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Q99N99

- S5A2_MOUSE

UniProt

Q99N99 - S5A2_MOUSE

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Protein

3-oxo-5-alpha-steroid 4-dehydrogenase 2

Gene
Srd5a2, 5art2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology By similarity.

Catalytic activityi

A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + NADPH.

GO - Molecular functioni

  1. 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: MGI
  2. amide binding Source: Ensembl
  3. cholestenone 5-alpha-reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. androgen biosynthetic process Source: MGI
  2. biphenyl metabolic process Source: Ensembl
  3. bone development Source: Ensembl
  4. cell differentiation Source: UniProtKB-KW
  5. dibenzo-p-dioxin metabolic process Source: Ensembl
  6. female genitalia development Source: Ensembl
  7. hippocampus development Source: Ensembl
  8. hypothalamus development Source: Ensembl
  9. male genitalia development Source: MGI
  10. male gonad development Source: Ensembl
  11. phthalate metabolic process Source: Ensembl
  12. response to drug Source: Ensembl
  13. response to follicle-stimulating hormone Source: Ensembl
  14. response to nutrient levels Source: Ensembl
  15. response to peptide hormone Source: Ensembl
  16. response to testosterone Source: Ensembl
  17. steroid biosynthetic process Source: MGI
  18. steroid catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Differentiation, Sexual differentiation

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (EC:1.3.1.22)
Alternative name(s):
5 alpha-SR2
SR type 2
Steroid 5-alpha-reductase 2
Short name:
S5AR 2
Gene namesi
Name:Srd5a2
Synonyms:5art2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:2150380. Srd5a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821Helical; Reviewed predictionAdd
BLAST
Transmembranei72 – 9221Helical; Reviewed predictionAdd
BLAST
Transmembranei146 – 16621Helical; Reviewed predictionAdd
BLAST
Transmembranei206 – 22621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell body fiber Source: Ensembl
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2542543-oxo-5-alpha-steroid 4-dehydrogenase 2PRO_0000213678Add
BLAST

Proteomic databases

PRIDEiQ99N99.

PTM databases

PhosphoSiteiQ99N99.

Expressioni

Gene expression databases

BgeeiQ99N99.
CleanExiMM_SRD5A2.
GenevestigatoriQ99N99.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048862.

Structurei

3D structure databases

ProteinModelPortaliQ99N99.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG282706.
GeneTreeiENSGT00510000046634.
HOGENOMiHOG000050133.
HOVERGENiHBG003402.
InParanoidiQ99N99.
KOiK12344.
OMAiHHRYYLK.
OrthoDBiEOG75QR56.
PhylomeDBiQ99N99.
TreeFamiTF314668.

Family and domain databases

InterProiIPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99N99-1 [UniParc]FASTAAdd to Basket

« Hide

MPIVCHQVPV LAGSATLATM GTLILCFGKP ASYGKHSESV SSGVPLLPAR    50
IAWFLQELPS FVVSVGMLAW QPRSLFGPPG NVLLGLFSAH YFHRTFIYSL 100
LTRGRPLSAV IFLKATAFCI GNGLLQAYYL VYCAEYPEEW YTDMRFSVGV 150
FFFILGMGIN IHSDCMLRQL RKPGEVIYRI PQGGLFTYVS GANFLGEIIE 200
WMGYALATWS VPAFAFAFFT LCFLGMQAFY HHRFYLKMFK DYPKSRKALI 250
PFIF 254
Length:254
Mass (Da):28,619
Last modified:June 1, 2001 - v1
Checksum:i8D25019E8DC4DF47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049456 mRNA. Translation: BAB40179.1.
AK138946 mRNA. Translation: BAE23830.1.
BC125510 mRNA. Translation: AAI25511.1.
CCDSiCCDS28968.1.
RefSeqiNP_444418.1. NM_053188.2.
UniGeneiMm.38933.

Genome annotation databases

EnsembliENSMUST00000043458; ENSMUSP00000048862; ENSMUSG00000038541.
GeneIDi94224.
KEGGimmu:94224.
UCSCiuc008dnt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049456 mRNA. Translation: BAB40179.1 .
AK138946 mRNA. Translation: BAE23830.1 .
BC125510 mRNA. Translation: AAI25511.1 .
CCDSi CCDS28968.1.
RefSeqi NP_444418.1. NM_053188.2.
UniGenei Mm.38933.

3D structure databases

ProteinModelPortali Q99N99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000048862.

PTM databases

PhosphoSitei Q99N99.

Proteomic databases

PRIDEi Q99N99.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043458 ; ENSMUSP00000048862 ; ENSMUSG00000038541 .
GeneIDi 94224.
KEGGi mmu:94224.
UCSCi uc008dnt.1. mouse.

Organism-specific databases

CTDi 6716.
MGIi MGI:2150380. Srd5a2.

Phylogenomic databases

eggNOGi NOG282706.
GeneTreei ENSGT00510000046634.
HOGENOMi HOG000050133.
HOVERGENi HBG003402.
InParanoidi Q99N99.
KOi K12344.
OMAi HHRYYLK.
OrthoDBi EOG75QR56.
PhylomeDBi Q99N99.
TreeFami TF314668.

Miscellaneous databases

NextBioi 352223.
PROi Q99N99.
SOURCEi Search...

Gene expression databases

Bgeei Q99N99.
CleanExi MM_SRD5A2.
Genevestigatori Q99N99.

Family and domain databases

InterProi IPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view ]
Pfami PF02544. Steroid_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transcriptional regulation of the mouse steroid 5alpha-reductase type II gene by progesterone in brain."
    Takeyama K., Kato S.
    Nucleic Acids Res. 30:1387-1393(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Aorta and Vein.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiS5A2_MOUSE
AccessioniPrimary (citable) accession number: Q99N99
Secondary accession number(s): Q3UTZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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