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Protein

Inositol polyphosphate multikinase

Gene

Ipmk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (By similarity).By similarity1 Publication

Catalytic activityi

2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.151. 5301.
ReactomeiR-RNO-1855191. Synthesis of IPs in the nucleus.
SABIO-RKQ99NI4.

Chemistry

SwissLipidsiSLP:000000959.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol polyphosphate multikinase (EC:2.7.1.151)
Alternative name(s):
Inositol 1,3,4,6-tetrakisphosphate 5-kinase
Gene namesi
Name:Ipmk
Synonyms:Impk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi620954. Ipmk.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 396395Inositol polyphosphate multikinasePRO_0000066872Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei19 – 191PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ99NI4.

PTM databases

iPTMnetiQ99NI4.
PhosphoSiteiQ99NI4.

Expressioni

Tissue specificityi

Highly expressed in kidney, and at lower levels in hippocampus, brain cortex, cerebellum, heart and lung.1 Publication

Gene expression databases

GenevisibleiQ99NI4. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000748.

Structurei

3D structure databases

ProteinModelPortaliQ99NI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1319Substrate bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi300 – 31011Nuclear localization signalAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1620. Eukaryota.
ENOG410YHQ3. LUCA.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000116306.
HOVERGENiHBG052124.
InParanoidiQ99NI4.
KOiK00915.
OMAiEVEVRMI.
OrthoDBiEOG7KH9K3.
PhylomeDBiQ99NI4.
TreeFamiTF321442.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99NI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEPPALRL RPPGSTGDSP PVPRLLGGCV PLSHQVAGHM YGKDKVGILQ
60 70 80 90 100
HPDGTVLKQL QPPPRGPREL EFYTMVYAAD CADAVLLELR KHLPKYYGVW
110 120 130 140 150
SPPSAPNDVY LKLEDVTHKF NKPCIMDVKI GRKSYDPFAS AEKIQQQVSK
160 170 180 190 200
YPLMEEIGFL VLGMRVYHLH SDSYETQNQH YGRGLTKETL KEGVSKFFHN
210 220 230 240 250
GFCLRKDAVA ASIQKVEKIL QWFENQKQLN FYASSLLFVY EGSSQPATTK
260 270 280 290 300
SNDRTLAGRF LSKGALSDAD VLECNNNFHL FSSPANGTSV GKSLSKAYSR
310 320 330 340 350
HRKLYAKKHQ SQTSLKVETL EQDNGWKSMS QEHLNGNVLS QLEKVFYHLP
360 370 380 390
AGRQEIAEAE VRMIDFAHVF PSNTVDEGYV YGLKHLIAVL RSILDS
Length:396
Mass (Da):44,410
Last modified:June 1, 2001 - v1
Checksum:i781BF569245FFA02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014898 mRNA. Translation: AAG42923.1.
RefSeqiNP_599244.1. NM_134417.1.
UniGeneiRn.15187.

Genome annotation databases

EnsembliENSRNOT00000000748; ENSRNOP00000000748; ENSRNOG00000000609.
GeneIDi171458.
KEGGirno:171458.
UCSCiRGD:620954. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014898 mRNA. Translation: AAG42923.1.
RefSeqiNP_599244.1. NM_134417.1.
UniGeneiRn.15187.

3D structure databases

ProteinModelPortaliQ99NI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000748.

Chemistry

SwissLipidsiSLP:000000959.

PTM databases

iPTMnetiQ99NI4.
PhosphoSiteiQ99NI4.

Proteomic databases

PaxDbiQ99NI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000748; ENSRNOP00000000748; ENSRNOG00000000609.
GeneIDi171458.
KEGGirno:171458.
UCSCiRGD:620954. rat.

Organism-specific databases

CTDi253430.
RGDi620954. Ipmk.

Phylogenomic databases

eggNOGiKOG1620. Eukaryota.
ENOG410YHQ3. LUCA.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000116306.
HOVERGENiHBG052124.
InParanoidiQ99NI4.
KOiK00915.
OMAiEVEVRMI.
OrthoDBiEOG7KH9K3.
PhylomeDBiQ99NI4.
TreeFamiTF321442.

Enzyme and pathway databases

BRENDAi2.7.1.151. 5301.
ReactomeiR-RNO-1855191. Synthesis of IPs in the nucleus.
SABIO-RKQ99NI4.

Miscellaneous databases

PROiQ99NI4.

Gene expression databases

GenevisibleiQ99NI4. RN.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PfamiPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate."
    Saiardi A., Nagata E., Luo H.R., Sawa A., Luo X., Snowman A.M., Snyder S.H.
    Proc. Natl. Acad. Sci. U.S.A. 98:2306-2311(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiIPMK_RAT
AccessioniPrimary (citable) accession number: Q99NI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.