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Q99NB4

- Q99NB4_RAT

UniProt

Q99NB4 - Q99NB4_RAT

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Protein
Submitted name:

Cyclin D1

Gene

Ccnd1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: Ensembl
  2. protein kinase activity Source: Ensembl
  3. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. canonical Wnt signaling pathway Source: Ensembl
  2. endoplasmic reticulum unfolded protein response Source: Ensembl
  3. fat cell differentiation Source: Ensembl
  4. lactation Source: Ensembl
  5. mammary gland alveolus development Source: Ensembl
  6. mammary gland epithelial cell proliferation Source: Ensembl
  7. mitotic G1 DNA damage checkpoint Source: Ensembl
  8. negative regulation of cell cycle arrest Source: Ensembl
  9. negative regulation of epithelial cell differentiation Source: Ensembl
  10. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. negative regulation of Wnt signaling pathway Source: Ensembl
  12. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  13. positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl
  14. positive regulation of mammary gland epithelial cell proliferation Source: Ensembl
  15. re-entry into mitotic cell cycle Source: Ensembl
  16. response to drug Source: Ensembl
  17. response to UV-A Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

CyclinUniRule annotationImported

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclin D1Imported
Gene namesi
Name:Ccnd1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi68384. Ccnd1.

Subcellular locationi

GO - Cellular componenti

  1. cyclin-dependent protein kinase holoenzyme complex Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nucleus Source: Ensembl
  4. tight junction Source: Ensembl
  5. transcriptional repressor complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ99NB4. baseline and differential.
GenevestigatoriQ99NB4.

Structurei

3D structure databases

ProteinModelPortaliQ99NB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG107315.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF67. PTHR10177:SF67. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99NB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEHQLLCCEV ETIRRAYPDT NLLNDRVLRA MLKTEETCAP SVSYFKCVQR
60 70 80 90 100
EIVPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPLKKSRLQ
110 120 130 140 150
LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPEELLQM ELLLVNKLKW
160 170 180 190
NLAAMTPHDF IEHFLSKMPE ADENKQIIRK HAQTFVALCA T
Length:191
Mass (Da):22,203
Last modified:June 1, 2001 - v1
Checksum:iAA97B6E0F332EDEE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei191 – 1911Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042564 Genomic DNA. Translation: BAB40333.1.
UniGeneiRn.22279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042564 Genomic DNA. Translation: BAB40333.1 .
UniGenei Rn.22279.

3D structure databases

ProteinModelPortali Q99NB4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 68384. Ccnd1.

Phylogenomic databases

HOVERGENi HBG107315.

Gene expression databases

ExpressionAtlasi Q99NB4. baseline and differential.
Genevestigatori Q99NB4.

Family and domain databases

Gene3Di 1.10.472.10. 1 hit.
InterProi IPR013763. Cyclin-like.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view ]
PANTHERi PTHR10177:SF67. PTHR10177:SF67. 1 hit.
Pfami PF00134. Cyclin_N. 1 hit.
[Graphical view ]
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 1 hit.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of rat cyclin D1 5' flanking region."
    Moriuchi A., Ido A., Tsubouchi H.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.

Entry informationi

Entry nameiQ99NB4_RAT
AccessioniPrimary (citable) accession number: Q99NB4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)