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Q99P27

- PG12B_MOUSE

UniProt

Q99P27 - PG12B_MOUSE

Protein

Group XIIB secretory phospholipase A2-like protein

Gene

Pla2g12b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Not known; does not seem to have catalytic activity.

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi89 – 891Calcium; via carbonyl oxygenBy similarity
    Metal bindingi91 – 911Calcium; via carbonyl oxygenBy similarity
    Metal bindingi93 – 931Calcium; via carbonyl oxygenBy similarity
    Metal bindingi116 – 1161CalciumBy similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. phospholipase A2 activity Source: InterPro

    GO - Biological processi

    1. cholesterol homeostasis Source: MGI
    2. lipid catabolic process Source: InterPro
    3. triglyceride homeostasis Source: MGI

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Group XIIB secretory phospholipase A2-like protein
    Alternative name(s):
    Group XIII secretory phospholipase A2-like protein
    Short name:
    GXIII sPLA2-like
    sPLA2-GXIIB
    Short name:
    GXIIB
    Gene namesi
    Name:Pla2g12b
    Synonyms:Pla2g13
    ORF Names:Fksg71
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1917086. Pla2g12b.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 195176Group XIIB secretory phospholipase A2-like proteinPRO_0000022773Add
    BLAST

    Proteomic databases

    MaxQBiQ99P27.
    PaxDbiQ99P27.
    PRIDEiQ99P27.

    PTM databases

    PhosphoSiteiQ99P27.

    Expressioni

    Gene expression databases

    CleanExiMM_PLA2G12B.
    GenevestigatoriQ99P27.

    Interactioni

    Protein-protein interaction databases

    IntActiQ99P27. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99P27.
    SMRiQ99P27. Positions 84-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phospholipase A2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG85984.
    HOGENOMiHOG000247019.
    HOVERGENiHBG053577.
    InParanoidiQ99P27.
    PhylomeDBiQ99P27.

    Family and domain databases

    Gene3Di1.20.90.10. 1 hit.
    InterProiIPR016090. PLipase_A2_dom.
    IPR010711. PLipase_A2_secretory_G12.
    [Graphical view]
    PANTHERiPTHR12824. PTHR12824. 1 hit.
    PfamiPF06951. PLA2G12. 1 hit.
    [Graphical view]
    SUPFAMiSSF48619. SSF48619. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99P27-1 [UniParc]FASTAAdd to Basket

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    MKLLCGFFLL WLGLVGNLAQ SDPSPKEEES YSDWGLRQLR GSFESVNSYV    50
    DSFMELLGGK NGVCQYRCRY GKAPMPRPGY KAQEPNGCSS YFLGIKVPGS 100
    MDLGIPAMTK CCNQLDVCYD TCGANKYRCD AKFRWCLHSI CSDLKRTLGF 150
    VSNVEAACDS LADTVFNTVW TLGCRPFMNS QRAACICAEE EKEEL 195
    Length:195
    Mass (Da):21,736
    Last modified:June 1, 2001 - v1
    Checksum:i86F8E653BD08DA24
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF339738 mRNA. Translation: AAK01739.1.
    CCDSiCCDS23864.1.
    UniGeneiMm.30268.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF339738 mRNA. Translation: AAK01739.1 .
    CCDSi CCDS23864.1.
    UniGenei Mm.30268.

    3D structure databases

    ProteinModelPortali Q99P27.
    SMRi Q99P27. Positions 84-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q99P27. 1 interaction.

    PTM databases

    PhosphoSitei Q99P27.

    Proteomic databases

    MaxQBi Q99P27.
    PaxDbi Q99P27.
    PRIDEi Q99P27.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1917086. Pla2g12b.

    Phylogenomic databases

    eggNOGi NOG85984.
    HOGENOMi HOG000247019.
    HOVERGENi HBG053577.
    InParanoidi Q99P27.
    PhylomeDBi Q99P27.

    Miscellaneous databases

    PROi Q99P27.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_PLA2G12B.
    Genevestigatori Q99P27.

    Family and domain databases

    Gene3Di 1.20.90.10. 1 hit.
    InterProi IPR016090. PLipase_A2_dom.
    IPR010711. PLipase_A2_secretory_G12.
    [Graphical view ]
    PANTHERi PTHR12824. PTHR12824. 1 hit.
    Pfami PF06951. PLA2G12. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48619. SSF48619. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of FKSG71, a novel gene encoding group XIII secreted phospholipase A2."
      Wang Y.-G., Gong L.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X DBA.

    Entry informationi

    Entry nameiPG12B_MOUSE
    AccessioniPrimary (citable) accession number: Q99P27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3