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Protein

Ran-binding protein 17

Gene

Ranbp17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as a nuclear transport receptor.By similarity

GO - Molecular functioni

  • nuclear export signal receptor activity Source: GO_Central
  • Ran GTPase binding Source: MGI

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • nucleocytoplasmic transport Source: MGI
  • protein export from nucleus Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-binding protein 17
Gene namesi
Name:Ranbp17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1929706. Ranbp17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 10881087Ran-binding protein 17PRO_0000204719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei569 – 5691PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ99NF8.
PaxDbiQ99NF8.
PRIDEiQ99NF8.

PTM databases

iPTMnetiQ99NF8.
PhosphoSiteiQ99NF8.

Expressioni

Tissue specificityi

Highly expressed in primary spermatocytes and very weakly in pancreas.1 Publication

Gene expression databases

BgeeiENSMUSG00000040594.
CleanExiMM_RANBP17.
ExpressionAtlasiQ99NF8. baseline and differential.
GenevisibleiQ99NF8. MM.

Interactioni

Subunit structurei

Binds to nucleoporins and the GTP-bound form of Ran.By similarity

GO - Molecular functioni

  • Ran GTPase binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099879.

Family & Domainsi

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

eggNOGiKOG1410. Eukaryota.
ENOG410XRPR. LUCA.
GeneTreeiENSGT00730000110927.
HOGENOMiHOG000018865.
HOVERGENiHBG018869.
InParanoidiQ99NF8.
OMAiMDTGLPQ.
OrthoDBiEOG091G0ONG.
PhylomeDBiQ99NF8.
TreeFamiTF314248.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99NF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALHFQSLAE LEVLCTHLYV GTDLTERIEA EKALLELIDS PECLSKCQLL
60 70 80 90 100
LEQGTTSYAQ LLAATCLSKL VTRINPLPIE QRIDIRNYIL NYVASQPKLA
110 120 130 140 150
PFVIQALIQV IAKLTKLGWF EVQKDEFVFR EIIADVKKFL QGTVEHCIIG
160 170 180 190 200
VIILCELTQE MNLVDYSRPS AKHRKIATSF RDTSLKDILV LACSLLKQVL
210 220 230 240 250
AKPLNLQDQD QQSLVMQVLK LVLSCLNFDF LGSSADESAD DLCTVQIPTT
260 270 280 290 300
WRTIFLEPET LDLFFNLYHS LPPLLSQLAL SCLVQFASTR RSLFSSPERA
310 320 330 340 350
KYLGNLIKGV KRILENPQGL SDPGNYHEFC RFLARLKTNY QLGELVLVKE
360 370 380 390 400
YAEVIGLIAN FTITSLQHWE FAPNSVHYLL TLWQRMVASV PFVKSAEPHL
410 420 430 440 450
LDTYAPEITK AFITSRLESV AIVVRDNLED PLDDTATVFQ QLEQLCTVSR
460 470 480 490 500
CEYEKTCTLL VQLFDQNAQN YQKLLHAAPG LAVDMAIQEG RLAWLIYLVG
510 520 530 540 550
TVVGGRLTYT STDEHDAMDG ELSCRVFQLI SLMDTRLPHC TNEKIELAVL
560 570 580 590 600
WFLDQFRKTY VGDQLQRTSK VYARMSEVLG ITDDNHVLET FMTKIVTNLK
610 620 630 640 650
YWGRCEPVIS RTLQFLSDLS VGYILLKKLV KIDAVKFMLK NHTSEHFPFL
660 670 680 690 700
GISETYNVGD FRCRTTFYTA LTRLLMVDLG EDEDEFENFM LPLTVSFETV
710 720 730 740 750
LQIFNNNFKQ EEVKRMLIGL ARDLRGIAFA LNTKTSYTML FDWIYPAYLP
760 770 780 790 800
VLQRAIERWY GEPACTTPIL KLLAELMQNR SQRLNFDVSS PNGILLFREA
810 820 830 840 850
SKMICTYGNQ ILSLGSLSKD KIYPMKLKGI SICYSALKSA LCGNYVSFGV
860 870 880 890 900
FKLYGDNHFD NVLQAFVKML LSVSHSDLLQ YRKLSQSYYP LLECLTQDHM
910 920 930 940 950
SFITNLEPPV LLYVLTSLSE GLTTLDTVVS SSCCTSLDYM VTYLFKHIAK
960 970 980 990 1000
EGKKPLRSRE AMQAGQRLLH FMQQNPDVLQ QMMSVLMNTI VFEDCRNQWS
1010 1020 1030 1040 1050
VSRPLLGLIL LNEKYFSELR ASLINSQPLP KQEVLGQCFR NLMEGVEQNL
1060 1070 1080
SVKNRDRFTQ NLSVFRRDVA EALRSDGHTD LSSLDMMS
Length:1,088
Mass (Da):124,054
Last modified:June 1, 2001 - v1
Checksum:i69D73355E358B6E3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281V → I in BAB30322 (PubMed:16141072).Curated
Sequence conflicti469 – 4691Q → K in BAB30322 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271458 mRNA. Translation: CAC28935.1.
AK016583 mRNA. Translation: BAB30322.1.
CCDSiCCDS24534.1.
RefSeqiNP_075635.1. NM_023146.2.
UniGeneiMm.383775.

Genome annotation databases

EnsembliENSMUST00000102815; ENSMUSP00000099879; ENSMUSG00000040594.
GeneIDi66011.
KEGGimmu:66011.
UCSCiuc007ikh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271458 mRNA. Translation: CAC28935.1.
AK016583 mRNA. Translation: BAB30322.1.
CCDSiCCDS24534.1.
RefSeqiNP_075635.1. NM_023146.2.
UniGeneiMm.383775.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099879.

PTM databases

iPTMnetiQ99NF8.
PhosphoSiteiQ99NF8.

Proteomic databases

MaxQBiQ99NF8.
PaxDbiQ99NF8.
PRIDEiQ99NF8.

Protocols and materials databases

DNASUi66011.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102815; ENSMUSP00000099879; ENSMUSG00000040594.
GeneIDi66011.
KEGGimmu:66011.
UCSCiuc007ikh.2. mouse.

Organism-specific databases

CTDi64901.
MGIiMGI:1929706. Ranbp17.

Phylogenomic databases

eggNOGiKOG1410. Eukaryota.
ENOG410XRPR. LUCA.
GeneTreeiENSGT00730000110927.
HOGENOMiHOG000018865.
HOVERGENiHBG018869.
InParanoidiQ99NF8.
OMAiMDTGLPQ.
OrthoDBiEOG091G0ONG.
PhylomeDBiQ99NF8.
TreeFamiTF314248.

Miscellaneous databases

PROiQ99NF8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040594.
CleanExiMM_RANBP17.
ExpressionAtlasiQ99NF8. baseline and differential.
GenevisibleiQ99NF8. MM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiRBP17_MOUSE
AccessioniPrimary (citable) accession number: Q99NF8
Secondary accession number(s): Q9D4E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.