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Protein

Hsp70-binding protein 1

Gene

Hspbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Hsp70-binding protein 1
Short name:
HspBP1
Alternative name(s):
Heat shock protein-binding protein 1
Hsp70-interacting protein 1
Gene namesi
Name:Hspbp1
Synonyms:Hspbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913495. Hspbp1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000840371 – 357Hsp70-binding protein 1Add BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei349PhosphoserineCombined sources1
Modified residuei354PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99P31.
MaxQBiQ99P31.
PaxDbiQ99P31.
PeptideAtlasiQ99P31.
PRIDEiQ99P31.

PTM databases

iPTMnetiQ99P31.
PhosphoSitePlusiQ99P31.

Expressioni

Gene expression databases

BgeeiENSMUSG00000063802.
CleanExiMM_1500019G21RIK.
ExpressionAtlasiQ99P31. baseline and differential.
GenevisibleiQ99P31. MM.

Interactioni

Subunit structurei

Interacts with the ATP-binding domain of HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211323. 1 interactor.
IntActiQ99P31. 2 interactors.
MINTiMINT-4124592.
STRINGi10090.ENSMUSP00000078886.

Structurei

3D structure databases

ProteinModelPortaliQ99P31.
SMRiQ99P31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati130 – 172ARM 1Add BLAST43
Repeati175 – 215ARM 2Add BLAST41
Repeati218 – 257ARM 3Add BLAST40
Repeati260 – 299ARM 4Add BLAST40

Sequence similaritiesi

Contains 4 ARM repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2160. Eukaryota.
ENOG410Y90B. LUCA.
GeneTreeiENSGT00510000048482.
HOGENOMiHOG000007740.
HOVERGENiHBG053282.
InParanoidiQ99P31.
KOiK09562.
OMAiCCLVEDC.
OrthoDBiEOG091G0HDF.
PhylomeDBiQ99P31.
TreeFamiTF324307.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013918. Nucleotide_exch_fac_Fes1.
[Graphical view]
PfamiPF08609. Fes1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99P31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKGSGGSR LPLALPPASQ GCSSGGSGSS AGGSGNPRPP RNLQGLLQMA
60 70 80 90 100
ITAGSQEPDP PPEPMSEERR QWLQEAMSAA FRGQREEVEQ MKNCLRVLSQ
110 120 130 140 150
ATPAMAGEAE LATDQQEREG ALELLADLCE NMDNAADFCQ LSGMHLLVGR
160 170 180 190 200
YLEAGAAGLR WRAAQLIGTC SQNVAAIQEQ VLGLGALRKL LRLLDRDSCD
210 220 230 240 250
TVRVKALFAI SCLVREQEAG LLQFLRLDGF SVLMRAMQQQ VQKLKVKSAF
260 270 280 290 300
LLQNLLVGHP EHKGTLCSMG MVQQLVALVR TEHSPFHEHV LGALCSLVTD
310 320 330 340 350
FPQGVRECRE PELGLEELLR HRCQLLQQRE EYQEELEFCE KLLQTCFSSP

TDDSMDR
Length:357
Mass (Da):39,167
Last modified:June 1, 2001 - v1
Checksum:i6D6BB583730E3474
GO

Sequence cautioni

The sequence BAB28756 differs from that shown. Reason: Frameshift at position 7.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109A → L in BAB28756 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338351 mRNA. Translation: AAK11657.1.
AK013263 mRNA. Translation: BAB28756.1. Frameshift.
AK088469 mRNA. Translation: BAC40373.1.
BC014758 mRNA. Translation: AAH14758.1.
CCDSiCCDS20740.1.
RefSeqiNP_077134.1. NM_024172.3.
XP_006540351.1. XM_006540288.3.
UniGeneiMm.6803.

Genome annotation databases

EnsembliENSMUST00000079970; ENSMUSP00000078886; ENSMUSG00000063802.
GeneIDi66245.
KEGGimmu:66245.
UCSCiuc009eyc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338351 mRNA. Translation: AAK11657.1.
AK013263 mRNA. Translation: BAB28756.1. Frameshift.
AK088469 mRNA. Translation: BAC40373.1.
BC014758 mRNA. Translation: AAH14758.1.
CCDSiCCDS20740.1.
RefSeqiNP_077134.1. NM_024172.3.
XP_006540351.1. XM_006540288.3.
UniGeneiMm.6803.

3D structure databases

ProteinModelPortaliQ99P31.
SMRiQ99P31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211323. 1 interactor.
IntActiQ99P31. 2 interactors.
MINTiMINT-4124592.
STRINGi10090.ENSMUSP00000078886.

PTM databases

iPTMnetiQ99P31.
PhosphoSitePlusiQ99P31.

Proteomic databases

EPDiQ99P31.
MaxQBiQ99P31.
PaxDbiQ99P31.
PeptideAtlasiQ99P31.
PRIDEiQ99P31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079970; ENSMUSP00000078886; ENSMUSG00000063802.
GeneIDi66245.
KEGGimmu:66245.
UCSCiuc009eyc.1. mouse.

Organism-specific databases

CTDi23640.
MGIiMGI:1913495. Hspbp1.

Phylogenomic databases

eggNOGiKOG2160. Eukaryota.
ENOG410Y90B. LUCA.
GeneTreeiENSGT00510000048482.
HOGENOMiHOG000007740.
HOVERGENiHBG053282.
InParanoidiQ99P31.
KOiK09562.
OMAiCCLVEDC.
OrthoDBiEOG091G0HDF.
PhylomeDBiQ99P31.
TreeFamiTF324307.

Miscellaneous databases

PROiQ99P31.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063802.
CleanExiMM_1500019G21RIK.
ExpressionAtlasiQ99P31. baseline and differential.
GenevisibleiQ99P31. MM.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013918. Nucleotide_exch_fac_Fes1.
[Graphical view]
PfamiPF08609. Fes1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHPBP1_MOUSE
AccessioniPrimary (citable) accession number: Q99P31
Secondary accession number(s): Q9CYV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.