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Q99NV8

- Q99NV8_MOUSE

UniProt

Q99NV8 - Q99NV8_MOUSE

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Protein
Submitted name:

Brain-derived neurotrophic factor

Gene

BDNF

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi

Functioni

GO - Biological processi

  1. cellular response to nerve growth factor stimulus Source: Ensembl
  2. cellular response to norepinephrine stimulus Source: Ensembl
  3. cellular response to tumor necrosis factor Source: Ensembl
  4. chronic inflammatory response Source: Ensembl
  5. learning Source: Ensembl
  6. mitochondrial electron transport, NADH to ubiquinone Source: Ensembl
  7. negative regulation of neuron death Source: Ensembl
  8. negative regulation of striated muscle tissue development Source: Ensembl
  9. neuron projection extension Source: Ensembl
  10. positive regulation of long-term neuronal synaptic plasticity Source: Ensembl
  11. positive regulation of synapse assembly Source: Ensembl
  12. regulation of axon extension Source: Ensembl
  13. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  14. regulation of short-term neuronal synaptic plasticity Source: Ensembl
  15. response to activity Source: Ensembl
  16. response to anesthetic Source: Ensembl
  17. response to auditory stimulus Source: Ensembl
  18. response to electrical stimulus Source: Ensembl
  19. response to fluoxetine Source: Ensembl
  20. response to food Source: Ensembl
  21. response to hormone Source: Ensembl
  22. response to hyperoxia Source: Ensembl
  23. response to hypoxia Source: Ensembl
  24. response to L-glutamate Source: Ensembl
  25. response to light intensity Source: Ensembl
  26. response to potassium ion Source: Ensembl
  27. response to vitamin A Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factorSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Brain-derived neurotrophic factorImported
Gene namesi
Name:BDNFImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. extracellular space Source: Ensembl
  3. mitochondrial crista Source: Ensembl
  4. perikaryon Source: Ensembl
  5. synaptic vesicle Source: Ensembl
  6. terminal bouton Source: Ensembl
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiQ99NV8.
ExpressionAtlasiQ99NV8. baseline and differential.
GenevestigatoriQ99NV8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057989.

Structurei

3D structure databases

ProteinModelPortaliQ99NV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG006494.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR020430. Brain-der_neurotrophic_factor.
IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01912. BDNFACTOR.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99NV8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
YFGCMKAAPM KEVNVHGQGN LAYPGVRTHG TLESVNGPRA GSRGLTTTSL
60 70 80 90 100
ADTFEHVIEE LLDEDQKVRP NEENHKDADL YTSRVMLSSQ VPLEPPLLFL
110 120 130 140 150
LEEYKNYLDA ANMSMRVRRH SDPARRGELS VCDSISEWVT AADKKTAVDM
160 170 180
SGGTVTVLEK VPVSKGQLKQ YFYETKCNPM GYTKEGCR
Length:188
Mass (Da):20,947
Last modified:June 1, 2001 - v1
Checksum:iBDD300ABAE065BDB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei188 – 1881Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY011461 Genomic DNA. Translation: AAG47494.1.
UniGeneiMm.1442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY011461 Genomic DNA. Translation: AAG47494.1 .
UniGenei Mm.1442.

3D structure databases

ProteinModelPortali Q99NV8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000057989.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG006494.

Gene expression databases

Bgeei Q99NV8.
ExpressionAtlasi Q99NV8. baseline and differential.
Genevestigatori Q99NV8.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR020430. Brain-der_neurotrophic_factor.
IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
[Graphical view ]
PANTHERi PTHR11589. PTHR11589. 1 hit.
Pfami PF00243. NGF. 1 hit.
[Graphical view ]
PIRSFi PIRSF001789. NGF. 1 hit.
PRINTSi PR01912. BDNFACTOR.
PR00268. NGF.
ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00140. NGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS50270. NGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular phylogenetics and the origins of placental mammals."
    Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A., O'Brien S.J.
    Nature 409:614-618(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ99NV8_MOUSE
AccessioniPrimary (citable) accession number: Q99NV8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)