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Protein
Submitted name:

Brain-derived neurotrophic factor

Gene

BDNF

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionGrowth factorSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Brain-derived neurotrophic factorImported
Gene namesi
Name:BDNFImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ99NV8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048482.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ99NV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 188NGFInterPro annotationAdd BLAST65

Sequence similaritiesi

Belongs to the NGF-beta family.SAAS annotation

Phylogenomic databases

eggNOGiENOG410IH7X. Eukaryota.
ENOG410XRPH. LUCA.
HOVERGENiHBG006494.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR020430. Brain-der_neurotrophic_factor.
IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF15. PTHR11589:SF15. 1 hit.
PfamiView protein in Pfam
PF00243. NGF. 1 hit.
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01912. BDNFACTOR.
PR00268. NGF.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052. Nerve_growth_factor-rel. 1 hit.
SMARTiView protein in SMART
SM00140. NGF. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q99NV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
YFGCMKAAPM KEVNVHGQGN LAYPGVRTHG TLESVNGPRA GSRGLTTTSL
60 70 80 90 100
ADTFEHVIEE LLDEDQKVRP NEENHKDADL YTSRVMLSSQ VPLEPPLLFL
110 120 130 140 150
LEEYKNYLDA ANMSMRVRRH SDPARRGELS VCDSISEWVT AADKKTAVDM
160 170 180
SGGTVTVLEK VPVSKGQLKQ YFYETKCNPM GYTKEGCR
Length:188
Mass (Da):20,947
Last modified:June 1, 2001 - v1
Checksum:iBDD300ABAE065BDB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei188Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY011461 Genomic DNA. Translation: AAG47494.1.
UniGeneiMm.1442.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ99NV8_MOUSE
AccessioniPrimary (citable) accession number: Q99NV8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: July 5, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)