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Q99NV8

- Q99NV8_MOUSE

UniProt

Q99NV8 - Q99NV8_MOUSE

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Protein
Submitted name:

Brain-derived neurotrophic factor

Gene
BDNF
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

GO - Biological processi

  1. chronic inflammatory response Source: Ensembl
  2. cognition Source: Ensembl
  3. mitochondrial electron transport, NADH to ubiquinone Source: Ensembl
  4. negative regulation of striated muscle tissue development Source: Ensembl
  5. positive regulation of long-term neuronal synaptic plasticity Source: Ensembl
  6. positive regulation of synapse assembly Source: Ensembl
  7. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  8. regulation of short-term neuronal synaptic plasticity Source: Ensembl
  9. response to anesthetic Source: Ensembl
  10. response to fluoxetine Source: Ensembl
  11. response to hormone Source: Ensembl
  12. response to hyperoxia Source: Ensembl
  13. response to hypoxia Source: Ensembl
  14. response to vitamin A Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Brain-derived neurotrophic factorImported
Gene namesi
Name:BDNFImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. synaptic vesicle Source: Ensembl
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiQ99NV8.
BgeeiQ99NV8.
GenevestigatoriQ99NV8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057989.

Structurei

3D structure databases

ProteinModelPortaliQ99NV8.

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG006494.
InParanoidiQ99NV8.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR020430. Brain-der_neurotrophic_factor.
IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01912. BDNFACTOR.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99NV8-1 [UniParc]FASTAAdd to Basket

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YFGCMKAAPM KEVNVHGQGN LAYPGVRTHG TLESVNGPRA GSRGLTTTSL    50
ADTFEHVIEE LLDEDQKVRP NEENHKDADL YTSRVMLSSQ VPLEPPLLFL 100
LEEYKNYLDA ANMSMRVRRH SDPARRGELS VCDSISEWVT AADKKTAVDM 150
SGGTVTVLEK VPVSKGQLKQ YFYETKCNPM GYTKEGCR 188
Length:188
Mass (Da):20,947
Last modified:June 1, 2001 - v1
Checksum:iBDD300ABAE065BDB
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei188 – 1881Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY011461 Genomic DNA. Translation: AAG47494.1.
UniGeneiMm.1442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY011461 Genomic DNA. Translation: AAG47494.1 .
UniGenei Mm.1442.

3D structure databases

ProteinModelPortali Q99NV8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000057989.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG006494.
InParanoidi Q99NV8.

Gene expression databases

ArrayExpressi Q99NV8.
Bgeei Q99NV8.
Genevestigatori Q99NV8.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR020430. Brain-der_neurotrophic_factor.
IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
[Graphical view ]
PANTHERi PTHR11589. PTHR11589. 1 hit.
Pfami PF00243. NGF. 1 hit.
[Graphical view ]
PIRSFi PIRSF001789. NGF. 1 hit.
PRINTSi PR01912. BDNFACTOR.
PR00268. NGF.
ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00140. NGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS50270. NGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular phylogenetics and the origins of placental mammals."
    Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A., O'Brien S.J.
    Nature 409:614-618(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ99NV8_MOUSE
AccessioniPrimary (citable) accession number: Q99NV8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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