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Q99NX2

- Q99NX2_RAT

UniProt

Q99NX2 - Q99NX2_RAT

Protein
Submitted name:

ATP7A

Gene

Atp7a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. copper-exporting ATPase activity Source: Ensembl
    2. superoxide dismutase copper chaperone activity Source: Ensembl

    GO - Biological processi

    1. blood vessel development Source: Ensembl
    2. blood vessel remodeling Source: Ensembl
    3. cartilage development Source: Ensembl
    4. cellular copper ion homeostasis Source: Ensembl
    5. cerebellar Purkinje cell differentiation Source: Ensembl
    6. collagen fibril organization Source: Ensembl
    7. copper ion import Source: Ensembl
    8. dendrite morphogenesis Source: Ensembl
    9. detoxification of copper ion Source: Ensembl
    10. dopamine metabolic process Source: Ensembl
    11. elastic fiber assembly Source: Ensembl
    12. elastin biosynthetic process Source: Ensembl
    13. epinephrine metabolic process Source: Ensembl
    14. hair follicle morphogenesis Source: Ensembl
    15. locomotory behavior Source: Ensembl
    16. lung alveolus development Source: Ensembl
    17. negative regulation of metalloenzyme activity Source: Ensembl
    18. negative regulation of neuron apoptotic process Source: Ensembl
    19. norepinephrine biosynthetic process Source: Ensembl
    20. peptidyl-lysine modification Source: Ensembl
    21. pigmentation Source: Ensembl
    22. positive regulation of metalloenzyme activity Source: Ensembl
    23. positive regulation of oxidoreductase activity Source: Ensembl
    24. pyramidal neuron development Source: Ensembl
    25. regulation of gene expression Source: Ensembl
    26. regulation of oxidative phosphorylation Source: Ensembl
    27. release of cytochrome c from mitochondria Source: Ensembl
    28. removal of superoxide radicals Source: Ensembl
    29. serotonin metabolic process Source: Ensembl
    30. T-helper cell differentiation Source: Ensembl
    31. tryptophan metabolic process Source: Ensembl
    32. tyrosine metabolic process Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ATP7AImported
    Gene namesi
    Name:Atp7aImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi2179. Atp7a.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. late endosome Source: Ensembl
    3. neuronal cell body Source: Ensembl
    4. neuron projection Source: Ensembl
    5. perinuclear region of cytoplasm Source: Ensembl
    6. trans-Golgi network Source: Ensembl
    7. trans-Golgi network transport vesicle Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ99NX2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99NX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000250397.
    InParanoidiQ99NX2.

    Family and domain databases

    InterProiIPR017969. Heavy-metal-associated_CS.
    IPR006121. HeavyMe-assoc_HMA.
    IPR006122. HMA_Cu_ion-bd.
    [Graphical view]
    PfamiPF00403. HMA. 2 hits.
    [Graphical view]
    SUPFAMiSSF55008. SSF55008. 2 hits.
    TIGRFAMsiTIGR00003. TIGR00003. 2 hits.
    PROSITEiPS01047. HMA_1. 2 hits.
    PS50846. HMA_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q99NX2-1 [UniParc]FASTAAdd to Basket

    « Hide

    IVYQPHLITA EEIKKQIEAV GFPAFIKKQP KYLKLGAIDV ERLKSTPVKS    50
    SEGSQQKSPA YPSDSAITFT IDGMHCKSCV SNIESALSTL QYVSSIVVSL 100
    ENRSAIVKYN ASLVTPEILR KAIEAVSPGQ YRVSISSEVE SPTSSPSSSS 150
    LQKMPLNLVS QPLTQEVVIN INGMTCNSCV QSIEGVISKK PGVKSIHVSL 200
    TNSTGTIEYD PLLTSPEPLR EAIED 225
    Length:225
    Mass (Da):24,309
    Last modified:June 1, 2001 - v1
    Checksum:i5E61F56D67802F0A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei225 – 2251Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY011398 Genomic DNA. Translation: AAG47432.1.
    UniGeneiRn.10554.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY011398 Genomic DNA. Translation: AAG47432.1 .
    UniGenei Rn.10554.

    3D structure databases

    ProteinModelPortali Q99NX2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 2179. Atp7a.

    Phylogenomic databases

    HOGENOMi HOG000250397.
    InParanoidi Q99NX2.

    Gene expression databases

    Genevestigatori Q99NX2.

    Family and domain databases

    InterProi IPR017969. Heavy-metal-associated_CS.
    IPR006121. HeavyMe-assoc_HMA.
    IPR006122. HMA_Cu_ion-bd.
    [Graphical view ]
    Pfami PF00403. HMA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55008. SSF55008. 2 hits.
    TIGRFAMsi TIGR00003. TIGR00003. 2 hits.
    PROSITEi PS01047. HMA_1. 2 hits.
    PS50846. HMA_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular phylogenetics and the origins of placental mammals."
      Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A., O'Brien S.J.
      Nature 409:614-618(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ99NX2_RAT
    AccessioniPrimary (citable) accession number: Q99NX2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)