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Q99NH5

- Q99NH5_RAT

UniProt

Q99NH5 - Q99NH5_RAT

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Protein
Submitted name:

GATA binding protein 3

Gene

Gata3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. core promoter proximal region sequence-specific DNA binding Source: UniProtKB
  2. E-box binding Source: UniProtKB
  3. enhancer sequence-specific DNA binding Source: Ensembl
  4. nucleic acid binding transcription factor activity Source: UniProtKB
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
  6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  7. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
  8. sequence-specific DNA binding Source: RGD
  9. sequence-specific DNA binding transcription factor activity Source: RGD
  10. transcription coactivator activity Source: UniProtKB
  11. transcription regulatory region DNA binding Source: UniProtKB
  12. zinc ion binding Source: InterPro

GO - Biological processi

  1. anatomical structure formation involved in morphogenesis Source: UniProtKB
  2. aortic valve morphogenesis Source: UniProtKB
  3. axon guidance Source: Ensembl
  4. canonical Wnt signaling pathway involved in metanephric kidney development Source: UniProtKB
  5. cardiac right ventricle morphogenesis Source: UniProtKB
  6. cell fate determination Source: UniProtKB
  7. cell maturation Source: Ensembl
  8. cellular response to BMP stimulus Source: Ensembl
  9. cellular response to interferon-alpha Source: Ensembl
  10. cellular response to interleukin-4 Source: Ensembl
  11. cellular response to tumor necrosis factor Source: Ensembl
  12. developmental growth Source: Ensembl
  13. ear development Source: UniProtKB
  14. embryonic hemopoiesis Source: Ensembl
  15. erythrocyte differentiation Source: Ensembl
  16. humoral immune response Source: Ensembl
  17. inner ear morphogenesis Source: Ensembl
  18. interferon-gamma secretion Source: Ensembl
  19. interleukin-4 secretion Source: Ensembl
  20. in utero embryonic development Source: Ensembl
  21. kidney development Source: UniProtKB
  22. lens development in camera-type eye Source: Ensembl
  23. lymphocyte migration Source: UniProtKB
  24. male gonad development Source: UniProtKB
  25. mast cell differentiation Source: Ensembl
  26. mesenchymal to epithelial transition Source: UniProtKB
  27. mesonephros development Source: UniProtKB
  28. negative regulation of cell cycle Source: UniProtKB
  29. negative regulation of cell motility Source: UniProtKB
  30. negative regulation of cell proliferation Source: UniProtKB
  31. negative regulation of cell proliferation involved in mesonephros development Source: UniProtKB
  32. negative regulation of endothelial cell apoptotic process Source: UniProtKB
  33. negative regulation of fat cell differentiation Source: UniProtKB
  34. negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation Source: UniProtKB
  35. negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation Source: UniProtKB
  36. negative regulation of inflammatory response Source: UniProtKB
  37. negative regulation of interferon-gamma production Source: Ensembl
  38. negative regulation of interleukin-2 production Source: Ensembl
  39. negative regulation of mammary gland epithelial cell proliferation Source: Ensembl
  40. negative regulation of transcription, DNA-templated Source: UniProtKB
  41. nephric duct formation Source: UniProtKB
  42. nephric duct morphogenesis Source: UniProtKB
  43. neuron migration Source: Ensembl
  44. norepinephrine biosynthetic process Source: UniProtKB
  45. otic vesicle development Source: Ensembl
  46. parathyroid gland development Source: Ensembl
  47. parathyroid hormone secretion Source: Ensembl
  48. pharyngeal system development Source: UniProtKB
  49. phosphatidylinositol 3-kinase signaling Source: UniProtKB
  50. positive regulation of endothelial cell migration Source: UniProtKB
  51. positive regulation of interleukin-13 secretion Source: UniProtKB
  52. positive regulation of interleukin-4 production Source: UniProtKB
  53. positive regulation of interleukin-5 secretion Source: UniProtKB
  54. positive regulation of protein kinase B signaling Source: UniProtKB
  55. positive regulation of signal transduction Source: UniProtKB
  56. positive regulation of T cell differentiation Source: UniProtKB
  57. positive regulation of thyroid hormone generation Source: UniProtKB
  58. positive regulation of transcription, DNA-templated Source: UniProtKB
  59. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  60. positive regulation of transcription regulatory region DNA binding Source: UniProtKB
  61. positive regulation of ureteric bud formation Source: UniProtKB
  62. post-embryonic development Source: Ensembl
  63. pro-T cell differentiation Source: Ensembl
  64. regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
  65. regulation of cellular response to X-ray Source: UniProtKB
  66. regulation of cytokine biosynthetic process Source: UniProtKB
  67. regulation of establishment of cell polarity Source: Ensembl
  68. regulation of histone H3-K27 methylation Source: Ensembl
  69. regulation of histone H3-K4 methylation Source: Ensembl
  70. regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
  71. regulation of neuron apoptotic process Source: Ensembl
  72. regulation of neuron projection development Source: Ensembl
  73. response to drug Source: RGD
  74. response to estrogen Source: Ensembl
  75. response to ethanol Source: RGD
  76. response to gamma radiation Source: RGD
  77. response to virus Source: Ensembl
  78. signal transduction Source: UniProtKB
  79. sympathetic nervous system development Source: UniProtKB
  80. T cell receptor signaling pathway Source: UniProtKB
  81. T-helper 2 cell differentiation Source: Ensembl
  82. thymic T cell selection Source: Ensembl
  83. thymus development Source: Ensembl
  84. TOR signaling Source: UniProtKB
  85. type IV hypersensitivity Source: RGD
  86. ureteric bud formation Source: UniProtKB
  87. ureter maturation Source: Ensembl
  88. uterus development Source: UniProtKB
  89. ventricular septum development Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196232. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Submitted name:
GATA binding protein 3Imported
Submitted name:
GATA-3Imported
Submitted name:
Protein Gata3Imported
Gene namesi
Name:Gata3Imported
ORF Names:rCG_55727Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi621250. Gata3.

