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Q99N27

- SNX1_RAT

UniProt

Q99N27 - SNX1_RAT

Protein

Sorting nexin-1

Gene

Snx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei186 – 1861Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei188 – 1881Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei214 – 2141Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei238 – 2381Phosphatidylinositol 3-phosphateBy similarity

    GO - Molecular functioni

    1. phosphatidylinositol binding Source: UniProtKB
    2. protein binding Source: RGD

    GO - Biological processi

    1. early endosome to Golgi transport Source: Ensembl
    2. endosomal transport Source: RGD
    3. intracellular protein transport Source: RefGenome
    4. positive regulation of protein catabolic process Source: RGD

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-1
    Gene namesi
    Name:Snx1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi68935. Snx1.

    Subcellular locationi

    Endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Golgi apparatustrans-Golgi network membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Early endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: RefGenome
    2. cytosol Source: RGD
    3. early endosome membrane Source: UniProtKB-SubCell
    4. endosome membrane Source: UniProtKB
    5. Golgi apparatus Source: UniProtKB-SubCell
    6. membrane Source: RGD
    7. retromer complex Source: InterPro

    Keywords - Cellular componenti

    Endosome, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Sorting nexin-1PRO_0000213837Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei32 – 321PhosphoserineBy similarity
    Modified residuei39 – 391PhosphoserineBy similarity
    Modified residuei188 – 1881PhosphoserineBy similarity
    Modified residuei237 – 2371N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ99N27.
    PRIDEiQ99N27.

    PTM databases

    PhosphoSiteiQ99N27.

    Expressioni

    Gene expression databases

    GenevestigatoriQ99N27.

    Interactioni

    Subunit structurei

    Self-assembles into a complex of approximately 300 kDa. Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts with SNX6 By similarity. Interacts with HGS.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ99N27. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99N27.
    SMRiQ99N27. Positions 142-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini143 – 272130PXPROSITE-ProRule annotationAdd
    BLAST
    Domaini302 – 522221BARAdd
    BLAST

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 BAR domain.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5391.
    GeneTreeiENSGT00740000114933.
    HOGENOMiHOG000293327.
    HOVERGENiHBG000618.
    InParanoidiQ99N27.
    KOiK17917.
    OMAiEIAEWES.
    OrthoDBiEOG7HHWSB.
    PhylomeDBiQ99N27.
    TreeFamiTF313698.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR001683. Phox.
    IPR028660. SNX1.
    IPR005329. Sorting_nexin_N.
    IPR015404. Vps5_C.
    [Graphical view]
    PANTHERiPTHR10555:SF129. PTHR10555:SF129. 1 hit.
    PfamiPF00787. PX. 1 hit.
    PF03700. Sorting_nexin. 1 hit.
    PF09325. Vps5. 1 hit.
    [Graphical view]
    SMARTiSM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99N27-1 [UniParc]FASTAAdd to Basket

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    MASGGGGCSA SERLPPPFPG MDPESEGAAG GSEPEAGDSD TEGEDIFTGA    50
    AAASKPQSPK KTTSLFPIKN GSKENGIHEE QDQEPQDLFA DATVELSLDS 100
    TQNNQKTMPG KTLIPHPTQE ATNSPKPQPS YEELEEEEQE DQFDLTVGIT 150
    DPEKIGDGMN AYVAYKVTTQ TSLPMFRSRQ FAVKRRFSDF LGLYEKLSEK 200
    HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA ALERYLQRIV 250
    NHPTMLQDPD VREFLEKEEL PRAVGTQALS GAGLLKMFNK ATDAVSKMTI 300
    KMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTALFAKS 350
    LAMLGSSEDN TALSRALSQL AEVEEKIEQL HQEQANNDFF LLAELLSDYI 400
    RLLAIVRAAF DQRMKTWQRW QDAQATLQKK RESEARLLWA NKPDKLQQAK 450
    DEITEWESRV TQYERDFERI STVVRKEVTR FEKEKSKDFK NHVIKYLETL 500
    LHSQQQLAKY WEAFLPEARA IS 522
    Length:522
    Mass (Da):59,044
    Last modified:June 1, 2001 - v1
    Checksum:iF0F05664087E4D24
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218916 mRNA. Translation: AAG59616.1.
    BC092201 mRNA. Translation: AAH92201.1.
    RefSeqiNP_445863.1. NM_053411.1.
    UniGeneiRn.144614.

    Genome annotation databases

    EnsembliENSRNOT00000022960; ENSRNOP00000022960; ENSRNOG00000017029.
    GeneIDi84471.
    KEGGirno:84471.
    UCSCiRGD:68935. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218916 mRNA. Translation: AAG59616.1 .
    BC092201 mRNA. Translation: AAH92201.1 .
    RefSeqi NP_445863.1. NM_053411.1.
    UniGenei Rn.144614.

    3D structure databases

    ProteinModelPortali Q99N27.
    SMRi Q99N27. Positions 142-269.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q99N27. 1 interaction.

    PTM databases

    PhosphoSitei Q99N27.

    Proteomic databases

    PaxDbi Q99N27.
    PRIDEi Q99N27.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022960 ; ENSRNOP00000022960 ; ENSRNOG00000017029 .
    GeneIDi 84471.
    KEGGi rno:84471.
    UCSCi RGD:68935. rat.

    Organism-specific databases

    CTDi 6642.
    RGDi 68935. Snx1.

    Phylogenomic databases

    eggNOGi COG5391.
    GeneTreei ENSGT00740000114933.
    HOGENOMi HOG000293327.
    HOVERGENi HBG000618.
    InParanoidi Q99N27.
    KOi K17917.
    OMAi EIAEWES.
    OrthoDBi EOG7HHWSB.
    PhylomeDBi Q99N27.
    TreeFami TF313698.

    Miscellaneous databases

    NextBioi 616956.
    PROi Q99N27.

    Gene expression databases

    Genevestigatori Q99N27.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR001683. Phox.
    IPR028660. SNX1.
    IPR005329. Sorting_nexin_N.
    IPR015404. Vps5_C.
    [Graphical view ]
    PANTHERi PTHR10555:SF129. PTHR10555:SF129. 1 hit.
    Pfami PF00787. PX. 1 hit.
    PF03700. Sorting_nexin. 1 hit.
    PF09325. Vps5. 1 hit.
    [Graphical view ]
    SMARTi SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor."
      Chin L.-S., Raynor M.C., Wei X., Chen H.-Q., Li L.
      J. Biol. Chem. 276:7069-7078(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH HGS.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiSNX1_RAT
    AccessioniPrimary (citable) accession number: Q99N27
    Secondary accession number(s): Q56A25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Binds phosphatidylinositol 3-phosphate (PtdIns-3P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2) in liposome-based assays. Can bind PtdIns(3,4,5)P3 in protein:lipid overlay assays, but not in liposome-based assays By similarity.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3