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Protein
Submitted name:

Protein Trpc6

Gene

Trpc6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • actin binding Source: RGD
  • actinin binding Source: RGD
  • ATPase binding Source: RGD
  • calcium channel activity Source: RGD
  • cation channel activity Source: RGD
  • clathrin binding Source: RGD
  • inositol 1,4,5 trisphosphate binding Source: Ensembl
  • store-operated calcium channel activity Source: Ensembl

GO - Biological processi

  • aging Source: RGD
  • cellular response to hydrogen peroxide Source: RGD
  • cellular response to hypoxia Source: RGD
  • negative regulation of dendrite morphogenesis Source: RGD
  • neuron differentiation Source: RGD
  • positive regulation of calcium ion transport Source: Ensembl
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of ion transmembrane transporter activity Source: Ensembl
  • positive regulation of neuron differentiation Source: RGD
  • positive regulation of peptidyl-threonine phosphorylation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation, ReceptorImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-114508. Effects of PIP2 hydrolysis.
R-RNO-139853. Elevation of cytosolic Ca2+ levels.
R-RNO-3295583. TRP channels.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Trpc6Imported
Submitted name:
Transient receptor potential Ca2+ channel 6AImported
Submitted name:
Transient receptor potential cation channel, subfamily C, member 6, isoform CRA_bImported
Gene namesi
Name:Trpc6Imported
Synonyms:trp6AImported
ORF Names:rCG_31778Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi619788. Trpc6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei403 – 42220HelicalSequence analysisAdd
BLAST
Transmembranei442 – 46120HelicalSequence analysisAdd
BLAST
Transmembranei489 – 50719HelicalSequence analysisAdd
BLAST
Transmembranei527 – 54620HelicalSequence analysisAdd
BLAST
Transmembranei633 – 65523HelicalSequence analysisAdd
BLAST
Transmembranei702 – 72322HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytosol Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: RGD
  • slit diaphragm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

GO - Molecular functioni

  • actin binding Source: RGD
  • actinin binding Source: RGD
  • ATPase binding Source: RGD
  • clathrin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008905.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 15451ANK_REP_REGIONInterPro annotationAdd
BLAST
Domaini217 – 24933ANK_REP_REGIONInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili883 – 91836Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. [View classification]SAAS annotation
Contains 1 ANK repeat.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotationSAAS annotation, Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.
KOiK04969.
OMAiQAPLPCY.
OrthoDBiEOG77HDD1.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005462. TRPC6_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 2 hits.
PTHR10117:SF7. PTHR10117:SF7. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01647. TRPCHANNEL6.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99N78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSPGFVTR RGGSPKAAPG AGARRNESQD YLLMDELGDD GYPQLQQPPY
60 70 80 90 100
GYYPSFRGNE NRLTHRRQTV LREKGRRLAN RGPAYMFNDH STSLSIEEER
110 120 130 140 150
FLDAAEYGNI PVVRKMLEEC LSLNVNCVDY MGQNALQLAV ANEHLEITEL
160 170 180 190 200
LLKKENLSRV GDALLLAISK GYVRIVEAIL NHPAFAEGKR LATSPSQSEL
210 220 230 240 250
QQDDFYAYDE DGTRFSHDVT PIILAAHCQE YEIVHTLLRK GARIERPHDY
260 270 280 290 300
FCKCTECSQK QKHDSFSHSR SRINAYKGLA SPAYLSLSSE DPVMTALELS
310 320 330 340 350
NELAVLANIE KEFKNDYRKL SMQCKDFVVG LLDLCRNTEE VEAILNGDAE
360 370 380 390 400
TRQPGDLARP NLSRLKLAIK YEVKKFVAHP NCQQQLLSIW YENLSGLRQQ
410 420 430 440 450
TMAVKFLVVL AVAIGLPFLA LIYWCAPCSK MGKILRGPFM KFVAHAASFT
460 470 480 490 500
IFLGLLVMNA ADRFEGTKLL PNETSTDNAR QLFRMKTSCF SWMEMLIISW
510 520 530 540 550
VIGMIWAECK EIWTQGPKEY LFELWNMLDF GMLAIFAASF IARFMAFWHA
560 570 580 590 600
SKAQSIIDAN DTLKDLTKVT LGDNVKYYNL ARIKWDPTDP QIISEGLYAI
610 620 630 640 650
AVVLSFSRIA YILPANESFG PLQISLGRTV KDIFKFMVIF IMVFVAFMIG
660 670 680 690 700
MFNLYSYYIG AKQNEAFTTV EESFKTLFWA IFGLSEVKSV VINYNHKFIE
710 720 730 740 750
NIGYVLYGVY NVTMVIVLLN MLIAMINSSF QEIEDDADVE WKFARAKLWF
760 770 780 790 800
SYFEEGRTLP VPFNLVPSPK SLLYLLLKFK KWMSELIQGH KKGFQEDAEM
810 820 830 840 850
NKRNEEKKFG ILGSHEDLSK FSLDRNQLAH NKQSSTRSSE DFHLNSFSNP
860 870 880 890 900
PRQYQKIMKR LIKRYVLQAQ IDKESDEVNE GELKEIKQDI SSLRYELLEE
910 920 930
KSQNTEDLAE LIRKLGERLS LESKQEESRR
Length:930
Mass (Da):106,560
Last modified:June 1, 2001 - v1
Checksum:iF3F333C23A0EB2CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069064 Genomic DNA. No translation available.
AABR07069065 Genomic DNA. No translation available.
AABR07069066 Genomic DNA. No translation available.
AB051212 Genomic DNA. Translation: BAB41215.1.
CH473993 Genomic DNA. Translation: EDL78511.1.
RefSeqiNP_446011.1. NM_053559.1.
UniGeneiRn.105986.

Genome annotation databases

EnsembliENSRNOT00000008905; ENSRNOP00000008905; ENSRNOG00000006324.
GeneIDi89823.
KEGGirno:89823.
UCSCiRGD:619788. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069064 Genomic DNA. No translation available.
AABR07069065 Genomic DNA. No translation available.
AABR07069066 Genomic DNA. No translation available.
AB051212 Genomic DNA. Translation: BAB41215.1.
CH473993 Genomic DNA. Translation: EDL78511.1.
RefSeqiNP_446011.1. NM_053559.1.
UniGeneiRn.105986.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008905.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008905; ENSRNOP00000008905; ENSRNOG00000006324.
GeneIDi89823.
KEGGirno:89823.
UCSCiRGD:619788. rat.

Organism-specific databases

CTDi7225.
RGDi619788. Trpc6.

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.
KOiK04969.
OMAiQAPLPCY.
OrthoDBiEOG77HDD1.
TreeFamiTF313147.

Enzyme and pathway databases

ReactomeiR-RNO-114508. Effects of PIP2 hydrolysis.
R-RNO-139853. Elevation of cytosolic Ca2+ levels.
R-RNO-3295583. TRP channels.

Miscellaneous databases

ChiTaRSiTrpc6. rat.
NextBioi617728.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005462. TRPC6_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 2 hits.
PTHR10117:SF7. PTHR10117:SF7. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01647. TRPCHANNEL6.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Muscarinic acetylcholine receptor regulation of TRP6 Ca2+ channel isoforms. Molecular structures and functional characterization."
    Zhang L., Saffen D.
    J. Biol. Chem. 276:13331-13339(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LungImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ99N78_RAT
AccessioniPrimary (citable) accession number: Q99N78
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.