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Q99N96

- RM01_MOUSE

UniProt

Q99N96 - RM01_MOUSE

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Protein

39S ribosomal protein L1, mitochondrial

Gene

Mrpl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_270125. Mitochondrial translation elongation.
REACT_270158. Mitochondrial translation termination.
REACT_271096. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L1, mitochondrial
Short name:
L1mt
Short name:
MRP-L1
Gene namesi
Name:Mrpl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2137202. Mrpl1.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. large ribosomal subunit Source: InterPro
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5050MitochondrionSequence AnalysisAdd
BLAST
Chaini51 – 33628639S ribosomal protein L1, mitochondrialPRO_0000252441Add
BLAST

Proteomic databases

MaxQBiQ99N96.
PaxDbiQ99N96.
PRIDEiQ99N96.

PTM databases

PhosphoSiteiQ99N96.

Expressioni

Gene expression databases

BgeeiQ99N96.
CleanExiMM_MRPL1.
ExpressionAtlasiQ99N96. baseline and differential.
GenevestigatoriQ99N96.

Interactioni

Protein-protein interaction databases

BioGridi220433. 1 interaction.
IntActiQ99N96. 1 interaction.
MINTiMINT-4124547.

Structurei

3D structure databases

ProteinModelPortaliQ99N96.
SMRiQ99N96. Positions 93-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 507Poly-Ala

Sequence similaritiesi

Belongs to the ribosomal protein L1P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0081.
GeneTreeiENSGT00390000003587.
HOGENOMiHOG000293225.
HOVERGENiHBG061212.
InParanoidiQ99N96.
KOiK02863.
OMAiLVPLKNK.
OrthoDBiEOG73BVDN.
PhylomeDBiQ99N96.

Family and domain databases

Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
InterProiIPR023674. Ribosomal_L1-like.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR024663. Ribosomal_L1_chr.
IPR005879. Ribosomal_L1_mit.
[Graphical view]
PfamiPF13003. MRL1. 1 hit.
[Graphical view]
SUPFAMiSSF56808. SSF56808. 1 hit.
TIGRFAMsiTIGR01170. rplA_mito. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99N96-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAVRCLRR VLIHHQRHCL CKMASQASLY PCSVNSLLHN RHFAAAAAAA
60 70 80 90 100
TKPARKIKKG AKEKTSDEKP VDDIEKIKSY TYMESDPEDD VYLKRLYPRR
110 120 130 140 150
IYEVEKAIHL LKKFQVLDFT NPKQGVYLDL TLDMALGKKK TVEPFASVIA
160 170 180 190 200
LPHLFSSEVN KVAVFTANAS EIKIAEENGA AFAGGTDLVK KIMDDEVVVD
210 220 230 240 250
FYVAVPEIMG ELNPLRKKLK KRFPKATRNS IGRDIPKMLE LFKTAHEIMV
260 270 280 290 300
DEERQNFLST KIATLDMPSD QIAANLQAVI NEVCKHRPLN LGPFVVRAFL
310 320 330
RSSTSEGLLL KTDSLLPKEA KTTEAETEET QTAEAA
Length:336
Mass (Da):37,597
Last modified:June 16, 2009 - v2
Checksum:i328783081296B824
GO

Sequence cautioni

The sequence AAH61042.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB26866.1 differs from that shown. Reason: Frameshift at position 7. Curated
The sequence BAB26866.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB40837.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561K → E in BAB26866. (PubMed:15489334)Curated
Sequence conflicti94 – 941K → R in BAB26866. (PubMed:15489334)Curated
Sequence conflicti118 – 1181D → G in BAB26866. (PubMed:15489334)Curated
Sequence conflicti131 – 1311T → R in BAB26866. (PubMed:15489334)Curated
Sequence conflicti140 – 1401K → R in BAB26866. (PubMed:15489334)Curated
Sequence conflicti180 – 1801A → V in BAB26866. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010343 mRNA. Translation: BAB26866.1. Sequence problems.
AK142249 mRNA. Translation: BAE24994.1.
BC028774 mRNA. Translation: AAH28774.1.
BC061042 mRNA. Translation: AAH61042.1. Different initiation.
AB049632 mRNA. Translation: BAB40837.1. Different initiation.
CCDSiCCDS19449.1.
RefSeqiNP_444388.2. NM_053158.3.
XP_006535355.1. XM_006535292.1.
UniGeneiMm.295499.

Genome annotation databases

EnsembliENSMUST00000036437; ENSMUSP00000037046; ENSMUSG00000029486.
ENSMUST00000117766; ENSMUSP00000112977; ENSMUSG00000029486.
GeneIDi94061.
KEGGimmu:94061.
UCSCiuc008yfi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010343 mRNA. Translation: BAB26866.1 . Sequence problems.
AK142249 mRNA. Translation: BAE24994.1 .
BC028774 mRNA. Translation: AAH28774.1 .
BC061042 mRNA. Translation: AAH61042.1 . Different initiation.
AB049632 mRNA. Translation: BAB40837.1 . Different initiation.
CCDSi CCDS19449.1.
RefSeqi NP_444388.2. NM_053158.3.
XP_006535355.1. XM_006535292.1.
UniGenei Mm.295499.

3D structure databases

ProteinModelPortali Q99N96.
SMRi Q99N96. Positions 93-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 220433. 1 interaction.
IntActi Q99N96. 1 interaction.
MINTi MINT-4124547.

PTM databases

PhosphoSitei Q99N96.

Proteomic databases

MaxQBi Q99N96.
PaxDbi Q99N96.
PRIDEi Q99N96.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036437 ; ENSMUSP00000037046 ; ENSMUSG00000029486 .
ENSMUST00000117766 ; ENSMUSP00000112977 ; ENSMUSG00000029486 .
GeneIDi 94061.
KEGGi mmu:94061.
UCSCi uc008yfi.1. mouse.

Organism-specific databases

CTDi 65008.
MGIi MGI:2137202. Mrpl1.

Phylogenomic databases

eggNOGi COG0081.
GeneTreei ENSGT00390000003587.
HOGENOMi HOG000293225.
HOVERGENi HBG061212.
InParanoidi Q99N96.
KOi K02863.
OMAi LVPLKNK.
OrthoDBi EOG73BVDN.
PhylomeDBi Q99N96.

Enzyme and pathway databases

Reactomei REACT_270125. Mitochondrial translation elongation.
REACT_270158. Mitochondrial translation termination.
REACT_271096. Mitochondrial translation initiation.

Miscellaneous databases

NextBioi 352027.
PROi Q99N96.
SOURCEi Search...

Gene expression databases

Bgeei Q99N96.
CleanExi MM_MRPL1.
ExpressionAtlasi Q99N96. baseline and differential.
Genevestigatori Q99N96.

Family and domain databases

Gene3Di 3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
InterProi IPR023674. Ribosomal_L1-like.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR024663. Ribosomal_L1_chr.
IPR005879. Ribosomal_L1_mit.
[Graphical view ]
Pfami PF13003. MRL1. 1 hit.
[Graphical view ]
SUPFAMi SSF56808. SSF56808. 1 hit.
TIGRFAMsi TIGR01170. rplA_mito. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell and Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland and Testis.
  3. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-336.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiRM01_MOUSE
AccessioniPrimary (citable) accession number: Q99N96
Secondary accession number(s): Q3UQP5, Q8K351, Q9CWW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 16, 2009
Last modified: November 26, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3