Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q99NB4

- Q99NB4_RAT

UniProt

Q99NB4 - Q99NB4_RAT

Protein
Submitted name:

Cyclin D1

Gene

Ccnd1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: Ensembl
    2. protein kinase activity Source: Ensembl
    3. transcription corepressor activity Source: Ensembl

    GO - Biological processi

    1. canonical Wnt signaling pathway Source: Ensembl
    2. endoplasmic reticulum unfolded protein response Source: Ensembl
    3. fat cell differentiation Source: Ensembl
    4. lactation Source: Ensembl
    5. mammary gland alveolus development Source: Ensembl
    6. mammary gland epithelial cell proliferation Source: Ensembl
    7. mitotic G1 DNA damage checkpoint Source: Ensembl
    8. negative regulation of epithelial cell differentiation Source: Ensembl
    9. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    10. negative regulation of Wnt signaling pathway Source: Ensembl
    11. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
    12. positive regulation of mammary gland epithelial cell proliferation Source: Ensembl
    13. re-entry into mitotic cell cycle Source: Ensembl
    14. response to drug Source: Ensembl
    15. response to UV-A Source: Ensembl

    Keywords - Molecular functioni

    CyclinUniRule annotationImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cyclin D1Imported
    Gene namesi
    Name:Ccnd1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi68384. Ccnd1.

    Subcellular locationi

    GO - Cellular componenti

    1. cyclin-dependent protein kinase holoenzyme complex Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. nucleus Source: Ensembl
    4. tight junction Source: Ensembl
    5. transcriptional repressor complex Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ99NB4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99NB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG107315.
    InParanoidiQ99NB4.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR013763. Cyclin-like.
    IPR015451. Cyclin_D.
    IPR006671. Cyclin_N.
    [Graphical view]
    PANTHERiPTHR10177:SF67. PTHR10177:SF67. 1 hit.
    PfamiPF00134. Cyclin_N. 1 hit.
    [Graphical view]
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 1 hit.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q99NB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHQLLCCEV ETIRRAYPDT NLLNDRVLRA MLKTEETCAP SVSYFKCVQR    50
    EIVPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPLKKSRLQ 100
    LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPEELLQM ELLLVNKLKW 150
    NLAAMTPHDF IEHFLSKMPE ADENKQIIRK HAQTFVALCA T 191
    Length:191
    Mass (Da):22,203
    Last modified:June 1, 2001 - v1
    Checksum:iAA97B6E0F332EDEE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei191 – 1911Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB042564 Genomic DNA. Translation: BAB40333.1.
    UniGeneiRn.22279.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB042564 Genomic DNA. Translation: BAB40333.1 .
    UniGenei Rn.22279.

    3D structure databases

    ProteinModelPortali Q99NB4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 68384. Ccnd1.

    Phylogenomic databases

    HOVERGENi HBG107315.
    InParanoidi Q99NB4.

    Gene expression databases

    Genevestigatori Q99NB4.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR013763. Cyclin-like.
    IPR015451. Cyclin_D.
    IPR006671. Cyclin_N.
    [Graphical view ]
    PANTHERi PTHR10177:SF67. PTHR10177:SF67. 1 hit.
    Pfami PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 1 hit.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of rat cyclin D1 5' flanking region."
      Moriuchi A., Ido A., Tsubouchi H.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WistarImported.

    Entry informationi

    Entry nameiQ99NB4_RAT
    AccessioniPrimary (citable) accession number: Q99NB4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)