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Protein

Brain-derived neurotrophic factor

Gene

BDNF

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-derived neurotrophic factorUniRule annotation
Short name:
BDNFUniRule annotation
Gene namesi
Name:BDNFImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ99NV8.

Interactioni

Subunit structurei

Monomers and homodimers. Binds to NTRK2/TRKB.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ99NV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 188NGFInterPro annotationAdd BLAST65

Sequence similaritiesi

Belongs to the NGF-beta family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IH7X. Eukaryota.
ENOG410XRPH. LUCA.
HOVERGENiHBG006494.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR020430. Brain-der_neurotrophic_factor.
IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF3. PTHR11589:SF3. 1 hit.
PfamiView protein in Pfam
PF00243. NGF. 1 hit.
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01912. BDNFACTOR.
PR00268. NGF.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052. Nerve_growth_factor-rel. 1 hit.
SMARTiView protein in SMART
SM00140. NGF. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q99NV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
YFGCMKAAPM KEVNVHGQGN LAYPGVRTHG TLESVNGPRA GSRGLTTTSL
60 70 80 90 100
ADTFEHVIEE LLDEDQKVRP NEENHKDADL YTSRVMLSSQ VPLEPPLLFL
110 120 130 140 150
LEEYKNYLDA ANMSMRVRRH SDPARRGELS VCDSISEWVT AADKKTAVDM
160 170 180
SGGTVTVLEK VPVSKGQLKQ YFYETKCNPM GYTKEGCR
Length:188
Mass (Da):20,947
Last modified:June 1, 2001 - v1
Checksum:iBDD300ABAE065BDB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei188Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY011461 Genomic DNA. Translation: AAG47494.1.
UniGeneiMm.1442.

Similar proteinsi

Entry informationi

Entry nameiQ99NV8_MOUSE
AccessioniPrimary (citable) accession number: Q99NV8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)