Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tachykinin-4

Gene

Tac4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Hemokinin induces plasma extravasation, mast cell degranulation, muscle contraction, salivary secretion and scratching behavior. Increases sperm motility. Induces potent analgesic effects and may play a role in pain modulation. Promotes survival of bone marrow B lineage cells and of cultured LPS-stimulated pre-B cells and may act as an autocrine factor required for B-cell survival and proliferation. Lowers systemic arterial pressure following intravenous injection. Induces interferon-gamma production and may play a role in the inflammatory response. Shows potent affinity and specificity for the NK-1 receptor.8 Publications

GO - Molecular functioni

  • receptor binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hypotensive agent

Keywords - Biological processi

Mast cell degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Tachykinin-4
Alternative name(s):
Preprotachykinin-C
Short name:
PPT-C
Cleaved into the following chain:
Alternative name(s):
HK1
Hemokinin-1
Hemokinin-I
Short name:
HK-I
Gene namesi
Name:Tac4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1931130. Tac4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Propeptidei17 – 5438By similarityPRO_0000320014Add
BLAST
Peptidei56 – 6611Hemokinin1 PublicationPRO_0000320015Add
BLAST
Propeptidei69 – 12860By similarityPRO_0000320016Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661Methionine amide1 PublicationSequence analysis

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ99N14.
PRIDEiQ99N14.

Expressioni

Tissue specificityi

Expressed in hematopoietic cells with highest levels in pre- and pro-B cells but not in later developmental stages. Also detected in uterus, skeletal muscle, brain, spleen, stomach, skin and lactating mammary gland and in cells of myeloid lineage including dendritic and microglial cells and macrophages. In uterus, highest expression is observed in non-pregnant diestrus mice and in day 5 pregnant mice. Compared with mice in diestrus, decreases 2.6-fold in uteri from non-pregnant mice in estrus and 10.2-fold in day 17 pregnant mice. Detected at sites of chronic inflammation such as granulomas.7 Publications

Gene expression databases

BgeeiQ99N14.
CleanExiMM_TAC4.
GenevisibleiQ99N14. MM.

Interactioni

GO - Molecular functioni

  • receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021242.

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2QI. Eukaryota.
ENOG41113ZV. LUCA.
GeneTreeiENSGT00390000015220.
HOGENOMiHOG000154596.
HOVERGENiHBG097570.
InParanoidiQ99N14.
KOiK05241.
OMAiYQLGRIV.
OrthoDBiEOG7NSB4F.
PhylomeDBiQ99N14.
TreeFamiTF338519.

Family and domain databases

InterProiIPR013055. Tachy_Neuro_lke_CS.
IPR008216. Tachykinin_fam.
[Graphical view]
PANTHERiPTHR11250. PTHR11250. 1 hit.
PROSITEiPS00267. TACHYKININ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99N14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLLALLLL IGPSVCTTAG DREELAFGAE AESWVTVNLK GIPVPSIELK
60 70 80 90 100
LQELKRSRTR QFYGLMGKRV GGYQLGRIVQ DLLGTRGLSI EGTCRQAASQ
110 120
QRARPGAVTR ESLQSREEDE APLTTSNV
Length:128
Mass (Da):13,937
Last modified:June 1, 2001 - v1
Checksum:iFED91DCAB39CB444
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235035 mRNA. Translation: AAK15025.1.
AF515827 mRNA. Translation: AAP30873.1.
AL627222 Genomic DNA. Translation: CAI24806.1.
BC119426 mRNA. Translation: AAI19427.1.
CCDSiCCDS25274.1.
RefSeqiNP_444323.1. NM_053093.1.
UniGeneiMm.40085.

Genome annotation databases

EnsembliENSMUST00000021242; ENSMUSP00000021242; ENSMUSG00000020872.
GeneIDi93670.
KEGGimmu:93670.
UCSCiuc007lac.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235035 mRNA. Translation: AAK15025.1.
AF515827 mRNA. Translation: AAP30873.1.
AL627222 Genomic DNA. Translation: CAI24806.1.
BC119426 mRNA. Translation: AAI19427.1.
CCDSiCCDS25274.1.
RefSeqiNP_444323.1. NM_053093.1.
UniGeneiMm.40085.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021242.

