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Protein

Polycomb group RING finger protein 6

Gene

Pcgf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri137 – 176RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 6
Alternative name(s):
Mel18 and Bmi1-like RING finger
RING finger protein 134
Gene namesi
Name:Pcgf6
Synonyms:Mblr, Rnf134
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1918291. Pcgf6.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
  • PcG protein complex Source: UniProtKB
  • PRC1 complex Source: UniProtKB

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559901 – 353Polycomb group RING finger protein 6Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineBy similarity1
Modified residuei118PhosphoserineCombined sources1
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Phosphorylated during mitosis.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99NA9.
MaxQBiQ99NA9.
PaxDbiQ99NA9.
PeptideAtlasiQ99NA9.
PRIDEiQ99NA9.

PTM databases

iPTMnetiQ99NA9.
PhosphoSitePlusiQ99NA9.

Expressioni

Tissue specificityi

Expressed in ovary, testis, stomach, liver, thymus and kidney (at protein level).1 Publication

Developmental stagei

Expressed in embryo at 10.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000025050.
CleanExiMM_PCGF6.
GenevisibleiQ99NA9. MM.

Interactioni

Subunit structurei

Component of a PRC1-like complex. Interacts with BMI1/PCGF4, RING1 and RNF2. Interacts with KDM5D. Interacts with CBX4, CBX6, CBX7 and CBX8 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214431. 7 interactors.
IntActiQ99NA9. 6 interactors.
STRINGi10090.ENSMUSP00000026032.

Structurei

3D structure databases

ProteinModelPortaliQ99NA9.
SMRiQ99NA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili71 – 112Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 42Pro-richAdd BLAST19
Compositional biasi82 – 123Glu-richAdd BLAST42

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri137 – 176RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
GeneTreeiENSGT00550000074463.
HOGENOMiHOG000231946.
HOVERGENiHBG052826.
InParanoidiQ99NA9.
KOiK11470.
OMAiCIVKHFF.
OrthoDBiEOG091G0EC9.
PhylomeDBiQ99NA9.
TreeFamiTF324206.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR029071. Ubiquitin-rel_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99NA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEAETDATE NKRASEAKRA SAMPPPPPPP PPISPPALIP APAAGEEGPA
60 70 80 90 100
SLGQAGAAGC SRSRPPALEP ERSLGRLRGR FEDYDEELEE EEEMEEEEEE
110 120 130 140 150
EEEMSHFSLR LESGRADSED EEERLINLVE LTPYILCSIC KGYLIDATTI
160 170 180 190 200
TECLHTFCKS CIVRHFYYSN RCPKCNIVVH QTQPLYNIRL DRQLQDIVYK
210 220 230 240 250
LVINLEEREK KQMHDFYKER GLEVPKPAAP QPVPSSKGKT KKVLESVFRI
260 270 280 290 300
PPELDMSLLL EFIGANEDTG HFKPLEKKFV RVSGEATIGH VEKFLRRKMG
310 320 330 340 350
LDPACQVDII CGDHLLERYQ TLREIRRAIG DTAMQDGLLV LHYGLVVSPL

KIT
Length:353
Mass (Da):39,820
Last modified:June 1, 2001 - v1
Checksum:i0D29B7FE065B5448
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047007 mRNA. Translation: BAB40780.1.
BC016195 mRNA. Translation: AAH16195.1.
BC089460 mRNA. Translation: AAH89460.1.
CCDSiCCDS29885.1.
RefSeqiNP_081930.1. NM_027654.3.
UniGeneiMm.35413.

Genome annotation databases

EnsembliENSMUST00000026032; ENSMUSP00000026032; ENSMUSG00000025050.
GeneIDi71041.
KEGGimmu:71041.
UCSCiuc008hul.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPCGF6_MOUSE
AccessioniPrimary (citable) accession number: Q99NA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot