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Q99NB4

- Q99NB4_RAT

UniProt

Q99NB4 - Q99NB4_RAT

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Protein
Submitted name:

Cyclin D1

Gene
Ccnd1
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: Ensembl
  2. protein kinase activity Source: Ensembl
  3. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. canonical Wnt signaling pathway Source: Ensembl
  2. endoplasmic reticulum unfolded protein response Source: Ensembl
  3. fat cell differentiation Source: Ensembl
  4. lactation Source: Ensembl
  5. mammary gland alveolus development Source: Ensembl
  6. mammary gland epithelial cell proliferation Source: Ensembl
  7. mitotic G1 DNA damage checkpoint Source: Ensembl
  8. negative regulation of epithelial cell differentiation Source: Ensembl
  9. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  10. negative regulation of Wnt signaling pathway Source: Ensembl
  11. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  12. positive regulation of mammary gland epithelial cell proliferation Source: Ensembl
  13. re-entry into mitotic cell cycle Source: Ensembl
  14. response to drug Source: Ensembl
  15. response to UV-A Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

CyclinUniRule annotationImported

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclin D1Imported
Gene namesi
Name:Ccnd1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi68384. Ccnd1.

Subcellular locationi

GO - Cellular componenti

  1. cyclin-dependent protein kinase holoenzyme complex Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nucleus Source: Ensembl
  4. tight junction Source: Ensembl
  5. transcriptional repressor complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ99NB4.

Structurei

3D structure databases

ProteinModelPortaliQ99NB4.

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG107315.
InParanoidiQ99NB4.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF67. PTHR10177:SF67. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99NB4-1 [UniParc]FASTAAdd to Basket

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MEHQLLCCEV ETIRRAYPDT NLLNDRVLRA MLKTEETCAP SVSYFKCVQR    50
EIVPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPLKKSRLQ 100
LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPEELLQM ELLLVNKLKW 150
NLAAMTPHDF IEHFLSKMPE ADENKQIIRK HAQTFVALCA T 191
Length:191
Mass (Da):22,203
Last modified:June 1, 2001 - v1
Checksum:iAA97B6E0F332EDEE
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei191 – 1911Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB042564 Genomic DNA. Translation: BAB40333.1.
UniGeneiRn.22279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB042564 Genomic DNA. Translation: BAB40333.1 .
UniGenei Rn.22279.

3D structure databases

ProteinModelPortali Q99NB4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 68384. Ccnd1.

Phylogenomic databases

HOVERGENi HBG107315.
InParanoidi Q99NB4.

Gene expression databases

Genevestigatori Q99NB4.

Family and domain databases

Gene3Di 1.10.472.10. 1 hit.
InterProi IPR013763. Cyclin-like.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view ]
PANTHERi PTHR10177:SF67. PTHR10177:SF67. 1 hit.
Pfami PF00134. Cyclin_N. 1 hit.
[Graphical view ]
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 1 hit.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of rat cyclin D1 5' flanking region."
    Moriuchi A., Ido A., Tsubouchi H.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.

Entry informationi

Entry nameiQ99NB4_RAT
AccessioniPrimary (citable) accession number: Q99NB4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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