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Protein

39S ribosomal protein L3, mitochondrial

Gene

Mrpl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L3, mitochondrial
Short name:
L3mt
Short name:
MRP-L3
Gene namesi
Name:Mrpl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2137204. Mrpl3.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial large ribosomal subunit Source: UniProtKB
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 34834839S ribosomal protein L3, mitochondrialPRO_0000077254Add
BLAST

Proteomic databases

EPDiQ99N95.
MaxQBiQ99N95.
PaxDbiQ99N95.
PRIDEiQ99N95.

PTM databases

iPTMnetiQ99N95.
PhosphoSiteiQ99N95.

Expressioni

Gene expression databases

BgeeiQ99N95.
CleanExiMM_MRPL3.
ExpressionAtlasiQ99N95. baseline and differential.
GenevisibleiQ99N95. MM.

Interactioni

Protein-protein interaction databases

BioGridi220434. 1 interaction.
IntActiQ99N95. 3 interactions.
MINTiMINT-4132705.
STRINGi10090.ENSMUSP00000035177.

Structurei

3D structure databases

ProteinModelPortaliQ99N95.
SMRiQ99N95. Positions 42-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L3P family.Curated

Phylogenomic databases

eggNOGiKOG3141. Eukaryota.
COG0087. LUCA.
GeneTreeiENSGT00390000011422.
HOGENOMiHOG000100369.
HOVERGENiHBG002294.
InParanoidiQ99N95.
KOiK02906.
OMAiKDEPWPL.
OrthoDBiEOG70GMFZ.
PhylomeDBiQ99N95.
TreeFamiTF105634.

Family and domain databases

InterProiIPR000597. Ribosomal_L3.
IPR019927. Ribosomal_L3_bac/org-type.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF00297. Ribosomal_L3. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
TIGRFAMsiTIGR03625. L3_bact. 1 hit.
PROSITEiPS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99N95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGWRLLAQA GARVLGCGAR GLGADPGLER RKNILFFVRN LHSKSSTWWD
60 70 80 90 100
EHLSEENLSF VKQLVSDENK TQLTSKLNPL KDEPWPLHPW EPGSFRVGLI
110 120 130 140 150
ALKLGMMPLW TKDGQKHAVT LLQVQDCHVL KYTPKEDHNG KIAALTVGGK
160 170 180 190 200
TVSRFYKPDS RLEFYRDLGL PPKQIHKIFH VTDNAVIKPG TPLYAAHFRP
210 220 230 240 250
GQYVDVTAKT IGKGFQGVMK RWGFKGQPAS HGQTKTHRRP GAISTGDIAR
260 270 280 290 300
VWPGTKMPGR MGNQNRTVYG LKVWRVNTKH NIIYVNGSVP GHKNCLVKIK
310 320 330 340
DSTLPAYKDS CKNLPFPTYF PDGDEEELPE DLFDESVWQP SEPSITFA
Length:348
Mass (Da):39,110
Last modified:June 1, 2001 - v1
Checksum:iA4596B5BAC91EFF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049633 mRNA. Translation: BAB40838.1.
AK077857 mRNA. Translation: BAC37036.1.
AK145687 mRNA. Translation: BAE26589.1.
AK169272 mRNA. Translation: BAE41032.1.
BC034877 mRNA. Translation: AAH34877.1.
CCDSiCCDS23462.1.
RefSeqiNP_444389.2. NM_053159.3.
UniGeneiMm.29746.

Genome annotation databases

EnsembliENSMUST00000035177; ENSMUSP00000035177; ENSMUSG00000032563.
GeneIDi94062.
KEGGimmu:94062.
UCSCiuc009rht.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049633 mRNA. Translation: BAB40838.1.
AK077857 mRNA. Translation: BAC37036.1.
AK145687 mRNA. Translation: BAE26589.1.
AK169272 mRNA. Translation: BAE41032.1.
BC034877 mRNA. Translation: AAH34877.1.
CCDSiCCDS23462.1.
RefSeqiNP_444389.2. NM_053159.3.
UniGeneiMm.29746.

3D structure databases

ProteinModelPortaliQ99N95.
SMRiQ99N95. Positions 42-347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220434. 1 interaction.
IntActiQ99N95. 3 interactions.
MINTiMINT-4132705.
STRINGi10090.ENSMUSP00000035177.

PTM databases

iPTMnetiQ99N95.
PhosphoSiteiQ99N95.

Proteomic databases

EPDiQ99N95.
MaxQBiQ99N95.
PaxDbiQ99N95.
PRIDEiQ99N95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035177; ENSMUSP00000035177; ENSMUSG00000032563.
GeneIDi94062.
KEGGimmu:94062.
UCSCiuc009rht.1. mouse.

Organism-specific databases

CTDi11222.
MGIiMGI:2137204. Mrpl3.

Phylogenomic databases

eggNOGiKOG3141. Eukaryota.
COG0087. LUCA.
GeneTreeiENSGT00390000011422.
HOGENOMiHOG000100369.
HOVERGENiHBG002294.
InParanoidiQ99N95.
KOiK02906.
OMAiKDEPWPL.
OrthoDBiEOG70GMFZ.
PhylomeDBiQ99N95.
TreeFamiTF105634.

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Miscellaneous databases

NextBioi352033.
PROiQ99N95.
SOURCEiSearch...

Gene expression databases

BgeeiQ99N95.
CleanExiMM_MRPL3.
ExpressionAtlasiQ99N95. baseline and differential.
GenevisibleiQ99N95. MM.

Family and domain databases

InterProiIPR000597. Ribosomal_L3.
IPR019927. Ribosomal_L3_bac/org-type.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF00297. Ribosomal_L3. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
TIGRFAMsiTIGR03625. L3_bact. 1 hit.
PROSITEiPS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Forelimb and Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Kidney, Liver and Lung.

Entry informationi

Entry nameiRM03_MOUSE
AccessioniPrimary (citable) accession number: Q99N95
Secondary accession number(s): Q3TF66, Q9CVE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: June 1, 2001
Last modified: April 13, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.