Q99MZ4 (GGT7_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 75.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Gamma-glutamyltransferase 7 Short name=GGT 7 EC=2.3.2.2 Alternative name(s): Gamma-glutamyltransferase-like 3 Gamma-glutamyltranspeptidase 7 Cleaved into the following 2 chains: | ||||
| Gene names |
| ||||
| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 662 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Cleaves glutathione conjugates By similarity. |
| Catalytic activity | (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid. Glutathione + H2O = L-cysteinylglycine + L-glutamate. |
| Pathway | |
| Subunit structure | Heterodimer composed of the light and heavy chains. The active site is located in the light chain. Interacts with FAM57A By similarity. |
| Subcellular location | Membrane; Single-pass type II membrane protein By similarity. |
| Sequence similarities | Belongs to the gamma-glutamyltransferase family. |
| Caution | The N-terminus was extended based on the genomic sequence, in analogy to ortholog sequences. |
| Sequence caution | The sequence AAK27971.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glutathione biosynthesis |
| Cellular component | Membrane |
| Domain | Signal-anchor Transmembrane Transmembrane helix |
| Molecular function | Acyltransferase Transferase |
| PTM | Glycoprotein Phosphoprotein Zymogen |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | glutathione biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | gamma-glutamyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 472 | 472 | Gamma-glutamyltransferase 7 heavy chain By similarity | PRO_0000011070 | |||||
| Chain | 473 – 662 | 190 | Gamma-glutamyltransferase 7 light chain By similarity | PRO_0000011071 | |||||
Regions | |||||||||
| Topological domain | 1 – 106 | 106 | Cytoplasmic Potential | ||||||
| Transmembrane | 107 – 127 | 21 | Helical; Signal-anchor for type II membrane protein; Potential | ||||||
| Topological domain | 128 – 662 | 535 | Extracellular Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 72 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 83 | 1 | Phosphoserine By similarity | ||||||
| Glycosylation | 198 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 267 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 283 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 330 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 353 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 394 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 519 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 523 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 586 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| [1] | "Rattus norvegicus gamma-glutamyltranspeptidase homolog mRNA complete code." Yamaguchi T., Araki K., Nawa H. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-662. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF244973 mRNA. Translation: AAK27971.1. Different initiation. |
| IPI | IPI00325117. |
| PIR | JC7331. |
| RefSeq | NP_569107.2. NM_130423.2. |
| UniGene | Rn.15462. |
3D structure databases | |
| ProteinModelPortal | Q99MZ4. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q99MZ4. |
Protein family/group databases | |
| MEROPS | T03.017. |
PTM databases | |
| PhosphoSite | Q99MZ4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSRNOT00000025315; ENSRNOP00000025315; ENSRNOG00000018441. |
| GeneID | 156275. |
| KEGG | rno:156275. |
| UCSC | NM_130423. rat. |
Organism-specific databases | |
| CTD | 2686. |
| RGD | 619870. Ggt7. |
Phylogenomic databases | |
| GeneTree | ENSGT00550000074591. |
| HOVERGEN | HBG039468. |
| InParanoid | Q99MZ4. |
| OMA | VTHDLAR. |
| OrthoDB | EOG483D48. |
| PhylomeDB | Q99MZ4. |
Gene expression databases | |
| ArrayExpress | Q99MZ4. |
| Genevestigator | Q99MZ4. |
| GermOnline | ENSRNOG00000018441. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR000101. GGT_peptidase. [Graphical view] |
| KO | K00681. |
| PANTHER | PTHR11686. GGT_peptidase. 1 hit. |
| Pfam | PF01019. G_glu_transpept. 1 hit. [Graphical view] |
| PRINTS | PR01210. GGTRANSPTASE. |
| PROSITE | PS00462. G_GLU_TRANSPEPTIDASE. False negative. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 620939. |
Entry information
| Entry name | GGT7_RAT | ||||||||
| Accession | Primary (citable) accession number: Q99MZ4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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