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Protein

Ankyrin repeat domain-containing protein 17

Gene

Ankrd17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could play pivotal roles in cell cycle and DNA regulation. Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways. Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too. Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (PubMed:19619540).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 17
Alternative name(s):
Ankyrin repeat domain-containing protein FOE
Gene trap ankyrin repeat protein
Gene namesi
Name:Ankrd17
Synonyms:Foe, Gtar, Kiaa0697
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1932101. Ankrd17.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Detected around the nucleolus.By similarity

GO - Cellular componenti

  • chromatin Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • membrane Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Deficient mice display embryonic lethality during organogenesis with hemorrhages, impaired vascular smooth muscle cell development, impaired vascular integrity and growth retardation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 26032603Ankyrin repeat domain-containing protein 17PRO_0000307918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei15 – 151PhosphoserineCombined sources
Modified residuei42 – 421PhosphoserineCombined sources
Modified residuei126 – 1261PhosphoserineBy similarity
Modified residuei130 – 1301PhosphoserineBy similarity
Modified residuei799 – 7991PhosphoserineBy similarity
Modified residuei1453 – 14531PhosphoserineBy similarity
Modified residuei1631 – 16311PhosphoserineBy similarity
Modified residuei1679 – 16791PhosphothreonineBy similarity
Modified residuei1692 – 16921PhosphoserineCombined sources
Modified residuei1696 – 16961PhosphoserineCombined sources
Modified residuei1705 – 17051PhosphoserineCombined sources
Modified residuei2038 – 20381PhosphoserineBy similarity
Modified residuei2040 – 20401PhosphoserineCombined sources
Modified residuei2041 – 20411PhosphoserineCombined sources
Modified residuei2043 – 20431PhosphoserineCombined sources
Modified residuei2055 – 20551PhosphoserineCombined sources
Modified residuei2063 – 20631PhosphoserineBy similarity
Modified residuei2401 – 24011PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated by CDK2.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99NH0.
MaxQBiQ99NH0.
PaxDbiQ99NH0.
PRIDEiQ99NH0.

PTM databases

iPTMnetiQ99NH0.
PhosphoSiteiQ99NH0.

Expressioni

Tissue specificityi

Highly expressed in fetal liver. Detected in adult liver cells, ovarian oocytes, seminiferous tubules of the testes and pelvic region of the kidney. It was not detected in heart, gut, lung, spleen and skeletal muscle. Earliest specific in situ marker of hepatic differentiation during embryogenesis, useful for characterization of inductive events involved in hepatic specification.3 Publications

Developmental stagei

Expressed at 8.0-8.5 dpc in the foregut endoderm and at 9.5 dpc in cells migrating into the septum transversum. At 10.5 dpc, highly expressed exclusively in the fetal liver. From 10.5 dpc, expressed in the developing liver throughout gestation and in neonates. At 17.5 dpc, detected in the dorsal root ganglia of the peripheral nervous system.1 Publication

Gene expression databases

BgeeiQ99NH0.
CleanExiMM_ANKRD17.
ExpressionAtlasiQ99NH0. baseline and differential.
GenevisibleiQ99NH0. MM.

Interactioni

Subunit structurei

Interacts (via N-terminus) with NOD2. Interacts with CDK2, MCM3, MCM5, MCM7, CDC6 and PCNA. Interacts with MAVS and IFIH1. Interacts (via the second ankyrin repeat cluster) with DDX58.By similarity

Protein-protein interaction databases

BioGridi219887. 2 interactions.
IntActiQ99NH0. 3 interactions.
MINTiMINT-4124581.
STRINGi10090.ENSMUSP00000014421.

