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Protein

Glutathione hydrolase 7

Gene

Ggt7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves glutathione conjugates.By similarity

Caution

The N-terminus was extended based on the genomic sequence, in analogy to ortholog sequences.Curated

Catalytic activityi

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathwayi: glutathione metabolism

This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Hydrolase, Transferase
Biological processGlutathione biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-174403 Glutathione synthesis and recycling
R-RNO-5423646 Aflatoxin activation and detoxification
UniPathwayiUPA00204

Protein family/group databases

MEROPSiT03.017

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione hydrolase 7 (EC:3.4.19.13)
Alternative name(s):
Gamma-glutamyltransferase 7 (EC:2.3.2.2)
Short name:
GGT 7
Gamma-glutamyltransferase-like 3
Gamma-glutamyltranspeptidase 7
Cleaved into the following 2 chains:
Gene namesi
Name:Ggt7
Synonyms:Ggtl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi619870 Ggt7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 106CytoplasmicSequence analysisAdd BLAST106
Transmembranei107 – 127Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini128 – 662ExtracellularSequence analysisAdd BLAST535

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000110701 – 472Glutathione hydrolase 7 heavy chainBy similarityAdd BLAST472
ChainiPRO_0000011071473 – 662Glutathione hydrolase 7 light chainBy similarityAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1
Modified residuei72PhosphoserineBy similarity1
Modified residuei79PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi523N-linked (GlcNAc...) asparagine; alternateSequence analysis1
Glycosylationi523N-linked (HexNAc...) asparagine; alternateCombined sources1
Glycosylationi586N-linked (GlcNAc...) asparagine; alternateSequence analysis1
Glycosylationi586N-linked (HexNAc...) asparagine; alternateCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

PaxDbiQ99MZ4
PRIDEiQ99MZ4

PTM databases

iPTMnetiQ99MZ4
PhosphoSitePlusiQ99MZ4
SwissPalmiQ99MZ4
UniCarbKBiQ99MZ4

Expressioni

Gene expression databases

BgeeiENSRNOG00000018441
GenevisibleiQ99MZ4 RN

Interactioni

Subunit structurei

Heterodimer composed of the light and heavy chains. The active site is located in the light chain. Interacts with FAM57A (By similarity).By similarity

Protein-protein interaction databases

BioGridi250899, 1 interactor
STRINGi10116.ENSRNOP00000025315

Structurei

3D structure databases

ProteinModelPortaliQ99MZ4
SMRiQ99MZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2410 Eukaryota
COG0405 LUCA
GeneTreeiENSGT00550000074591
HOGENOMiHOG000231793
HOVERGENiHBG039468
InParanoidiQ99MZ4
KOiK00681
OMAiFNVTHDL
OrthoDBiEOG091G030G
PhylomeDBiQ99MZ4
TreeFamiTF333329

Family and domain databases

InterProiView protein in InterPro
IPR000101 GGT_peptidase
IPR029055 Ntn_hydrolases_N
PANTHERiPTHR11686 PTHR11686, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99MZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAENEASQE SALGAYSPVD YMSITSFPRL PEDEPAPAAP LRGRKDEDAF
60 70 80 90 100
LGDPDTDPDS FLKSARLQRL PSSSSEMGSQ DGSPLRETRK DPFSAAAAEC
110 120 130 140 150
SCRQDGLTVI VTACLTFATG VTVALVMQIY FGDPQIFQQG AVVTDASCCT
160 170 180 190 200
ALGMEVLSKQ GSSVDAAVAA ALCLGIVAPH SSGLGGGGVM LVHDIRRNES
210 220 230 240 250
HLIDFRESAP GALREEALQR SWDTKPGLLV GVPGMVKGLY EAHQLYGRLP
260 270 280 290 300
WSQVLAFAAA VAQDGFNVTH DLAHALAEQL PPNASDRFLE TFLPLGHPPL
310 320 330 340 350
PGSLLRRPDL AEVLDILGIS GPAAFYNGGN LTLEMVAEVQ HAGGVMTEED
360 370 380 390 400
FSNYSALTEK PVCGVYRGHL VLSPPPPHTG PALISALNIL EGFNLTSLVS
410 420 430 440 450
REQALHWVAE TLKIALALAS RLGDPVYDST ISESMDDMLS KVEAANFRGH
460 470 480 490 500
ISDSQAAPAP LLPVYELDGA PTAAQVLVMG PDDFIVAMVS SLNRPFGSGL
510 520 530 540 550
LTPSGILLNS QMLDFSWPNR TANHSAPSLE NSVQPGKRPL SFLLPTVVRP
560 570 580 590 600
AEGLCGTYLA LGANGAARGL SGLTQVLLNV LTLNRNLSDS LARGRLHPDL
610 620 630 640 650
QSNVLQVDSE FTEEEIEFLE ARGHHVEKVD VLSWVHGSRR TNNFIIGVKD
660
PRSLDATGAS IL
Length:662
Mass (Da):70,383
Last modified:August 29, 2003 - v2
Checksum:iFB8B7643700BB03A
GO

Sequence cautioni

The sequence AAK27971 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244973 mRNA Translation: AAK27971.1 Different initiation.
PIRiJC7331
RefSeqiNP_569107.2, NM_130423.2
UniGeneiRn.15462

Genome annotation databases

EnsembliENSRNOT00000025315; ENSRNOP00000025315; ENSRNOG00000018441
GeneIDi156275
KEGGirno:156275
UCSCiRGD:619870 rat

Similar proteinsi

Entry informationi

Entry nameiGGT7_RAT
AccessioniPrimary (citable) accession number: Q99MZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: May 23, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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