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Q99MZ4 (GGT7_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyltransferase 7
Short name=GGT 7
EC=2.3.2.2
Alternative name(s):
Gamma-glutamyltransferase-like 3
Gamma-glutamyltranspeptidase 7

Cleaved into the following 2 chains:

  1. Gamma-glutamyltransferase 7 heavy chain
  2. Gamma-glutamyltransferase 7 light chain
Gene names
Name:Ggt7
Synonyms:Ggtl3
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length662 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cleaves glutathione conjugates By similarity.

Catalytic activity

(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.

Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathway

Sulfur metabolism; glutathione metabolism.

Subunit structure

Heterodimer composed of the light and heavy chains. The active site is located in the light chain. Interacts with FAM57A By similarity.

Subcellular location

Membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the gamma-glutamyltransferase family.

Caution

The N-terminus was extended based on the genomic sequence, in analogy to ortholog sequences.

Sequence caution

The sequence AAK27971.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGlutathione biosynthesis
   Cellular componentMembrane
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionAcyltransferase
Transferase
   PTMGlycoprotein
Phosphoprotein
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processglutathione biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functiongamma-glutamyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472Gamma-glutamyltransferase 7 heavy chain By similarity
PRO_0000011070
Chain473 – 662190Gamma-glutamyltransferase 7 light chain By similarity
PRO_0000011071

Regions

Topological domain1 – 106106Cytoplasmic Potential
Transmembrane107 – 12721Helical; Signal-anchor for type II membrane protein; Potential
Topological domain128 – 662535Extracellular Potential

Amino acid modifications

Modified residue721Phosphoserine By similarity
Modified residue831Phosphoserine By similarity
Glycosylation1981N-linked (GlcNAc...) Potential
Glycosylation2671N-linked (GlcNAc...) Potential
Glycosylation2831N-linked (GlcNAc...) Potential
Glycosylation3301N-linked (GlcNAc...) Potential
Glycosylation3531N-linked (GlcNAc...) Potential
Glycosylation3941N-linked (GlcNAc...) Potential
Glycosylation5191N-linked (GlcNAc...) Potential
Glycosylation5231N-linked (GlcNAc...) Potential
Glycosylation5861N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q99MZ4 [UniParc].

Last modified August 29, 2003. Version 2.
Checksum: FB8B7643700BB03A

FASTA66270,383
        10         20         30         40         50         60 
MAAENEASQE SALGAYSPVD YMSITSFPRL PEDEPAPAAP LRGRKDEDAF LGDPDTDPDS 

        70         80         90        100        110        120 
FLKSARLQRL PSSSSEMGSQ DGSPLRETRK DPFSAAAAEC SCRQDGLTVI VTACLTFATG 

       130        140        150        160        170        180 
VTVALVMQIY FGDPQIFQQG AVVTDASCCT ALGMEVLSKQ GSSVDAAVAA ALCLGIVAPH 

       190        200        210        220        230        240 
SSGLGGGGVM LVHDIRRNES HLIDFRESAP GALREEALQR SWDTKPGLLV GVPGMVKGLY 

       250        260        270        280        290        300 
EAHQLYGRLP WSQVLAFAAA VAQDGFNVTH DLAHALAEQL PPNASDRFLE TFLPLGHPPL 

       310        320        330        340        350        360 
PGSLLRRPDL AEVLDILGIS GPAAFYNGGN LTLEMVAEVQ HAGGVMTEED FSNYSALTEK 

       370        380        390        400        410        420 
PVCGVYRGHL VLSPPPPHTG PALISALNIL EGFNLTSLVS REQALHWVAE TLKIALALAS 

       430        440        450        460        470        480 
RLGDPVYDST ISESMDDMLS KVEAANFRGH ISDSQAAPAP LLPVYELDGA PTAAQVLVMG 

       490        500        510        520        530        540 
PDDFIVAMVS SLNRPFGSGL LTPSGILLNS QMLDFSWPNR TANHSAPSLE NSVQPGKRPL 

       550        560        570        580        590        600 
SFLLPTVVRP AEGLCGTYLA LGANGAARGL SGLTQVLLNV LTLNRNLSDS LARGRLHPDL 

       610        620        630        640        650        660 
QSNVLQVDSE FTEEEIEFLE ARGHHVEKVD VLSWVHGSRR TNNFIIGVKD PRSLDATGAS 


IL

« Hide

References

[1]"Rattus norvegicus gamma-glutamyltranspeptidase homolog mRNA complete code."
Yamaguchi T., Araki K., Nawa H.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-662.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF244973 mRNA. Translation: AAK27971.1. Different initiation.
IPIIPI00325117.
PIRJC7331.
RefSeqNP_569107.2. NM_130423.2.
UniGeneRn.15462.

3D structure databases

ProteinModelPortalQ99MZ4.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ99MZ4.

Protein family/group databases

MEROPST03.017.

PTM databases

PhosphoSiteQ99MZ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000025315; ENSRNOP00000025315; ENSRNOG00000018441.
GeneID156275.
KEGGrno:156275.
UCSCNM_130423. rat.

Organism-specific databases

CTD2686.
RGD619870. Ggt7.

Phylogenomic databases

GeneTreeENSGT00550000074591.
HOVERGENHBG039468.
InParanoidQ99MZ4.
OMAVTHDLAR.
OrthoDBEOG483D48.
PhylomeDBQ99MZ4.

Gene expression databases

ArrayExpressQ99MZ4.
GenevestigatorQ99MZ4.
GermOnlineENSRNOG00000018441. Rattus norvegicus.

Family and domain databases

InterProIPR000101. GGT_peptidase.
[Graphical view]
KOK00681.
PANTHERPTHR11686. GGT_peptidase. 1 hit.
PfamPF01019. G_glu_transpept. 1 hit.
[Graphical view]
PRINTSPR01210. GGTRANSPTASE.
PROSITEPS00462. G_GLU_TRANSPEPTIDASE. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio620939.

Entry information

Entry nameGGT7_RAT
AccessionPrimary (citable) accession number: Q99MZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: November 16, 2011
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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