Structurei

3D structure databases

ProteinModelPortaliQ99NH0.
SMRiQ99NH0. Positions 198-793, 1034-1504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati229 – 25830ANK 1Add
BLAST
Repeati262 – 29130ANK 2Add
BLAST
Repeati296 – 32530ANK 3Add
BLAST
Repeati329 – 35830ANK 4Add
BLAST
Repeati362 – 39130ANK 5Add
BLAST
Repeati396 – 42530ANK 6Add
BLAST
Repeati429 – 45830ANK 7Add
BLAST
Repeati462 – 49130ANK 8Add
BLAST
Repeati495 – 52430ANK 9Add
BLAST
Repeati529 – 55830ANK 10Add
BLAST
Repeati559 – 58830ANK 11Add
BLAST
Repeati592 – 62130ANK 12Add
BLAST
Repeati625 – 65430ANK 13Add
BLAST
Repeati659 – 68830ANK 14Add
BLAST
Repeati692 – 72130ANK 15Add
BLAST
Repeati1078 – 110730ANK 16Add
BLAST
Repeati1111 – 114030ANK 17Add
BLAST
Repeati1145 – 117430ANK 18Add
BLAST
Repeati1178 – 120730ANK 19Add
BLAST
Repeati1213 – 124230ANK 20Add
BLAST
Repeati1247 – 127630ANK 21Add
BLAST
Repeati1280 – 130930ANK 22Add
BLAST
Repeati1315 – 134430ANK 23Add
BLAST
Repeati1348 – 137730ANK 24Add
BLAST
Repeati1381 – 141030ANK 25Add
BLAST
Domaini1721 – 178565KHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1438 – 152285Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 4037Ala-richAdd
BLAST
Compositional biasi94 – 10613Gly-richAdd
BLAST
Compositional biasi854 – 1004151Gln-richAdd
BLAST
Compositional biasi1533 – 15375Poly-Thr
Compositional biasi1599 – 169698Ser-richAdd
BLAST
Compositional biasi1946 – 2102157Ser-richAdd
BLAST

Sequence similaritiesi

Contains 25 ANK repeats.PROSITE-ProRule annotation
Contains 1 KH domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4369. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000033942.
HOVERGENiHBG071352.
InParanoidiQ99NH0.
KOiK16726.
OMAiDCGTASP.
OrthoDBiEOG7MPRDH.
PhylomeDBiQ99NH0.
TreeFamiTF328552.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
3.30.1370.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF12796. Ank_2. 10 hits.
PF00013. KH_1. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 25 hits.
SM00322. KH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
SSF54791. SSF54791. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 20 hits.
PS50084. KH_TYPE_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: The N-terminus of another isoform lacking the first 141 amino acids is described in.1 Publication

