ID   RM01_MOUSE              Reviewed;         336 AA.
AC   Q99N96; Q3UQP5; Q8K351; Q9CWW4;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 2.
DT   24-JAN-2024, entry version 143.
DE   RecName: Full=Large ribosomal subunit protein uL1m {ECO:0000305};
DE   AltName: Full=39S ribosomal protein L1, mitochondrial;
DE            Short=L1mt;
DE            Short=MRP-L1;
DE   Flags: Precursor;
GN   Name=Mrpl1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryonic stem cell, and Heart;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Mammary gland, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 11-336.
RX   PubMed=11279069; DOI=10.1074/jbc.m100432200;
RA   Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA   Watanabe K.;
RT   "Structural compensation for the deficit of rRNA with proteins in the
RT   mammalian mitochondrial ribosome. Systematic analysis of protein components
RT   of the large ribosomal subunit from mammalian mitochondria.";
RL   J. Biol. Chem. 276:21724-21736(2001).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA   Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT   "Comprehensive identification of phosphorylation sites in postsynaptic
RT   density preparations.";
RL   Mol. Cell. Proteomics 5:914-922(2006).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Pancreas,
RC   and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL1 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH61042.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB26866.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAB26866.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAB40837.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK010343; BAB26866.1; ALT_SEQ; mRNA.
DR   EMBL; AK142249; BAE24994.1; -; mRNA.
DR   EMBL; BC028774; AAH28774.1; -; mRNA.
DR   EMBL; BC061042; AAH61042.1; ALT_INIT; mRNA.
DR   EMBL; AB049632; BAB40837.1; ALT_INIT; mRNA.
DR   CCDS; CCDS19449.1; -.
DR   RefSeq; NP_444388.2; NM_053158.3.
DR   RefSeq; XP_006535355.1; XM_006535292.1.
DR   AlphaFoldDB; Q99N96; -.
DR   SMR; Q99N96; -.
DR   BioGRID; 220433; 27.
DR   ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR   STRING; 10090.ENSMUSP00000112977; -.
DR   iPTMnet; Q99N96; -.
DR   PhosphoSitePlus; Q99N96; -.
DR   EPD; Q99N96; -.
DR   jPOST; Q99N96; -.
DR   MaxQB; Q99N96; -.
DR   PaxDb; 10090-ENSMUSP00000112451; -.
DR   PeptideAtlas; Q99N96; -.
DR   ProteomicsDB; 299905; -.
DR   Pumba; Q99N96; -.
DR   Antibodypedia; 24877; 240 antibodies from 27 providers.
DR   DNASU; 94061; -.
DR   Ensembl; ENSMUST00000117766.8; ENSMUSP00000112977.2; ENSMUSG00000029486.15.
DR   GeneID; 94061; -.
DR   KEGG; mmu:94061; -.
DR   UCSC; uc008yfi.2; mouse.
DR   AGR; MGI:2137202; -.
DR   CTD; 65008; -.
DR   MGI; MGI:2137202; Mrpl1.
DR   VEuPathDB; HostDB:ENSMUSG00000029486; -.
DR   eggNOG; KOG1569; Eukaryota.
DR   GeneTree; ENSGT00940000162168; -.
DR   HOGENOM; CLU_074129_0_0_1; -.
DR   InParanoid; Q99N96; -.
DR   OMA; FKHNEKR; -.
DR   OrthoDB; 5353955at2759; -.
DR   PhylomeDB; Q99N96; -.
DR   Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR   Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR   BioGRID-ORCS; 94061; 3 hits in 76 CRISPR screens.
DR   ChiTaRS; Mrpl1; mouse.
DR   PRO; PR:Q99N96; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q99N96; Protein.
DR   Bgee; ENSMUSG00000029486; Expressed in interventricular septum and 252 other cell types or tissues.
DR   ExpressionAtlas; Q99N96; baseline and differential.
DR   GO; GO:0005743; C:mitochondrial inner membrane; NAS:ComplexPortal.
DR   GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISO:MGI.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISO:MGI.
DR   GO; GO:0032543; P:mitochondrial translation; NAS:ComplexPortal.
DR   GO; GO:0006412; P:translation; ISO:MGI.
DR   Gene3D; 3.30.190.20; -; 1.
DR   Gene3D; 3.40.50.790; -; 1.
DR   InterPro; IPR023674; Ribosomal_uL1-like.
DR   InterPro; IPR028364; Ribosomal_uL1/biogenesis.
DR   InterPro; IPR016095; Ribosomal_uL1_3-a/b-sand.
DR   InterPro; IPR005879; Ribosomal_uL1_mit.
DR   NCBIfam; TIGR01170; rplA_mito; 1.
DR   PANTHER; PTHR36427:SF3; 39S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR36427; 54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL; 1.
DR   Pfam; PF00687; Ribosomal_L1; 1.
DR   SUPFAM; SSF56808; Ribosomal protein L1; 1.
DR   Genevisible; Q99N96; MM.
PE   1: Evidence at protein level;
KW   Mitochondrion; Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein; Transit peptide.
FT   TRANSIT         1..50
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           51..336
FT                   /note="Large ribosomal subunit protein uL1m"
FT                   /id="PRO_0000252441"
FT   MOD_RES         85
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   CONFLICT        56
FT                   /note="K -> E (in Ref. 2; BAB26866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        94
FT                   /note="K -> R (in Ref. 2; BAB26866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        118
FT                   /note="D -> G (in Ref. 2; BAB26866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        131
FT                   /note="T -> R (in Ref. 2; BAB26866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        140
FT                   /note="K -> R (in Ref. 2; BAB26866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        180
FT                   /note="A -> V (in Ref. 2; BAB26866)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   336 AA;  37597 MW;  328783081296B824 CRC64;
     MAAAVRCLRR VLIHHQRHCL CKMASQASLY PCSVNSLLHN RHFAAAAAAA TKPARKIKKG
     AKEKTSDEKP VDDIEKIKSY TYMESDPEDD VYLKRLYPRR IYEVEKAIHL LKKFQVLDFT
     NPKQGVYLDL TLDMALGKKK TVEPFASVIA LPHLFSSEVN KVAVFTANAS EIKIAEENGA
     AFAGGTDLVK KIMDDEVVVD FYVAVPEIMG ELNPLRKKLK KRFPKATRNS IGRDIPKMLE
     LFKTAHEIMV DEERQNFLST KIATLDMPSD QIAANLQAVI NEVCKHRPLN LGPFVVRAFL
     RSSTSEGLLL KTDSLLPKEA KTTEAETEET QTAEAA
//