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Q99P03 (Q99P03_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Adrb2 EMBL AAG35430.1
OrganismMus musculus (Mouse) EMBL AAG35430.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length275 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. RuleBase RU000688

Ontologies

Keywords
   Cellular componentCell membrane SAAS SAAS002233
Membrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS002233
   Molecular functionG-protein coupled receptor RuleBase RU000688 SAAS SAAS002233
Receptor
Transducer
Gene Ontology (GO)
   Biological_processactivation of adenylate cyclase activity

Inferred from electronic annotation. Source: Ensembl

adenylate cyclase-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

desensitization of G-protein coupled receptor protein signaling pathway by arrestin

Inferred from electronic annotation. Source: Ensembl

positive regulation of MAPK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein ubiquitination

Inferred from electronic annotation. Source: Ensembl

receptor-mediated endocytosis

Inferred from electronic annotation. Source: Ensembl

regulation of smooth muscle contraction

Inferred from electronic annotation. Source: InterPro

regulation of vasodilation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of plasma membrane

Inferred from electronic annotation. Source: Ensembl

receptor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionbeta2-adrenergic receptor activity

Inferred from electronic annotation. Source: Ensembl

norepinephrine binding

Inferred from electronic annotation. Source: Ensembl

potassium channel regulator activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAG35430.1
Non-terminal residue2751 EMBL AAG35430.1

Sequences

Sequence LengthMass (Da)Tools
Q99P03 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 3A14AE4784D7C670

FASTA27531,468
        10         20         30         40         50         60 
VLVITAIAKF ERLQTVTNYF IISLACADLV MGLAVVPFGA SHILMKMWNF GNFWCEFWTS 

        70         80         90        100        110        120 
IDVLCVTASI ETLCVIAVDR YVAITSPFKY QSLLTKNKAR VVILMVWIVS GLTSFLPIQM 

       130        140        150        160        170        180 
HWYRATHKKA IDCYTEETCC DFFTNQAYAI ASSIVSFYVP LVVMVFVYSR VFQVAKRQLQ 

       190        200        210        220        230        240 
KIDKSEGRFH AQNLSQVEQD GRSGHGLRRS SKFCLKEHKA LKTLGIIMGT FTLCWLPFFI 

       250        260        270 
VNIVHVIRDN LIPKEVYILL NWLGYVNSAF NPLIY 

« Hide

References

[1]"Molecular phylogenetics and the origins of placental mammals."
Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A., O'Brien S.J.
Nature 409:614-618(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY011270 Genomic DNA. Translation: AAG35430.1.
UniGeneMm.5598.

3D structure databases

ProteinModelPortalQ99P03.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000062256.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106962.
InParanoidQ99P03.

Gene expression databases

ArrayExpressQ99P03.
BgeeQ99P03.
GenevestigatorQ99P03.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR002233. ADR_fam.
IPR000332. ADRB2_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24248. PTHR24248. 1 hit.
PTHR24248:SF21. PTHR24248:SF21. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00562. ADRENRGCB2AR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ99P03_MOUSE
AccessionPrimary (citable) accession number: Q99P03
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)