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Protein

Regulating synaptic membrane exocytosis protein 1

Gene

Rims1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Rab effector involved in exocytosis (PubMed:11797009). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (PubMed:11797009). Plays a role in dendrite formation by melanocytes (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri133 – 19361FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • ion channel binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: MGI
  • Rab GTPase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • calcium ion-regulated exocytosis of neurotransmitter Source: MGI
  • intracellular protein transport Source: InterPro
  • neurotransmitter secretion Source: MGI
  • positive regulation of dendrite extension Source: MGI
  • positive regulation of excitatory postsynaptic potential Source: ParkinsonsUK-UCL
  • positive regulation of gene expression Source: ParkinsonsUK-UCL
  • positive regulation of inhibitory postsynaptic potential Source: ParkinsonsUK-UCL
  • protein complex assembly Source: MGI
  • regulation of long-term neuronal synaptic plasticity Source: MGI
  • regulation of membrane potential Source: MGI
  • spontaneous neurotransmitter secretion Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Biological processi

Differentiation, Exocytosis, Neurotransmitter transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 1
Alternative name(s):
Rab-3-interacting molecule 1
Short name:
RIM 1
Rab-3-interacting protein 1
Gene namesi
Name:Rims1
Synonyms:Kiaa0340, Rab3ip1, Rim1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2152971. Rims1.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • plasma membrane Source: ParkinsonsUK-UCL
  • postsynaptic density Source: MGI
  • presynaptic active zone Source: InterPro
  • presynaptic membrane Source: UniProtKB
  • synapse Source: MGI
  • vesicle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi33 – 331R → G: Abolishes interaction with RAB3A. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14631463Regulating synaptic membrane exocytosis protein 1PRO_0000190199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei413 – 4131PhosphoserineBy similarity
Modified residuei563 – 5631PhosphoserineCombined sources
Modified residuei566 – 5661PhosphoserineCombined sources
Modified residuei716 – 7161PhosphoserineCombined sources
Modified residuei812 – 8121PhosphoserineBy similarity
Modified residuei866 – 8661PhosphoserineCombined sources
Modified residuei1023 – 10231PhosphoserineCombined sources
Modified residuei1027 – 10271PhosphoserineCombined sources
Modified residuei1079 – 10791PhosphoserineBy similarity
Modified residuei1081 – 10811PhosphoserineBy similarity
Modified residuei1082 – 10821PhosphoserineBy similarity
Modified residuei1110 – 11101PhosphoserineCombined sources
Modified residuei1111 – 11111PhosphoserineCombined sources
Modified residuei1113 – 11131PhosphoserineCombined sources
Modified residuei1187 – 11871PhosphoserineBy similarity
Modified residuei1448 – 14481PhosphoserineCombined sources
Modified residuei1451 – 14511PhosphoserineCombined sources
Modified residuei1454 – 14541PhosphoserineBy similarity
Modified residuei1463 – 14631PhosphoserineBy similarity
Isoform 7 (identifier: Q99NE5-7)
Modified residuei413 – 4131PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated by BRSK1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99NE5.
PRIDEiQ99NE5.

PTM databases

iPTMnetiQ99NE5.

Expressioni

Gene expression databases

CleanExiMM_RIMS1.

Interactioni

Subunit structurei

Binds SNAP25, SYT1 and CACNA1B. Interaction with SYT1 is enhanced by calcium ions. Interaction with SNAP25 is weaker in the presence of calcium ions. Interacts with BZRAP1/RIMBP1 and RIMBP2; interacts with PPFIA3 and PPFIA4. Interacts with ERC1 (By similarity). Interacts with RAB3A, RAB3B and RAB3D that have been activated by GTP-binding. Interacts with RAB3C, RAB10, RAB26 AND RAB37. Binds UNC13A.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Fbxl20Q9CZV84EBI-775541,EBI-1551033

GO - Molecular functioni

  • ion channel binding Source: MGI
  • Rab GTPase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi228025. 9 interactions.
IntActiQ99NE5. 2 interactions.
MINTiMINT-1210408.

