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Q99NH8

- TREM2_MOUSE

UniProt

Q99NH8 - TREM2_MOUSE

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Protein
Triggering receptor expressed on myeloid cells 2
Gene
Trem2, Trem2a, Trem2b, Trem2c
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.1 Publication

GO - Molecular functioni

  1. lipopolysaccharide binding Source: MGI
  2. protein binding Source: MGI
  3. transmembrane signaling receptor activity Source: MGI

GO - Biological processi

  1. signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_188185. DAP12 signaling.
REACT_188188. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Triggering receptor expressed on myeloid cells 2
Short name:
TREM-2
Alternative name(s):
Triggering receptor expressed on monocytes 2
Gene namesi
Name:Trem2
Synonyms:Trem2a, Trem2b, Trem2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1913150. Trem2.

Subcellular locationi

Isoform 2 : Secreted Reviewed prediction

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 171153Extracellular Reviewed prediction
Add
BLAST
Transmembranei172 – 19221Helical; Reviewed prediction
Add
BLAST
Topological domaini193 – 22735Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 227209Triggering receptor expressed on myeloid cells 2
PRO_0000014988Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi36 ↔ 110 Reviewed prediction
Disulfide bondi51 ↔ 60 Reviewed prediction
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99NH8.
PRIDEiQ99NH8.

PTM databases

PhosphoSiteiQ99NH8.

Expressioni

Tissue specificityi

Expressed at higher levels in the CNS, heart and lung than in lymph nodes or in other non-lymphoid tissues such as kidney, liver and testis. In the CNS not all microglia express TREM2. Brain regions with an incomplete blood-brain barrier had the lowest percentages of TREM2 expressing microglia, whereas the lateral entorhinal and cingulate cortex had the highest percentages.2 Publications

Gene expression databases

BgeeiQ99NH8.
CleanExiMM_TREM2.
GenevestigatoriQ99NH8.

Interactioni

Subunit structurei

Interacts with TYROBP/DAP12.1 Publication

Protein-protein interaction databases

DIPiDIP-59896N.

Structurei

3D structure databases

ProteinModelPortaliQ99NH8.
SMRiQ99NH8. Positions 26-110.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 11284Ig-like V-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42611.
GeneTreeiENSGT00470000042297.
HOGENOMiHOG000118075.
HOVERGENiHBG058623.
KOiK14378.
OMAiQVEHSTS.
OrthoDBiEOG7B8S4S.
PhylomeDBiQ99NH8.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99NH8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGPLHQFLLL LITALSQALN TTVLQGMAGQ SLRVSCTYDA LKHWGRRKAW    50
CRQLGEEGPC QRVVSTHGVW LLAFLKKRNG STVIADDTLA GTVTITLKNL 100
QAGDAGLYQC QSLRGREAEV LQKVLVEVLE DPLDDQDAGD LWVPEESSSF 150
EGAQVEHSTS RNQETSFPPT SILLLLACVL LSKFLAASIL WAVARGRQKP 200
GTPVVRGLDC GQDAGHQLQI LTGPGGT 227
Length:227
Mass (Da):24,527
Last modified:June 1, 2001 - v1
Checksum:i740EEA8D90BF9773
GO
Isoform 2 (identifier: Q99NH8-2) [UniParc]FASTAAdd to Basket

Also known as: svTREM-2b

The sequence of this isoform differs from the canonical sequence as follows:
     162-227: NQETSFPPTS...LQILTGPGGT → QVSSCGSPLA...HWTRRYVREF

Show »
Length:249
Mass (Da):27,304
Checksum:i99D0BC9909FDA704
GO

Sequence cautioni

The sequence AAF69825.1 differs from that shown. Reason: Frameshift at positions 70 and 78.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781R → W in strain: FVB/N. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei162 – 22766NQETS…GPGGT → QVSSCGSPLAYHLPPLSKES RDLLPTHLHSSPPGLRSPEQ VSCSQHPLGCGQGQAEAGNT CGQRAGLWPRCWAPTSDPHW TRRYVREF in isoform 2.
VSP_010794Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051A → S in AAK01465. 1 Publication
Sequence conflicti105 – 1051A → S in AAH32959. 1 Publication
Sequence conflicti118 – 1181A → R in AAF69825. 1 Publication
Sequence conflicti122 – 1221Q → K in AAK01465. 1 Publication
Sequence conflicti122 – 1221Q → K in AAH32959. 1 Publication
Sequence conflicti148 – 1481S → E in AAK01465. 1 Publication
Sequence conflicti148 – 1481S → E in AAH32959. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF213458 mRNA. Translation: AAF69825.1. Frameshift.
AY024348 mRNA. Translation: AAK01465.1.
AY024349 mRNA. Translation: AAK01466.1.
AY187009 mRNA. Translation: AAO06114.1.
AK039477 mRNA. Translation: BAC30362.1.
BC032959 mRNA. Translation: AAH32959.1.
BC033485 mRNA. Translation: AAH33485.1.
BC052784 mRNA. Translation: AAH52784.1.
CCDSiCCDS28865.1. [Q99NH8-1]
CCDS70825.1. [Q99NH8-2]
RefSeqiNP_001259007.1. NM_001272078.1. [Q99NH8-2]
NP_112544.1. NM_031254.3. [Q99NH8-1]
UniGeneiMm.261623.

