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Q99N27

- SNX1_RAT

UniProt

Q99N27 - SNX1_RAT

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Protein

Sorting nexin-1

Gene

Snx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei186 – 1861Phosphatidylinositol 3-phosphateBy similarity
Binding sitei188 – 1881Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei214 – 2141Phosphatidylinositol 3-phosphateBy similarity
Binding sitei238 – 2381Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

  1. phosphatidylinositol binding Source: UniProtKB

GO - Biological processi

  1. early endosome to Golgi transport Source: Ensembl
  2. endosomal transport Source: RGD
  3. intracellular protein transport Source: RefGenome
  4. positive regulation of protein catabolic process Source: RGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-1
Gene namesi
Name:Snx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi68935. Snx1.

Subcellular locationi

Endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Golgi apparatustrans-Golgi network membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Early endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: RefGenome
  2. cytosol Source: RGD
  3. early endosome membrane Source: Ensembl
  4. endosome membrane Source: UniProtKB
  5. Golgi apparatus Source: UniProtKB-KW
  6. membrane Source: RGD
  7. retromer complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Sorting nexin-1PRO_0000213837Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei32 – 321PhosphoserineBy similarity
Modified residuei39 – 391PhosphoserineBy similarity
Modified residuei188 – 1881PhosphoserineBy similarity
Modified residuei237 – 2371N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ99N27.
PRIDEiQ99N27.

PTM databases

PhosphoSiteiQ99N27.

Expressioni

Gene expression databases

GenevestigatoriQ99N27.

Interactioni

Subunit structurei

Self-assembles into a complex of approximately 300 kDa. Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts with SNX6 (By similarity). Interacts with HGS.By similarity1 Publication

Protein-protein interaction databases

IntActiQ99N27. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ99N27.
SMRiQ99N27. Positions 142-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 272130PXPROSITE-ProRule annotationAdd
BLAST
Domaini302 – 522221BARAdd
BLAST

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 BAR domain.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5391.
GeneTreeiENSGT00760000119259.
HOGENOMiHOG000293327.
HOVERGENiHBG000618.
InParanoidiQ99N27.
KOiK17917.
OMAiEIAEWES.
OrthoDBiEOG7HHWSB.
PhylomeDBiQ99N27.
TreeFamiTF313698.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR028660. SNX1.
IPR005329. Sorting_nexin_N.
IPR015404. Vps5_C.
[Graphical view]
PANTHERiPTHR10555:SF129. PTHR10555:SF129. 1 hit.
PfamiPF00787. PX. 1 hit.
PF03700. Sorting_nexin. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99N27-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASGGGGCSA SERLPPPFPG MDPESEGAAG GSEPEAGDSD TEGEDIFTGA
60 70 80 90 100
AAASKPQSPK KTTSLFPIKN GSKENGIHEE QDQEPQDLFA DATVELSLDS
110 120 130 140 150
TQNNQKTMPG KTLIPHPTQE ATNSPKPQPS YEELEEEEQE DQFDLTVGIT
160 170 180 190 200
DPEKIGDGMN AYVAYKVTTQ TSLPMFRSRQ FAVKRRFSDF LGLYEKLSEK
210 220 230 240 250
HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA ALERYLQRIV
260 270 280 290 300
NHPTMLQDPD VREFLEKEEL PRAVGTQALS GAGLLKMFNK ATDAVSKMTI
310 320 330 340 350
KMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTALFAKS
360 370 380 390 400
LAMLGSSEDN TALSRALSQL AEVEEKIEQL HQEQANNDFF LLAELLSDYI
410 420 430 440 450
RLLAIVRAAF DQRMKTWQRW QDAQATLQKK RESEARLLWA NKPDKLQQAK
460 470 480 490 500
DEITEWESRV TQYERDFERI STVVRKEVTR FEKEKSKDFK NHVIKYLETL
510 520
LHSQQQLAKY WEAFLPEARA IS
Length:522
Mass (Da):59,044
Last modified:June 1, 2001 - v1
Checksum:iF0F05664087E4D24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF218916 mRNA. Translation: AAG59616.1.
BC092201 mRNA. Translation: AAH92201.1.
RefSeqiNP_445863.1. NM_053411.1.
UniGeneiRn.144614.

Genome annotation databases

EnsembliENSRNOT00000022960; ENSRNOP00000022960; ENSRNOG00000017029.
GeneIDi84471.
KEGGirno:84471.
UCSCiRGD:68935. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF218916 mRNA. Translation: AAG59616.1 .
BC092201 mRNA. Translation: AAH92201.1 .
RefSeqi NP_445863.1. NM_053411.1.
UniGenei Rn.144614.

3D structure databases

ProteinModelPortali Q99N27.
SMRi Q99N27. Positions 142-269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q99N27. 1 interaction.

PTM databases

PhosphoSitei Q99N27.

Proteomic databases

PaxDbi Q99N27.
PRIDEi Q99N27.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000022960 ; ENSRNOP00000022960 ; ENSRNOG00000017029 .
GeneIDi 84471.
KEGGi rno:84471.
UCSCi RGD:68935. rat.

Organism-specific databases

CTDi 6642.
RGDi 68935. Snx1.

Phylogenomic databases

eggNOGi COG5391.
GeneTreei ENSGT00760000119259.
HOGENOMi HOG000293327.
HOVERGENi HBG000618.
InParanoidi Q99N27.
KOi K17917.
OMAi EIAEWES.
OrthoDBi EOG7HHWSB.
PhylomeDBi Q99N27.
TreeFami TF313698.

Miscellaneous databases

NextBioi 616956.
PROi Q99N27.

Gene expression databases

Genevestigatori Q99N27.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
IPR028660. SNX1.
IPR005329. Sorting_nexin_N.
IPR015404. Vps5_C.
[Graphical view ]
PANTHERi PTHR10555:SF129. PTHR10555:SF129. 1 hit.
Pfami PF00787. PX. 1 hit.
PF03700. Sorting_nexin. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view ]
SMARTi SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor."
    Chin L.-S., Raynor M.C., Wei X., Chen H.-Q., Li L.
    J. Biol. Chem. 276:7069-7078(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH HGS.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiSNX1_RAT
AccessioniPrimary (citable) accession number: Q99N27
Secondary accession number(s): Q56A25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds phosphatidylinositol 3-phosphate (PtdIns-3P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2) in liposome-based assays. Can bind PtdIns(3,4,5)P3 in protein:lipid overlay assays, but not in liposome-based assays (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3