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Protein

Synaptotagmin-like protein 3

Gene

Sytl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB
  • calcium ion binding Source: GO_Central
  • clathrin binding Source: GO_Central
  • neurexin family protein binding Source: UniProtKB
  • phospholipid binding Source: MGI
  • Rab GTPase binding Source: InterPro
  • syntaxin binding Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-like protein 3
Alternative name(s):
Exophilin-6
Gene namesi
Name:Sytl3
Synonyms:Slp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1933367 Sytl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi336 – 337EE → QQ: Binds phospholipids only in the absence of divalent cations. 1 Publication2
Mutagenesisi359 – 361KRK → QQQ: Binds phospholipids only in the absence of divalent cations. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001902151 – 607Synaptotagmin-like protein 3Add BLAST607

Proteomic databases

EPDiQ99N48
PaxDbiQ99N48
PRIDEiQ99N48

PTM databases

iPTMnetiQ99N48
PhosphoSitePlusiQ99N48

Expressioni

Tissue specificityi

Highly expressed in spleen and lung. Detected at lower levels in heart and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000041831
CleanExiMM_SYTL3
ExpressionAtlasiQ99N48 baseline and differential
GenevisibleiQ99N48 MM

Interactioni

Subunit structurei

Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding via its N-terminus.

GO - Molecular functioni

  • clathrin binding Source: GO_Central
  • neurexin family protein binding Source: UniProtKB
  • Rab GTPase binding Source: InterPro
  • syntaxin binding Source: GO_Central

Protein-protein interaction databases

IntActiQ99N48, 2 interactors
STRINGi10090.ENSMUSP00000095041

Structurei

3D structure databases

ProteinModelPortaliQ99N48
SMRiQ99N48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 123RabBDPROSITE-ProRule annotationAdd BLAST120
Domaini307 – 411C2 1PROSITE-ProRule annotationAdd BLAST105
Domaini464 – 568C2 2PROSITE-ProRule annotationAdd BLAST105

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00810000125376
HOVERGENiHBG103087
InParanoidiQ99N48
KOiK17598
OMAiFVKGCLT
OrthoDBiEOG091G06N8
PhylomeDBiQ99N48

Family and domain databases

Gene3Di2.60.40.150, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR010911 Rab_BD
IPR028704 SYTL3
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10024:SF222 PTHR10024:SF222, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
SMARTiView protein in SMART
SM00239 C2, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50916 RABBD, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99N48-1) [UniParc]FASTAAdd to basket
Also known as: Slp3-a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHEVDLESF KELERDIILR VLYRDQTVQS TEEERVRKLK SHLQHLRWKG
60 70 80 90 100
AKSSSQEYKE KCCARCQRAL GLLLNRGAVC QGCSHRVCSE CRVFLRRTRA
110 120 130 140 150
WKCTVCFEDR NVKIKTGEWF FEERARKFPT AGRRETAGAK LLQSYQRLSK
160 170 180 190 200
ISVVPPTPPP FSESQCSSSS RLQELGHFRG FNKSVENLFL SVTTQMRKLS
210 220 230 240 250
KSQNDMTSEK HLLAMDPRQC VGHTERRSQS DTAVNVTSRK ASTPDILKAF
260 270 280 290 300
HQEDPKHPPD PVLKQDTPPS SPTHSAVFSG GLRHGSLISI NSTCTEMGNF
310 320 330 340 350
DNANVTGEIE FAIHYCVKSC SLEICIKTCK NLAYGEEKKR KCNPYVKTYL
360 370 380 390 400
LPDRSSQGKR KTRVQKNTLD PTFEETLKYQ VDPGQLMTRR LQVSVWHLGT
410 420 430 440 450
LARRVFLGEV ILPLAMWDFK DSTAQNARWY PLRAKAEKYE ENIPQNNGEL
460 470 480 490 500
AVRAKLVLPA GPRKPQEAQE GQLALNGQLC LVVLGAKNLP VRSDGTLNSF
510 520 530 540 550
VKGCLTLPNQ QKLRVKSPVL KKQACPQWKH SFVFNGVSSS QLRQSTLELT
560 570 580 590 600
VWDQAIFGMN DRLLGEARLG SKGGAAGCPD SGSQSKLQWH RVLSSPNLWT

DMTLVLH
Length:607
Mass (Da):68,568
Last modified:July 25, 2003 - v2
Checksum:iF9F404D2D77A6351
GO
Isoform 2 (identifier: Q99N48-2) [UniParc]FASTAAdd to basket
Also known as: Slp3-a + 3S-I

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.

Show »
Length:412
Mass (Da):45,955
Checksum:iAB1EDD538CCCB218
GO
Isoform 3 (identifier: Q99N48-3) [UniParc]FASTAAdd to basket
Also known as: Slp3-b, Slp3-a delta 3S-II

The sequence of this isoform differs from the canonical sequence as follows:
     1-214: Missing.

Show »
Length:393
Mass (Da):43,755
Checksum:iD6D27768F455F91B
GO
Isoform 4 (identifier: Q99N48-4) [UniParc]FASTAAdd to basket
Also known as: Slp3-b + 3S-III

The sequence of this isoform differs from the canonical sequence as follows:
     1-296: Missing.

Show »
Length:311
Mass (Da):34,884
Checksum:i91986B928DC510E0
GO
Isoform 5 (identifier: Q99N48-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-114: NVKI → ANGR
     115-607: Missing.

Note: No experimental confirmation available.
Show »
Length:114
Mass (Da):13,429
Checksum:i5EBD2E5BBFDAE4C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229Q → R in BAB32653 (PubMed:11243866).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0078971 – 296Missing in isoform 4. 1 PublicationAdd BLAST296
Alternative sequenceiVSP_0078961 – 214Missing in isoform 3. 2 PublicationsAdd BLAST214
Alternative sequenceiVSP_0078951 – 195Missing in isoform 2. 2 PublicationsAdd BLAST195
Alternative sequenceiVSP_007898111 – 114NVKI → ANGR in isoform 5. 1 Publication4
Alternative sequenceiVSP_007899115 – 607Missing in isoform 5. 1 PublicationAdd BLAST493

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050743 mRNA Translation: BAB32653.1
AB057758 mRNA Translation: BAB41086.1
AB057764 mRNA Translation: BAB41092.1
AB057765 mRNA Translation: BAB41093.1
AB057766 mRNA Translation: BAB41094.1
BC022608 mRNA Translation: AAH22608.1
BC106102 mRNA Translation: AAI06103.1
AK079850 mRNA Translation: BAC37766.1
CCDSiCCDS28372.2 [Q99N48-1]
CCDS28374.3 [Q99N48-2]
RefSeqiNP_113572.1, NM_031395.2 [Q99N48-1]
NP_899226.2, NM_183370.2 [Q99N48-2]
XP_006523322.1, XM_006523259.2 [Q99N48-1]
XP_006523324.1, XM_006523261.3 [Q99N48-2]
XP_006523326.1, XM_006523263.1 [Q99N48-2]
XP_006523327.1, XM_006523264.1 [Q99N48-2]
XP_011244483.1, XM_011246181.2 [Q99N48-1]
XP_017173221.1, XM_017317732.1 [Q99N48-2]
UniGeneiMm.442201

Genome annotation databases

EnsembliENSMUST00000097430; ENSMUSP00000095041; ENSMUSG00000041831 [Q99N48-1]
ENSMUST00000160483; ENSMUSP00000123996; ENSMUSG00000041831 [Q99N48-2]
GeneIDi83672
KEGGimmu:83672
UCSCiuc008ahq.2 mouse [Q99N48-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSYTL3_MOUSE
AccessioniPrimary (citable) accession number: Q99N48
Secondary accession number(s): Q3KQQ0
, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: July 25, 2003
Last modified: March 28, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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