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Protein

Transcription cofactor vestigial-like protein 1

Gene

Vgll1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May act as a specific coactivator for the mammalian TEFs.By similarity

GO - Molecular functioni

  • protein C-terminus binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 1
Short name:
Vgl-1
Alternative name(s):
Vestigial-related factor
Gene namesi
Name:Vgll1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2655768. Vgll1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Transcription cofactor vestigial-like protein 1PRO_0000191348Add
BLAST

Proteomic databases

PaxDbiQ99NC0.
PRIDEiQ99NC0.

PTM databases

PhosphoSiteiQ99NC0.

Expressioni

Gene expression databases

BgeeiQ99NC0.
CleanExiMM_VGLL1.
ExpressionAtlasiQ99NC0. differential.
GenevisibleiQ99NC0. MM.

Interactioni

Subunit structurei

Interacts with TEFs.By similarity

GO - Molecular functioni

  • protein C-terminus binding Source: MGI

Protein-protein interaction databases

DIPiDIP-59848N.
STRINGi10090.ENSMUSP00000033465.

Structurei

Secondary structure

1
307
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 315Combined sources
Beta strandi33 – 353Combined sources
Helixi37 – 4610Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EAZX-ray2.80C/D20-51[»]
ProteinModelPortaliQ99NC0.
SMRiQ99NC0. Positions 20-51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vestigial family.Curated

Phylogenomic databases

eggNOGiENOG410IZ27. Eukaryota.
ENOG410YSUV. LUCA.
GeneTreeiENSGT00730000111322.
HOGENOMiHOG000231385.
HOVERGENiHBG055872.
InParanoidiQ99NC0.
OMAiPAARENC.
OrthoDBiEOG7K9K52.
PhylomeDBiQ99NC0.
TreeFamiTF326340.

Family and domain databases

InterProiIPR011520. Vg_fam.
[Graphical view]
PANTHERiPTHR15950. PTHR15950. 2 hits.
PfamiPF07545. Vg_Tdu. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99NC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEMKKNGVW IPESSQKPVK TEWNAGSVIF TYFEGDINSM VDEHFSRALR
60 70 80 90 100
NLKRPHKCSS SSHSDNLTLK NGVNKTRTDT SHTDRERKVE SSQTENSGEL
110 120 130 140 150
KDVPVEEKGT NKSMPPNQRH LSSWTIAQPA ASPENGARSS SLDEYGLKAM
160 170 180 190 200
DQHSLSMPKT PSALPLEPWH FSSLARPGFI APAYFPVFPD RHLTPEVYRV
210 220 230 240 250
FPDRHLTPEV YHVFPDRHLT PEVYPDGRCG PLQHLVQQDR YQNHPLEPAA
260 270 280 290 300
RENCSPAKIA GSTGSLMNLP PYPVHYKKKI CARGAASASL DDERSPSPKR

RRDAYYY
Length:307
Mass (Da):34,691
Last modified:June 1, 2001 - v1
Checksum:i1AC4714CF93C27E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036708 mRNA. Translation: BAB40534.1.
AL672128 Genomic DNA. Translation: CAM15572.1.
CCDSiCCDS30151.1.
RefSeqiNP_001300692.1. NM_001313763.1.
NP_573514.1. NM_133251.2.
UniGeneiMm.190616.

Genome annotation databases

EnsembliENSMUST00000033465; ENSMUSP00000033465; ENSMUSG00000031131.
ENSMUST00000114745; ENSMUSP00000110393; ENSMUSG00000031131.
ENSMUST00000114746; ENSMUSP00000110394; ENSMUSG00000031131.
GeneIDi170828.
KEGGimmu:170828.
UCSCiuc009tgz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036708 mRNA. Translation: BAB40534.1.
AL672128 Genomic DNA. Translation: CAM15572.1.
CCDSiCCDS30151.1.
RefSeqiNP_001300692.1. NM_001313763.1.
NP_573514.1. NM_133251.2.
UniGeneiMm.190616.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EAZX-ray2.80C/D20-51[»]
ProteinModelPortaliQ99NC0.
SMRiQ99NC0. Positions 20-51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59848N.
STRINGi10090.ENSMUSP00000033465.

PTM databases

PhosphoSiteiQ99NC0.

Proteomic databases

PaxDbiQ99NC0.
PRIDEiQ99NC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033465; ENSMUSP00000033465; ENSMUSG00000031131.
ENSMUST00000114745; ENSMUSP00000110393; ENSMUSG00000031131.
ENSMUST00000114746; ENSMUSP00000110394; ENSMUSG00000031131.
GeneIDi170828.
KEGGimmu:170828.
UCSCiuc009tgz.1. mouse.

Organism-specific databases

CTDi51442.
MGIiMGI:2655768. Vgll1.

Phylogenomic databases

eggNOGiENOG410IZ27. Eukaryota.
ENOG410YSUV. LUCA.
GeneTreeiENSGT00730000111322.
HOGENOMiHOG000231385.
HOVERGENiHBG055872.
InParanoidiQ99NC0.
OMAiPAARENC.
OrthoDBiEOG7K9K52.
PhylomeDBiQ99NC0.
TreeFamiTF326340.

Miscellaneous databases

PROiQ99NC0.
SOURCEiSearch...

Gene expression databases

BgeeiQ99NC0.
CleanExiMM_VGLL1.
ExpressionAtlasiQ99NC0. differential.
GenevisibleiQ99NC0. MM.

Family and domain databases

InterProiIPR011520. Vg_fam.
[Graphical view]
PANTHERiPTHR15950. PTHR15950. 2 hits.
PfamiPF07545. Vg_Tdu. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a cDNA encoding mouse vestigial-related factor that interacts with the TEAD family transcription factors."
    Yasunami M.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiVGLL1_MOUSE
AccessioniPrimary (citable) accession number: Q99NC0
Secondary accession number(s): A2AFJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.