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Q99N27

- SNX1_RAT

UniProt

Q99N27 - SNX1_RAT

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Protein
Sorting nexin-1
Gene
Snx1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei186 – 1861Phosphatidylinositol 3-phosphate By similarity
Binding sitei188 – 1881Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei214 – 2141Phosphatidylinositol 3-phosphate By similarity
Binding sitei238 – 2381Phosphatidylinositol 3-phosphate By similarity

GO - Molecular functioni

  1. phosphatidylinositol binding Source: UniProtKB
  2. protein binding Source: RGD

GO - Biological processi

  1. early endosome to Golgi transport Source: Ensembl
  2. endosomal transport Source: RGD
  3. intracellular protein transport Source: RefGenome
  4. positive regulation of protein catabolic process Source: RGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-1
Gene namesi
Name:Snx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi68935. Snx1.

Subcellular locationi

Endosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Golgi apparatustrans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity
Note: Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) By similarity.

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. cytoplasmic membrane-bounded vesicle Source: RefGenome
  3. cytosol Source: RGD
  4. early endosome membrane Source: UniProtKB-SubCell
  5. endosome membrane Source: UniProtKB
  6. membrane Source: RGD
  7. retromer complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Sorting nexin-1
PRO_0000213837Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei32 – 321Phosphoserine By similarity
Modified residuei39 – 391Phosphoserine By similarity
Modified residuei188 – 1881Phosphoserine By similarity
Modified residuei237 – 2371N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ99N27.
PRIDEiQ99N27.

PTM databases

PhosphoSiteiQ99N27.

Expressioni

Gene expression databases

GenevestigatoriQ99N27.

Interactioni

Subunit structurei

Self-assembles into a complex of approximately 300 kDa. Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts with SNX6 By similarity. Interacts with HGS.1 Publication

Protein-protein interaction databases

IntActiQ99N27. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ99N27.
SMRiQ99N27. Positions 142-269.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 272130PX
Add
BLAST
Domaini302 – 522221BAR
Add
BLAST

Sequence similaritiesi

Belongs to the sorting nexin family.
Contains 1 BAR domain.

Phylogenomic databases

eggNOGiCOG5391.
GeneTreeiENSGT00740000114933.
HOGENOMiHOG000293327.
HOVERGENiHBG000618.
InParanoidiQ99N27.
KOiK17917.
OMAiEIAEWES.
OrthoDBiEOG7HHWSB.
PhylomeDBiQ99N27.
TreeFamiTF313698.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR028660. SNX1.
IPR005329. Sorting_nexin_N.
IPR015404. Vps5_C.
[Graphical view]
PANTHERiPTHR10555:SF129. PTHR10555:SF129. 1 hit.
PfamiPF00787. PX. 1 hit.
PF03700. Sorting_nexin. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99N27-1 [UniParc]FASTAAdd to Basket

« Hide

MASGGGGCSA SERLPPPFPG MDPESEGAAG GSEPEAGDSD TEGEDIFTGA    50
AAASKPQSPK KTTSLFPIKN GSKENGIHEE QDQEPQDLFA DATVELSLDS 100
TQNNQKTMPG KTLIPHPTQE ATNSPKPQPS YEELEEEEQE DQFDLTVGIT 150
DPEKIGDGMN AYVAYKVTTQ TSLPMFRSRQ FAVKRRFSDF LGLYEKLSEK 200
HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA ALERYLQRIV 250
NHPTMLQDPD VREFLEKEEL PRAVGTQALS GAGLLKMFNK ATDAVSKMTI 300
KMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTALFAKS 350
LAMLGSSEDN TALSRALSQL AEVEEKIEQL HQEQANNDFF LLAELLSDYI 400
RLLAIVRAAF DQRMKTWQRW QDAQATLQKK RESEARLLWA NKPDKLQQAK 450
DEITEWESRV TQYERDFERI STVVRKEVTR FEKEKSKDFK NHVIKYLETL 500
LHSQQQLAKY WEAFLPEARA IS 522
Length:522
Mass (Da):59,044
Last modified:June 1, 2001 - v1
Checksum:iF0F05664087E4D24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF218916 mRNA. Translation: AAG59616.1.
BC092201 mRNA. Translation: AAH92201.1.
RefSeqiNP_445863.1. NM_053411.1.
UniGeneiRn.144614.

Genome annotation databases

EnsembliENSRNOT00000022960; ENSRNOP00000022960; ENSRNOG00000017029.
GeneIDi84471.
KEGGirno:84471.
UCSCiRGD:68935. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF218916 mRNA. Translation: AAG59616.1 .
BC092201 mRNA. Translation: AAH92201.1 .
RefSeqi NP_445863.1. NM_053411.1.
UniGenei Rn.144614.

3D structure databases

ProteinModelPortali Q99N27.
SMRi Q99N27. Positions 142-269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q99N27. 1 interaction.

PTM databases

PhosphoSitei Q99N27.

Proteomic databases

PaxDbi Q99N27.
PRIDEi Q99N27.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000022960 ; ENSRNOP00000022960 ; ENSRNOG00000017029 .
GeneIDi 84471.
KEGGi rno:84471.
UCSCi RGD:68935. rat.

Organism-specific databases

CTDi 6642.
RGDi 68935. Snx1.

Phylogenomic databases

eggNOGi COG5391.
GeneTreei ENSGT00740000114933.
HOGENOMi HOG000293327.
HOVERGENi HBG000618.
InParanoidi Q99N27.
KOi K17917.
OMAi EIAEWES.
OrthoDBi EOG7HHWSB.
PhylomeDBi Q99N27.
TreeFami TF313698.

Miscellaneous databases

NextBioi 616956.
PROi Q99N27.

Gene expression databases

Genevestigatori Q99N27.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
IPR028660. SNX1.
IPR005329. Sorting_nexin_N.
IPR015404. Vps5_C.
[Graphical view ]
PANTHERi PTHR10555:SF129. PTHR10555:SF129. 1 hit.
Pfami PF00787. PX. 1 hit.
PF03700. Sorting_nexin. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view ]
SMARTi SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor."
    Chin L.-S., Raynor M.C., Wei X., Chen H.-Q., Li L.
    J. Biol. Chem. 276:7069-7078(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH HGS.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiSNX1_RAT
AccessioniPrimary (citable) accession number: Q99N27
Secondary accession number(s): Q56A25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds phosphatidylinositol 3-phosphate (PtdIns-3P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2) in liposome-based assays. Can bind PtdIns(3,4,5)P3 in protein:lipid overlay assays, but not in liposome-based assays By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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