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Protein

28S ribosomal protein S5, mitochondrial

Gene

Mrps5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S5, mitochondrial
Short name:
MRP-S5
Short name:
S5mt
Gene namesi
Name:Mrps5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1924971. Mrps5.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
  • ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 43243228S ribosomal protein S5, mitochondrialPRO_0000131686Add
BLAST

Proteomic databases

EPDiQ99N87.
MaxQBiQ99N87.
PaxDbiQ99N87.
PRIDEiQ99N87.

PTM databases

iPTMnetiQ99N87.
PhosphoSiteiQ99N87.

Expressioni

Gene expression databases

BgeeiQ99N87.
CleanExiMM_MRPS5.
ExpressionAtlasiQ99N87. baseline and differential.
GenevisibleiQ99N87. MM.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028852.

Structurei

3D structure databases

ProteinModelPortaliQ99N87.
SMRiQ99N87. Positions 91-432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini220 – 28465S5 DRBMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein S5P family.Curated
Contains 1 S5 DRBM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2646. Eukaryota.
COG0098. LUCA.
GeneTreeiENSGT00390000001878.
HOGENOMiHOG000231482.
HOVERGENiHBG030178.
InParanoidiQ99N87.
KOiK02988.
OMAiIRMKKQN.
OrthoDBiEOG7353WT.
PhylomeDBiQ99N87.
TreeFamiTF313823.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
3.30.230.10. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000851. Ribosomal_S5.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
[Graphical view]
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiPF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
PROSITEiPS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99N87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVRAAGC LPALCSLQAG HFLSRQLSLN AFPVAATSFL AVKTALSHGS
60 70 80 90 100
LSSRETRRNH CLTSLSHVLQ TQCCVSSPGN WTGQQCRPYS FFTKLTAEEL
110 120 130 140 150
WKGALAETGA GARKGRGKRT KKKKRKDLNR GQIIGEGRSG FLWPGLNVPL
160 170 180 190 200
IKSGVVQNIG QRSKEEQQKV EATMVEQREE WDRKRKIKVK RERGWSGNTW
210 220 230 240 250
GGVSIGPPDP GPNGETYEDF DTRILEVRNV FNMTAKEGRK KSVRVLVAVG
260 270 280 290 300
NGNGAAGFAI GKAADRGDAF RKAKNRAIHY LHYIERYEGH TIFHDISLRF
310 320 330 340 350
KRTQIRMKKQ PRGYGLRCHR AIITICRLIG IKDMYARVTG SMNMLNLTRG
360 370 380 390 400
LFHGLARQET HQHLADKKGL HVVEFREECG PLPIVVASPH GALSKEPEPE
410 420 430
PEVPDTKLDW QDVKAMQGLK RSVWFNLKRP AT
Length:432
Mass (Da):48,207
Last modified:June 1, 2001 - v1
Checksum:iAC98D3131C389A8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049941 mRNA. Translation: BAB40994.1.
AK083366 mRNA. Translation: BAC38885.1.
BC021947 mRNA. Translation: AAH21947.1.
CCDSiCCDS16706.1.
RefSeqiNP_084239.1. NM_029963.2.
UniGeneiMm.274601.
Mm.439980.

Genome annotation databases

EnsembliENSMUST00000028852; ENSMUSP00000028852; ENSMUSG00000027374.
GeneIDi77721.
KEGGimmu:77721.
UCSCiuc008mfu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049941 mRNA. Translation: BAB40994.1.
AK083366 mRNA. Translation: BAC38885.1.
BC021947 mRNA. Translation: AAH21947.1.
CCDSiCCDS16706.1.
RefSeqiNP_084239.1. NM_029963.2.
UniGeneiMm.274601.
Mm.439980.

3D structure databases

ProteinModelPortaliQ99N87.
SMRiQ99N87. Positions 91-432.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028852.

PTM databases

iPTMnetiQ99N87.
PhosphoSiteiQ99N87.

Proteomic databases

EPDiQ99N87.
MaxQBiQ99N87.
PaxDbiQ99N87.
PRIDEiQ99N87.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028852; ENSMUSP00000028852; ENSMUSG00000027374.
GeneIDi77721.
KEGGimmu:77721.
UCSCiuc008mfu.1. mouse.

Organism-specific databases

CTDi64969.
MGIiMGI:1924971. Mrps5.

Phylogenomic databases

eggNOGiKOG2646. Eukaryota.
COG0098. LUCA.
GeneTreeiENSGT00390000001878.
HOGENOMiHOG000231482.
HOVERGENiHBG030178.
InParanoidiQ99N87.
KOiK02988.
OMAiIRMKKQN.
OrthoDBiEOG7353WT.
PhylomeDBiQ99N87.
TreeFamiTF313823.

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Miscellaneous databases

PROiQ99N87.
SOURCEiSearch...

Gene expression databases

BgeeiQ99N87.
CleanExiMM_MRPS5.
ExpressionAtlasiQ99N87. baseline and differential.
GenevisibleiQ99N87. MM.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
3.30.230.10. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000851. Ribosomal_S5.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
[Graphical view]
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiPF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
PROSITEiPS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver and Testis.

Entry informationi

Entry nameiRT05_MOUSE
AccessioniPrimary (citable) accession number: Q99N87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.