Q99N69 (LPXN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leupaxin

Gene names

Name:

Lpxn

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Contributes to the regulation of cell adhesion, spreading and cell migration By similarity.
Subunit structure	Interacts with unphosphorylated ITGA4. Interacts with PTK2B/PYK2. Interacts with PTPN12 By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the paxillin family. Contains 4 LIM zinc-binding domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	LIM domain Repeat
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 386	386	Leupaxin		PRO_0000075837
Regions
	Domain	150 – 208	59	LIM zinc-binding 1
	Domain	209 – 267	59	LIM zinc-binding 2
	Domain	268 – 326	59	LIM zinc-binding 3
	Domain	327 – 386	60	LIM zinc-binding 4
	Motif	3 – 15	13	LD motif 1
	Motif	70 – 82	13	LD motif 2
	Motif	92 – 103	12	LD motif 3
Amino acid modifications
	Modified residue	19	1	Phosphoserine By similarity
	Modified residue	22	1	Phosphotyrosine Ref.3
	Modified residue	62	1	Phosphotyrosine Ref.3
	Modified residue	72	1	Phosphotyrosine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q99N69 [UniParc]. Last modified October 1, 2002. Version 2. Checksum: AA7EB76AEF5983C7	FASTA	386	43,478
	10 20 30 40 50 60 MEELDALLEE LERCTFQDSE EYSNPVSCHL DQQSTEESKI PQTPKTLSSQ GNTSPLKVQL 70 80 90 100 110 120 VYATNIQEPN VYSEVQEPKE SVLPPKTSAA AQLDELMAHL SEMQAKVSVK ADTSRKPLPD 130 140 150 160 170 180 QQDHKASLDS MLGDLEQELQ DLGIATVPKG YCASCQKPIA GKVIHALGQS WHPEHFVCTH 190 200 210 220 230 240 CKEELGSSPF FERSGLAYCS KDYHRLFSPR CAYCAAPITD KVLTAMNKTW HPEHFFCSHC 250 260 270 280 290 300 GEVFGAEGFH EKDKKPYCRK DFLAMFSPKC GGCNRPVLEN YLSAMNTVWH PECFVCGDCF 310 320 330 340 350 360 SSFSSGSFFE LDGRPFCELH YHHRRGTLCH DCGQPITGRC ISAMGHKFHP EHFVCAFCLT 370 380 QLPKGIFKEQ NNKTYCEKCF TKLFSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The noncatalytic domain of protein-tyrosine phosphatase-PEST forms a complex with leupaxin that is a novel LIM domain protein." Ishizuka H., Amano N., Watanabe N., Mashima K. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Spleen.
[2]	"Identification of novel genes involved in lymphocyte migration by gene expression profiling." Tanaka T., Murata S., Moriwaki K., Kondo T., Miyasaka M. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Spleen.
[3]	"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling." Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R. J. Immunol. 179:5864-5876(2007) [PubMed: 17947660] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-22; TYR-62 AND TYR-72, MASS SPECTROMETRY. Tissue: Mast cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB053936 mRNA. Translation: BAB40667.2. AB071194 mRNA. Translation: BAC22615.1.
IPI	IPI00387515.
RefSeq	NP_598913.1. NM_134152.3.
UniGene	Mm.313136.
3D structure databases
ProteinModelPortal	Q99N69.
SMR	Q99N69. Positions 148-386.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99N69. 1 interaction.
STRING	Q99N69.
PTM databases
PhosphoSite	Q99N69.
Proteomic databases
PRIDE	Q99N69.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000025601; ENSMUSP00000025601; ENSMUSG00000024696.
GeneID	107321.
KEGG	mmu:107321.
UCSC	uc008guq.1. mouse.
Organism-specific databases
CTD	9404.
MGI	MGI:2147677. Lpxn.
Phylogenomic databases
GeneTree	ENSGT00580000081283.
HOGENOM	HBG505340.
HOVERGEN	HBG001512.
InParanoid	Q99N69.
OMA	YSEVQEP.
OrthoDB	EOG4TMR25.
PhylomeDB	Q99N69.
Gene expression databases
ArrayExpress	Q99N69.
Bgee	Q99N69.
CleanEx	MM_LPXN.
Genevestigator	Q99N69.
GermOnline	ENSMUSG00000024696. Mus musculus.
Family and domain databases
InterPro	IPR017305. Leupaxin. IPR001781. Znf_LIM. [Graphical view]
Gene3D	G3DSA:2.10.110.10. Znf_LIM. 4 hits.
Pfam	PF00412. LIM. 4 hits. [Graphical view]
PIRSF	PIRSF037881. Leupaxin. 1 hit.
SMART	SM00132. LIM. 4 hits. [Graphical view]
PROSITE	PS00478. LIM_DOMAIN_1. 4 hits. PS50023. LIM_DOMAIN_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	358680.
SOURCE	Search...

Entry information

Entry name

LPXN_MOUSE

Accession

Primary (citable) accession number: Q99N69

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program