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Protein

Pre-B-cell leukemia transcription factor 4

Gene

Pbx4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi215 – 27763Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: BHF-UCL
  • regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-B-cell leukemia transcription factor 4
Alternative name(s):
Homeobox protein PBX4
Gene namesi
Name:Pbx4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1931321. Pbx4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: BHF-UCL
  • XY body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Pre-B-cell leukemia transcription factor 4PRO_0000049242Add
BLAST

Proteomic databases

PaxDbiQ99NE9.
PRIDEiQ99NE9.

PTM databases

PhosphoSiteiQ99NE9.

Expressioni

Tissue specificityi

Almost exclusively expressed in testis.1 Publication

Developmental stagei

Expressed in spermatocytes in the pachytene stage of the first meiotic prophase.

Gene expression databases

BgeeiQ99NE9.
CleanExiMM_PBX4.
ExpressionAtlasiQ99NE9. baseline and differential.
GenevisibleiQ99NE9. MM.

Interactioni

Protein-protein interaction databases

BioGridi219800. 9 interactions.
STRINGi10090.ENSMUSP00000080219.

Structurei

3D structure databases

ProteinModelPortaliQ99NE9.
SMRiQ99NE9. Positions 220-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0774. Eukaryota.
ENOG410XRVF. LUCA.
GeneTreeiENSGT00390000016426.
HOGENOMiHOG000266972.
HOVERGENiHBG000122.
InParanoidiQ99NE9.
KOiK15611.
OMAiQEEATMY.
PhylomeDBiQ99NE9.
TreeFamiTF314340.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99NE9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPLRPVPP QPAPRRLPTT APLGHDTSDV LQQIMAITDQ SLDEAQARKH
60 70 80 90 100
ALNCHRMKSA LFSVLCEIKG KTAVSIQFQE EDPPDAQLLR LDNMLLAEGV
110 120 130 140 150
SRPEKRGRGA AAGSTATPGG CPNDNSIEHS DYRAKLSQIR QIYHSELEKY
160 170 180 190 200
EQACREFTTH VTNLLREQSR VRPVSCREME HMVNTIQSKF SAIQRQLKQS
210 220 230 240 250
TCEAVMTLRS RFLDARRKRR NFSKQATDVL NEYFYSHLSN PYPSEETKEE
260 270 280 290 300
LARKGGITVS QVSNWFGNKR IRYKKNTGKF QEEATMYTGK ASTVTKARRP
310 320 330 340 350
RGQSSCQSTP SPGPCGPLPL TNGSDVVLTL RTLAFLQPPT GGVCLQPLVH
360 370
SNWQRAAPQP ASSPAGESGS FNWDAASN
Length:378
Mass (Da):41,961
Last modified:October 24, 2003 - v2
Checksum:iE3A8DEA28E428AA0
GO
Isoform 2 (identifier: Q99NE9-2) [UniParc]FASTAAdd to basket

Also known as: Truncated

The sequence of this isoform differs from the canonical sequence as follows:
     73-74: AV → GL
     75-378: Missing.

Show »
Length:74
Mass (Da):8,040
Checksum:i152E4891DDBEFC48
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei73 – 742AV → GL in isoform 2. 2 PublicationsVSP_008617
Alternative sequencei75 – 378304Missing in isoform 2. 2 PublicationsVSP_008618Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ300183 mRNA. Translation: CAC28213.1.
AJ300184 mRNA. Translation: CAC28214.1.
AK010506 mRNA. Translation: BAC25299.1.
BC032875 mRNA. Translation: AAH32875.1.
CCDSiCCDS22352.1. [Q99NE9-1]
RefSeqiNP_001020125.1. NM_001024954.1. [Q99NE9-1]
XP_006509865.1. XM_006509802.2.
XP_006509866.1. XM_006509803.1.
UniGeneiMm.210823.
Mm.417606.

Genome annotation databases

EnsembliENSMUST00000081503; ENSMUSP00000080219; ENSMUSG00000031860. [Q99NE9-1]
ENSMUST00000132899; ENSMUSP00000118287; ENSMUSG00000031860. [Q99NE9-2]
GeneIDi80720.
KEGGimmu:80720.
UCSCiuc009lxx.1. mouse. [Q99NE9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ300183 mRNA. Translation: CAC28213.1.
AJ300184 mRNA. Translation: CAC28214.1.
AK010506 mRNA. Translation: BAC25299.1.
BC032875 mRNA. Translation: AAH32875.1.
CCDSiCCDS22352.1. [Q99NE9-1]
RefSeqiNP_001020125.1. NM_001024954.1. [Q99NE9-1]
XP_006509865.1. XM_006509802.2.
XP_006509866.1. XM_006509803.1.
UniGeneiMm.210823.
Mm.417606.

3D structure databases

ProteinModelPortaliQ99NE9.
SMRiQ99NE9. Positions 220-276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219800. 9 interactions.
STRINGi10090.ENSMUSP00000080219.

PTM databases

PhosphoSiteiQ99NE9.

Proteomic databases

PaxDbiQ99NE9.
PRIDEiQ99NE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081503; ENSMUSP00000080219; ENSMUSG00000031860. [Q99NE9-1]
ENSMUST00000132899; ENSMUSP00000118287; ENSMUSG00000031860. [Q99NE9-2]
GeneIDi80720.
KEGGimmu:80720.
UCSCiuc009lxx.1. mouse. [Q99NE9-1]

Organism-specific databases

CTDi80714.
MGIiMGI:1931321. Pbx4.

Phylogenomic databases

eggNOGiKOG0774. Eukaryota.
ENOG410XRVF. LUCA.
GeneTreeiENSGT00390000016426.
HOGENOMiHOG000266972.
HOVERGENiHBG000122.
InParanoidiQ99NE9.
KOiK15611.
OMAiQEEATMY.
PhylomeDBiQ99NE9.
TreeFamiTF314340.

Miscellaneous databases

NextBioi350079.
PROiQ99NE9.
SOURCEiSearch...

Gene expression databases

BgeeiQ99NE9.
CleanExiMM_PBX4.
ExpressionAtlasiQ99NE9. baseline and differential.
GenevisibleiQ99NE9. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Pbx4, a new Pbx family member on mouse chromosome 8 is expressed during spermatogenesis."
    Wagner K., Mincheva A., Korn B., Lichter P., Poepperl H.
    Mech. Dev. 103:127-131(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-296 (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Strain: FVB/N.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 179-378 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Thymus.

Entry informationi

Entry nameiPBX4_MOUSE
AccessioniPrimary (citable) accession number: Q99NE9
Secondary accession number(s): Q8CFL2, Q99NE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: November 11, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.