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Q99NV8

- Q99NV8_MOUSE

UniProt

Q99NV8 - Q99NV8_MOUSE

Protein
Submitted name:

Brain-derived neurotrophic factor

Gene

BDNF

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. chronic inflammatory response Source: Ensembl
    2. cognition Source: Ensembl
    3. mitochondrial electron transport, NADH to ubiquinone Source: Ensembl
    4. negative regulation of striated muscle tissue development Source: Ensembl
    5. positive regulation of long-term neuronal synaptic plasticity Source: Ensembl
    6. positive regulation of synapse assembly Source: Ensembl
    7. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    8. regulation of short-term neuronal synaptic plasticity Source: Ensembl
    9. response to anesthetic Source: Ensembl
    10. response to fluoxetine Source: Ensembl
    11. response to hormone Source: Ensembl
    12. response to hyperoxia Source: Ensembl
    13. response to hypoxia Source: Ensembl
    14. response to vitamin A Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Brain-derived neurotrophic factorImported
    Gene namesi
    Name:BDNFImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Subcellular locationi

    GO - Cellular componenti

    1. synaptic vesicle Source: Ensembl

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiQ99NV8.
    BgeeiQ99NV8.
    GenevestigatoriQ99NV8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000057989.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99NV8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG006494.
    InParanoidiQ99NV8.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR020430. Brain-der_neurotrophic_factor.
    IPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    [Graphical view]
    PANTHERiPTHR11589. PTHR11589. 1 hit.
    PfamiPF00243. NGF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001789. NGF. 1 hit.
    PRINTSiPR01912. BDNFACTOR.
    PR00268. NGF.
    ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00140. NGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS50270. NGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q99NV8-1 [UniParc]FASTAAdd to Basket

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    YFGCMKAAPM KEVNVHGQGN LAYPGVRTHG TLESVNGPRA GSRGLTTTSL    50
    ADTFEHVIEE LLDEDQKVRP NEENHKDADL YTSRVMLSSQ VPLEPPLLFL 100
    LEEYKNYLDA ANMSMRVRRH SDPARRGELS VCDSISEWVT AADKKTAVDM 150
    SGGTVTVLEK VPVSKGQLKQ YFYETKCNPM GYTKEGCR 188
    Length:188
    Mass (Da):20,947
    Last modified:June 1, 2001 - v1
    Checksum:iBDD300ABAE065BDB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei188 – 1881Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY011461 Genomic DNA. Translation: AAG47494.1.
    UniGeneiMm.1442.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY011461 Genomic DNA. Translation: AAG47494.1 .
    UniGenei Mm.1442.

    3D structure databases

    ProteinModelPortali Q99NV8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000057989.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG006494.
    InParanoidi Q99NV8.

    Gene expression databases

    ArrayExpressi Q99NV8.
    Bgeei Q99NV8.
    Genevestigatori Q99NV8.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR020430. Brain-der_neurotrophic_factor.
    IPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    [Graphical view ]
    PANTHERi PTHR11589. PTHR11589. 1 hit.
    Pfami PF00243. NGF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001789. NGF. 1 hit.
    PRINTSi PR01912. BDNFACTOR.
    PR00268. NGF.
    ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00140. NGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS50270. NGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular phylogenetics and the origins of placental mammals."
      Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A., O'Brien S.J.
      Nature 409:614-618(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ99NV8_MOUSE
    AccessioniPrimary (citable) accession number: Q99NV8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)