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Q99N42

- TYPH_MOUSE

UniProt

Q99N42 - TYPH_MOUSE

Protein

Thymidine phosphorylase

Gene

Tymp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis By similarity.By similarity

    Catalytic activityi

    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei102 – 1021SubstrateBy similarity
    Binding sitei188 – 1881SubstrateBy similarity
    Binding sitei203 – 2031SubstrateBy similarity
    Binding sitei207 – 2071SubstrateBy similarity

    GO - Molecular functioni

    1. phosphorylase activity Source: MGI
    2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
    3. thymidine phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. chemotaxis Source: MGI
    2. organ morphogenesis Source: MGI
    3. pyrimidine nucleobase metabolic process Source: InterPro
    4. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    SABIO-RKQ99N42.
    UniPathwayiUPA00578; UER00638.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine phosphorylase (EC:2.4.2.4)
    Short name:
    TP
    Alternative name(s):
    TdRPase
    Gene namesi
    Name:Tymp
    Synonyms:Ecgf1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1920212. Tymp.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 471471Thymidine phosphorylasePRO_0000059047Add
    BLAST

    Proteomic databases

    PaxDbiQ99N42.
    PRIDEiQ99N42.

    PTM databases

    PhosphoSiteiQ99N42.

    Expressioni

    Gene expression databases

    BgeeiQ99N42.
    CleanExiMM_TYMP.
    GenevestigatoriQ99N42.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000023285.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99N42.
    SMRiQ99N42. Positions 18-465.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0213.
    GeneTreeiENSGT00390000009250.
    HOGENOMiHOG000047313.
    HOVERGENiHBG000082.
    InParanoidiQ99N42.
    KOiK00758.
    OMAiESVPGFH.
    OrthoDBiEOG744T97.
    PhylomeDBiQ99N42.
    TreeFamiTF332198.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    InterProiIPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR018090. Pyrmidine_PPas_bac/euk.
    IPR000053. Pyrmidine_PPase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02644. Y_phosphoryl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q99N42-1 [UniParc]FASTAAdd to Basket

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    MAAPGTPPPS ASGGGGGEPR QLPELIRLKR DGGHLREADI RNFVHAVIDG    50
    RAQDTQIGAM LMAIRLQGMN LEETSVLTRA LAESGQQLEW PKAWHQQLVD 100
    KHSTGGVGDK VSLVLAPALA ACGCKVPMIS GRSLGHTGGT LDKLESIPGF 150
    GVTQSPEQML HILEEVGCCI VGQSAKLVPA DGILYAARDV TATVDSVPLI 200
    TASILSKKAV EGLSTLVVDV KFGGAAVFPD QEKARELAKM LVRVGVSLGL 250
    KVAAALTAMD NPLGRSVGHT LEVEEALLCL DGAGPPDLRD LVIRLGGAIL 300
    WISGQAETQD QGAARVAAAL DDGSARRRFQ LMLSAQGVDP GLAKALCSGS 350
    PTQRRQLLPH AREQEELLAP ADGIVECVRA LPLARVLHDL GAGRSRAGQP 400
    IRPGVGAEVL VDVGQCLSRG TPWLRVHLDG PALSSQQRRT LQGALVLSDR 450
    APFKVPSPFA ELVLPPTIAQ P 471
    Length:471
    Mass (Da):49,336
    Last modified:June 1, 2001 - v1
    Checksum:iC6AC64FC004DFF7E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB060274 mRNA. Translation: BAB41208.1.
    CCDSiCCDS27747.1.
    RefSeqiNP_612175.1. NM_138302.1.
    UniGeneiMm.287977.

    Genome annotation databases

    EnsembliENSMUST00000023285; ENSMUSP00000023285; ENSMUSG00000022615.
    GeneIDi72962.
    KEGGimmu:72962.
    UCSCiuc007xgl.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB060274 mRNA. Translation: BAB41208.1 .
    CCDSi CCDS27747.1.
    RefSeqi NP_612175.1. NM_138302.1.
    UniGenei Mm.287977.

    3D structure databases

    ProteinModelPortali Q99N42.
    SMRi Q99N42. Positions 18-465.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000023285.

    Chemistry

    BindingDBi Q99N42.
    ChEMBLi CHEMBL2606.

    PTM databases

    PhosphoSitei Q99N42.

    Proteomic databases

    PaxDbi Q99N42.
    PRIDEi Q99N42.

    Protocols and materials databases

    DNASUi 72962.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023285 ; ENSMUSP00000023285 ; ENSMUSG00000022615 .
    GeneIDi 72962.
    KEGGi mmu:72962.
    UCSCi uc007xgl.2. mouse.

    Organism-specific databases

    CTDi 1890.
    MGIi MGI:1920212. Tymp.

    Phylogenomic databases

    eggNOGi COG0213.
    GeneTreei ENSGT00390000009250.
    HOGENOMi HOG000047313.
    HOVERGENi HBG000082.
    InParanoidi Q99N42.
    KOi K00758.
    OMAi ESVPGFH.
    OrthoDBi EOG744T97.
    PhylomeDBi Q99N42.
    TreeFami TF332198.

    Enzyme and pathway databases

    UniPathwayi UPA00578 ; UER00638 .
    SABIO-RK Q99N42.

    Miscellaneous databases

    NextBioi 337237.
    PROi Q99N42.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99N42.
    CleanExi MM_TYMP.
    Genevestigatori Q99N42.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    InterProi IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR018090. Pyrmidine_PPas_bac/euk.
    IPR000053. Pyrmidine_PPase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02644. Y_phosphoryl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Mouse thymidine phosphorylase."
      Ishikawa F., Toyoshima H., Miyazono K., Haraguchi M.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTYPH_MOUSE
    AccessioniPrimary (citable) accession number: Q99N42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3