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Protein

Solute carrier organic anion transporter family member 4A1

Gene

Slco4a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent transport of organic anions such as the thyroid hormone T3 (triiodo-L-thyronine) and of taurocholate.

GO - Molecular functioni

  • thyroid hormone transmembrane transporter activity Source: RGD

GO - Biological processi

  • ion transport Source: UniProtKB-KW
  • thyroid hormone metabolic process Source: RGD
  • thyroid hormone transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 4A1
Alternative name(s):
Organic anion-transporting polypeptide E
Short name:
OATP-E
Sodium-independent organic anion transporter E
Solute carrier family 21 member 12
Gene namesi
Name:Slco4a1
Synonyms:Oatp4a1, Oatpe, Slc21a12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620228. Slco4a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 102102CytoplasmicSequence analysisAdd
BLAST
Transmembranei103 – 12321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini124 – 14219ExtracellularSequence analysisAdd
BLAST
Transmembranei143 – 16321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini164 – 1696CytoplasmicSequence analysis
Transmembranei170 – 19425Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini195 – 22733ExtracellularSequence analysisAdd
BLAST
Transmembranei228 – 25831Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini259 – 27719CytoplasmicSequence analysisAdd
BLAST
Transmembranei278 – 29821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini299 – 31214ExtracellularSequence analysisAdd
BLAST
Transmembranei313 – 33725Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini338 – 38043CytoplasmicSequence analysisAdd
BLAST
Transmembranei381 – 40222Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini403 – 42220ExtracellularSequence analysisAdd
BLAST
Transmembranei423 – 44624Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini447 – 4504CytoplasmicSequence analysis
Transmembranei451 – 47323Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini474 – 582109ExtracellularSequence analysisAdd
BLAST
Transmembranei583 – 60523Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini606 – 6149CytoplasmicSequence analysis
Transmembranei615 – 64026Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini641 – 67333ExtracellularSequence analysisAdd
BLAST
Transmembranei674 – 69118Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini692 – 72332CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2073701.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Solute carrier organic anion transporter family member 4A1PRO_0000191069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391PhosphoserineBy similarity
Modified residuei42 – 421PhosphoserineBy similarity
Modified residuei45 – 451PhosphoserineBy similarity
Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence analysis
Disulfide bondi506 ↔ 532PROSITE-ProRule annotation
Disulfide bondi511 ↔ 521PROSITE-ProRule annotation
Disulfide bondi512 ↔ 536PROSITE-ProRule annotation
Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ99N01.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030414.

Structurei

3D structure databases

ProteinModelPortaliQ99N01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini500 – 55758Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOGENOMiHOG000231270.
HOVERGENiHBG100565.
InParanoidiQ99N01.
PhylomeDBiQ99N01.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99N01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQHAMGDKH FLSLPKHLFT STSSTTDSGC DTPPSSRASP ASLRSAHGAL
60 70 80 90 100
GSSSQPLFEP QVEKRSSQAA CEVQYLSSGP QSTLCGWQSF TPKCLQVFNT
110 120 130 140 150
PKGFLFFLCA ASFLQGMTVN GFINTVITSI ERRFDLHSYQ SGLIASSYDI
160 170 180 190 200
AACLCLTFVS YFGGNGHKPR WLGWGALVLG IGSLVFALPH FTAGRYEVEI
210 220 230 240 250
DDEGLGTETG TCLTNQSQVE CKDRASGLSS YRLIFMLGQL LHGVGATPLY
260 270 280 290 300
TLGVTYLDEN VKSSYSPIYI AIFYTAAILG PAAGYLIGGA MLNVYTEVGQ
310 320 330 340 350
RTELTTDSPL WVGAWWIGFL GAGIAAFLIA IPILGYPRQL PGSQRYVVMR
360 370 380 390 400
AAETQQLKDH SRDNPAFGKT VRDLPLSVWI LLRNPTFILL CLAGATEATL
410 420 430 440 450
IAGMSTFGPK FFEAQFSLSA SEAATLFGYL VVPAGGGGTL LGGFLVNKFK
460 470 480 490 500
LRGSGIIRFC LFCTLTSLLA FFVFLMHCPN VHMAGVTTGY VGSLLPKGQL
510 520 530 540 550
DLKAACNALY CCQPRHYSPL CGSDGTMYYS PCYAGCPEGA VTGPGGQKVY
560 570 580 590 600
RGCSCILEKA SSGWGNATAG KCASTCQSKP LLLVLVFVVI IFTFLSSIPA
610 620 630 640 650
LTATLRCVCD RQRSFALGIQ WIVVRTLGSI PGPIAFGWVI DKACLLWQDQ
660 670 680 690 700
CGHQGSCFVY KNEAMSRYLL IAGLTFKVLG FLFFVAAYFL YKSPSVSSDG
710 720
LEASLPSQSS ASDSPTEQLQ SNV
Length:723
Mass (Da):77,634
Last modified:June 1, 2001 - v1
Checksum:iDB857B514654497B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239262 mRNA. Translation: AAK30042.1.
UniGeneiRn.67081.

Genome annotation databases

UCSCiRGD:620228. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239262 mRNA. Translation: AAK30042.1.
UniGeneiRn.67081.

3D structure databases

ProteinModelPortaliQ99N01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030414.

Chemistry

ChEMBLiCHEMBL2073701.

Proteomic databases

PaxDbiQ99N01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620228. rat.

Organism-specific databases

RGDi620228. Slco4a1.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOGENOMiHOG000231270.
HOVERGENiHBG100565.
InParanoidiQ99N01.
PhylomeDBiQ99N01.

Miscellaneous databases

PROiQ99N01.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner."
    Fujiwara K., Adachi H., Nishio T., Unno M., Tokui T., Okabe M., Onogawa T., Suzuki T., Asano N., Tanemoto M., Seki M., Shiiba K., Suzuki M., Kondo Y., Nunoki K., Shimosegawa T., Iinuma K., Ito S., Matsuno S., Abe T.
    Endocrinology 142:2005-2012(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.

Entry informationi

Entry nameiSO4A1_RAT
AccessioniPrimary (citable) accession number: Q99N01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.