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Protein

Pituitary homeobox 1

Gene

Pitx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi89 – 148HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary homeobox 1
Alternative name(s):
Homeobox protein PITX1
Paired-like homeodomain transcription factor 1
Gene namesi
Name:Pitx1
Synonyms:Ptx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi69253 Pitx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492201 – 315Pituitary homeobox 1Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei46PhosphoserineBy similarity1
Modified residuei48PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ99NA7

PTM databases

iPTMnetiQ99NA7
PhosphoSitePlusiQ99NA7

Expressioni

Gene expression databases

BgeeiENSRNOG00000011423
GenevisibleiQ99NA7 RN

Interactioni

Subunit structurei

Interacts with POU1F1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015307

Structurei

3D structure databases

ProteinModelPortaliQ99NA7
SMRiQ99NA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni149 – 280Interaction with PIT-1By similarityAdd BLAST132

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi281 – 294OARPROSITE-ProRule annotationAdd BLAST14
Motifi287 – 291Nuclear localization signalSequence analysis5

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0486 Eukaryota
ENOG410ZZ6J LUCA
GeneTreeiENSGT00900000140776
HOGENOMiHOG000273886
HOVERGENiHBG068770
InParanoidiQ99NA7
KOiK09356
OMAiNNWTNKG
OrthoDBiEOG091G0H7U
PhylomeDBiQ99NA7
TreeFamiTF351940

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR016233 Homeobox_Pitx/unc30
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
PIRSFiPIRSF000563 Homeobox_protein_Pitx/Unc30, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit

Sequencei

Sequence statusi: Complete.

Q99NA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAFKGGMSL ERLPEGLRPP PPPPHDMGPS FHLARTADPR EPLENSASES
60 70 80 90 100
SDADLPDKER GGEAKVPEDG GAGSAGCGSA EDPAKKKKQR RQRTHFTSQQ
110 120 130 140 150
LQELEATFQR NRYPDMSMRE EIAVWTNLTE PRVRVWFKNR RAKWRKRERN
160 170 180 190 200
QQLDLCKGGY VPQFSGLVQP YEDVYAAAGY SYNNWAAKSL APAPLSTKSF
210 220 230 240 250
TFFNSMSPLS SQSMFSAPSS ISSMTMPSSM GPGSVPGMPN SGLNNINNLT
260 270 280 290 300
GSSLNSAMSP GACPYGTPAS PYSVYRDTCN SSLASLRLKS KQHSSFGYGG
310
LQGPASGLNA CQYNS
Length:315
Mass (Da):34,207
Last modified:June 1, 2001 - v1
Checksum:iBACBA7E43C0A9B1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047298 mRNA Translation: BAB41202.1
BC061966 mRNA Translation: AAH61966.1
RefSeqiNP_446076.1, NM_053624.2
XP_006253631.1, XM_006253569.3
UniGeneiRn.74248

Genome annotation databases

EnsembliENSRNOT00000015307; ENSRNOP00000015307; ENSRNOG00000011423
GeneIDi113983
KEGGirno:113983
UCSCiRGD:69253 rat

Similar proteinsi

Entry informationi

Entry nameiPITX1_RAT
AccessioniPrimary (citable) accession number: Q99NA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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