Subcellular locationi

GO - Cellular componenti

  1. nuclear chromatin Source: UniProtKB
  2. nucleolus Source: Ensembl
  3. nucleus Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ99NH5.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026187.

Structurei

3D structure databases

SMRiQ99NH5. Positions 259-303, 309-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG5641.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
KOiK17895.
OMAiQRYPPTH.
OrthoDBiEOG7CCBRF.
PhylomeDBiQ99NH5.
TreeFamiTF315391.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029521. GATA-3.
IPR016374. TF_GATA-1/2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF106. PTHR10071:SF106. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99NH5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVTTDQPRW VSHHHPAVLN GQHPDTHHPG LGHSYMDPAQ YPLTEEVDVL
60 70 80 90 100
FNIDGQGNHV PSYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG
110 120 130 140 150
KALSSHHTAS PWNLSPFSKT SIHHGSPGPL SVYPPASSSS LAAGHSSPHL
160 170 180 190 200
FTFPPTPPKD VSPDPSLSTP GSAGSARQDE KECLKYQVQL PDSMKLETSH
210 220 230 240 250
SRGSMTTLGG ASSSAHHPIT TYPPYVPEYS SGLFPPSSLL GGSPTGFGCK
260 270 280 290 300
SRPKARSSTE GRECVNCGAT STPLWRRDGT GHYLCNACGL YHKMNGQNRP
310 320 330 340 350
LIKPKRRLSA ARRAGTSCAN CQTTTTTLWR RNANGDPVCN ACGLYYKLHN
360 370 380 390 400
INRPLTMKKE GIQTRNRKMS SKSKKCKKVH DALEDFPKSS SFNPAALSRH
410 420 430 440
MSSLSHISPF SHSSHMLTTP TPMHPPSGLS FGPHHPSSMV TAMG
Length:444
Mass (Da):48,081
Last modified:June 1, 2001 - v1
Checksum:i427384F766659388
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06092817 Genomic DNA. No translation available.
AABR06092818 Genomic DNA. No translation available.
AY024364 mRNA. Translation: AAK00586.1.
CH473990 Genomic DNA. Translation: EDL78630.1.
RefSeqiNP_579827.1. NM_133293.1.
XP_006254315.1. XM_006254253.2.
UniGeneiRn.229174.

Genome annotation databases

EnsembliENSRNOT00000026187; ENSRNOP00000026187; ENSRNOG00000019336.
GeneIDi85471.
KEGGirno:85471.
UCSCiRGD:621250. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06092817 Genomic DNA. No translation available.
AABR06092818 Genomic DNA. No translation available.
AY024364 mRNA. Translation: AAK00586.1 .
CH473990 Genomic DNA. Translation: EDL78630.1 .
RefSeqi NP_579827.1. NM_133293.1.
XP_006254315.1. XM_006254253.2.
UniGenei Rn.229174.

3D structure databases

SMRi Q99NH5. Positions 259-303, 309-366.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000026187.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026187 ; ENSRNOP00000026187 ; ENSRNOG00000019336 .
GeneIDi 85471.
KEGGi rno:85471.
UCSCi RGD:621250. rat.

Organism-specific databases

CTDi 2625.
RGDi 621250. Gata3.

Phylogenomic databases

eggNOGi COG5641.
GeneTreei ENSGT00760000119221.
HOGENOMi HOG000047701.
HOVERGENi HBG051705.
KOi K17895.
OMAi QRYPPTH.
OrthoDBi EOG7CCBRF.
PhylomeDBi Q99NH5.
TreeFami TF315391.

Enzyme and pathway databases

Reactomei REACT_196232. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

NextBioi 617554.
PROi Q99NH5.

Gene expression databases

Genevestigatori Q99NH5.

Family and domain databases

Gene3Di 3.30.50.10. 2 hits.
InterProi IPR029521. GATA-3.
IPR016374. TF_GATA-1/2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
PANTHERi PTHR10071:SF106. PTHR10071:SF106. 1 hit.
Pfami PF00320. GATA. 2 hits.
[Graphical view ]
PIRSFi PIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSi PR00619. GATAZNFINGER.
SMARTi SM00401. ZnF_GATA. 2 hits.
[Graphical view ]
PROSITEi PS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete coding sequence of the rat GATA-3 gene."
    Kaufman M., Bisotto S., Fixman E.D.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ99NH5_RAT
AccessioniPrimary (citable) accession number: Q99NH5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.