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Protein
Submitted name:

Transient receptor potential Ca2+ channel 6C

Gene

trp6C

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation, ReceptorImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Transient receptor potential Ca2+ channel 6CImported
Gene namesi
Name:trp6CImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei349 – 36820HelicalSequence analysisAdd
BLAST
Transmembranei388 – 40720HelicalSequence analysisAdd
BLAST
Transmembranei435 – 45319HelicalSequence analysisAdd
BLAST
Transmembranei473 – 49220HelicalSequence analysisAdd
BLAST
Transmembranei538 – 55922HelicalSequence analysisAdd
BLAST
Transmembranei579 – 60123HelicalSequence analysisAdd
BLAST
Transmembranei648 – 67225HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ99N76.
PRIDEiQ99N76.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008905.

Structurei

3D structure databases

ProteinModelPortaliQ99N76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 10051ANK_REP_REGIONInterPro annotationAdd
BLAST
Domaini163 – 19533ANK_REP_REGIONInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili761 – 79636Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. [View classification]SAAS annotation
Contains 1 ANK repeat.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotationSAAS annotation, Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005462. TRPC6_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF7. PTHR10117:SF7. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01647. TRPCHANNEL6.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99N76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRGNENRLT HRRQTVLREK GRRLANRGPA YMFNDHSTSL SIEEERFLDA
60 70 80 90 100
AEYGNIPVVR KMLEECLSLN VNCVDYMGQN ALQLAVANEH LEITELLLKK
110 120 130 140 150
ENLSRVGDAL LLAISKGYVR IVEAILNHPA FAEGKRLATS PSQSELQQDD
160 170 180 190 200
FYAYDEDGTR FSHDVTPIIL AAHCQEYEIV HTLLRKGARI ERPHDYFCKC
210 220 230 240 250
TECSQKQKHD SFSHSRSRIN AYKGLASPAY LSLSSEDPVM TALELSNELA
260 270 280 290 300
VLANIEKEFK NDYRKLSMQC KDFVVGLLDL CRNTEEVEAI LNGDAETRQP
310 320 330 340 350
GDLARPNLSR LKLAIKYEVK KFVAHPNCQQ QLLSIWYENL SGLRQQTMAV
360 370 380 390 400
KFLVVLAVAI GLPFLALIYW CAPCSKMGKI LRGPFMKFVA HAASFTIFLG
410 420 430 440 450
LLVMNAADRF EGTKLLPNET STDNARQLFR MKTSCFSWME MLIISWVIGM
460 470 480 490 500
IWAECKEIWT QGPKEYLFEL WNMLDFGMLA IFAASFIARF MAFWHASKAQ
510 520 530 540 550
SIIDANDTLK DLTKVTLGDN VKYYNLARIK WDPTDPQIIS EGLYAIAVVL
560 570 580 590 600
SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVIFIMVF VAFMIGMFNL
610 620 630 640 650
YSYYIGAKQN EAFTTVEESF KTLFWAIFGL SEVRSVVINY NHKFIENIGY
660 670 680 690 700
VLYGVYNVTM VIVLLNMLIA MINSSFQEIE RNEEKKFGIL GSHEDLSKFS
710 720 730 740 750
LDRNQLAHNK QSSTRSSEDF HLNSFSNPPR QYQKIMKRLI KRYVLQAQID
760 770 780 790 800
KESDEVNEGE LKEIKQDISS LRYELLEEKS QNTEDLAELI RRLGERLSLE

SKQEESRR
Length:808
Mass (Da):92,651
Last modified:June 1, 2001 - v1
Checksum:i4C9281176DE8CAB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051214 Genomic DNA. Translation: BAB43812.1.
UniGeneiRn.105986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051214 Genomic DNA. Translation: BAB43812.1.
UniGeneiRn.105986.

3D structure databases

ProteinModelPortaliQ99N76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008905.

Proteomic databases

PaxDbiQ99N76.
PRIDEiQ99N76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005462. TRPC6_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF7. PTHR10117:SF7. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01647. TRPCHANNEL6.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Muscarinic acetylcholine receptor regulation of TRP6 Ca2+ channel isoforms. Molecular structures and functional characterization."
    Zhang L., Saffen D.
    J. Biol. Chem. 276:13331-13339(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ99N76_RAT
AccessioniPrimary (citable) accession number: Q99N76
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.