Q99MZ7 (PECR_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 96.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Peroxisomal trans-2-enoyl-CoA reductase Short name=TERP EC=1.3.1.38 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) [Reference proteome] | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 303 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity By similarity. |
| Catalytic activity | Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH. |
| Pathway | |
| Subunit structure | Interacts with PEX5, probably required to target it into peroxisomes By similarity. |
| Subcellular location | Peroxisome By similarity. |
| Tissue specificity | Highly expressed in liver and kidney. Expressed at lowe level in heart and skeletal muscle. Expressed at weak level in other tissues. Ref.1 |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism |
| Cellular component | Peroxisome |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | fatty acid elongation Inferred from sequence alignment Ref.1. Source: MGI phytol metabolic processInferred from electronic annotation. Source: Compara |
| Cellular_component | mitochondrion Inferred from direct assay PubMed 14651853. Source: UniProtKB peroxisomal membraneInferred from sequence or structural similarity Ref.1. Source: UniProtKB |
| Molecular_function | nucleotide binding Inferred from electronic annotation. Source: InterPro trans-2-enoyl-CoA reductase (NADPH) activityInferred from sequence or structural similarity Ref.1. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 303 | 303 | Peroxisomal trans-2-enoyl-CoA reductase | PRO_0000054741 | |||||
Regions | |||||||||
| Nucleotide binding | 23 – 47 | 25 | NADP By similarity | ||||||
| Motif | 301 – 303 | 3 | Microbody targeting signal By similarity | ||||||
Sites | |||||||||
| Active site | 179 | 1 | Proton acceptor By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 89 | 1 | N → Y in BAB26803. Ref.3 | ||||||
| Sequence conflict | 230 – 232 | 3 | AKR → VSA in AAF69800. Ref.1 | ||||||
| Sequence conflict | 241 – 244 | 4 | PLVC → LLAR in AAF69800. Ref.1 | ||||||
| Sequence conflict | 268 | 1 | Y → H in AAF69800. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs." Das A.K., Uhler M.D., Hajra A.K. J. Biol. Chem. 275:24333-24340(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Liver. |
| [2] | "Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology." Amery L., Mannaerts G.P., Subramani S., Van Veldhoven P.P., Fransen M. Comb. Chem. High Throughput Screen. 4:545-552(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.  Hayashizaki Y.Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF232011 mRNA. Translation: AAF69800.1. AF242204 mRNA. Translation: AAK28336.1. AK010260 mRNA. Translation: BAB26803.1. BC013530 mRNA. Translation: AAH13530.1. |
| IPI | IPI00331596. |
| RefSeq | NP_076012.3. NM_023523.5. |
| UniGene | Mm.281738. |
3D structure databases | |
| ProteinModelPortal | Q99MZ7. |
| SMR | Q99MZ7. Positions 7-303. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q99MZ7. |
2D gel databases | |
| REPRODUCTION-2DPAGE | Q99MZ7. |
Proteomic databases | |
| PaxDb | Q99MZ7. |
| PRIDE | Q99MZ7. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000027381; ENSMUSP00000027381; ENSMUSG00000026189. |
| GeneID | 111175. |
| KEGG | mmu:111175. |
| UCSC | uc007bki.2. mouse. |
Organism-specific databases | |
| CTD | 55825. |
| MGI | MGI:2148199. Pecr. |
Phylogenomic databases | |
| eggNOG | COG1028. |
| GeneTree | ENSGT00690000101945. |
| HOVERGEN | HBG105268. |
| InParanoid | Q99MZ7. |
| KO | K07753. |
| OMA | CNIRNED. |
| OrthoDB | EOG415GF8. |
Enzyme and pathway databases | |
| UniPathway | UPA00094. |
Gene expression databases | |
| ArrayExpress | Q99MZ7. |
| Bgee | Q99MZ7. |
| CleanEx | MM_PECR. |
| Genevestigator | Q99MZ7. |
| GermOnline | ENSMUSG00000026189. Mus musculus. |
Family and domain databases | |
| Gene3D | 3.40.50.720. 1 hit. |
| InterPro | IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| PRINTS | PR00081. GDHRDH. |
| PROSITE | PS00061. ADH_SHORT. False negative. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 365461. |
| SOURCE | Search... |
Entry information
| Entry name | PECR_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q99MZ7 Secondary accession number(s): Q9CX01, Q9JIF4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |