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Protein

RWD domain-containing protein 1

Gene

Rwdd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protects DRG2 from proteolytic degradation.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
RWD domain-containing protein 1
Alternative name(s):
Small androgen receptor-interacting protein
Gene namesi
Name:Rwdd1
Synonyms:Sarip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi631337. Rwdd1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 243242RWD domain-containing protein 1PRO_0000097542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity
Modified residuei144 – 1441PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ99ND9.
PRIDEiQ99ND9.

Interactioni

Subunit structurei

Interacts with DRG2 (By similarity). Interacts with androgen receptor.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062656.

Structurei

3D structure databases

ProteinModelPortaliQ99ND9.
SMRiQ99ND9. Positions 1-121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 114105RWDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni142 – 19756Interaction with DRG2By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the RWDD1/GIR2 family.Curated
Contains 1 RWD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4018. Eukaryota.
ENOG410XT0M. LUCA.
GeneTreeiENSGT00390000009168.
HOVERGENiHBG060864.
InParanoidiQ99ND9.
OMAiPPLWEIY.
OrthoDBiEOG779NZV.
PhylomeDBiQ99ND9.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR032378. ZC3H15/TMA46_C.
[Graphical view]
PfamiPF16543. DFRP_C. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99ND9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDYGEEQRN ELEALESIYP DSFTVLSENP PSFTITVTSE AGENDETVQT
60 70 80 90 100
TLKFTYSEKY PDEAPLYEIF SQENLEDNDV SDILKLLALQ AEENLGMVMI
110 120 130 140 150
FTLVTAVQEK LNEIVDQIKT RREEEKKQKE KEAEEAEKKL FHGTPVTIEN
160 170 180 190 200
FLSWKAKFDA ELLEIKKKRM KEEEQAGKNK LSGKQLFETD HNLDTSDIQF
210 220 230 240
LEDAGNNVEV DESLFQEMDD LELEDGEDDP DYNPVAPGSD SSD
Length:243
Mass (Da):27,782
Last modified:June 1, 2001 - v1
Checksum:i57EA63249E2B3813
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132390 mRNA. Translation: CAC24710.1.
RefSeqiNP_671487.1. NM_147146.2.
UniGeneiRn.234293.
Rn.23942.

Genome annotation databases

EnsembliENSRNOT00000068777; ENSRNOP00000062656; ENSRNOG00000042916.
GeneIDi259218.
KEGGirno:259218.
UCSCiRGD:631337. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132390 mRNA. Translation: CAC24710.1.
RefSeqiNP_671487.1. NM_147146.2.
UniGeneiRn.234293.
Rn.23942.

3D structure databases

ProteinModelPortaliQ99ND9.
SMRiQ99ND9. Positions 1-121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062656.

Proteomic databases

PaxDbiQ99ND9.
PRIDEiQ99ND9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000068777; ENSRNOP00000062656; ENSRNOG00000042916.
GeneIDi259218.
KEGGirno:259218.
UCSCiRGD:631337. rat.

Organism-specific databases

CTDi51389.
RGDi631337. Rwdd1.

Phylogenomic databases

eggNOGiKOG4018. Eukaryota.
ENOG410XT0M. LUCA.
GeneTreeiENSGT00390000009168.
HOVERGENiHBG060864.
InParanoidiQ99ND9.
OMAiPPLWEIY.
OrthoDBiEOG779NZV.
PhylomeDBiQ99ND9.

Miscellaneous databases

PROiQ99ND9.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR032378. ZC3H15/TMA46_C.
[Graphical view]
PfamiPF16543. DFRP_C. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A small novel protein interacts with androgen receptor."
    Rouleau N., Reeben M., Palvimo J.J., Janne O.A.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiRWDD1_RAT
AccessioniPrimary (citable) accession number: Q99ND9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.