ID   Q99NV8_MOUSE            Unreviewed;       188 AA.
AC   Q99NV8;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   22-FEB-2023, entry version 93.
DE   RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|RuleBase:RU364086};
DE            Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE   Flags: Fragment;
GN   Name=BDNF {ECO:0000313|EMBL:AAG47494.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAG47494.1};
RN   [1] {ECO:0000313|EMBL:AAG47494.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11214319; DOI=10.1038/35054550;
RA   Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A.,
RA   O'Brien S.J.;
RT   "Molecular phylogenetics and the origins of placental mammals.";
RL   Nature 409:614-618(2001).
CC   -!- FUNCTION: During development, promotes the survival and differentiation
CC       of selected neuronal populations of the peripheral and central nervous
CC       systems. Participates in axonal growth, pathfinding and in the
CC       modulation of dendritic growth and morphology. Major regulator of
CC       synaptic transmission and plasticity at adult synapses in many regions
CC       of the CNS. {ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
CC       {ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR   EMBL; AY011461; AAG47494.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q99NV8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   PANTHER; PTHR11589:SF3; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Growth factor {ECO:0000256|RuleBase:RU364086};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          124..188
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAG47494.1"
FT   NON_TER         188
FT                   /evidence="ECO:0000313|EMBL:AAG47494.1"
SQ   SEQUENCE   188 AA;  20947 MW;  BDD300ABAE065BDB CRC64;
     YFGCMKAAPM KEVNVHGQGN LAYPGVRTHG TLESVNGPRA GSRGLTTTSL ADTFEHVIEE
     LLDEDQKVRP NEENHKDADL YTSRVMLSSQ VPLEPPLLFL LEEYKNYLDA ANMSMRVRRH
     SDPARRGELS VCDSISEWVT AADKKTAVDM SGGTVTVLEK VPVSKGQLKQ YFYETKCNPM
     GYTKEGCR
//