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Q99NU3

- Q99NU3_MOUSE

UniProt

Q99NU3 - Q99NU3_MOUSE

Protein
Submitted name:

Cannabinoid receptor 1

Gene

Cnr1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cannabinoid receptor activity Source: Ensembl
    2. drug binding Source: Ensembl

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: Ensembl
    2. aging Source: Ensembl
    3. maternal process involved in female pregnancy Source: Ensembl
    4. memory Source: Ensembl
    5. negative regulation of action potential Source: Ensembl
    6. negative regulation of blood pressure Source: Ensembl
    7. negative regulation of dopamine secretion Source: Ensembl
    8. negative regulation of fatty acid beta-oxidation Source: Ensembl
    9. negative regulation of mast cell activation Source: Ensembl
    10. negative regulation of nitric-oxide synthase activity Source: Ensembl
    11. positive regulation of acute inflammatory response to antigenic stimulus Source: Ensembl
    12. positive regulation of apoptotic process Source: Ensembl
    13. positive regulation of blood pressure Source: Ensembl
    14. positive regulation of fever generation Source: Ensembl
    15. positive regulation of neuron projection development Source: Ensembl
    16. regulation of feeding behavior Source: Ensembl
    17. regulation of insulin secretion Source: Ensembl
    18. regulation of penile erection Source: Ensembl
    19. regulation of synaptic transmission, GABAergic Source: Ensembl
    20. regulation of synaptic transmission, glutamatergic Source: Ensembl
    21. response to cocaine Source: Ensembl
    22. response to ethanol Source: Ensembl
    23. response to lipopolysaccharide Source: Ensembl
    24. response to morphine Source: Ensembl
    25. response to nicotine Source: Ensembl
    26. response to nutrient Source: Ensembl
    27. sensory perception of pain Source: Ensembl
    28. spermatogenesis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cannabinoid receptor 1Imported
    Gene namesi
    Name:Cnr1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiQ99NU3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99NU3.
    BgeeiQ99NU3.
    GenevestigatoriQ99NU3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000081787.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99NU3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG051045.
    InParanoidiQ99NU3.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000810. Canbinoid_rcpt_1.
    IPR002230. Cnbnoid_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR22750:SF10. PTHR22750:SF10. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00522. CANABINOID1R.
    PR00362. CANNABINOIDR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q99NU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    FRGSPFQEKM TAGDNSPLVP AGDTTNITEF YNKSLSSFKE NEDNIQCGEN    50
    FMDMECFMIL NPSQQLAIAV LSLTLGTFTV LENLLVLCVI LHSRSLRCRP 100
    SYHFIGSLAV ADLLGSVIFV YSFVDFHVFH RKDSPNVFLF KLGGVTASFT 150
    ASVGSLFLTA IDRYISIHRP LAYKRIVTRP KAVVAFCLMW TIAIVIAVLP 200
    LLGWNCKKLQ SVCSDIFPLI DETYLMFWIG VTSVLLLFIV YAYMYILWKA 250
    HSHAVRMIQR GTQKSIIIHT SEDGKVQVTR PDQARMDIRL AKTLVLILVV 300
    LIICWGPLLA IMVYDVFGKM NKLIKTVFAF C 331
    Length:331
    Mass (Da):37,316
    Last modified:June 1, 2001 - v1
    Checksum:i795EC0BA3F594881
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei331 – 3311Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY011579 Genomic DNA. Translation: AAG37743.1.
    UniGeneiMm.7992.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY011579 Genomic DNA. Translation: AAG37743.1 .
    UniGenei Mm.7992.

    3D structure databases

    ProteinModelPortali Q99NU3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000081787.

    Chemistry

    BindingDBi Q99NU3.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q99NU3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG051045.
    InParanoidi Q99NU3.

    Gene expression databases

    ArrayExpressi Q99NU3.
    Bgeei Q99NU3.
    Genevestigatori Q99NU3.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000810. Canbinoid_rcpt_1.
    IPR002230. Cnbnoid_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR22750:SF10. PTHR22750:SF10. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00522. CANABINOID1R.
    PR00362. CANNABINOIDR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular phylogenetics and the origins of placental mammals."
      Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A., O'Brien S.J.
      Nature 409:614-618(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ99NU3_MOUSE
    AccessioniPrimary (citable) accession number: Q99NU3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)