Structurei

3D structure databases

ProteinModelPortaliQ99NE5.
SMRiQ99NE5. Positions 136-193, 418-526, 580-706, 1295-1442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 205184RabBDPROSITE-ProRule annotationAdd
BLAST
Domaini440 – 52687PDZPROSITE-ProRule annotationAdd
BLAST
Domaini579 – 685107C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini1309 – 1411103C2 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 RabBD (Rab-binding) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri133 – 19361FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG058147.
InParanoidiQ99NE5.
KOiK15291.
PhylomeDBiQ99NE5.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
2.60.40.150. 2 hits.
3.30.40.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR001478. PDZ.
IPR010911. Rab_BD.
IPR030630. RIM1.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12157:SF19. PTHR12157:SF19. 2 hits.
PfamiPF00168. C2. 2 hits.
PF02318. FYVE_2. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF50156. SSF50156. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEiPS50004. C2. 2 hits.
PS50106. PDZ. 1 hit.
PS50916. RABBD. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced.

Isoform 1 (identifier: Q99NE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE
60 70 80 90 100
EAMLKCVVRD MAKPAACKTP RNAESQPHQP PLNIFRCVCV PRKPSSEEGG
110 120 130 140 150
PDRNWRLHQQ FESYKEQVRK IGEEARRYQG EHKDDAPTCG ICHKTKFADG
160 170 180 190 200
CGHLCSYCRT KFCARCGGRV SLRSNNEDKV VMWVCNLCRK QQEILTKSGA
210 220 230 240 250
WFFGSGPQQP SQDGTLSDTA TGAGSEVPRE KKARLQERSR SQTPLSTAAV
260 270 280 290 300
SSQDTASHGA PLDRNKGAEP SQQALGPEQK QASRSRSEPP RERKKAPGLS
310 320 330 340 350
EQNGKGGQKS ERKRVPKSVV QPGEGTADER ERKERRETRR LEKGRSQDYP
360 370 380 390 400
DRLEKREDGR VAEDEKQRKE EEGVSTPEYT SCEDVELESE SVSEKGDLDY
410 420 430 440 450
WLDPATWHSR ETSPISSHPV TWQPSKEGDR LIGRVILNKR TTMPKESGAL
460 470 480 490 500
LGLKVVGGKM TDLGRLGAFI TKVKKGSLAD VVGHLRAGDE VLEWNGKPLP
510 520 530 540 550
GATNEEVYNI ILESKSEPQV EIIVSRPIGD IPRIPESSHP PLESSSSSFE
560 570 580 590 600
SQKMERPSIS VISPTSPGAL KDAPQVLPGQ LSVKLWYDKV GHQLIVNVLQ
610 620 630 640 650
ATDLPPRVDG RPRNPYVKMY FLPDRSDKSK RRTKTVKKLL EPKWNQTFVY
660 670 680 690 700
SHVHRRDFRE RMLEITVWDQ PRVQDEESEF LGEILIELET ALLDDEPHWY
710 720 730 740 750
KLQTHDESSL PLPQPSPFMP RRHIHGESSS KKLQRSQRIS DSDISDYEVD
760 770 780 790 800
DGIGVVPPVG YRASARESKA TTLTVPEQQR TTHHRSRSVS PHRGDDQGRP
810 820 830 840 850
RSRLPNVPLQ RSLDEIHPTR RSRSPTRHHD ASRSLADHRS RHAESQYSSE
860 870 880 890 900
PDSELLMLPR AKRGRSAECL HMTSELQPSL DRARSASTNC LRPDTSLHSP
910 920 930 940 950
ERERGRWSPS LARRRPASPR IQIQHASPEN DRHSRKSERS SIQKQSRKGT
960 970 980 990 1000
ASDADRVLPP CLSRRGYAIP RATDQPVIRG KHTTRSRSSE HSSIRTLCSM
1010 1020 1030 1040 1050
HHLAPGGSAP PSPLLTRTHR QGSPTQSPPA DTSFGSRRGR QLPQVPVRSG
1060 1070 1080 1090 1100
SIEQASLVVE ERTRQMKMKV HRFKQTTGSG SSQELDHEQY SKYNIHKDQY
1110 1120 1130 1140 1150
RSCDNASAKS SDSDVSDVSA ISRASSTSRL SSTSFMSEQS ERPRGRISSF
1160 1170 1180 1190 1200
TPKMQGRRMG TSGRAIIKST SVSGEIYTLE HNDGSQSDTA VGTVGAGGKK
1210 1220 1230 1240 1250
RRSSLSAKVV AIVSRRSRST SQLSQTESGH KKLKSTIQRS TETGMAAEMR
1260 1270 1280 1290 1300
KMVRQPSRES TDGSINSYSS EGNLIFPGVR VGPDSQFSDF LDGLGPAQLV
1310 1320 1330 1340 1350
GRQTLATPAM GDIQIGMEDK KGQLEVEVIR ARSLTQKPGS KSTPAPYVKV
1360 1370 1380 1390 1400
YLLENGACIA KKKTRIARKT LDPLYQQSLV FDESPQGKVL QVIVWGDYGR
1410 1420 1430 1440 1450
MDHKCFMGVA QILLEELDLS SMVIGWYKLF PPSSLVDPTL TPLTRRASQS
1460
SLESSSGPPC IRS
Length:1,463
Mass (Da):163,161
Last modified:January 9, 2007 - v2
Checksum:i1E0BE5D522924738
GO
Isoform 2 (identifier: Q99NE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     373-388: GVSTPEYTSCEDVELE → YQTRYRSDPNLARYPV
     389-1463: Missing.

Show »
Length:388
Mass (Da):43,845
Checksum:iD928680A7C9516D9
GO
Isoform 3 (identifier: Q99NE5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     904-931: Missing.

Note: No experimental confirmation available.
Show »
Length:1,435
Mass (Da):159,940
Checksum:i1FC9923B9DB475D0
GO
Isoform 4 (identifier: Q99NE5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     904-931: Missing.
     956-1016: Missing.

Note: No experimental confirmation available.
Show »
Length:1,374
Mass (Da):153,345
Checksum:i6C99725DAB7FFE0D
GO
Isoform 5 (identifier: Q99NE5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     904-1016: Missing.

Note: No experimental confirmation available.
Show »
Length:1,350
Mass (Da):150,647
Checksum:i1DAECF1761B05766
GO
Isoform 6 (identifier: Q99NE5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     853-1016: Missing.

Note: No experimental confirmation available.
Show »
Length:1,299
Mass (Da):144,930
Checksum:i0D0D326E71A9C39A
GO
Isoform 7 (identifier: Q99NE5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     369-369: K → KEEEYQTRYR...KRRQMSVSSS
     853-1016: Missing.
     1150-1170: FTPKMQGRRMGTSGRAIIKST → LTLVLLMMALPYKFVQKSRLF
     1171-1463: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:1,184
Mass (Da):132,994
Checksum:i40271B0A3D3ACD08
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei369 – 3691K → KEEEYQTRYRSDPNLARYPV KAPLEEQQMRMHARVSRARH ERRHSDVALPHTEAAAAVSA ETTAGKRAQTTARVSPPESP RARAPAAQPPAEHGPPPPRP APGPAEPPEPRVPEPLRKQG RLDPGSAVLLRKAKREKAES MLRNDSLSSDQSESVRPSPP KPHRPKRGGKRRQMSVSSS in isoform 7. 1 PublicationVSP_022230
Alternative sequencei373 – 38816GVSTP…DVELE → YQTRYRSDPNLARYPV in isoform 2. 1 PublicationVSP_022231Add
BLAST
Alternative sequencei389 – 14631075Missing in isoform 2. 1 PublicationVSP_022232Add
BLAST
Alternative sequencei853 – 1016164Missing in isoform 6 and isoform 7. 2 PublicationsVSP_022233Add
BLAST
Alternative sequencei904 – 1016113Missing in isoform 5. 1 PublicationVSP_022234Add
BLAST
Alternative sequencei904 – 93128Missing in isoform 3 and isoform 4. 1 PublicationVSP_022235Add
BLAST
Alternative sequencei956 – 101661Missing in isoform 4. 1 PublicationVSP_022236Add
BLAST
Alternative sequencei1150 – 117021FTPKM…IIKST → LTLVLLMMALPYKFVQKSRL F in isoform 7. 1 PublicationVSP_022237Add
BLAST
Alternative sequencei1171 – 1463293Missing in isoform 7. 1 PublicationVSP_022238Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310531 mRNA. Translation: CAC32041.1.
AY356534 mRNA. Translation: AAR14797.1.
AY356535 mRNA. Translation: AAR14798.1.
AY356536 mRNA. Translation: AAR14799.1.
AY356537 mRNA. Translation: AAR14800.1.
AY356538 mRNA. Translation: AAR14801.1.
AK220335 mRNA. Translation: BAD90402.1.
RefSeqiNP_001012641.1. NM_001012623.1. [Q99NE5-4]
NP_001012642.1. NM_001012624.1. [Q99NE5-5]
NP_001012643.1. NM_001012625.1. [Q99NE5-6]
NP_444500.1. NM_053270.1. [Q99NE5-1]
NP_898839.2. NM_183018.2. [Q99NE5-3]
UniGeneiMm.380549.
Mm.416993.
Mm.461684.
Mm.60061.

