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Q99N20

- BRMS1_MOUSE

UniProt

Q99N20 - BRMS1_MOUSE

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Protein
Breast cancer metastasis-suppressor 1 homolog
Gene
Brms1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cellular process Source: MGI
  3. negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  4. negative regulation of transcription, DNA-templated Source: UniProtKB
  5. positive regulation of anoikis Source: UniProtKB
  6. positive regulation of protein deacetylation Source: UniProtKB
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Breast cancer metastasis-suppressor 1 homolog
Gene namesi
Name:Brms1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:2388804. Brms1.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: Predominantly nuclear By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Breast cancer metastasis-suppressor 1 homolog
PRO_0000064989Add
BLAST

Post-translational modificationi

Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation By similarity.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ99N20.

PTM databases

PhosphoSiteiQ99N20.

Expressioni

Gene expression databases

ArrayExpressiQ99N20.
BgeeiQ99N20.
CleanExiMM_BRMS1.
GenevestigatoriQ99N20.

Interactioni

Subunit structurei

Homohexamer Reviewed prediction. Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2. Interacts with SPOP; this recruits the protein to a ubiquitin ligase complex containing SPOP and CUL3 By similarity.

Protein-protein interaction databases

BioGridi223258. 2 interactions.
IntActiQ99N20. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ99N20.
SMRiQ99N20. Positions 54-94.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili51 – 9848 By similarity
Add
BLAST

Domaini

Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form homohexamers (By similarity).

Sequence similaritiesi

Belongs to the BRMS1 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG260250.
GeneTreeiENSGT00530000063177.
HOGENOMiHOG000007483.
HOVERGENiHBG050734.
InParanoidiQ99N20.
OMAiRGSSKTW.
OrthoDBiEOG783MZ0.
PhylomeDBiQ99N20.
TreeFamiTF323740.

Family and domain databases

InterProiIPR013907. Sds3.
[Graphical view]
PfamiPF08598. Sds3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99N20-1 [UniParc]FASTAAdd to Basket

« Hide

MPIQPSGKET EEMEAEGDSA AEMNGEADES EEERSGSQTE SEEESSEMDD    50
EDYERRRSEC VSEMLDLEKQ FSELKEKLFR ERLSQLRLRL EEVGAERAPE 100
YTEPLGGLQQ SLKIRIQVAG IYKGFCLDVI RNKYECELQG AKQHLESEKM 150
LLYDTLLGEL QERIQRLEED RQSLDISSEW WDDKLHSRSS SKAGDAMPPS 200
KRKKAPLVSG PYIVYMLQEI DILEDWTAIK KARAAVSPQK RKADGP 246
Length:246
Mass (Da):28,210
Last modified:June 1, 2001 - v1
Checksum:i3825F0B5CB84E575
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF233580 mRNA. Translation: AAK15007.1.
AF368292 Genomic DNA. Translation: AAK51553.1.
BC016108 mRNA. Translation: AAH16108.1.
CCDSiCCDS50355.1.
RefSeqiNP_598916.1. NM_134155.1.
UniGeneiMm.29628.

Genome annotation databases

EnsembliENSMUST00000116567; ENSMUSP00000112266; ENSMUSG00000080268.
GeneIDi107392.
KEGGimmu:107392.
UCSCiuc008gbz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF233580 mRNA. Translation: AAK15007.1 .
AF368292 Genomic DNA. Translation: AAK51553.1 .
BC016108 mRNA. Translation: AAH16108.1 .
CCDSi CCDS50355.1.
RefSeqi NP_598916.1. NM_134155.1.
UniGenei Mm.29628.

3D structure databases

ProteinModelPortali Q99N20.
SMRi Q99N20. Positions 54-94.
ModBasei Search...

Protein-protein interaction databases

BioGridi 223258. 2 interactions.
IntActi Q99N20. 1 interaction.

PTM databases

PhosphoSitei Q99N20.

Proteomic databases

PRIDEi Q99N20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000116567 ; ENSMUSP00000112266 ; ENSMUSG00000080268 .
GeneIDi 107392.
KEGGi mmu:107392.
UCSCi uc008gbz.1. mouse.

Organism-specific databases

CTDi 25855.
MGIi MGI:2388804. Brms1.

Phylogenomic databases

eggNOGi NOG260250.
GeneTreei ENSGT00530000063177.
HOGENOMi HOG000007483.
HOVERGENi HBG050734.
InParanoidi Q99N20.
OMAi RGSSKTW.
OrthoDBi EOG783MZ0.
PhylomeDBi Q99N20.
TreeFami TF323740.

Miscellaneous databases

NextBioi 358740.
PROi Q99N20.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99N20.
Bgeei Q99N20.
CleanExi MM_BRMS1.
Genevestigatori Q99N20.

Family and domain databases

InterProi IPR013907. Sds3.
[Graphical view ]
Pfami PF08598. Sds3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Brms1: murine homolog of human breast metastasis suppressor gene-1 (BRMS1)."
    Samant R.S., Debies M.T., Welch D.R.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1)."
    Samant R.S., Debies M.T., Shevde L.A., Verderame M.F., Welch D.R.
    Int. J. Cancer 97:15-20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiBRMS1_MOUSE
AccessioniPrimary (citable) accession number: Q99N20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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