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Protein

Solute carrier organic anion transporter family member 3A1

Gene

Slco3a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent transport of organic anions. Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin.By similarity

GO - Molecular functioni

GO - Biological processi

  • prostaglandin transport Source: RGD
  • sodium-independent organic anion transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 3A1
Alternative name(s):
Organic anion-transporting polypeptide D
Short name:
OATP-D
Prostaglandin transporter subtype 2
Sodium-independent organic anion transporter D
Solute carrier family 21 member 11
Gene namesi
Name:Slco3a1
Synonyms:Oatp3a1, Oatpd, Pgt2, Slc21a11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620227. Slco3a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040CytoplasmicSequence analysisAdd
BLAST
Transmembranei41 – 6020Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini61 – 7919ExtracellularSequence analysisAdd
BLAST
Transmembranei80 – 10021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini101 – 1066CytoplasmicSequence analysis
Transmembranei107 – 13125Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini132 – 17443ExtracellularSequence analysisAdd
BLAST
Transmembranei175 – 20329Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini204 – 22219CytoplasmicSequence analysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini244 – 26118ExtracellularSequence analysisAdd
BLAST
Transmembranei262 – 28625Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini287 – 34458CytoplasmicSequence analysisAdd
BLAST
Transmembranei345 – 36622Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini367 – 38620ExtracellularSequence analysisAdd
BLAST
Transmembranei387 – 41024Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini411 – 4144CytoplasmicSequence analysis
Transmembranei415 – 43824Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini439 – 539101ExtracellularSequence analysisAdd
BLAST
Transmembranei540 – 56223Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini563 – 5719CytoplasmicSequence analysis
Transmembranei572 – 59726Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini598 – 63033ExtracellularSequence analysisAdd
BLAST
Transmembranei631 – 64818Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini649 – 70557CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2073689.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 710710Solute carrier organic anion transporter family member 3A1PRO_0000191066Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence analysis
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence analysis
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi471 ↔ 497PROSITE-ProRule annotation
Disulfide bondi475 ↔ 486PROSITE-ProRule annotation
Disulfide bondi477 ↔ 501PROSITE-ProRule annotation
Glycosylationi502 – 5021N-linked (GlcNAc...)Sequence analysis
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence analysis
Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99N02.

Expressioni

Tissue specificityi

Expressed in many brain regions, including frontal cortex, brain stem and cerebellum. Associated with neuronal bodies in a punctated matter. Little expression, if any, in oligodendrocytes.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049659.

Structurei

3D structure databases

ProteinModelPortaliQ99N02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini465 – 51349Kazal-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 326Poly-Lys

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOVERGENiHBG098539.
InParanoidiQ99N02.
KOiK14353.
PhylomeDBiQ99N02.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99N02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM
60 70 80 90 100
LAQGTVGAYL VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG
110 120 130 140 150
ARGHRPRLIG CGGIVMALGA LLSALPEFLT HQYKYEAGEI RWGAEGRDVC
160 170 180 190 200
ATNGSSSDEG PDPDLICRNR TATNMMYLLL IGAQVLLGIG ATPVQPLGVS
210 220 230 240 250
YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY VDAVFIDTSN
260 270 280 290 300
LDITPDDPRW IGAWWGGFLL CGALLFFSSL LMFGFPQSLP PHSEPGMESE
310 320 330 340 350
QAMLPEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV
360 370 380 390 400
FTCIVLAACM EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC
410 420 430 440 450
LGIFLGGLLV KKLSLSALGA IRMAMLVNLV STACYVSFLF LGCDTVPVAG
460 470 480 490 500
VTVRYGNNSA RGSPLDPYSP CNNNCECQTD SFTPVCGADG ITYLSACFAG
510 520 530 540 550
CNSTNLTGCA CLTTVPPENA TVVPGKCPSP GCQEAFLTFL CVMCVCSLIG
560 570 580 590 600
AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST
610 620 630 640 650
CLFWSTFCGE QGACVLYDNV VYRYLYVSIA IALKSFAFIL YTTTWQCLRK
660 670 680 690 700
NYKRYIKNHE GGLSTSEFLA STLTLDNLGR DPVPAHQTHR TKFIYNLEDH
710
EWCENMESVL
Length:710
Mass (Da):76,825
Last modified:June 1, 2001 - v1
Checksum:i9E0CE36087E6BD17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239219 mRNA. Translation: AAK15063.1.
RefSeqiNP_803434.1. NM_177481.1.
UniGeneiRn.229665.

Genome annotation databases

GeneIDi140915.
KEGGirno:140915.
UCSCiRGD:620227. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239219 mRNA. Translation: AAK15063.1.
RefSeqiNP_803434.1. NM_177481.1.
UniGeneiRn.229665.

3D structure databases

ProteinModelPortaliQ99N02.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049659.

Chemistry

ChEMBLiCHEMBL2073689.

Proteomic databases

PaxDbiQ99N02.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140915.
KEGGirno:140915.
UCSCiRGD:620227. rat.

Organism-specific databases

CTDi28232.
RGDi620227. Slco3a1.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOVERGENiHBG098539.
InParanoidiQ99N02.
KOiK14353.
PhylomeDBiQ99N02.

Miscellaneous databases

PROiQ99N02.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular identification of a novel human prostaglandin transporter PGT2."
    Adachi H., Abe T.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain."
    Huber R.D., Gao B., Sidler Pfaendler M.-A., Zhang-Fu W., Leuthold S., Hagenbuch B., Folkers G., Meier P.J., Stieger B.
    Am. J. Physiol. 292:C795-C806(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiSO3A1_RAT
AccessioniPrimary (citable) accession number: Q99N02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.