SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q99MZ5

- Q99MZ5_RAT

UniProt

Q99MZ5 - Q99MZ5_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: CASP8 and FADD-like apoptosis regulator, isoform CRA_b
Gene
Cflar, rCG_22405
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: RefGenome
  2. death effector domain binding Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. negative regulation of apoptotic process Source: RGD
  2. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: RefGenome
  3. proteolysis Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
CASP8 and FADD-like apoptosis regulator, isoform CRA_bImported
Submitted name:
FLIP short formImported
Gene namesi
Name:CflarImported
ORF Names:rCG_22405Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620847. Cflar.

Subcellular locationi

GO - Cellular componenti

  1. CD95 death-inducing signaling complex Source: RGD
  2. cytoplasm Source: RefGenome
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ99MZ5.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG054259.
InParanoidiQ99MZ5.
KOiK04724.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
InterProiIPR011029. DEATH-like_dom.
IPR001875. DED.
[Graphical view]
PfamiPF01335. DED. 2 hits.
[Graphical view]
SMARTiSM00031. DED. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS50168. DED. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MZ5-1 [UniParc]FASTAAdd to Basket

« Hide

MALSTVSAEV IHQVEESLDE DEKEMMLFLC RDVTENLAPP NVRDLLDCLS    50
ERGQLSFAAL AELLYRVRRF DLLKRILKTD KAAVEDHLCR SPHLVSDYRV 100
LLMEIGENLN QSDVSSLIFL TKDYTGRGKV AKDKSFLDLV IELEKLNLIG 150
SDQLNLLEKC LKSIHRIDLK TKIQKYTQSS QEARSNMNAL QASLPKLSIK 200
EHLYNSRVSL EPVCGISA 218
Length:218
Mass (Da):24,719
Last modified:June 1, 2001 - v1
Checksum:i9DA9EBAF3441967B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF244366 mRNA. Translation: AAK28358.1.
CH473965 Genomic DNA. Translation: EDL98981.1.
CH473965 Genomic DNA. Translation: EDL98982.1.
RefSeqiNP_476479.1. NM_057138.2.
UniGeneiRn.204752.

Genome annotation databases

GeneIDi117279.
KEGGirno:117279.
UCSCiRGD:620847. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF244366 mRNA. Translation: AAK28358.1 .
CH473965 Genomic DNA. Translation: EDL98981.1 .
CH473965 Genomic DNA. Translation: EDL98982.1 .
RefSeqi NP_476479.1. NM_057138.2.
UniGenei Rn.204752.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 117279.
KEGGi rno:117279.
UCSCi RGD:620847. rat.

Organism-specific databases

CTDi 8837.
RGDi 620847. Cflar.

Phylogenomic databases

HOVERGENi HBG054259.
InParanoidi Q99MZ5.
KOi K04724.

Miscellaneous databases

NextBioi 620225.

Gene expression databases

Genevestigatori Q99MZ5.

Family and domain databases

Gene3Di 1.10.533.10. 2 hits.
InterProi IPR011029. DEATH-like_dom.
IPR001875. DED.
[Graphical view ]
Pfami PF01335. DED. 2 hits.
[Graphical view ]
SMARTi SM00031. DED. 2 hits.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 2 hits.
PROSITEi PS50168. DED. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nuclear factor kappaB-mediated induction of Flice-like inhibitory protein prevents tumor necrosis factor alpha-induced apoptosis in rat granulosa cells."
    Xiao C.W., Asselin E., Tsang B.K.
    Biol. Reprod. 67:436-441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.

Entry informationi

Entry nameiQ99MZ5_RAT
AccessioniPrimary (citable) accession number: Q99MZ5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi