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Protein

Triggering receptor expressed on myeloid cells 2

Gene

Trem2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines.1 Publication

GO - Molecular functioni

  • lipopolysaccharide binding Source: BHF-UCL
  • lipoteichoic acid binding Source: BHF-UCL
  • peptidoglycan binding Source: BHF-UCL
  • phospholipid binding Source: UniProtKB
  • scaffold protein binding Source: MGI
  • transmembrane signaling receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-2172127. DAP12 interactions.
R-MMU-2424491. DAP12 signaling.
R-MMU-416700. Other semaphorin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Triggering receptor expressed on myeloid cells 2
Short name:
TREM-2
Alternative name(s):
Triggering receptor expressed on monocytes 2
Gene namesi
Name:Trem2
Synonyms:Trem2a, Trem2b, Trem2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1913150. Trem2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 171ExtracellularSequence analysisAdd BLAST153
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 227CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001498819 – 227Triggering receptor expressed on myeloid cells 2Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi36 ↔ 110By similarity
Disulfide bondi51 ↔ 60By similarity
Glycosylationi79N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99NH8.
PeptideAtlasiQ99NH8.
PRIDEiQ99NH8.

PTM databases

iPTMnetiQ99NH8.
PhosphoSitePlusiQ99NH8.

Expressioni

Tissue specificityi

Expressed at higher levels in the CNS, heart and lung than in lymph nodes or in other non-lymphoid tissues such as kidney, liver and testis. In the CNS not all microglia express TREM2. Brain regions with an incomplete blood-brain barrier had the lowest percentages of TREM2 expressing microglia, whereas the lateral entorhinal and cingulate cortex had the highest percentages.2 Publications

Gene expression databases

BgeeiENSMUSG00000023992.
CleanExiMM_TREM2.
GenevisibleiQ99NH8. MM.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with TYROBP/DAP12 (PubMed:11241283).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-59896N.
STRINGi10090.ENSMUSP00000024791.

Structurei

3D structure databases

ProteinModelPortaliQ99NH8.
SMRiQ99NH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 112Ig-like V-typeAdd BLAST84

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXBY. Eukaryota.
ENOG410YZ1S. LUCA.
GeneTreeiENSGT00470000042297.
HOGENOMiHOG000118075.
HOVERGENiHBG058623.
InParanoidiQ99NH8.
KOiK14378.
OMAiWAAAWHG.
OrthoDBiEOG091G0LFM.
PhylomeDBiQ99NH8.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99NH8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLHQFLLL LITALSQALN TTVLQGMAGQ SLRVSCTYDA LKHWGRRKAW
60 70 80 90 100
CRQLGEEGPC QRVVSTHGVW LLAFLKKRNG STVIADDTLA GTVTITLKNL
110 120 130 140 150
QAGDAGLYQC QSLRGREAEV LQKVLVEVLE DPLDDQDAGD LWVPEESSSF
160 170 180 190 200
EGAQVEHSTS RNQETSFPPT SILLLLACVL LSKFLAASIL WAVARGRQKP
210 220
GTPVVRGLDC GQDAGHQLQI LTGPGGT
Length:227
Mass (Da):24,527
Last modified:June 1, 2001 - v1
Checksum:i740EEA8D90BF9773
GO
Isoform 2 (identifier: Q99NH8-2) [UniParc]FASTAAdd to basket
Also known as: svTREM-2b

The sequence of this isoform differs from the canonical sequence as follows:
     162-227: NQETSFPPTS...LQILTGPGGT → QVSSCGSPLA...HWTRRYVREF

Show »
Length:249
Mass (Da):27,304
Checksum:i99D0BC9909FDA704
GO

Sequence cautioni

The sequence AAF69825 differs from that shown. Reason: Frameshift at positions 70 and 78.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105A → S in AAK01465 (PubMed:11241283).Curated1
Sequence conflicti105A → S in AAH32959 (PubMed:15489334).Curated1
Sequence conflicti118A → R in AAF69825 (PubMed:10799849).Curated1
Sequence conflicti122Q → K in AAK01465 (PubMed:11241283).Curated1
Sequence conflicti122Q → K in AAH32959 (PubMed:15489334).Curated1
Sequence conflicti148S → E in AAK01465 (PubMed:11241283).Curated1
Sequence conflicti148S → E in AAH32959 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti78R → W in strain: FVB/N. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010794162 – 227NQETS…GPGGT → QVSSCGSPLAYHLPPLSKES RDLLPTHLHSSPPGLRSPEQ VSCSQHPLGCGQGQAEAGNT CGQRAGLWPRCWAPTSDPHW TRRYVREF in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF213458 mRNA. Translation: AAF69825.1. Frameshift.
AY024348 mRNA. Translation: AAK01465.1.
AY024349 mRNA. Translation: AAK01466.1.
AY187009 mRNA. Translation: AAO06114.1.
AK039477 mRNA. Translation: BAC30362.1.
BC032959 mRNA. Translation: AAH32959.1.
BC033485 mRNA. Translation: AAH33485.1.
BC052784 mRNA. Translation: AAH52784.1.
CCDSiCCDS28865.1. [Q99NH8-1]
CCDS70825.1. [Q99NH8-2]
RefSeqiNP_001259007.1. NM_001272078.1. [Q99NH8-2]
NP_112544.1. NM_031254.3. [Q99NH8-1]
UniGeneiMm.261623.

Genome annotation databases

EnsembliENSMUST00000024791; ENSMUSP00000024791; ENSMUSG00000023992. [Q99NH8-1]
ENSMUST00000113237; ENSMUSP00000108863; ENSMUSG00000023992. [Q99NH8-2]
GeneIDi83433.
KEGGimmu:83433.
UCSCiuc008cxj.2. mouse. [Q99NH8-1]
uc008cxk.2. mouse. [Q99NH8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTREM2_MOUSE
AccessioniPrimary (citable) accession number: Q99NH8
Secondary accession number(s): Q8CGK4
, Q8CIA6, Q99NH9, Q9JL34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot