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Q99P03

- Q99P03_MOUSE

UniProt

Q99P03 - Q99P03_MOUSE

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Protein
Submitted name:

Beta-2 adrenergic receptor

Gene

Adrb2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. beta2-adrenergic receptor activity Source: Ensembl
  2. norepinephrine binding Source: Ensembl
  3. potassium channel regulator activity Source: Ensembl

GO - Biological processi

  1. activation of adenylate cyclase activity Source: Ensembl
  2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: InterPro
  3. desensitization of G-protein coupled receptor protein signaling pathway by arrestin Source: Ensembl
  4. positive regulation of MAPK cascade Source: Ensembl
  5. positive regulation of protein ubiquitination Source: Ensembl
  6. receptor-mediated endocytosis Source: Ensembl
  7. regulation of smooth muscle contraction Source: InterPro
  8. regulation of vasodilation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-2 adrenergic receptorImported
Gene namesi
Name:Adrb2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: Ensembl
  2. receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiQ99P03.
ExpressionAtlasiQ99P03. baseline and differential.
GenevestigatoriQ99P03.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062256.

Structurei

3D structure databases

ProteinModelPortaliQ99P03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

HOVERGENiHBG106962.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000332. ADRB2_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF21. PTHR24248:SF21. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00562. ADRENRGCB2AR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99P03 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
VLVITAIAKF ERLQTVTNYF IISLACADLV MGLAVVPFGA SHILMKMWNF
60 70 80 90 100
GNFWCEFWTS IDVLCVTASI ETLCVIAVDR YVAITSPFKY QSLLTKNKAR
110 120 130 140 150
VVILMVWIVS GLTSFLPIQM HWYRATHKKA IDCYTEETCC DFFTNQAYAI
160 170 180 190 200
ASSIVSFYVP LVVMVFVYSR VFQVAKRQLQ KIDKSEGRFH AQNLSQVEQD
210 220 230 240 250
GRSGHGLRRS SKFCLKEHKA LKTLGIIMGT FTLCWLPFFI VNIVHVIRDN
260 270
LIPKEVYILL NWLGYVNSAF NPLIY
Length:275
Mass (Da):31,468
Last modified:June 1, 2001 - v1
Checksum:i3A14AE4784D7C670
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei275 – 2751Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY011270 Genomic DNA. Translation: AAG35430.1.
UniGeneiMm.5598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY011270 Genomic DNA. Translation: AAG35430.1 .
UniGenei Mm.5598.

3D structure databases

ProteinModelPortali Q99P03.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000062256.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106962.

Gene expression databases

Bgeei Q99P03.
ExpressionAtlasi Q99P03. baseline and differential.
Genevestigatori Q99P03.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000332. ADRB2_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24248:SF21. PTHR24248:SF21. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00562. ADRENRGCB2AR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular phylogenetics and the origins of placental mammals."
    Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A., O'Brien S.J.
    Nature 409:614-618(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ99P03_MOUSE
AccessioniPrimary (citable) accession number: Q99P03
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)