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Protein
Submitted name:

Cannabinoid receptor 1

Gene

Cnr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. cannabinoid receptor activity Source: InterPro
  2. drug binding Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: Ensembl
  2. aging Source: Ensembl
  3. maternal process involved in female pregnancy Source: Ensembl
  4. memory Source: Ensembl
  5. negative regulation of action potential Source: Ensembl
  6. negative regulation of blood pressure Source: Ensembl
  7. negative regulation of dopamine secretion Source: Ensembl
  8. negative regulation of fatty acid beta-oxidation Source: Ensembl
  9. negative regulation of mast cell activation Source: Ensembl
  10. negative regulation of nitric-oxide synthase activity Source: Ensembl
  11. positive regulation of acute inflammatory response to antigenic stimulus Source: Ensembl
  12. positive regulation of apoptotic process Source: Ensembl
  13. positive regulation of blood pressure Source: Ensembl
  14. positive regulation of fever generation Source: Ensembl
  15. positive regulation of neuron projection development Source: Ensembl
  16. regulation of feeding behavior Source: Ensembl
  17. regulation of insulin secretion Source: Ensembl
  18. regulation of penile erection Source: Ensembl
  19. regulation of synaptic transmission, GABAergic Source: Ensembl
  20. regulation of synaptic transmission, glutamatergic Source: Ensembl
  21. response to cocaine Source: Ensembl
  22. response to ethanol Source: Ensembl
  23. response to lipopolysaccharide Source: Ensembl
  24. response to morphine Source: Ensembl
  25. response to nicotine Source: Ensembl
  26. response to nutrient Source: Ensembl
  27. sensory perception of pain Source: Ensembl
  28. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Cannabinoid receptor 1Imported
Gene namesi
Name:Cnr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular membrane-bounded organelle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ99NU3.

Expressioni

Gene expression databases

BgeeiQ99NU3.
ExpressionAtlasiQ99NU3. baseline and differential.
GenevestigatoriQ99NU3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081787.

Structurei

3D structure databases

ProteinModelPortaliQ99NU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

HOVERGENiHBG051045.

Family and domain databases

InterProiIPR000810. Canbinoid_rcpt_1.
IPR002230. Cnbnoid_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR22750:SF10. PTHR22750:SF10. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00522. CANABINOID1R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99NU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FRGSPFQEKM TAGDNSPLVP AGDTTNITEF YNKSLSSFKE NEDNIQCGEN
60 70 80 90 100
FMDMECFMIL NPSQQLAIAV LSLTLGTFTV LENLLVLCVI LHSRSLRCRP
110 120 130 140 150
SYHFIGSLAV ADLLGSVIFV YSFVDFHVFH RKDSPNVFLF KLGGVTASFT
160 170 180 190 200
ASVGSLFLTA IDRYISIHRP LAYKRIVTRP KAVVAFCLMW TIAIVIAVLP
210 220 230 240 250
LLGWNCKKLQ SVCSDIFPLI DETYLMFWIG VTSVLLLFIV YAYMYILWKA
260 270 280 290 300
HSHAVRMIQR GTQKSIIIHT SEDGKVQVTR PDQARMDIRL AKTLVLILVV
310 320 330
LIICWGPLLA IMVYDVFGKM NKLIKTVFAF C
Length:331
Mass (Da):37,316
Last modified:May 31, 2001 - v1
Checksum:i795EC0BA3F594881
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei331 – 3311Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY011579 Genomic DNA. Translation: AAG37743.1.
UniGeneiMm.7992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY011579 Genomic DNA. Translation: AAG37743.1.
UniGeneiMm.7992.

3D structure databases

ProteinModelPortaliQ99NU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081787.

Chemistry

BindingDBiQ99NU3.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ99NU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG051045.

Gene expression databases

BgeeiQ99NU3.
ExpressionAtlasiQ99NU3. baseline and differential.
GenevestigatoriQ99NU3.

Family and domain databases

InterProiIPR000810. Canbinoid_rcpt_1.
IPR002230. Cnbnoid_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR22750:SF10. PTHR22750:SF10. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00522. CANABINOID1R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular phylogenetics and the origins of placental mammals."
    Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A., O'Brien S.J.
    Nature 409:614-618(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ99NU3_MOUSE
AccessioniPrimary (citable) accession number: Q99NU3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2001
Last sequence update: May 31, 2001
Last modified: January 6, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.