Genome annotation databases

EnsembliENSMUST00000024791; ENSMUSP00000024791; ENSMUSG00000023992. [Q99NH8-1]
ENSMUST00000113237; ENSMUSP00000108863; ENSMUSG00000023992. [Q99NH8-2]
GeneIDi83433.
KEGGimmu:83433.
UCSCiuc008cxj.1. mouse. [Q99NH8-1]
uc008cxk.1. mouse. [Q99NH8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF213458 mRNA. Translation: AAF69825.1 . Frameshift.
AY024348 mRNA. Translation: AAK01465.1 .
AY024349 mRNA. Translation: AAK01466.1 .
AY187009 mRNA. Translation: AAO06114.1 .
AK039477 mRNA. Translation: BAC30362.1 .
BC032959 mRNA. Translation: AAH32959.1 .
BC033485 mRNA. Translation: AAH33485.1 .
BC052784 mRNA. Translation: AAH52784.1 .
CCDSi CCDS28865.1. [Q99NH8-1 ]
CCDS70825.1. [Q99NH8-2 ]
RefSeqi NP_001259007.1. NM_001272078.1. [Q99NH8-2 ]
NP_112544.1. NM_031254.3. [Q99NH8-1 ]
UniGenei Mm.261623.

3D structure databases

ProteinModelPortali Q99NH8.
SMRi Q99NH8. Positions 26-110.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59896N.

PTM databases

PhosphoSitei Q99NH8.

Proteomic databases

PaxDbi Q99NH8.
PRIDEi Q99NH8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024791 ; ENSMUSP00000024791 ; ENSMUSG00000023992 . [Q99NH8-1 ]
ENSMUST00000113237 ; ENSMUSP00000108863 ; ENSMUSG00000023992 . [Q99NH8-2 ]
GeneIDi 83433.
KEGGi mmu:83433.
UCSCi uc008cxj.1. mouse. [Q99NH8-1 ]
uc008cxk.1. mouse. [Q99NH8-2 ]

Organism-specific databases

CTDi 54209.
MGIi MGI:1913150. Trem2.

Phylogenomic databases

eggNOGi NOG42611.
GeneTreei ENSGT00470000042297.
HOGENOMi HOG000118075.
HOVERGENi HBG058623.
KOi K14378.
OMAi QVEHSTS.
OrthoDBi EOG7B8S4S.
PhylomeDBi Q99NH8.
TreeFami TF334441.

Enzyme and pathway databases

Reactomei REACT_188185. DAP12 signaling.
REACT_188188. DAP12 interactions.

Miscellaneous databases

NextBioi 350558.
PROi Q99NH8.
SOURCEi Search...

Gene expression databases

Bgeei Q99NH8.
CleanExi MM_TREM2.
Genevestigatori Q99NH8.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes."
    Bouchon A., Dietrich J., Colonna M.
    J. Immunol. 164:4991-4995(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family."
    Daws M.R., Lanier L.L., Seaman W.E., Ryan J.C.
    Eur. J. Immunol. 31:783-791(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH TYROBP/DAP12.
    Strain: BALB/c.
    Tissue: Macrophage.
  3. "Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia."
    Schmid C.D., Sautkulis L.N., Danielson P.E., Cooper J., Hasel K.W., Hilbush B.S., Sutcliffe J.G., Carson M.J.
    J. Neurochem. 83:1309-1320(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Spinal cord.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TRP-78.
    Strain: Czech II and FVB/N.
    Tissue: Lung and Mammary gland.

Entry informationi

Entry nameiTREM2_MOUSE
AccessioniPrimary (citable) accession number: Q99NH8
Secondary accession number(s): Q8CGK4
, Q8CIA6, Q99NH9, Q9JL34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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