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Protein

Cell adhesion molecule 3

Gene

Cadm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cell recognition Source: GO_Central
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: HGNC
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: HGNC
  • protein localization Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.
R-MMU-420597. Nectin/Necl trans heterodimerization.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 3
Alternative name(s):
Immunoglobulin superfamily member 4B
Short name:
IgSF4B
Nectin-like protein 1
Short name:
NECL-1
Synaptic cell adhesion molecule 3
TSLC1-like protein 1
Gene namesi
Name:Cadm3
Synonyms:Igsf4b, Necl1, Syncam3, Tsll1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2137858. Cadm3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 328ExtracellularSequence analysisAdd BLAST306
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 396CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000004606823 – 396Cell adhesion molecule 3Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 108PROSITE-ProRule annotation
Disulfide bondi150 ↔ 207PROSITE-ProRule annotation
Disulfide bondi252 ↔ 297PROSITE-ProRule annotation
Glycosylationi288N-linked (GlcNAc...)Sequence analysis1
Modified residuei386PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ99N28.
PaxDbiQ99N28.
PeptideAtlasiQ99N28.
PRIDEiQ99N28.

PTM databases

iPTMnetiQ99N28.
PhosphoSitePlusiQ99N28.

Expressioni

Tissue specificityi

Mainly expressed in brain, in neuronal cell bodies of cerebellum, cortex, hippocampus, hypothalamus and spinal cord. In spinal cord predominantly expressed in motor neurons. Expressed in axons, presynaptic nerve terminals, glia cell processes.3 Publications

Developmental stagei

At E14.5 predominantly expressed in the nervous system.1 Publication

Gene expression databases

BgeeiENSMUSG00000005338.
CleanExiMM_CADM3.
ExpressionAtlasiQ99N28. baseline and differential.
GenevisibleiQ99N28. MM.

Interactioni

Subunit structurei

Homodimer. Can form trans-heterodimers with NECTIN3. Interacts with EPB41L1, DLG3, MPP6 and CASK.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi220505. 3 interactors.
IntActiQ99N28. 3 interactors.
MINTiMINT-4124499.
STRINGi10090.ENSMUSP00000106851.

Structurei

3D structure databases

ProteinModelPortaliQ99N28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 124Ig-like V-typeAdd BLAST102
Domaini128 – 226Ig-like C2-type 1Add BLAST99
Domaini231 – 313Ig-like C2-type 2Add BLAST83

Domaini

The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFCE. Eukaryota.
ENOG411017U. LUCA.
GeneTreeiENSGT00770000120518.
HOGENOMiHOG000036057.
HOVERGENiHBG057086.
InParanoidiQ99N28.
KOiK06780.
PhylomeDBiQ99N28.
TreeFamiTF326804.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR003585. Neurexin-like.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99N28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAPSALPLL LLLACSWAPG GANLSQDDSQ PWTSDETVVA GGTVVLKCQV
60 70 80 90 100
KDHEDSSLQW SNPAQQTLYF GEKRALRDNR IQLVSSTPHE LSISISNVAL
110 120 130 140 150
ADEGEYTCSI FTMPVRTAKS LVTVLGIPQK PIITGYKSSL REKETATLNC
160 170 180 190 200
QSSGSKPAAQ LTWRKGDQEL HGDQTRIQED PNGKTFTVSS SVSFQVTRED
210 220 230 240 250
DGANIVCSVN HESLKGADRS TSQRIEVLYT PTAMIRPEPA HPREGQKLLL
260 270 280 290 300
HCEGRGNPVP QQYVWVKEGS EPPLKMTQES ALIFPFLNKS DSGTYGCTAT
310 320 330 340 350
SNMGSYTAYF TLNVNDPSPV PSSSSTYHAI IGGIVAFIVF LLLILLIFLG
360 370 380 390
HYLIRHKGTY LTHEAKGSDD APDADTAIIN AEGGQSGGDD KKEYFI
Length:396
Mass (Da):42,964
Last modified:June 1, 2001 - v1
Checksum:iC1ADF8B57D141F3A
GO

Sequence cautioni

The sequence AAH29659 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY059393 mRNA. Translation: AAL29691.1.
AF195662 mRNA. Translation: AAG35584.1.
AK030782 mRNA. Translation: BAC27137.1.
AK038917 mRNA. Translation: BAC30168.1.
AK053077 mRNA. Translation: BAC35258.1.
BC029659 mRNA. Translation: AAH29659.1. Different initiation.
CCDSiCCDS15528.1.
RefSeqiNP_444429.1. NM_053199.3.
UniGeneiMm.330524.

Genome annotation databases

EnsembliENSMUST00000111220; ENSMUSP00000106851; ENSMUSG00000005338.
GeneIDi94332.
KEGGimmu:94332.
UCSCiuc007drh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY059393 mRNA. Translation: AAL29691.1.
AF195662 mRNA. Translation: AAG35584.1.
AK030782 mRNA. Translation: BAC27137.1.
AK038917 mRNA. Translation: BAC30168.1.
AK053077 mRNA. Translation: BAC35258.1.
BC029659 mRNA. Translation: AAH29659.1. Different initiation.
CCDSiCCDS15528.1.
RefSeqiNP_444429.1. NM_053199.3.
UniGeneiMm.330524.

3D structure databases

ProteinModelPortaliQ99N28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220505. 3 interactors.
IntActiQ99N28. 3 interactors.
MINTiMINT-4124499.
STRINGi10090.ENSMUSP00000106851.

PTM databases

iPTMnetiQ99N28.
PhosphoSitePlusiQ99N28.

Proteomic databases

MaxQBiQ99N28.
PaxDbiQ99N28.
PeptideAtlasiQ99N28.
PRIDEiQ99N28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111220; ENSMUSP00000106851; ENSMUSG00000005338.
GeneIDi94332.
KEGGimmu:94332.
UCSCiuc007drh.1. mouse.

Organism-specific databases

CTDi57863.
MGIiMGI:2137858. Cadm3.

Phylogenomic databases

eggNOGiENOG410IFCE. Eukaryota.
ENOG411017U. LUCA.
GeneTreeiENSGT00770000120518.
HOGENOMiHOG000036057.
HOVERGENiHBG057086.
InParanoidiQ99N28.
KOiK06780.
PhylomeDBiQ99N28.
TreeFamiTF326804.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.
R-MMU-420597. Nectin/Necl trans heterodimerization.

Miscellaneous databases

ChiTaRSiCadm3. mouse.
PROiQ99N28.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005338.
CleanExiMM_CADM3.
ExpressionAtlasiQ99N28. baseline and differential.
GenevisibleiQ99N28. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR003585. Neurexin-like.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADM3_MOUSE
AccessioniPrimary (citable) accession number: Q99N28
Secondary accession number(s): Q8BSQ8, Q8K1H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.