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Q99NH5 (Q99NH5_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

GATA-3 EMBL AAK00586.1

Protein Gata3 Ensembl ENSRNOP00000026187
Gene names
Name:Gata3 RGD 621250 Ensembl ENSRNOP00000026187 EMBL EDL78630.1
ORF Names:rCG_55727 EMBL EDL78630.1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

T-helper 2 cell differentiation

Inferred from electronic annotation. Source: Ensembl

TOR signaling

Inferred from sequence or structural similarity. Source: UniProtKB

anatomical structure formation involved in morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

aortic valve morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

axon guidance

Inferred from electronic annotation. Source: Ensembl

canonical Wnt signaling pathway involved in metanephric kidney development

Inferred from sequence or structural similarity. Source: UniProtKB

cardiac right ventricle morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

cell fate determination

Inferred from sequence or structural similarity. Source: UniProtKB

cell maturation

Inferred from electronic annotation. Source: Ensembl

cellular response to BMP stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to interferon-alpha

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-4

Inferred from electronic annotation. Source: Ensembl

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

developmental growth

Inferred from electronic annotation. Source: Ensembl

ear development

Inferred from sequence or structural similarity. Source: UniProtKB

embryonic hemopoiesis

Inferred from electronic annotation. Source: Ensembl

erythrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

humoral immune response

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

inner ear morphogenesis

Inferred from electronic annotation. Source: Ensembl

interferon-gamma secretion

Inferred from electronic annotation. Source: Ensembl

interleukin-4 secretion

Inferred from electronic annotation. Source: Ensembl

kidney development

Inferred from sequence or structural similarity. Source: UniProtKB

lens development in camera-type eye

Inferred from electronic annotation. Source: Ensembl

lymphocyte migration

Inferred from sequence or structural similarity. Source: UniProtKB

male gonad development

Inferred from sequence or structural similarity. Source: UniProtKB

mast cell differentiation

Inferred from electronic annotation. Source: Ensembl

mesenchymal to epithelial transition

Inferred from sequence or structural similarity. Source: UniProtKB

mesonephros development

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell cycle

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell motility

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell proliferation involved in mesonephros development

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of endothelial cell apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of fat cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of inflammatory response

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of interferon-gamma production

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-2 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of mammary gland epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

nephric duct formation

Inferred from sequence or structural similarity. Source: UniProtKB

nephric duct morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

neuron migration

Inferred from electronic annotation. Source: Ensembl

norepinephrine biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

otic vesicle development

Inferred from electronic annotation. Source: Ensembl

parathyroid gland development

Inferred from electronic annotation. Source: Ensembl

parathyroid hormone secretion

Inferred from electronic annotation. Source: Ensembl

pharyngeal system development

Inferred from sequence or structural similarity. Source: UniProtKB

phosphatidylinositol 3-kinase signaling

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of T cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of endothelial cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of interleukin-13 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-13 secretion

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of interleukin-4 production

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of interleukin-5 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-5 secretion

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein kinase B signaling

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of signal transduction

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of thyroid hormone generation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription regulatory region DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of ureteric bud formation

Inferred from sequence or structural similarity. Source: UniProtKB

post-embryonic development

Inferred from electronic annotation. Source: Ensembl

pro-T cell differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of CD4-positive, alpha-beta T cell differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of cellular response to X-ray

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of cytokine biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of establishment of cell polarity

Inferred from electronic annotation. Source: Ensembl

regulation of histone H3-K27 methylation

Inferred from electronic annotation. Source: Ensembl

regulation of histone H3-K4 methylation

Inferred from electronic annotation. Source: Ensembl

regulation of nephron tubule epithelial cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from expression pattern PubMed 19428696. Source: RGD

response to estrogen

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from expression pattern PubMed 19428696. Source: RGD

response to gamma radiation

Inferred from expression pattern PubMed 19084914. Source: RGD

response to virus

Inferred from electronic annotation. Source: Ensembl

signal transduction

Inferred from sequence or structural similarity. Source: UniProtKB

sympathetic nervous system development

Inferred from sequence or structural similarity. Source: UniProtKB

thymic T cell selection

Inferred from electronic annotation. Source: Ensembl

thymus development

Inferred from electronic annotation. Source: Ensembl

type IV hypersensitivity

Inferred from expression pattern PubMed 16336837. Source: RGD

ureter maturation

Inferred from electronic annotation. Source: Ensembl

ureteric bud formation

Inferred from sequence or structural similarity. Source: UniProtKB

uterus development

Inferred from sequence or structural similarity. Source: UniProtKB

ventricular septum development

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentnuclear chromatin

Inferred from sequence or structural similarity. Source: UniProtKB

nucleolus

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay PubMed 19428696. Source: RGD

   Molecular_functionE-box binding

Inferred from sequence or structural similarity. Source: UniProtKB

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription

Inferred from sequence or structural similarity. Source: UniProtKB

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II core promoter sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

core promoter proximal region sequence-specific DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

enhancer sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

nucleic acid binding transcription factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

sequence-specific DNA binding

Inferred from mutant phenotype PubMed 9125153. Source: RGD

sequence-specific DNA binding transcription factor activity

Inferred from mutant phenotype PubMed 9125153. Source: RGD

transcription coactivator activity

Inferred from sequence or structural similarity. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q99NH5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 427384F766659388

FASTA44448,081
        10         20         30         40         50         60 
MEVTTDQPRW VSHHHPAVLN GQHPDTHHPG LGHSYMDPAQ YPLTEEVDVL FNIDGQGNHV 

        70         80         90        100        110        120 
PSYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG KALSSHHTAS PWNLSPFSKT 

       130        140        150        160        170        180 
SIHHGSPGPL SVYPPASSSS LAAGHSSPHL FTFPPTPPKD VSPDPSLSTP GSAGSARQDE 

       190        200        210        220        230        240 
KECLKYQVQL PDSMKLETSH SRGSMTTLGG ASSSAHHPIT TYPPYVPEYS SGLFPPSSLL 

       250        260        270        280        290        300 
GGSPTGFGCK SRPKARSSTE GRECVNCGAT STPLWRRDGT GHYLCNACGL YHKMNGQNRP 

       310        320        330        340        350        360 
LIKPKRRLSA ARRAGTSCAN CQTTTTTLWR RNANGDPVCN ACGLYYKLHN INRPLTMKKE 

       370        380        390        400        410        420 
GIQTRNRKMS SKSKKCKKVH DALEDFPKSS SFNPAALSRH MSSLSHISPF SHSSHMLTTP 

       430        440 
TPMHPPSGLS FGPHHPSSMV TAMG 

« Hide

References

« Hide 'large scale' references
[1]"Complete coding sequence of the rat GATA-3 gene."
Kaufman M., Bisotto S., Fixman E.D.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000026187.
[3]"Gene and alternative splicing annotation with AIR."
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G.
Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL78630.1.
[4]Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. expand/collapse author list , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL78630.1.
[5]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000026187.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06092817 Genomic DNA. No translation available.
AABR06092818 Genomic DNA. No translation available.
AY024364 mRNA. Translation: AAK00586.1.
CH473990 Genomic DNA. Translation: EDL78630.1.
RefSeqNP_579827.1. NM_133293.1.
XP_006254315.1. XM_006254253.1.
UniGeneRn.229174.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000026187.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000026187; ENSRNOP00000026187; ENSRNOG00000019336.
GeneID85471.
KEGGrno:85471.
UCSCRGD:621250. rat.

Organism-specific databases

CTD2625.
RGD621250. Gata3.

Phylogenomic databases

eggNOGCOG5641.
GeneTreeENSGT00750000117454.
HOGENOMHOG000047701.
HOVERGENHBG051705.
InParanoidQ99NH5.
KOK17895.
OMAHHPSSMV.
OrthoDBEOG7CCBRF.
TreeFamTF315391.

Gene expression databases

GenevestigatorQ99NH5.

Family and domain databases

Gene3D3.30.50.10. 2 hits.
InterProIPR016374. TF_GATA-1/2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00320. GATA. 2 hits.
[Graphical view]
PIRSFPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSPR00619. GATAZNFINGER.
SMARTSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio617554.
PROQ99NH5.

Entry information

Entry nameQ99NH5_RAT
AccessionPrimary (citable) accession number: Q99NH5
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)