Proteomic databases

PaxDbiQ99N14.
PRIDEiQ99N14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021242; ENSMUSP00000021242; ENSMUSG00000020872.
GeneIDi93670.
KEGGimmu:93670.
UCSCiuc007lac.1. mouse.

Organism-specific databases

CTDi255061.
MGIiMGI:1931130. Tac4.

Phylogenomic databases

eggNOGiENOG410J2QI. Eukaryota.
ENOG41113ZV. LUCA.
GeneTreeiENSGT00390000015220.
HOGENOMiHOG000154596.
HOVERGENiHBG097570.
InParanoidiQ99N14.
KOiK05241.
OMAiYQLGRIV.
OrthoDBiEOG7NSB4F.
PhylomeDBiQ99N14.
TreeFamiTF338519.

Miscellaneous databases

PROiQ99N14.
SOURCEiSearch...

Gene expression databases

BgeeiQ99N14.
CleanExiMM_TAC4.
GenevisibleiQ99N14. MM.

Family and domain databases

InterProiIPR013055. Tachy_Neuro_lke_CS.
IPR008216. Tachykinin_fam.
[Graphical view]
PANTHERiPTHR11250. PTHR11250. 1 hit.
PROSITEiPS00267. TACHYKININ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis."
    Zhang Y., Lu L., Furlonger C., Wu G.E., Paige C.J.
    Nat. Immunol. 1:392-397(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "Characterization of the endokinins: human tachykinins with cardiovascular activity."
    Page N.M., Bell N.J., Gardiner S.M., Manyonda I.T., Brayley K.J., Strange P.G., Lowry P.J.
    Proc. Natl. Acad. Sci. U.S.A. 100:6245-6250(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: CD-1Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Hemokinin 1 is a full agonist at the substance P receptor."
    Morteau O., Lu B., Gerard C., Gerard N.P.
    Nat. Immunol. 2:1088-1088(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: SYNTHESIS, FUNCTION.
  7. "Identification, localization and receptor characterization of novel mammalian substance P-like peptides."
    Kurtz M.M., Wang R., Clements M.K., Cascieri M.A., Austin C.P., Cunningham B.R., Chicchi G.G., Liu Q.
    Gene 296:205-212(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Pharmacological profile of hemokinin 1: a novel member of the tachykinin family."
    Camarda V., Rizzi A., Calo G., Guerrini R., Salvadori S., Regoli D.
    Life Sci. 71:363-370(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SYNTHESIS, FUNCTION.
  9. "Centrally administered hemokinin-1 (HK-1), a neurokinin NK1 receptor agonist, produces substance P-like behavioral effects in mice and gerbils."
    Duffy R.A., Hedrick J.A., Randolph G., Morgan C.A., Cohen-Williams M.E., Vassileva G., Lachowicz J.E., Laverty M., Maguire M., Shan L.-S., Gustafson E., Varty G.B.
    Neuropharmacology 45:242-250(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  10. "Hemokinin has substance P-like function and expression in inflammation."
    Metwali A., Blum A.M., Elliott D.E., Setiawan T., Weinstock J.V.
    J. Immunol. 172:6528-6532(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  11. "Expression of hemokinin 1 mRNA by murine dendritic cells."
    Nelson D.A., Marriott I., Bost K.L.
    J. Neuroimmunol. 155:94-102(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  12. "Functional and molecular characterization of tachykinins and tachykinin receptors in the mouse uterus."
    Patak E., Pinto F.M., Story M.E., Pintado C.O., Fleming A., Page N.M., Pennefather J.N., Candenas M.L.
    Biol. Reprod. 72:1125-1133(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  13. "Effects and mechanisms of supraspinal administration of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on nociception in mice."
    Fu C.-Y., Kong Z.-Q., Wang K.-R., Yang Q., Zhai K., Chen Q., Wang R.
    Brain Res. 1056:51-58(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SYNTHESIS, FUNCTION.
  14. "Cardiovascular responses to rat/mouse hemokinin-1, a mammalian tachykinin peptide: systemic study in anesthetized rats."
    Fu C.-Y., Kong Z.-Q., Long Y., Chen Q., Wang R.
    Eur. J. Pharmacol. 572:175-181(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SYNTHESIS, FUNCTION.

Entry informationi

Entry nameiTKN4_MOUSE
AccessioniPrimary (citable) accession number: Q99N14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.