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Q99N42

- TYPH_MOUSE

UniProt

Q99N42 - TYPH_MOUSE

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Protein

Thymidine phosphorylase

Gene

Tymp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity).By similarity

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021SubstrateBy similarity
Binding sitei188 – 1881SubstrateBy similarity
Binding sitei203 – 2031SubstrateBy similarity
Binding sitei207 – 2071SubstrateBy similarity

GO - Molecular functioni

  1. phosphorylase activity Source: MGI
  2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. chemotaxis Source: MGI
  2. organ morphogenesis Source: MGI
  3. pyrimidine nucleobase metabolic process Source: InterPro
  4. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

SABIO-RKQ99N42.
UniPathwayiUPA00578; UER00638.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylase (EC:2.4.2.4)
Short name:
TP
Alternative name(s):
TdRPase
Gene namesi
Name:Tymp
Synonyms:Ecgf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1920212. Tymp.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Thymidine phosphorylasePRO_0000059047Add
BLAST

Proteomic databases

PaxDbiQ99N42.
PRIDEiQ99N42.

PTM databases

PhosphoSiteiQ99N42.

Expressioni

Gene expression databases

BgeeiQ99N42.
CleanExiMM_TYMP.
GenevestigatoriQ99N42.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023285.

Structurei

3D structure databases

ProteinModelPortaliQ99N42.
SMRiQ99N42. Positions 18-465.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0213.
GeneTreeiENSGT00390000009250.
HOGENOMiHOG000047313.
HOVERGENiHBG000082.
InParanoidiQ99N42.
KOiK00758.
OMAiESVPGFH.
OrthoDBiEOG744T97.
PhylomeDBiQ99N42.
TreeFamiTF332198.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02644. Y_phosphoryl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99N42 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPGTPPPS ASGGGGGEPR QLPELIRLKR DGGHLREADI RNFVHAVIDG
60 70 80 90 100
RAQDTQIGAM LMAIRLQGMN LEETSVLTRA LAESGQQLEW PKAWHQQLVD
110 120 130 140 150
KHSTGGVGDK VSLVLAPALA ACGCKVPMIS GRSLGHTGGT LDKLESIPGF
160 170 180 190 200
GVTQSPEQML HILEEVGCCI VGQSAKLVPA DGILYAARDV TATVDSVPLI
210 220 230 240 250
TASILSKKAV EGLSTLVVDV KFGGAAVFPD QEKARELAKM LVRVGVSLGL
260 270 280 290 300
KVAAALTAMD NPLGRSVGHT LEVEEALLCL DGAGPPDLRD LVIRLGGAIL
310 320 330 340 350
WISGQAETQD QGAARVAAAL DDGSARRRFQ LMLSAQGVDP GLAKALCSGS
360 370 380 390 400
PTQRRQLLPH AREQEELLAP ADGIVECVRA LPLARVLHDL GAGRSRAGQP
410 420 430 440 450
IRPGVGAEVL VDVGQCLSRG TPWLRVHLDG PALSSQQRRT LQGALVLSDR
460 470
APFKVPSPFA ELVLPPTIAQ P
Length:471
Mass (Da):49,336
Last modified:June 1, 2001 - v1
Checksum:iC6AC64FC004DFF7E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB060274 mRNA. Translation: BAB41208.1.
CCDSiCCDS27747.1.
RefSeqiNP_612175.1. NM_138302.1.
UniGeneiMm.287977.

Genome annotation databases

EnsembliENSMUST00000023285; ENSMUSP00000023285; ENSMUSG00000022615.
GeneIDi72962.
KEGGimmu:72962.
UCSCiuc007xgl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB060274 mRNA. Translation: BAB41208.1 .
CCDSi CCDS27747.1.
RefSeqi NP_612175.1. NM_138302.1.
UniGenei Mm.287977.

3D structure databases

ProteinModelPortali Q99N42.
SMRi Q99N42. Positions 18-465.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000023285.

Chemistry

BindingDBi Q99N42.
ChEMBLi CHEMBL2606.

PTM databases

PhosphoSitei Q99N42.

Proteomic databases

PaxDbi Q99N42.
PRIDEi Q99N42.

Protocols and materials databases

DNASUi 72962.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023285 ; ENSMUSP00000023285 ; ENSMUSG00000022615 .
GeneIDi 72962.
KEGGi mmu:72962.
UCSCi uc007xgl.2. mouse.

Organism-specific databases

CTDi 1890.
MGIi MGI:1920212. Tymp.

Phylogenomic databases

eggNOGi COG0213.
GeneTreei ENSGT00390000009250.
HOGENOMi HOG000047313.
HOVERGENi HBG000082.
InParanoidi Q99N42.
KOi K00758.
OMAi ESVPGFH.
OrthoDBi EOG744T97.
PhylomeDBi Q99N42.
TreeFami TF332198.

Enzyme and pathway databases

UniPathwayi UPA00578 ; UER00638 .
SABIO-RK Q99N42.

Miscellaneous databases

NextBioi 337237.
PROi Q99N42.
SOURCEi Search...

Gene expression databases

Bgeei Q99N42.
CleanExi MM_TYMP.
Genevestigatori Q99N42.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProi IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR02644. Y_phosphoryl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Mouse thymidine phosphorylase."
    Ishikawa F., Toyoshima H., Miyazono K., Haraguchi M.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTYPH_MOUSE
AccessioniPrimary (citable) accession number: Q99N42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2001
Last modified: October 1, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3