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Q99N42 (TYPH_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

Short name=TP
EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:Tymp
Synonyms:Ecgf1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis By similarity.

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Thymidine phosphorylase
PRO_0000059047

Sites

Binding site1021Substrate By similarity
Binding site1881Substrate By similarity
Binding site2031Substrate By similarity
Binding site2071Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99N42 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: C6AC64FC004DFF7E

FASTA47149,336
        10         20         30         40         50         60 
MAAPGTPPPS ASGGGGGEPR QLPELIRLKR DGGHLREADI RNFVHAVIDG RAQDTQIGAM 

        70         80         90        100        110        120 
LMAIRLQGMN LEETSVLTRA LAESGQQLEW PKAWHQQLVD KHSTGGVGDK VSLVLAPALA 

       130        140        150        160        170        180 
ACGCKVPMIS GRSLGHTGGT LDKLESIPGF GVTQSPEQML HILEEVGCCI VGQSAKLVPA 

       190        200        210        220        230        240 
DGILYAARDV TATVDSVPLI TASILSKKAV EGLSTLVVDV KFGGAAVFPD QEKARELAKM 

       250        260        270        280        290        300 
LVRVGVSLGL KVAAALTAMD NPLGRSVGHT LEVEEALLCL DGAGPPDLRD LVIRLGGAIL 

       310        320        330        340        350        360 
WISGQAETQD QGAARVAAAL DDGSARRRFQ LMLSAQGVDP GLAKALCSGS PTQRRQLLPH 

       370        380        390        400        410        420 
AREQEELLAP ADGIVECVRA LPLARVLHDL GAGRSRAGQP IRPGVGAEVL VDVGQCLSRG 

       430        440        450        460        470 
TPWLRVHLDG PALSSQQRRT LQGALVLSDR APFKVPSPFA ELVLPPTIAQ P 

« Hide

References

[1]"Mouse thymidine phosphorylase."
Ishikawa F., Toyoshima H., Miyazono K., Haraguchi M.
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB060274 mRNA. Translation: BAB41208.1.
RefSeqNP_612175.1. NM_138302.1.
UniGeneMm.287977.

3D structure databases

ProteinModelPortalQ99N42.
SMRQ99N42. Positions 18-465.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000023285.

Chemistry

BindingDBQ99N42.
ChEMBLCHEMBL2606.

PTM databases

PhosphoSiteQ99N42.

Proteomic databases

PaxDbQ99N42.
PRIDEQ99N42.

Protocols and materials databases

DNASU72962.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023285; ENSMUSP00000023285; ENSMUSG00000022615.
GeneID72962.
KEGGmmu:72962.
UCSCuc007xgl.2. mouse.

Organism-specific databases

CTD1890.
MGIMGI:1920212. Tymp.

Phylogenomic databases

eggNOGCOG0213.
GeneTreeENSGT00390000009250.
HOGENOMHOG000047313.
HOVERGENHBG000082.
InParanoidQ99N42.
KOK00758.
OMAESVPGFH.
OrthoDBEOG744T97.
PhylomeDBQ99N42.
TreeFamTF332198.

Enzyme and pathway databases

SABIO-RKQ99N42.
UniPathwayUPA00578; UER00638.

Gene expression databases

BgeeQ99N42.
CleanExMM_TYMP.
GenevestigatorQ99N42.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02644. Y_phosphoryl. 1 hit.
ProtoNetSearch...

Other

NextBio337237.
PROQ99N42.
SOURCESearch...

Entry information

Entry nameTYPH_MOUSE
AccessionPrimary (citable) accession number: Q99N42
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot