.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 372206.
    PROi Q99P50.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99P50.
    CleanExi MM_GHSR.
    Genevestigatori Q99P50.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR003905. GHS-R.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01417. GHSRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Spinal cord.
    2. "Cloning of mouse ghrelin/growth hormone secretagogue receptor cDNA by rapid amplification of cDNA ends (RACE)."
      Kacsoh B.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-183.
      Strain: C57BL/6J.
      Tissue: Hypothalamus.
    3. Peng X., Frohman L.A., Kineman R.D.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-257.
      Strain: 129S3/SvImJ.

    Entry informationi

    Entry nameiGHSR_MOUSE
    AccessioniPrimary (citable) accession number: Q99P50
    Secondary accession number(s): Q8BWX8, Q91Z82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 113 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3