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Q99N20

- BRMS1_MOUSE

UniProt

Q99N20 - BRMS1_MOUSE

Protein

Breast cancer metastasis-suppressor 1 homolog

Gene

Brms1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cellular process Source: MGI
    3. negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
    4. negative regulation of transcription, DNA-templated Source: UniProtKB
    5. positive regulation of anoikis Source: UniProtKB
    6. positive regulation of protein deacetylation Source: UniProtKB
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Apoptosis, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Breast cancer metastasis-suppressor 1 homolog
    Gene namesi
    Name:Brms1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:2388804. Brms1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity
    Note: Predominantly nuclear.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Breast cancer metastasis-suppressor 1 homologPRO_0000064989Add
    BLAST

    Post-translational modificationi

    Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PRIDEiQ99N20.

    PTM databases

    PhosphoSiteiQ99N20.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99N20.
    BgeeiQ99N20.
    CleanExiMM_BRMS1.
    GenevestigatoriQ99N20.

    Interactioni

    Subunit structurei

    Homohexamer Potential. Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2. Interacts with SPOP; this recruits the protein to a ubiquitin ligase complex containing SPOP and CUL3 By similarity.By similarityCurated

    Protein-protein interaction databases

    BioGridi223258. 2 interactions.
    IntActiQ99N20. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99N20.
    SMRiQ99N20. Positions 54-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili51 – 9848By similarityAdd
    BLAST

    Domaini

    Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form homohexamers.By similarity

    Sequence similaritiesi

    Belongs to the BRMS1 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG260250.
    GeneTreeiENSGT00530000063177.
    HOGENOMiHOG000007483.
    HOVERGENiHBG050734.
    InParanoidiQ99N20.
    OMAiRGSSKTW.
    OrthoDBiEOG783MZ0.
    PhylomeDBiQ99N20.
    TreeFamiTF323740.

    Family and domain databases

    InterProiIPR013907. Sds3.
    [Graphical view]
    PfamiPF08598. Sds3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99N20-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPIQPSGKET EEMEAEGDSA AEMNGEADES EEERSGSQTE SEEESSEMDD    50
    EDYERRRSEC VSEMLDLEKQ FSELKEKLFR ERLSQLRLRL EEVGAERAPE 100
    YTEPLGGLQQ SLKIRIQVAG IYKGFCLDVI RNKYECELQG AKQHLESEKM 150
    LLYDTLLGEL QERIQRLEED RQSLDISSEW WDDKLHSRSS SKAGDAMPPS 200
    KRKKAPLVSG PYIVYMLQEI DILEDWTAIK KARAAVSPQK RKADGP 246
    Length:246
    Mass (Da):28,210
    Last modified:June 1, 2001 - v1
    Checksum:i3825F0B5CB84E575
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF233580 mRNA. Translation: AAK15007.1.
    AF368292 Genomic DNA. Translation: AAK51553.1.
    BC016108 mRNA. Translation: AAH16108.1.
    CCDSiCCDS50355.1.
    RefSeqiNP_598916.1. NM_134155.1.
    UniGeneiMm.29628.

    Genome annotation databases

    EnsembliENSMUST00000116567; ENSMUSP00000112266; ENSMUSG00000080268.
    GeneIDi107392.
    KEGGimmu:107392.
    UCSCiuc008gbz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF233580 mRNA. Translation: AAK15007.1 .
    AF368292 Genomic DNA. Translation: AAK51553.1 .
    BC016108 mRNA. Translation: AAH16108.1 .
    CCDSi CCDS50355.1.
    RefSeqi NP_598916.1. NM_134155.1.
    UniGenei Mm.29628.

    3D structure databases

    ProteinModelPortali Q99N20.
    SMRi Q99N20. Positions 54-94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 223258. 2 interactions.
    IntActi Q99N20. 1 interaction.

    PTM databases

    PhosphoSitei Q99N20.

    Proteomic databases

    PRIDEi Q99N20.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000116567 ; ENSMUSP00000112266 ; ENSMUSG00000080268 .
    GeneIDi 107392.
    KEGGi mmu:107392.
    UCSCi uc008gbz.1. mouse.

    Organism-specific databases

    CTDi 25855.
    MGIi MGI:2388804. Brms1.

    Phylogenomic databases

    eggNOGi NOG260250.
    GeneTreei ENSGT00530000063177.
    HOGENOMi HOG000007483.
    HOVERGENi HBG050734.
    InParanoidi Q99N20.
    OMAi RGSSKTW.
    OrthoDBi EOG783MZ0.
    PhylomeDBi Q99N20.
    TreeFami TF323740.

    Miscellaneous databases

    NextBioi 358740.
    PROi Q99N20.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99N20.
    Bgeei Q99N20.
    CleanExi MM_BRMS1.
    Genevestigatori Q99N20.

    Family and domain databases

    InterProi IPR013907. Sds3.
    [Graphical view ]
    Pfami PF08598. Sds3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Brms1: murine homolog of human breast metastasis suppressor gene-1 (BRMS1)."
      Samant R.S., Debies M.T., Welch D.R.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1)."
      Samant R.S., Debies M.T., Shevde L.A., Verderame M.F., Welch D.R.
      Int. J. Cancer 97:15-20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiBRMS1_MOUSE
    AccessioniPrimary (citable) accession number: Q99N20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3