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Protein

Gamma-glutamyltransferase 7

Gene

Ggt7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cleaves glutathione conjugates.By similarity

Catalytic activityi

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathwayi: glutathione metabolism

This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Hydrolase, Transferase

Keywords - Biological processi

Glutathione biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00204.

Protein family/group databases

MEROPSiT03.017.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyltransferase 7 (EC:2.3.2.2)
Short name:
GGT 7
Alternative name(s):
Gamma-glutamyltransferase-like 3
Gamma-glutamyltranspeptidase 7
Glutathione hydrolase 7 (EC:3.4.19.13)
Cleaved into the following 2 chains:
Gene namesi
Name:Ggt7
Synonyms:Ggtl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi619870. Ggt7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 106106CytoplasmicSequence analysisAdd
BLAST
Transmembranei107 – 12721Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini128 – 662535ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Gamma-glutamyltransferase 7 heavy chainBy similarityPRO_0000011070Add
BLAST
Chaini473 – 662190Gamma-glutamyltransferase 7 light chainBy similarityPRO_0000011071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171PhosphoserineCombined sources
Modified residuei79 – 791PhosphoserineCombined sources
Modified residuei83 – 831PhosphoserineCombined sources
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence analysis
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence analysis
Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence analysis
Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence analysis
Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence analysis
Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence analysis
Glycosylationi523 – 5231N-linked (GlcNAc...)Sequence analysis
Glycosylationi586 – 5861N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

PaxDbiQ99MZ4.
PRIDEiQ99MZ4.

PTM databases

iPTMnetiQ99MZ4.
PhosphoSiteiQ99MZ4.
SwissPalmiQ99MZ4.
UniCarbKBiQ99MZ4.

Expressioni

Gene expression databases

GenevisibleiQ99MZ4. RN.

Interactioni

Subunit structurei

Heterodimer composed of the light and heavy chains. The active site is located in the light chain. Interacts with FAM57A (By similarity).By similarity

Protein-protein interaction databases

BioGridi250899. 1 interaction.
STRINGi10116.ENSRNOP00000025315.

Structurei

3D structure databases

ProteinModelPortaliQ99MZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2410. Eukaryota.
COG0405. LUCA.
GeneTreeiENSGT00550000074591.
HOGENOMiHOG000231793.
HOVERGENiHBG039468.
InParanoidiQ99MZ4.
KOiK00681.
OMAiMLVHDIR.
OrthoDBiEOG7DNNTR.
PhylomeDBiQ99MZ4.
TreeFamiTF333329.

Family and domain databases

InterProiIPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
PANTHERiPTHR11686. PTHR11686. 1 hit.
PfamiPF01019. G_glu_transpept. 1 hit.
[Graphical view]
PRINTSiPR01210. GGTRANSPTASE.
SUPFAMiSSF56235. SSF56235. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99MZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAENEASQE SALGAYSPVD YMSITSFPRL PEDEPAPAAP LRGRKDEDAF
60 70 80 90 100
LGDPDTDPDS FLKSARLQRL PSSSSEMGSQ DGSPLRETRK DPFSAAAAEC
110 120 130 140 150
SCRQDGLTVI VTACLTFATG VTVALVMQIY FGDPQIFQQG AVVTDASCCT
160 170 180 190 200
ALGMEVLSKQ GSSVDAAVAA ALCLGIVAPH SSGLGGGGVM LVHDIRRNES
210 220 230 240 250
HLIDFRESAP GALREEALQR SWDTKPGLLV GVPGMVKGLY EAHQLYGRLP
260 270 280 290 300
WSQVLAFAAA VAQDGFNVTH DLAHALAEQL PPNASDRFLE TFLPLGHPPL
310 320 330 340 350
PGSLLRRPDL AEVLDILGIS GPAAFYNGGN LTLEMVAEVQ HAGGVMTEED
360 370 380 390 400
FSNYSALTEK PVCGVYRGHL VLSPPPPHTG PALISALNIL EGFNLTSLVS
410 420 430 440 450
REQALHWVAE TLKIALALAS RLGDPVYDST ISESMDDMLS KVEAANFRGH
460 470 480 490 500
ISDSQAAPAP LLPVYELDGA PTAAQVLVMG PDDFIVAMVS SLNRPFGSGL
510 520 530 540 550
LTPSGILLNS QMLDFSWPNR TANHSAPSLE NSVQPGKRPL SFLLPTVVRP
560 570 580 590 600
AEGLCGTYLA LGANGAARGL SGLTQVLLNV LTLNRNLSDS LARGRLHPDL
610 620 630 640 650
QSNVLQVDSE FTEEEIEFLE ARGHHVEKVD VLSWVHGSRR TNNFIIGVKD
660
PRSLDATGAS IL
Length:662
Mass (Da):70,383
Last modified:August 29, 2003 - v2
Checksum:iFB8B7643700BB03A
GO

Sequence cautioni

The sequence AAK27971.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244973 mRNA. Translation: AAK27971.1. Different initiation.
PIRiJC7331.
RefSeqiNP_569107.2. NM_130423.2.
UniGeneiRn.15462.

Genome annotation databases

EnsembliENSRNOT00000025315; ENSRNOP00000025315; ENSRNOG00000018441.
GeneIDi156275.
KEGGirno:156275.
UCSCiRGD:619870. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244973 mRNA. Translation: AAK27971.1. Different initiation.
PIRiJC7331.
RefSeqiNP_569107.2. NM_130423.2.
UniGeneiRn.15462.

3D structure databases

ProteinModelPortaliQ99MZ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250899. 1 interaction.
STRINGi10116.ENSRNOP00000025315.

Protein family/group databases

MEROPSiT03.017.

PTM databases

iPTMnetiQ99MZ4.
PhosphoSiteiQ99MZ4.
SwissPalmiQ99MZ4.
UniCarbKBiQ99MZ4.

Proteomic databases

PaxDbiQ99MZ4.
PRIDEiQ99MZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025315; ENSRNOP00000025315; ENSRNOG00000018441.
GeneIDi156275.
KEGGirno:156275.
UCSCiRGD:619870. rat.

Organism-specific databases

CTDi2686.
RGDi619870. Ggt7.

Phylogenomic databases

eggNOGiKOG2410. Eukaryota.
COG0405. LUCA.
GeneTreeiENSGT00550000074591.
HOGENOMiHOG000231793.
HOVERGENiHBG039468.
InParanoidiQ99MZ4.
KOiK00681.
OMAiMLVHDIR.
OrthoDBiEOG7DNNTR.
PhylomeDBiQ99MZ4.
TreeFamiTF333329.

Enzyme and pathway databases

UniPathwayiUPA00204.

Miscellaneous databases

PROiQ99MZ4.

Gene expression databases

GenevisibleiQ99MZ4. RN.

Family and domain databases

InterProiIPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
PANTHERiPTHR11686. PTHR11686. 1 hit.
PfamiPF01019. G_glu_transpept. 1 hit.
[Graphical view]
PRINTSiPR01210. GGTRANSPTASE.
SUPFAMiSSF56235. SSF56235. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rattus norvegicus gamma-glutamyltranspeptidase homolog mRNA complete code."
    Yamaguchi T., Araki K., Nawa H.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-662.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; SER-79 AND SER-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGGT7_RAT
AccessioniPrimary (citable) accession number: Q99MZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: June 8, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

The N-terminus was extended based on the genomic sequence, in analogy to ortholog sequences.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.