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Q99NH5

- Q99NH5_RAT

UniProt

Q99NH5 - Q99NH5_RAT

Protein
Submitted name:

GATA binding protein 3

Gene

Gata3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. core promoter proximal region sequence-specific DNA binding Source: UniProtKB
    2. E-box binding Source: UniProtKB
    3. enhancer sequence-specific DNA binding Source: Ensembl
    4. nucleic acid binding transcription factor activity Source: UniProtKB
    5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
    6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
    7. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
    8. sequence-specific DNA binding Source: RGD
    9. sequence-specific DNA binding transcription factor activity Source: RGD
    10. transcription coactivator activity Source: UniProtKB
    11. transcription regulatory region DNA binding Source: UniProtKB
    12. zinc ion binding Source: InterPro

    GO - Biological processi

    1. anatomical structure formation involved in morphogenesis Source: UniProtKB
    2. aortic valve morphogenesis Source: UniProtKB
    3. axon guidance Source: Ensembl
    4. canonical Wnt signaling pathway involved in metanephric kidney development Source: UniProtKB
    5. cardiac right ventricle morphogenesis Source: UniProtKB
    6. cell fate determination Source: UniProtKB
    7. cell maturation Source: Ensembl
    8. cellular response to BMP stimulus Source: Ensembl
    9. cellular response to interferon-alpha Source: Ensembl
    10. cellular response to interleukin-4 Source: Ensembl
    11. cellular response to tumor necrosis factor Source: Ensembl
    12. developmental growth Source: Ensembl
    13. ear development Source: UniProtKB
    14. embryonic hemopoiesis Source: Ensembl
    15. erythrocyte differentiation Source: Ensembl
    16. humoral immune response Source: Ensembl
    17. inner ear morphogenesis Source: Ensembl
    18. interferon-gamma secretion Source: Ensembl
    19. interleukin-4 secretion Source: Ensembl
    20. in utero embryonic development Source: Ensembl
    21. kidney development Source: UniProtKB
    22. lens development in camera-type eye Source: Ensembl
    23. lymphocyte migration Source: UniProtKB
    24. male gonad development Source: UniProtKB
    25. mast cell differentiation Source: Ensembl
    26. mesenchymal to epithelial transition Source: UniProtKB
    27. mesonephros development Source: UniProtKB
    28. negative regulation of cell cycle Source: UniProtKB
    29. negative regulation of cell motility Source: UniProtKB
    30. negative regulation of cell proliferation Source: UniProtKB
    31. negative regulation of cell proliferation involved in mesonephros development Source: UniProtKB
    32. negative regulation of endothelial cell apoptotic process Source: UniProtKB
    33. negative regulation of fat cell differentiation Source: UniProtKB
    34. negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation Source: UniProtKB
    35. negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation Source: UniProtKB
    36. negative regulation of inflammatory response Source: UniProtKB
    37. negative regulation of interferon-gamma production Source: Ensembl
    38. negative regulation of interleukin-2 production Source: Ensembl
    39. negative regulation of mammary gland epithelial cell proliferation Source: Ensembl
    40. negative regulation of transcription, DNA-templated Source: UniProtKB
    41. nephric duct formation Source: UniProtKB
    42. nephric duct morphogenesis Source: UniProtKB
    43. neuron migration Source: Ensembl
    44. norepinephrine biosynthetic process Source: UniProtKB
    45. otic vesicle development Source: Ensembl
    46. parathyroid gland development Source: Ensembl
    47. parathyroid hormone secretion Source: Ensembl
    48. pharyngeal system development Source: UniProtKB
    49. phosphatidylinositol 3-kinase signaling Source: UniProtKB
    50. positive regulation of endothelial cell migration Source: UniProtKB
    51. positive regulation of interleukin-13 production Source: Ensembl
    52. positive regulation of interleukin-13 secretion Source: UniProtKB
    53. positive regulation of interleukin-4 production Source: UniProtKB
    54. positive regulation of interleukin-5 production Source: Ensembl
    55. positive regulation of interleukin-5 secretion Source: UniProtKB
    56. positive regulation of protein kinase B signaling Source: UniProtKB
    57. positive regulation of signal transduction Source: UniProtKB
    58. positive regulation of T cell differentiation Source: UniProtKB
    59. positive regulation of thyroid hormone generation Source: UniProtKB
    60. positive regulation of transcription, DNA-templated Source: UniProtKB
    61. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    62. positive regulation of transcription regulatory region DNA binding Source: UniProtKB
    63. positive regulation of ureteric bud formation Source: UniProtKB
    64. post-embryonic development Source: Ensembl
    65. pro-T cell differentiation Source: Ensembl
    66. regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
    67. regulation of cellular response to X-ray Source: UniProtKB
    68. regulation of cytokine biosynthetic process Source: UniProtKB
    69. regulation of establishment of cell polarity Source: Ensembl
    70. regulation of histone H3-K27 methylation Source: Ensembl
    71. regulation of histone H3-K4 methylation Source: Ensembl
    72. regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
    73. regulation of neuron apoptotic process Source: Ensembl
    74. response to drug Source: RGD
    75. response to estrogen Source: Ensembl
    76. response to ethanol Source: RGD
    77. response to gamma radiation Source: RGD
    78. response to virus Source: Ensembl
    79. signal transduction Source: UniProtKB
    80. sympathetic nervous system development Source: UniProtKB
    81. T cell receptor signaling pathway Source: UniProtKB
    82. T-helper 2 cell differentiation Source: Ensembl
    83. thymic T cell selection Source: Ensembl
    84. thymus development Source: Ensembl
    85. TOR signaling Source: UniProtKB
    86. type IV hypersensitivity Source: RGD
    87. ureteric bud formation Source: UniProtKB
    88. ureter maturation Source: Ensembl
    89. uterus development Source: UniProtKB
    90. ventricular septum development Source: UniProtKB

