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Protein

Alpha-amylase

Gene

Amy1a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.UniRule annotationSAAS annotation

GO - Molecular functioni

  • alpha-amylase activity Source: RGD
  • cation binding Source: InterPro

GO - Biological processi

  • carbohydrate metabolic process Source: RGD

Keywordsi

Molecular functionGlycosidaseUniRule annotationSAAS annotation, Hydrolase
Biological processCarbohydrate metabolismUniRule annotation

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-amylaseUniRule annotation (EC:3.2.1.1UniRule annotation)
Gene namesi
Name:Amy1aImported
Synonyms:Amy1Imported
ORF Names:rCG_28696Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2113. Amy1a.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500971687826 – 521Alpha-amylaseSequence analysisAdd BLAST496

Expressioni

Gene expression databases

BgeeiENSRNOG00000033529.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022496.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 423AamyInterPro annotationAdd BLAST388
Domaini432 – 520Aamy_CInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2212. Eukaryota.
COG0366. LUCA.
HOGENOMiHOG000253313.
HOVERGENiHBG000061.
KOiK01176.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiView protein in InterPro
IPR006048. A-amylase/branching_C.
IPR031319. A-amylase_C.
IPR006046. Alpha_amylase.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PRINTSiPR00110. ALPHAAMYLASE.
SMARTiView protein in SMART
SM00642. Aamy. 1 hit.
SM00632. Aamy_C. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99N59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREYCQHHSR MKFFLLLSLI GLCWAQYDPH TFYGRSSIVH LFEWRWVDIA
60 70 80 90 100
KECERYLAPN GFGGVQVSPP NENIVVNSPF RPWWERYQPI SYKICSRSGN
110 120 130 140 150
EDEFRDMVNR CNNVGVRIYV DAVINHMCGV GAEAGQSSTC GSYFNPNNRD
160 170 180 190 200
FPGVPYSGFD FNDGKCKTGS GGIENYNDAA QVRDCRLSGL LDLALEKDYV
210 220 230 240 250
RTKVADYMNH LIDIGVAGFR LDASKHMWPG DIKAVLDKLH NLNTKWFSEG
260 270 280 290 300
SKPFIYQEVI DLGGEAVSSN EYFGNGRVTE FKYGAKLGKV LRKWDGEKMA
310 320 330 340 350
YLKNWGEGWG FMPSDRALVF VDNHDNQRGH GAGGSSILTF WDARLYKMAV
360 370 380 390 400
GFMLAHPYGF TRVMSSFHWP RYFENGKDVN DWVGPPNNNG ATKEVTINSD
410 420 430 440 450
STCGNDWVCE HRWRQIRNMV AFRNVVNGQP FANWWDNGSN QVAFGRGNKG
460 470 480 490 500
FIVFNNDDWD LSTTLQTGLP AGTYCDVISG DKVDGNCTGI KVYVGSDGNA
510 520
YFSISNSAED PFIAIHVESK I
Length:521
Mass (Da):58,830
Last modified:June 1, 2001 - v1
Checksum:i8546B2D17EA41589
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB057450 mRNA. Translation: BAB39466.1.
CH473952 Genomic DNA. Translation: EDL81999.1.
CH473952 Genomic DNA. Translation: EDL82000.1.
RefSeqiNP_001010970.1. NM_001010970.1.
UniGeneiRn.116361.

Genome annotation databases

GeneIDi24203.
KEGGirno:24203.
UCSCiRGD:2113. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB057450 mRNA. Translation: BAB39466.1.
CH473952 Genomic DNA. Translation: EDL81999.1.
CH473952 Genomic DNA. Translation: EDL82000.1.
RefSeqiNP_001010970.1. NM_001010970.1.
UniGeneiRn.116361.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022496.

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24203.
KEGGirno:24203.
UCSCiRGD:2113. rat.

Organism-specific databases

CTDi276.
RGDi2113. Amy1a.

Phylogenomic databases

eggNOGiKOG2212. Eukaryota.
COG0366. LUCA.
HOGENOMiHOG000253313.
HOVERGENiHBG000061.
KOiK01176.

Gene expression databases

BgeeiENSRNOG00000033529.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiView protein in InterPro
IPR006048. A-amylase/branching_C.
IPR031319. A-amylase_C.
IPR006046. Alpha_amylase.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PRINTSiPR00110. ALPHAAMYLASE.
SMARTiView protein in SMART
SM00642. Aamy. 1 hit.
SM00632. Aamy_C. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ99N59_RAT
AccessioniPrimary (citable) accession number: Q99N59
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: March 15, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.