Genome annotation databases

GeneIDi116837.
KEGGimmu:116837.
UCSCiuc029qni.1. mouse. [Q99NE5-1]
uc029qnj.1. mouse. [Q99NE5-3]
uc029qnk.1. mouse. [Q99NE5-4]
uc029qnm.1. mouse. [Q99NE5-6]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310531 mRNA. Translation: CAC32041.1.
AY356534 mRNA. Translation: AAR14797.1.
AY356535 mRNA. Translation: AAR14798.1.
AY356536 mRNA. Translation: AAR14799.1.
AY356537 mRNA. Translation: AAR14800.1.
AY356538 mRNA. Translation: AAR14801.1.
AK220335 mRNA. Translation: BAD90402.1.
RefSeqiNP_001012641.1. NM_001012623.1. [Q99NE5-4]
NP_001012642.1. NM_001012624.1. [Q99NE5-5]
NP_001012643.1. NM_001012625.1. [Q99NE5-6]
NP_444500.1. NM_053270.1. [Q99NE5-1]
NP_898839.2. NM_183018.2. [Q99NE5-3]
UniGeneiMm.380549.
Mm.416993.
Mm.461684.
Mm.60061.

3D structure databases

ProteinModelPortaliQ99NE5.
SMRiQ99NE5. Positions 136-193, 418-526, 580-706, 1295-1442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228025. 9 interactions.
IntActiQ99NE5. 2 interactions.
MINTiMINT-1210408.

PTM databases

iPTMnetiQ99NE5.

Proteomic databases

MaxQBiQ99NE5.
PRIDEiQ99NE5.

Protocols and materials databases

DNASUi116837.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116837.
KEGGimmu:116837.
UCSCiuc029qni.1. mouse. [Q99NE5-1]
uc029qnj.1. mouse. [Q99NE5-3]
uc029qnk.1. mouse. [Q99NE5-4]
uc029qnm.1. mouse. [Q99NE5-6]

Organism-specific databases

CTDi22999.
MGIiMGI:2152971. Rims1.
RougeiSearch...

Phylogenomic databases

HOVERGENiHBG058147.
InParanoidiQ99NE5.
KOiK15291.
PhylomeDBiQ99NE5.

Miscellaneous databases

ChiTaRSiRims1. mouse.
PROiQ99NE5.
SOURCEiSearch...

Gene expression databases

CleanExiMM_RIMS1.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
2.60.40.150. 2 hits.
3.30.40.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR001478. PDZ.
IPR010911. Rab_BD.
IPR030630. RIM1.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12157:SF19. PTHR12157:SF19. 2 hits.
PfamiPF00168. C2. 2 hits.
PF02318. FYVE_2. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF50156. SSF50156. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEiPS50004. C2. 2 hits.
PS50106. PDZ. 1 hit.
PS50916. RABBD. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rim1 and rabphilin-3 bind Rab3-GTP by composite determinants partially related through N-terminal alpha-helix motifs."
    Wang X., Hu B., Zimmermann B., Kilimann M.W.
    J. Biol. Chem. 276:32480-32488(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, MUTAGENESIS OF ARG-33, INTERACTION WITH RAB3A; RAB3B AND RAB3D.
    Tissue: Brain.
  2. Wang X., Hu B., Kilimann M.W.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4; 5 AND 6).
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 202-1463 (ISOFORM 7).
    Tissue: Brain.
  4. "RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone."
    Schoch S., Castillo P.E., Jo T., Mukherjee K., Geppert M., Wang Y., Schmitz F., Malenka R.C., Suedhof T.C.
    Nature 415:321-326(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2."
    Fukuda M.
    J. Biol. Chem. 278:15373-15380(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAB3A; RAB3B; RAB3C; RAB3D; RAB10; RAB26 AND RAB37.
  6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  7. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-563; SER-566; SER-716; SER-866; SER-1023; SER-1027; SER-1110; SER-1111; SER-1113; SER-1448 AND SER-1451, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413 (ISOFORM 7), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Testis.

Entry informationi

Entry nameiRIMS1_MOUSE
AccessioniPrimary (citable) accession number: Q99NE5
Secondary accession number(s): Q5DU35
, Q5J8K0, Q5J8K1, Q5J8K2, Q5J8K3, Q5J8K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: January 9, 2007
Last modified: June 8, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.