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Q99P03

- Q99P03_MOUSE

UniProt

Q99P03 - Q99P03_MOUSE

Protein
Submitted name:

Beta-2 adrenergic receptor

Gene

Adrb2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. beta2-adrenergic receptor activity Source: Ensembl
    2. norepinephrine binding Source: Ensembl
    3. potassium channel regulator activity Source: Ensembl

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: Ensembl
    2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: InterPro
    3. desensitization of G-protein coupled receptor protein signaling pathway by arrestin Source: Ensembl
    4. positive regulation of MAPK cascade Source: Ensembl
    5. positive regulation of protein ubiquitination Source: Ensembl
    6. receptor-mediated endocytosis Source: Ensembl
    7. regulation of smooth muscle contraction Source: InterPro
    8. regulation of vasodilation Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Beta-2 adrenergic receptorImported
    Gene namesi
    Name:Adrb2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: Ensembl
    2. receptor complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiQ99P03.
    BgeeiQ99P03.
    GenevestigatoriQ99P03.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000062256.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99P03.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG106962.
    InParanoidiQ99P03.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000332. ADRB2_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24248:SF21. PTHR24248:SF21. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00562. ADRENRGCB2AR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q99P03-1 [UniParc]FASTAAdd to Basket

    « Hide

    VLVITAIAKF ERLQTVTNYF IISLACADLV MGLAVVPFGA SHILMKMWNF    50
    GNFWCEFWTS IDVLCVTASI ETLCVIAVDR YVAITSPFKY QSLLTKNKAR 100
    VVILMVWIVS GLTSFLPIQM HWYRATHKKA IDCYTEETCC DFFTNQAYAI 150
    ASSIVSFYVP LVVMVFVYSR VFQVAKRQLQ KIDKSEGRFH AQNLSQVEQD 200
    GRSGHGLRRS SKFCLKEHKA LKTLGIIMGT FTLCWLPFFI VNIVHVIRDN 250
    LIPKEVYILL NWLGYVNSAF NPLIY 275
    Length:275
    Mass (Da):31,468
    Last modified:June 1, 2001 - v1
    Checksum:i3A14AE4784D7C670
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei275 – 2751Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY011270 Genomic DNA. Translation: AAG35430.1.
    UniGeneiMm.5598.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY011270 Genomic DNA. Translation: AAG35430.1 .
    UniGenei Mm.5598.

    3D structure databases

    ProteinModelPortali Q99P03.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000062256.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106962.
    InParanoidi Q99P03.

    Gene expression databases

    ArrayExpressi Q99P03.
    Bgeei Q99P03.
    Genevestigatori Q99P03.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000332. ADRB2_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24248:SF21. PTHR24248:SF21. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00562. ADRENRGCB2AR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular phylogenetics and the origins of placental mammals."
      Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A., O'Brien S.J.
      Nature 409:614-618(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ99P03_MOUSE
    AccessioniPrimary (citable) accession number: Q99P03
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)