Q99NU3 (Q99NU3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cannabinoid receptor 1 EMBL AAG37743.1

Gene names

Name:

Cnr1 EMBL AAG37743.1 MGI 104615

Organism

Mus musculus (Mouse) EMBL AAG37743.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	331 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. RuleBase RU000688

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane RuleBase RU000688
Molecular function	G-protein coupled receptor RuleBase RU000688 Receptor Transducer
Gene Ontology (GO)
Biological_process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara aging Inferred from electronic annotation. Source: Compara maternal process involved in female pregnancy Inferred from electronic annotation. Source: Compara memory Inferred from electronic annotation. Source: Compara negative regulation of action potential Inferred from electronic annotation. Source: Compara negative regulation of blood pressure Inferred from electronic annotation. Source: Compara negative regulation of dopamine secretion Inferred from electronic annotation. Source: Compara negative regulation of fatty acid beta-oxidation Inferred from electronic annotation. Source: Compara negative regulation of mast cell activation Inferred from electronic annotation. Source: Compara negative regulation of nitric-oxide synthase activity Inferred from electronic annotation. Source: Compara positive regulation of acute inflammatory response to antigenic stimulus Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of blood pressure Inferred from electronic annotation. Source: Compara positive regulation of fever generation Inferred from electronic annotation. Source: Compara positive regulation of neuron projection development Inferred from electronic annotation. Source: Compara regulation of feeding behavior Inferred from electronic annotation. Source: Compara regulation of insulin secretion Inferred from electronic annotation. Source: Compara regulation of penile erection Inferred from electronic annotation. Source: Compara regulation of synaptic transmission, GABAergic Inferred from electronic annotation. Source: Compara regulation of synaptic transmission, glutamatergic Inferred from electronic annotation. Source: Compara response to cocaine Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara response to morphine Inferred from electronic annotation. Source: Compara response to nicotine Inferred from electronic annotation. Source: Compara response to nutrient Inferred from electronic annotation. Source: Compara response to stress Inferred from electronic annotation. Source: Compara sensory perception of pain Inferred from electronic annotation. Source: Compara spermatogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cannabinoid receptor activity Inferred from electronic annotation. Source: Compara drug binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAG37743.1
	Non-terminal residue	331	1	EMBL AAG37743.1

Sequences

	Sequence		Length	Mass (Da)
	Q99NU3 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 795EC0BA3F594881	FASTA	331	37,316
	10 20 30 40 50 60 FRGSPFQEKM TAGDNSPLVP AGDTTNITEF YNKSLSSFKE NEDNIQCGEN FMDMECFMIL 70 80 90 100 110 120 NPSQQLAIAV LSLTLGTFTV LENLLVLCVI LHSRSLRCRP SYHFIGSLAV ADLLGSVIFV 130 140 150 160 170 180 YSFVDFHVFH RKDSPNVFLF KLGGVTASFT ASVGSLFLTA IDRYISIHRP LAYKRIVTRP 190 200 210 220 230 240 KAVVAFCLMW TIAIVIAVLP LLGWNCKKLQ SVCSDIFPLI DETYLMFWIG VTSVLLLFIV 250 260 270 280 290 300 YAYMYILWKA HSHAVRMIQR GTQKSIIIHT SEDGKVQVTR PDQARMDIRL AKTLVLILVV 310 320 330 LIICWGPLLA IMVYDVFGKM NKLIKTVFAF C

References

[1]	"Molecular phylogenetics and the origins of placental mammals." Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A., O'Brien S.J. Nature 409:614-618(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY011579 Genomic DNA. Translation: AAG37743.1.
IPI	IPI00111245.
UniGene	Mm.7992.
3D structure databases
ProteinModelPortal	Q99NU3.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000081787. Q99NU3.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q99NU3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG051045.
InParanoid	Q99NU3.
Gene expression databases
ArrayExpress	Q99NU3.
Bgee	Q99NU3.
Genevestigator	Q99NU3.
Family and domain databases
InterPro	IPR002230. Cnbnoid_rcpt. IPR000810. Cnoid_rcpt_1. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR22750:SF10. PTHR22750:SF10. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00522. CANABINOID1R. PR00362. CANNABINOIDR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q99NU3.

Entry information

Entry name

Q99NU3_MOUSE

Accession

Primary (citable) accession number: Q99NU3

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)