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Q99MZ5

- Q99MZ5_RAT

UniProt

Q99MZ5 - Q99MZ5_RAT

Protein
Submitted name:

CASP8 and FADD-like apoptosis regulator, isoform CRA_b

Gene

Cflar

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: RefGenome
    2. death effector domain binding Source: RefGenome
    3. death receptor binding Source: RGD
    4. protease binding Source: RGD
    5. protein complex binding Source: RGD

    GO - Biological processi

    1. negative regulation of apoptotic process Source: RGD
    2. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: RefGenome
    3. proteolysis Source: GOC

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    CASP8 and FADD-like apoptosis regulator, isoform CRA_bImported
    Submitted name:
    FLIP short formImported
    Gene namesi
    Name:CflarImported
    ORF Names:rCG_22405Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi620847. Cflar.

    Subcellular locationi

    GO - Cellular componenti

    1. CD95 death-inducing signaling complex Source: RGD
    2. cytoplasm Source: RefGenome
    3. death-inducing signaling complex Source: RGD
    4. membrane raft Source: RGD

    Expressioni

    Gene expression databases

    GenevestigatoriQ99MZ5.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG054259.
    InParanoidiQ99MZ5.
    KOiK04724.

    Family and domain databases

    Gene3Di1.10.533.10. 2 hits.
    InterProiIPR011029. DEATH-like_dom.
    IPR001875. DED.
    [Graphical view]
    PfamiPF01335. DED. 2 hits.
    [Graphical view]
    SMARTiSM00031. DED. 2 hits.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 2 hits.
    PROSITEiPS50168. DED. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99MZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSTVSAEV IHQVEESLDE DEKEMMLFLC RDVTENLAPP NVRDLLDCLS    50
    ERGQLSFAAL AELLYRVRRF DLLKRILKTD KAAVEDHLCR SPHLVSDYRV 100
    LLMEIGENLN QSDVSSLIFL TKDYTGRGKV AKDKSFLDLV IELEKLNLIG 150
    SDQLNLLEKC LKSIHRIDLK TKIQKYTQSS QEARSNMNAL QASLPKLSIK 200
    EHLYNSRVSL EPVCGISA 218
    Length:218
    Mass (Da):24,719
    Last modified:June 1, 2001 - v1
    Checksum:i9DA9EBAF3441967B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244366 mRNA. Translation: AAK28358.1.
    CH473965 Genomic DNA. Translation: EDL98981.1.
    CH473965 Genomic DNA. Translation: EDL98982.1.
    RefSeqiNP_476479.1. NM_057138.2.
    UniGeneiRn.204752.

    Genome annotation databases

    GeneIDi117279.
    KEGGirno:117279.
    UCSCiRGD:620847. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244366 mRNA. Translation: AAK28358.1 .
    CH473965 Genomic DNA. Translation: EDL98981.1 .
    CH473965 Genomic DNA. Translation: EDL98982.1 .
    RefSeqi NP_476479.1. NM_057138.2.
    UniGenei Rn.204752.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 117279.
    KEGGi rno:117279.
    UCSCi RGD:620847. rat.

    Organism-specific databases

    CTDi 8837.
    RGDi 620847. Cflar.

    Phylogenomic databases

    HOVERGENi HBG054259.
    InParanoidi Q99MZ5.
    KOi K04724.

    Miscellaneous databases

    NextBioi 620225.

    Gene expression databases

    Genevestigatori Q99MZ5.

    Family and domain databases

    Gene3Di 1.10.533.10. 2 hits.
    InterProi IPR011029. DEATH-like_dom.
    IPR001875. DED.
    [Graphical view ]
    Pfami PF01335. DED. 2 hits.
    [Graphical view ]
    SMARTi SM00031. DED. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 2 hits.
    PROSITEi PS50168. DED. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nuclear factor kappaB-mediated induction of Flice-like inhibitory protein prevents tumor necrosis factor alpha-induced apoptosis in rat granulosa cells."
      Xiao C.W., Asselin E., Tsang B.K.
      Biol. Reprod. 67:436-441(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.

    Entry informationi

    Entry nameiQ99MZ5_RAT
    AccessioniPrimary (citable) accession number: Q99MZ5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)