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Protein

Peroxisomal trans-2-enoyl-CoA reductase

Gene

Pecr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity (By similarity).By similarity

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 47NADPBy similarityAdd BLAST25

GO - Molecular functioni

  • signaling receptor binding Source: MGI
  • trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Enzyme and pathway databases

BRENDAi1.3.1.38 3474
ReactomeiR-MMU-389599 Alpha-oxidation of phytanate
R-MMU-9033241 Peroxisomal protein import
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal trans-2-enoyl-CoA reductase (EC:1.3.1.38)
Short name:
TERP
Gene namesi
Name:Pecr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2148199 Pecr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000547412 – 303Peroxisomal trans-2-enoyl-CoA reductaseAdd BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineCombined sources1
Modified residuei5N6-succinyllysineCombined sources1
Modified residuei17N6-acetyllysine; alternateCombined sources1
Modified residuei17N6-succinyllysine; alternateCombined sources1
Modified residuei32N6-succinyllysineCombined sources1
Modified residuei49PhosphoserineBy similarity1
Modified residuei83N6-acetyllysineCombined sources1
Modified residuei97N6-acetyllysineCombined sources1
Modified residuei179PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99MZ7
MaxQBiQ99MZ7
PaxDbiQ99MZ7
PeptideAtlasiQ99MZ7
PRIDEiQ99MZ7

2D gel databases

REPRODUCTION-2DPAGEQ99MZ7

PTM databases

iPTMnetiQ99MZ7
PhosphoSitePlusiQ99MZ7
SwissPalmiQ99MZ7

Expressioni

Tissue specificityi

Highly expressed in liver and kidney. Expressed at lowe level in heart and skeletal muscle. Expressed at weak level in other tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000026189
CleanExiMM_PECR
ExpressionAtlasiQ99MZ7 baseline and differential
GenevisibleiQ99MZ7 MM

Interactioni

Subunit structurei

Interacts with PEX5, probably required to target it into peroxisomes.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ99MZ7, 2 interactors
MINTiQ99MZ7
STRINGi10090.ENSMUSP00000027381

Structurei

3D structure databases

ProteinModelPortaliQ99MZ7
SMRiQ99MZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi301 – 303Microbody targeting signalBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00910000144022
HOVERGENiHBG105268
InParanoidiQ99MZ7
KOiK07753
OMAiINVHGAF
OrthoDBiEOG091G0GO6
PhylomeDBiQ99MZ7
TreeFamiTF315256

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99MZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSWKTGQSY LAAGLLKNQV AVVTGGGTGI GKAVSRELLH LGCNVVIASR
60 70 80 90 100
KLDRLTAAVD ELRASLPPSS SAEVSAIQCN IRKEEEVSNL VKSTLAKYGK
110 120 130 140 150
INFLVNNGGG QFMAPVEDIT AKGWHAVIET NLTGTFYMCK EVYNSWMREH
160 170 180 190 200
GGSIVNIIVL LNNGFPTAAH TGAAREGVYN LTKSMALAWA SSGVRINCVA
210 220 230 240 250
PGTIYSQTAV DNYGEMGQTL FEMAFDSIPA KRLGVPEEIS PLVCFLLSPA
260 270 280 290 300
ASYITGQLIN VDGGQALYTH AFSIPDHDNW PVGAGDLSIV KRIKESFKKK

AKL
Length:303
Mass (Da):32,410
Last modified:June 1, 2001 - v1
Checksum:i97AD4047A20B30D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89N → Y in BAB26803 (PubMed:16141072).Curated1
Sequence conflicti230 – 232AKR → VSA in AAF69800 (PubMed:10811639).Curated3
Sequence conflicti241 – 244PLVC → LLAR in AAF69800 (PubMed:10811639).Curated4
Sequence conflicti268Y → H in AAF69800 (PubMed:10811639).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF232011 mRNA Translation: AAF69800.1
AF242204 mRNA Translation: AAK28336.1
AK010260 mRNA Translation: BAB26803.1
BC013530 mRNA Translation: AAH13530.1
CCDSiCCDS35607.1
RefSeqiNP_076012.3, NM_023523.5
UniGeneiMm.281738

Genome annotation databases

EnsembliENSMUST00000027381; ENSMUSP00000027381; ENSMUSG00000026189
GeneIDi111175
KEGGimmu:111175
UCSCiuc007bki.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPECR_MOUSE
AccessioniPrimary (citable) accession number: Q99MZ7
Secondary accession number(s): Q9CX01, Q9JIF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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