Isoform 1 (identifier: Q99NH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKATVPAAA EGEGSPPAAA AVAAPPAAAA AEVGGGARPA SSPRGMVRVC
60 70 80 90 100
DLLLKKKPPQ QQQQQQPPHH KAKRNRTCRP PSSSESSSDS DNSGGGGGGG
110 120 130 140 150
GGGGGGTSSN NSEEEEDDDD EEEEVSEVES FILDQDDLEN PMLETASKLL
160 170 180 190 200
LSGTADGADL RTVDPETQAR LEALLEAAGI GKLSTADGKA FADPEVLRRL
210 220 230 240 250
TSSVSCALDE AAAALTRMRA ESTANAGQSD NRSLAEACSE GDVNAVRKLL
260 270 280 290 300
IEGRSVNEHT EEGESLLCLA CSAGYYELAQ VLLAMHANVE DRGIKGDITP
310 320 330 340 350
LMAAANGGHV KIVKLLLAHK ADVNAQSSTG NTALTYACAG GYVDVVKVLL
360 370 380 390 400
ESGASIEDHN ENGHTPLMEA GSAGHVEVAR LLLENGAGIN THSNEFKESA
410 420 430 440 450
LTLACYKGHL EMVRFLLEAG ADQEHKTDEM HTALMEACMD GHVEVARLLL
460 470 480 490 500
DSGAQVNMPA DSFESPLTLA ACGGHVELAA LLIERGASLE EVNDEGYTPL
510 520 530 540 550
MEAAREGHEE MVALLLGQGA NINAQTEETQ ETALTLACCG GFLEVADFLI
560 570 580 590 600
KAGADIELGC STPLMEAAQE GHLELVKYLL AAGANVHATT ATGDTALTYA
610 620 630 640 650
CENGHTDVAD VLLQAGADLE HESEGGRTPL MKAARAGHVC TVQFLISKGA
660 670 680 690 700
NVNRTTANND HTVLSLACAG GHLAVVELLL AHGADPTHRL KDGSTMLIEA
710 720 730 740 750
AKGGHTSVVC YLLDYPNNLL AAPPPDVTQL TPPSHDLNRA PRVPVQALPM
760 770 780 790 800
VVPPQEPDKP PANLAATLPV RSKAASKQKS NSHLPANSQD VQGYITNQSP
810 820 830 840 850
ESIVEEAQGK LTELEQRIKE AIEKNAQLQS LELAHADQLT KEKIEELNKT
860 870 880 890 900
REEQIQKKQK ILEELQKVER ELQLKTQQQL KKQYLEVKAQ RIQLQQQQQQ
910 920 930 940 950
SCQHLGLFTS VGVGEQLSEG DYARLQQVDP VLLKDEPQQT AAQMGFAPIQ
960 970 980 990 1000
PLAMPQALPL ATGPLPPGSI ANLTELQGVI VGQPVLGQAQ LAGLGQGILT
1010 1020 1030 1040 1050
ETQQGLMVAS PAQTLNDTLD DIMAAVSGRA SAMSNTPTHS IAASVSQPQT
1060 1070 1080 1090 1100
PTPSPIISPS AMLPIYPAID IDAQTESNHD TALTLACAGG HEELVQTLLE
1110 1120 1130 1140 1150
RGASIEHRDK KGFTPLILAA TAGHVGVVEI LLDNGADIEA QSERTKDTPL
1160 1170 1180 1190 1200
SLACSGGRQE VVELLLARGA NKEHRNVSDY TPLSLAASGG YVNIIKILLN
1210 1220 1230 1240 1250
AGAEINSRTG SKLGISPLML AAMNGHTAAV KLLLDMGSDI NAQIETNRNT
1260 1270 1280 1290 1300
ALTLACFQGR TEVVSLLLDR KANVEHRAKT GLTPLMEAAS GGYAEVGRVL
1310 1320 1330 1340 1350
LDKGADVNAP PVPSSRDTAL TIAADKGHYK FCELLIGKGA HIDVRNKKGN
1360 1370 1380 1390 1400
TPLWLAANGG HLDVVQLLVQ ATADVDAADN RKITPLMAAF RKGHVKVVRY
1410 1420 1430 1440 1450
LVKEVNQFPS DSECMRYIAT ITDKEMLKKC HLCMESIVQA KDRQAAEANK
1460 1470 1480 1490 1500
NASILLEELD LEKLREESRR LALAAKREKR KEKRRKKKEE QRRKLEEIEA
1510 1520 1530 1540 1550
KNKENFELQA AQEKEKLKVE EEPEVLTEPP SATTTTTIGI SATWTTLAGS
1560 1570 1580 1590 1600
HGKRNNTITT TSSKRKNRKN KITPENVQII FDDPLPISYS QPEKVNGESK
1610 1620 1630 1640 1650
SSSTSESGDS DNMRISSCSD ESSNSNSSRK SNNHASAVVT TTMASKKQPS
1660 1670 1680 1690 1700
VLVTFPKEER KSVSGKASIK LSETVNEGTS NSLSTCTKSG PSPLSSPNGK
1710 1720 1730 1740 1750
LTVASPKRGP KREEGWKEVV RRSKKVSVPS TVISRVIGRG GCNINAIREC
1760 1770 1780 1790 1800
TGAHIDIDKQ KDKTGDRIIT IRGGTESTRQ ATQLINALIK DPDKEIDELI
1810 1820 1830 1840 1850
PKNRLKSSTA NSKIGSSAPT TTAANSSLMG IKMTTVALSS TSQTATALTV
1860 1870 1880 1890 1900
PAISSASTHK TIKNPVNNVR PGFPVSLPLA YPPPQFAHAL LAAQTFQQIR
1910 1920 1930 1940 1950
PPRLPMTHFG GTFPPAQSTW GPFPVRPLSP ARATNSPKPH MVPRHSNQNS
1960 1970 1980 1990 2000
SGSQVNSAGS LTSSPTTTAS SSASAVPGTT SNGSPSSPSV RRQLFVTVVK
2010 2020 2030 2040 2050
TSNATTTTVT TTASNNSTAP TNATYPMPTA KEHYPVSSPS SPSPPAQPGG
2060 2070 2080 2090 2100
VSRNSPLDCG SASPNKGASA SEQEASSPPV VEPANSRPPH SSSSSGSSSG
2110 2120 2130 2140 2150
HSTQQQPPGS VPQEPRPPLQ QSQVPSPDVR MTVPPTATSS APVAVPSTAP
2160 2170 2180 2190 2200
VTYPMPQTQM GCSQPPKMEA PAIRPPSHAT AAPHKTPAPV QSSSASVLNV
2210 2220 2230 2240 2250
NHIKRPHSVP SSVQLPSTLS TQSACQNSVH PANKPVAPNF SAPLPFGPFS
2260 2270 2280 2290 2300
TLFENNPTNA HAFWGGPVVS SQSTPESMLS GKSSYLPNSD PLHQSDTSKA
2310 2320 2330 2340 2350
PGFRPPLQRP APSPSGIVNM DTPYGSVTPS STHLGNFASS LSGGQMYGPG
2360 2370 2380 2390 2400
APLGGAPLGG APTAANFNRQ HFSPLSLLTP CSSASNESPA QSVSSGVRAP
2410 2420 2430 2440 2450
SPAPSSVPLG SEKPSSVSQD RKVPVPIGTE RSARIRQTGT SAPSVIGSNL
2460 2470 2480 2490 2500
STSVGHSGIW SFEGIGGNQD KVDWCNPGMG NPMIHRPMSD PGVFSQHQAM
2510 2520 2530 2540 2550
ERDSTGIVTP SGTFHQHVPA GYMDFPKVGS MPFSVYGNAM LPPVAPIADG
2560 2570 2580 2590 2600
AGGPIFNGPH SAEPSWNSLI KMVSSSTENN GPQTVWTGPW APHMNSVHMN

QLG
Length:2,603
Mass (Da):274,213
Last modified:October 23, 2007 - v2
Checksum:i246DAA0E473C3D55
GO
Isoform 2 (identifier: Q99NH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.
     774-1024: Missing.
     1723-2603: Missing.

Note: No experimental confirmation available.
Show »
Length:1,330
Mass (Da):141,475
Checksum:i62113D2B852B4D12
GO
Isoform 3 (identifier: Q99NH0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1024-1024: Missing.
     1597-1600: GESK → VSFL
     1601-2603: Missing.

Note: No experimental confirmation available.
Show »
Length:1,599
Mass (Da):170,377
Checksum:i4F1E675363174B52
GO

Sequence cautioni

The sequence AAH39213.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC98003.1 differs from that shown.The sequence differs from that shown because it seems to be derived from a pre-mRNA.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti347 – 3471K → E in AAK07672 (PubMed:11165478).Curated
Sequence conflicti357 – 3571E → G in AAK07672 (PubMed:11165478).Curated
Sequence conflicti908 – 9081F → L in AAK07672 (PubMed:11165478).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 141141Missing in isoform 2. 1 PublicationVSP_028866Add
BLAST
Alternative sequencei774 – 1024251Missing in isoform 2. 1 PublicationVSP_028867Add
BLAST
Alternative sequencei1024 – 10241Missing in isoform 3. 1 PublicationVSP_028868
Alternative sequencei1597 – 16004GESK → VSFL in isoform 3. 1 PublicationVSP_028869
Alternative sequencei1601 – 26031003Missing in isoform 3. 1 PublicationVSP_028870Add
BLAST
Alternative sequencei1723 – 2603881Missing in isoform 2. 1 PublicationVSP_028871Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130371 mRNA. Translation: AAQ13559.1.
AC117578 Genomic DNA. No translation available.
AC162171 Genomic DNA. No translation available.
AY026253 mRNA. Translation: AAK07672.1.
AK160263 mRNA. Translation: BAE35720.1.
AK129193 Transcribed RNA. Translation: BAC98003.1. Sequence problems.
BC039213 mRNA. Translation: AAH39213.1. Different initiation.
BC057195 mRNA. Translation: AAH57195.1.
CCDSiCCDS57354.1. [Q99NH0-1]
RefSeqiNP_112148.2. NM_030886.2. [Q99NH0-1]
UniGeneiMm.245522.
Mm.441490.