    Enzyme and pathway databases

    ReactomeiREACT_196232. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    GATA binding protein 3Imported
    Submitted name:
    GATA-3Imported
    Submitted name:
    Protein Gata3Imported
    Gene namesi
    Name:Gata3Imported
    ORF Names:rCG_55727Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi621250. Gata3.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear chromatin Source: UniProtKB
    2. nucleolus Source: Ensembl
    3. nucleus Source: RGD

    Expressioni

    Gene expression databases

    GenevestigatoriQ99NH5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000026187.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG5641.
    GeneTreeiENSGT00750000117454.
    HOGENOMiHOG000047701.
    HOVERGENiHBG051705.
    InParanoidiQ99NH5.
    KOiK17895.
    OMAiHGSQVCR.
    OrthoDBiEOG7CCBRF.
    TreeFamiTF315391.

    Family and domain databases

    Gene3Di3.30.50.10. 2 hits.
    InterProiIPR029521. GATA-3.
    IPR016374. TF_GATA-1/2/3.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PANTHERiPTHR10071:SF106. PTHR10071:SF106. 1 hit.
    PfamiPF00320. GATA. 2 hits.
    [Graphical view]
    PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
    PRINTSiPR00619. GATAZNFINGER.
    SMARTiSM00401. ZnF_GATA. 2 hits.
    [Graphical view]
    PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
    PS50114. GATA_ZN_FINGER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99NH5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVTTDQPRW VSHHHPAVLN GQHPDTHHPG LGHSYMDPAQ YPLTEEVDVL    50
    FNIDGQGNHV PSYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG 100
    KALSSHHTAS PWNLSPFSKT SIHHGSPGPL SVYPPASSSS LAAGHSSPHL 150
    FTFPPTPPKD VSPDPSLSTP GSAGSARQDE KECLKYQVQL PDSMKLETSH 200
    SRGSMTTLGG ASSSAHHPIT TYPPYVPEYS SGLFPPSSLL GGSPTGFGCK 250
    SRPKARSSTE GRECVNCGAT STPLWRRDGT GHYLCNACGL YHKMNGQNRP 300
    LIKPKRRLSA ARRAGTSCAN CQTTTTTLWR RNANGDPVCN ACGLYYKLHN 350
    INRPLTMKKE GIQTRNRKMS SKSKKCKKVH DALEDFPKSS SFNPAALSRH 400
    MSSLSHISPF SHSSHMLTTP TPMHPPSGLS FGPHHPSSMV TAMG 444
    Length:444
    Mass (Da):48,081
    Last modified:June 1, 2001 - v1
    Checksum:i427384F766659388
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06092817 Genomic DNA. No translation available.
    AABR06092818 Genomic DNA. No translation available.
    AY024364 mRNA. Translation: AAK00586.1.
    CH473990 Genomic DNA. Translation: EDL78630.1.
    RefSeqiNP_579827.1. NM_133293.1.
    XP_006254315.1. XM_006254253.1.
    UniGeneiRn.229174.

    Genome annotation databases

    EnsembliENSRNOT00000026187; ENSRNOP00000026187; ENSRNOG00000019336.
    GeneIDi85471.
    KEGGirno:85471.
    UCSCiRGD:621250. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06092817 Genomic DNA. No translation available.
    AABR06092818 Genomic DNA. No translation available.
    AY024364 mRNA. Translation: AAK00586.1 .
    CH473990 Genomic DNA. Translation: EDL78630.1 .
    RefSeqi NP_579827.1. NM_133293.1.
    XP_006254315.1. XM_006254253.1.
    UniGenei Rn.229174.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000026187.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026187 ; ENSRNOP00000026187 ; ENSRNOG00000019336 .
    GeneIDi 85471.
    KEGGi rno:85471.
    UCSCi RGD:621250. rat.

    Organism-specific databases

    CTDi 2625.
    RGDi 621250. Gata3.

    Phylogenomic databases

    eggNOGi COG5641.
    GeneTreei ENSGT00750000117454.
    HOGENOMi HOG000047701.
    HOVERGENi HBG051705.
    InParanoidi Q99NH5.
    KOi K17895.
    OMAi HGSQVCR.
    OrthoDBi EOG7CCBRF.
    TreeFami TF315391.

    Enzyme and pathway databases

    Reactomei REACT_196232. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    NextBioi 617554.
    PROi Q99NH5.

    Gene expression databases

    Genevestigatori Q99NH5.

    Family and domain databases

    Gene3Di 3.30.50.10. 2 hits.
    InterProi IPR029521. GATA-3.
    IPR016374. TF_GATA-1/2/3.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    PANTHERi PTHR10071:SF106. PTHR10071:SF106. 1 hit.
    Pfami PF00320. GATA. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF003027. TF_GATA-1/2/3. 1 hit.
    PRINTSi PR00619. GATAZNFINGER.
    SMARTi SM00401. ZnF_GATA. 2 hits.
    [Graphical view ]
    PROSITEi PS00344. GATA_ZN_FINGER_1. 2 hits.
    PS50114. GATA_ZN_FINGER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete coding sequence of the rat GATA-3 gene."
      Kaufman M., Bisotto S., Fixman E.D.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ99NH5_RAT
    AccessioniPrimary (citable) accession number: Q99NH5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3