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Protein

Hsp70-binding protein 1

Gene

Hspbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Hsp70-binding protein 1
Short name:
HspBP1
Alternative name(s):
Heat shock protein-binding protein 1
Hsp70-interacting protein 1
Gene namesi
Name:Hspbp1
Synonyms:Hspbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913495 Hspbp1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000840371 – 357Hsp70-binding protein 1Add BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei349PhosphoserineCombined sources1
Modified residuei354PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99P31
MaxQBiQ99P31
PaxDbiQ99P31
PeptideAtlasiQ99P31
PRIDEiQ99P31

PTM databases

iPTMnetiQ99P31
PhosphoSitePlusiQ99P31

Expressioni

Gene expression databases

BgeeiENSMUSG00000063802
CleanExiMM_1500019G21RIK
ExpressionAtlasiQ99P31 baseline and differential
GenevisibleiQ99P31 MM

Interactioni

Subunit structurei

Interacts with the ATP-binding domain of HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211323, 1 interactor
IntActiQ99P31, 2 interactors
MINTiQ99P31
STRINGi10090.ENSMUSP00000078886

Structurei

3D structure databases

ProteinModelPortaliQ99P31
SMRiQ99P31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati130 – 172ARM 1Add BLAST43
Repeati175 – 215ARM 2Add BLAST41
Repeati218 – 257ARM 3Add BLAST40
Repeati260 – 299ARM 4Add BLAST40

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2160 Eukaryota
ENOG410Y90B LUCA
GeneTreeiENSGT00510000048482
HOGENOMiHOG000007740
HOVERGENiHBG053282
InParanoidiQ99P31
KOiK09562
OMAiLCCLVED
OrthoDBiEOG091G0HDF
PhylomeDBiQ99P31
TreeFamiTF324307

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013918 Nucleotide_exch_fac_Fes1
PfamiView protein in Pfam
PF08609 Fes1, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

Q99P31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKGSGGSR LPLALPPASQ GCSSGGSGSS AGGSGNPRPP RNLQGLLQMA
60 70 80 90 100
ITAGSQEPDP PPEPMSEERR QWLQEAMSAA FRGQREEVEQ MKNCLRVLSQ
110 120 130 140 150
ATPAMAGEAE LATDQQEREG ALELLADLCE NMDNAADFCQ LSGMHLLVGR
160 170 180 190 200
YLEAGAAGLR WRAAQLIGTC SQNVAAIQEQ VLGLGALRKL LRLLDRDSCD
210 220 230 240 250
TVRVKALFAI SCLVREQEAG LLQFLRLDGF SVLMRAMQQQ VQKLKVKSAF
260 270 280 290 300
LLQNLLVGHP EHKGTLCSMG MVQQLVALVR TEHSPFHEHV LGALCSLVTD
310 320 330 340 350
FPQGVRECRE PELGLEELLR HRCQLLQQRE EYQEELEFCE KLLQTCFSSP

TDDSMDR
Length:357
Mass (Da):39,167
Last modified:June 1, 2001 - v1
Checksum:i6D6BB583730E3474
GO

Sequence cautioni

The sequence BAB28756 differs from that shown. Reason: Frameshift at position 7.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109A → L in BAB28756 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338351 mRNA Translation: AAK11657.1
AK013263 mRNA Translation: BAB28756.1 Frameshift.
AK088469 mRNA Translation: BAC40373.1
BC014758 mRNA Translation: AAH14758.1
CCDSiCCDS20740.1
RefSeqiNP_077134.1, NM_024172.3
XP_006540351.1, XM_006540288.3
UniGeneiMm.6803

Genome annotation databases

EnsembliENSMUST00000079970; ENSMUSP00000078886; ENSMUSG00000063802
GeneIDi66245
KEGGimmu:66245
UCSCiuc009eyc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHPBP1_MOUSE
AccessioniPrimary (citable) accession number: Q99P31
Secondary accession number(s): Q9CYV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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