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Q99MZ5

- Q99MZ5_RAT

UniProt

Q99MZ5 - Q99MZ5_RAT

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Protein
Submitted name:

CASP8 and FADD-like apoptosis regulator, isoform CRA_b

Gene

Cflar

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: RefGenome
  2. death effector domain binding Source: RefGenome
  3. death receptor binding Source: RGD
  4. protease binding Source: RGD
  5. protein complex binding Source: RGD

GO - Biological processi

  1. negative regulation of apoptotic process Source: RGD
  2. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: RefGenome
  3. proteolysis Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
CASP8 and FADD-like apoptosis regulator, isoform CRA_bImported
Submitted name:
FLIP short formImported
Gene namesi
Name:CflarImported
ORF Names:rCG_22405Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620847. Cflar.

Subcellular locationi

GO - Cellular componenti

  1. CD95 death-inducing signaling complex Source: RGD
  2. cytoplasm Source: RefGenome
  3. death-inducing signaling complex Source: RGD
  4. membrane raft Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ99MZ5.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG054259.
KOiK04724.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
InterProiIPR011029. DEATH-like_dom.
IPR001875. DED.
[Graphical view]
PfamiPF01335. DED. 2 hits.
[Graphical view]
SMARTiSM00031. DED. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS50168. DED. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MZ5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALSTVSAEV IHQVEESLDE DEKEMMLFLC RDVTENLAPP NVRDLLDCLS
60 70 80 90 100
ERGQLSFAAL AELLYRVRRF DLLKRILKTD KAAVEDHLCR SPHLVSDYRV
110 120 130 140 150
LLMEIGENLN QSDVSSLIFL TKDYTGRGKV AKDKSFLDLV IELEKLNLIG
160 170 180 190 200
SDQLNLLEKC LKSIHRIDLK TKIQKYTQSS QEARSNMNAL QASLPKLSIK
210
EHLYNSRVSL EPVCGISA
Length:218
Mass (Da):24,719
Last modified:June 1, 2001 - v1
Checksum:i9DA9EBAF3441967B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF244366 mRNA. Translation: AAK28358.1.
CH473965 Genomic DNA. Translation: EDL98981.1.
CH473965 Genomic DNA. Translation: EDL98982.1.
RefSeqiNP_476479.1. NM_057138.2.
UniGeneiRn.204752.

Genome annotation databases

GeneIDi117279.
KEGGirno:117279.
UCSCiRGD:620847. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF244366 mRNA. Translation: AAK28358.1 .
CH473965 Genomic DNA. Translation: EDL98981.1 .
CH473965 Genomic DNA. Translation: EDL98982.1 .
RefSeqi NP_476479.1. NM_057138.2.
UniGenei Rn.204752.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 117279.
KEGGi rno:117279.
UCSCi RGD:620847. rat.

Organism-specific databases

CTDi 8837.
RGDi 620847. Cflar.

Phylogenomic databases

HOVERGENi HBG054259.
KOi K04724.

Miscellaneous databases

NextBioi 620225.

Gene expression databases

Genevestigatori Q99MZ5.

Family and domain databases

Gene3Di 1.10.533.10. 2 hits.
InterProi IPR011029. DEATH-like_dom.
IPR001875. DED.
[Graphical view ]
Pfami PF01335. DED. 2 hits.
[Graphical view ]
SMARTi SM00031. DED. 2 hits.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 2 hits.
PROSITEi PS50168. DED. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nuclear factor kappaB-mediated induction of Flice-like inhibitory protein prevents tumor necrosis factor alpha-induced apoptosis in rat granulosa cells."
    Xiao C.W., Asselin E., Tsang B.K.
    Biol. Reprod. 67:436-441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.

Entry informationi

Entry nameiQ99MZ5_RAT
AccessioniPrimary (citable) accession number: Q99MZ5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)