Genome annotation databases

EnsembliENSMUST00000014421; ENSMUSP00000014421; ENSMUSG00000055204. [Q99NH0-1]
GeneIDi81702.
KEGGimmu:81702.
UCSCiuc008yav.1. mouse. [Q99NH0-2]
uc008yay.1. mouse. [Q99NH0-3]
uc029vje.1. mouse. [Q99NH0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130371 mRNA. Translation: AAQ13559.1.
AC117578 Genomic DNA. No translation available.
AC162171 Genomic DNA. No translation available.
AY026253 mRNA. Translation: AAK07672.1.
AK160263 mRNA. Translation: BAE35720.1.
AK129193 Transcribed RNA. Translation: BAC98003.1. Sequence problems.
BC039213 mRNA. Translation: AAH39213.1. Different initiation.
BC057195 mRNA. Translation: AAH57195.1.
CCDSiCCDS57354.1. [Q99NH0-1]
RefSeqiNP_112148.2. NM_030886.2. [Q99NH0-1]
UniGeneiMm.245522.
Mm.441490.

3D structure databases

ProteinModelPortaliQ99NH0.
SMRiQ99NH0. Positions 198-793, 1034-1504.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219887. 2 interactions.
IntActiQ99NH0. 3 interactions.
MINTiMINT-4124581.
STRINGi10090.ENSMUSP00000014421.

PTM databases

iPTMnetiQ99NH0.
PhosphoSiteiQ99NH0.

Proteomic databases

EPDiQ99NH0.
MaxQBiQ99NH0.
PaxDbiQ99NH0.
PRIDEiQ99NH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014421; ENSMUSP00000014421; ENSMUSG00000055204. [Q99NH0-1]
GeneIDi81702.
KEGGimmu:81702.
UCSCiuc008yav.1. mouse. [Q99NH0-2]
uc008yay.1. mouse. [Q99NH0-3]
uc029vje.1. mouse. [Q99NH0-1]

Organism-specific databases

CTDi26057.
MGIiMGI:1932101. Ankrd17.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4369. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000033942.
HOVERGENiHBG071352.
InParanoidiQ99NH0.
KOiK16726.
OMAiDCGTASP.
OrthoDBiEOG7MPRDH.
PhylomeDBiQ99NH0.
TreeFamiTF328552.

Miscellaneous databases

ChiTaRSiAnkrd17. mouse.
NextBioi350426.
PROiQ99NH0.
SOURCEiSearch...

Gene expression databases

BgeeiQ99NH0.
CleanExiMM_ANKRD17.
ExpressionAtlasiQ99NH0. baseline and differential.
GenevisibleiQ99NH0. MM.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
3.30.1370.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF12796. Ank_2. 10 hits.
PF00013. KH_1. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 25 hits.
SM00322. KH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
SSF54791. SSF54791. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 20 hits.
PS50084. KH_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel ankyrin repeat domain-containing protein."
    Chen X., Shen J.C.-K.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "A gene trap integration provides an early in situ marker for hepatic specification of the foregut endoderm."
    Watt A.J., Jones E.A., Ure J.M., Peddie D., Wilson D.I., Forrester L.M.
    Mech. Dev. 100:205-215(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), ALTERNATIVE SPLICING, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: 129/Sv.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1034-1482 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Testis.
  5. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1482-2603 (ISOFORM 1).
    Tissue: Embryonic tail.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1902-2603 (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor and Salivary gland.
  7. "Hepatic differentiation of murine embryonic stem cells."
    Jones E.A., Tosh D., Wilson D.I., Lindsay S., Forrester L.M.
    Exp. Cell Res. 272:15-22(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2043, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. "Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis."
    Hou S.C., Chan L.W., Chou Y.C., Su C.Y., Chen X., Shih Y.L., Tsai P.C., Shen C.K., Yan Y.T.
    FEBS Lett. 583:2765-2771(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-42; SER-1692; SER-1696; SER-1705; SER-2040; SER-2041; SER-2043; SER-2055 AND SER-2401, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiANR17_MOUSE
AccessioniPrimary (citable) accession number: Q99NH0
Secondary accession number(s): Q3TV99
, Q5F4T7, Q6PG69, Q6ZQ66, Q8CHT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: May 11, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.