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Q99NX2

- Q99NX2_RAT

UniProt

Q99NX2 - Q99NX2_RAT

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Protein
Submitted name:

ATP7A

Gene

Atp7a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. copper-exporting ATPase activity Source: Ensembl
  2. superoxide dismutase copper chaperone activity Source: Ensembl

GO - Biological processi

  1. blood vessel development Source: Ensembl
  2. blood vessel remodeling Source: Ensembl
  3. cartilage development Source: Ensembl
  4. cellular copper ion homeostasis Source: Ensembl
  5. cerebellar Purkinje cell differentiation Source: Ensembl
  6. collagen fibril organization Source: Ensembl
  7. copper ion import Source: Ensembl
  8. dendrite morphogenesis Source: Ensembl
  9. detoxification of copper ion Source: Ensembl
  10. dopamine metabolic process Source: Ensembl
  11. elastic fiber assembly Source: Ensembl
  12. elastin biosynthetic process Source: Ensembl
  13. epinephrine metabolic process Source: Ensembl
  14. hair follicle morphogenesis Source: Ensembl
  15. locomotory behavior Source: Ensembl
  16. lung alveolus development Source: Ensembl
  17. negative regulation of metalloenzyme activity Source: Ensembl
  18. negative regulation of neuron apoptotic process Source: Ensembl
  19. norepinephrine biosynthetic process Source: Ensembl
  20. peptidyl-lysine modification Source: Ensembl
  21. pigmentation Source: Ensembl
  22. positive regulation of metalloenzyme activity Source: Ensembl
  23. positive regulation of oxidoreductase activity Source: Ensembl
  24. pyramidal neuron development Source: Ensembl
  25. regulation of gene expression Source: Ensembl
  26. regulation of oxidative phosphorylation Source: Ensembl
  27. release of cytochrome c from mitochondria Source: Ensembl
  28. removal of superoxide radicals Source: Ensembl
  29. serotonin metabolic process Source: Ensembl
  30. T-helper cell differentiation Source: Ensembl
  31. tryptophan metabolic process Source: Ensembl
  32. tyrosine metabolic process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ATP7AImported
Gene namesi
Name:Atp7aImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2179. Atp7a.

Subcellular locationi

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. late endosome Source: Ensembl
  3. neuronal cell body Source: Ensembl
  4. neuron projection Source: Ensembl
  5. perinuclear region of cytoplasm Source: Ensembl
  6. trans-Golgi network Source: Ensembl
  7. trans-Golgi network transport vesicle Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ99NX2. baseline and differential.
GenevestigatoriQ99NX2.

Structurei

3D structure databases

ProteinModelPortaliQ99NX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000250397.

Family and domain databases

InterProiIPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR006122. HMA_Cu_ion-bd.
[Graphical view]
PfamiPF00403. HMA. 2 hits.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 2 hits.
TIGRFAMsiTIGR00003. TIGR00003. 2 hits.
PROSITEiPS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99NX2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
IVYQPHLITA EEIKKQIEAV GFPAFIKKQP KYLKLGAIDV ERLKSTPVKS
60 70 80 90 100
SEGSQQKSPA YPSDSAITFT IDGMHCKSCV SNIESALSTL QYVSSIVVSL
110 120 130 140 150
ENRSAIVKYN ASLVTPEILR KAIEAVSPGQ YRVSISSEVE SPTSSPSSSS
160 170 180 190 200
LQKMPLNLVS QPLTQEVVIN INGMTCNSCV QSIEGVISKK PGVKSIHVSL
210 220
TNSTGTIEYD PLLTSPEPLR EAIED
Length:225
Mass (Da):24,309
Last modified:June 1, 2001 - v1
Checksum:i5E61F56D67802F0A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei225 – 2251Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY011398 Genomic DNA. Translation: AAG47432.1.
UniGeneiRn.10554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY011398 Genomic DNA. Translation: AAG47432.1 .
UniGenei Rn.10554.

3D structure databases

ProteinModelPortali Q99NX2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 2179. Atp7a.

Phylogenomic databases

HOGENOMi HOG000250397.

Gene expression databases

ExpressionAtlasi Q99NX2. baseline and differential.
Genevestigatori Q99NX2.

Family and domain databases

InterProi IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR006122. HMA_Cu_ion-bd.
[Graphical view ]
Pfami PF00403. HMA. 2 hits.
[Graphical view ]
SUPFAMi SSF55008. SSF55008. 2 hits.
TIGRFAMsi TIGR00003. TIGR00003. 2 hits.
PROSITEi PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular phylogenetics and the origins of placental mammals."
    Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A., O'Brien S.J.
    Nature 409:614-618(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ99NX2_RAT
AccessioniPrimary (citable) accession number: Q99NX2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)