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Protein

Group XIIB secretory phospholipase A2-like protein

Gene

Pla2g12b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Not known; does not seem to have catalytic activity.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi89Calcium; via carbonyl oxygenBy similarity1
Metal bindingi91Calcium; via carbonyl oxygenBy similarity1
Metal bindingi93Calcium; via carbonyl oxygenBy similarity1
Metal bindingi116CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • arachidonic acid secretion Source: InterPro
  • cholesterol homeostasis Source: MGI
  • lipid catabolic process Source: InterPro
  • phospholipid metabolic process Source: InterPro
  • triglyceride homeostasis Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Group XIIB secretory phospholipase A2-like protein
Alternative name(s):
Group XIII secretory phospholipase A2-like protein
Short name:
GXIII sPLA2-like
sPLA2-GXIIB
Short name:
GXIIB
Gene namesi
Name:Pla2g12b
Synonyms:Pla2g13
ORF Names:Fksg71
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1917086. Pla2g12b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002277320 – 195Group XIIB secretory phospholipase A2-like proteinAdd BLAST176

Proteomic databases

MaxQBiQ99P27.
PaxDbiQ99P27.
PRIDEiQ99P27.

Expressioni

Gene expression databases

CleanExiMM_PLA2G12B.

Interactioni

Protein-protein interaction databases

IntActiQ99P27. 1 interactor.
STRINGi10090.ENSMUSP00000009790.

Structurei

3D structure databases

ProteinModelPortaliQ99P27.
SMRiQ99P27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVIH. Eukaryota.
ENOG410Z7K4. LUCA.
HOGENOMiHOG000247019.
HOVERGENiHBG053577.
InParanoidiQ99P27.
PhylomeDBiQ99P27.

Family and domain databases

Gene3Di1.20.90.10. 1 hit.
InterProiIPR010711. PLA2G12.
IPR016090. PLipase_A2_dom.
[Graphical view]
PANTHERiPTHR12824. PTHR12824. 1 hit.
PfamiPF06951. PLA2G12. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLCGFFLL WLGLVGNLAQ SDPSPKEEES YSDWGLRQLR GSFESVNSYV
60 70 80 90 100
DSFMELLGGK NGVCQYRCRY GKAPMPRPGY KAQEPNGCSS YFLGIKVPGS
110 120 130 140 150
MDLGIPAMTK CCNQLDVCYD TCGANKYRCD AKFRWCLHSI CSDLKRTLGF
160 170 180 190
VSNVEAACDS LADTVFNTVW TLGCRPFMNS QRAACICAEE EKEEL
Length:195
Mass (Da):21,736
Last modified:June 1, 2001 - v1
Checksum:i86F8E653BD08DA24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF339738 mRNA. Translation: AAK01739.1.
CCDSiCCDS23864.1.
UniGeneiMm.30268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF339738 mRNA. Translation: AAK01739.1.
CCDSiCCDS23864.1.
UniGeneiMm.30268.

3D structure databases

ProteinModelPortaliQ99P27.
SMRiQ99P27.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99P27. 1 interactor.
STRINGi10090.ENSMUSP00000009790.

Proteomic databases

MaxQBiQ99P27.
PaxDbiQ99P27.
PRIDEiQ99P27.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1917086. Pla2g12b.

Phylogenomic databases

eggNOGiENOG410IVIH. Eukaryota.
ENOG410Z7K4. LUCA.
HOGENOMiHOG000247019.
HOVERGENiHBG053577.
InParanoidiQ99P27.
PhylomeDBiQ99P27.

Miscellaneous databases

PROiQ99P27.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PLA2G12B.

Family and domain databases

Gene3Di1.20.90.10. 1 hit.
InterProiIPR010711. PLA2G12.
IPR016090. PLipase_A2_dom.
[Graphical view]
PANTHERiPTHR12824. PTHR12824. 1 hit.
PfamiPF06951. PLA2G12. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPG12B_MOUSE
AccessioniPrimary (citable) accession number: Q99P27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.