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Q99N20 (BRMS1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Breast cancer metastasis-suppressor 1 homolog
Gene names
Name:Brms1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis By similarity.

Subunit structure

Homohexamer Potential. Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2. Interacts with SPOP; this recruits the protein to a ubiquitin ligase complex containing SPOP and CUL3 By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Note: Predominantly nuclear By similarity.

Domain

Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form homohexamers By similarity.

Post-translational modification

Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation By similarity.

Sequence similarities

Belongs to the BRMS1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Breast cancer metastasis-suppressor 1 homolog
PRO_0000064989

Regions

Coiled coil51 – 9848 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99N20 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 3825F0B5CB84E575

FASTA24628,210
        10         20         30         40         50         60 
MPIQPSGKET EEMEAEGDSA AEMNGEADES EEERSGSQTE SEEESSEMDD EDYERRRSEC 

        70         80         90        100        110        120 
VSEMLDLEKQ FSELKEKLFR ERLSQLRLRL EEVGAERAPE YTEPLGGLQQ SLKIRIQVAG 

       130        140        150        160        170        180 
IYKGFCLDVI RNKYECELQG AKQHLESEKM LLYDTLLGEL QERIQRLEED RQSLDISSEW 

       190        200        210        220        230        240 
WDDKLHSRSS SKAGDAMPPS KRKKAPLVSG PYIVYMLQEI DILEDWTAIK KARAAVSPQK 


RKADGP 

« Hide

References

« Hide 'large scale' references
[1]"Brms1: murine homolog of human breast metastasis suppressor gene-1 (BRMS1)."
Samant R.S., Debies M.T., Welch D.R.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1)."
Samant R.S., Debies M.T., Shevde L.A., Verderame M.F., Welch D.R.
Int. J. Cancer 97:15-20(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF233580 mRNA. Translation: AAK15007.1.
AF368292 Genomic DNA. Translation: AAK51553.1.
BC016108 mRNA. Translation: AAH16108.1.
CCDSCCDS50355.1.
RefSeqNP_598916.1. NM_134155.1.
UniGeneMm.29628.

3D structure databases

ProteinModelPortalQ99N20.
SMRQ99N20. Positions 54-94.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid223258. 2 interactions.
IntActQ99N20. 1 interaction.

PTM databases

PhosphoSiteQ99N20.

Proteomic databases

PRIDEQ99N20.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000116567; ENSMUSP00000112266; ENSMUSG00000080268.
GeneID107392.
KEGGmmu:107392.
UCSCuc008gbz.1. mouse.

Organism-specific databases

CTD25855.
MGIMGI:2388804. Brms1.

Phylogenomic databases

eggNOGNOG260250.
GeneTreeENSGT00530000063177.
HOGENOMHOG000007483.
HOVERGENHBG050734.
InParanoidQ99N20.
OMARGSSKTW.
OrthoDBEOG783MZ0.
PhylomeDBQ99N20.
TreeFamTF323740.

Gene expression databases

ArrayExpressQ99N20.
BgeeQ99N20.
CleanExMM_BRMS1.
GenevestigatorQ99N20.

Family and domain databases

InterProIPR013907. Sds3.
[Graphical view]
PfamPF08598. Sds3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio358740.
PROQ99N20.
SOURCESearch...

Entry information

Entry nameBRMS1_MOUSE
AccessionPrimary (citable) accession number: Q99N20
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot