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Q99MY8

- ASH1L_MOUSE

UniProt

Q99MY8 - ASH1L_MOUSE

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Protein

Histone-lysine N-methyltransferase ASH1L

Gene

Ash1l

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi885 – 89713A.T hook 1Add
BLAST
DNA bindingi1345 – 135713A.T hook 2Add
BLAST
DNA bindingi1843 – 185513A.T hook 3Add
BLAST
Zinc fingeri2574 – 262047PHD-typeAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. DNA binding Source: InterPro
  3. histone methyltransferase activity (H3-K4 specific) Source: MGI
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. histone H3-K4 methylation Source: MGI
  2. interleukin-6 production Source: MGI
  3. negative regulation of acute inflammatory response Source: MGI
  4. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  5. negative regulation of inflammatory response Source: MGI
  6. negative regulation of MAPK cascade Source: MGI
  7. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase ASH1L (EC:2.1.1.43)
Alternative name(s):
ASH1-like protein
Absent small and homeotic disks protein 1 homolog
Gene namesi
Name:Ash1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:2183158. Ash1l.

Subcellular locationi

Nucleus By similarity. Cell junctiontight junction By similarity. Chromosome By similarity
Note: The relevance of tight junction localization is however unclear.By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
  3. tight junction Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Chromosome, Nucleus, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 29582958Histone-lysine N-methyltransferase ASH1LPRO_0000259517Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei373 – 3731N6-acetyllysineBy similarity
Cross-linki400 – 400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki404 – 404Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei2307 – 23071N6-acetyllysine1 Publication
Modified residuei2309 – 23091N6-acetyllysine1 Publication
Modified residuei2313 – 23131N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ99MY8.
PaxDbiQ99MY8.
PRIDEiQ99MY8.

PTM databases

PhosphoSiteiQ99MY8.

Expressioni

Gene expression databases

BgeeiQ99MY8.
GenevestigatoriQ99MY8.

Interactioni

Protein-protein interaction databases

BioGridi228672. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ99MY8.
SMRiQ99MY8. Positions 2064-2275, 2425-2550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2081 – 213252AWSPROSITE-ProRule annotationAdd
BLAST
Domaini2135 – 2251117SETPROSITE-ProRule annotationAdd
BLAST
Domaini2259 – 227517Post-SETPROSITE-ProRule annotationAdd
BLAST
Domaini2452 – 252271BromoPROSITE-ProRule annotationAdd
BLAST
Domaini2650 – 2787138BAHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2059 – 2278220Catalytic domainBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1378 – 142245Pro-richAdd
BLAST
Compositional biasi1555 – 1787233Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
Contains 3 A.T hook DNA-binding domains.Curated
Contains 1 AWS domain.PROSITE-ProRule annotation
Contains 1 BAH domain.PROSITE-ProRule annotation
Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.Curated
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri2574 – 262047PHD-typeAdd
BLAST

Keywords - Domaini

Bromodomain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG2940.
GeneTreeiENSGT00760000118855.
HOVERGENiHBG080871.
InParanoidiQ99MY8.
KOiK06101.
OMAiPENSFRK.
OrthoDBiEOG7ZPNJ4.
TreeFamiTF106416.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR006560. AWS_dom.
IPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00628. PHD. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00384. AT_hook. 4 hits.
SM00570. AWS. 1 hit.
SM00439. BAH. 1 hit.
SM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS51038. BAH. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MY8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPRNTAMLG LGSDSEGFSR KSPSTINPGT LASKREAEIE GATEEEDPRK
60 70 80 90 100
RNRERGTEAG KEDGSTDAQQ QFSVKETNFS EGNLKLKIGL QAKRTKKPPK
110 120 130 140 150
NLENYVCRPA IKTTIKHSRK ALKSGKMTDE KNEHCPSKWD SSKLFKKAGD
160 170 180 190 200
ATAIDCQAEE SIHLHSQGES NPLSKKLSPV HSQMADYISA APSLVGSRDP
210 220 230 240 250
DIKDRALLNG GTSVTEKLAQ LIATCPPSKS SKAKPKKLGT GTTVGLVSKD
260 270 280 290 300
LIRKPGVGSI AGIIHKDLIK KPALSTAVGL VTKDPGKKPM FNAAVGLINK
310 320 330 340 350
DSVKKLGTGT TAVFINKDLG KKPGAITTVG LLSKESGKKL GIGIVPGLVN
360 370 380 390 400
KESGKKLGLG TVVGLVNKEL GKKLSSTVGL VAKDVTKKIV ASSAMGLVNK
410 420 430 440 450
DIGKKLLNCP MAGQLGSKDA LNLKSEALLP TQEQLKASCS ANISNHDSQE
460 470 480 490 500
LPESLKDSAT GKAFEKSVMR HSKESMLEKF SVRKEITNLE KEMFNEGTCI
510 520 530 540 550
QQDNFSSSER GAFETSKHEK QPPVYCTSPD FQIGGASDAS TAKSPFSAVG
560 570 580 590 600
ESNLPSSSPT VSVNPVTRSP PEASSQLVPN PLLLNSTAEQ MEEISESIGK
610 620 630 640 650
SQFTAESTHL NVGHRSLGHS LSIECKGIDK ELNESKNTHL DIPRISSSLG
660 670 680 690 700
KKPSLTSDSG IHAITPSVVN FTSLFSNKPF LKLGAVTAPD KHCQVAESLS
710 720 730 740 750
SSFQSKPLKK RKGRKPRWTK VVARSTCRSP KGLDLERSEL FKNVSCSSLS
760 770 780 790 800
NSSEPAKFMK TIGASSFVDH DFLKRRLPKL SKSSAPSLAL LTDSEKPSHK
810 820 830 840 850
SFITHKLSSS MCVTSDLLSD IYKPKRGRPK SKEMPQLEGP PKRTLKIPAS
860 870 880 890 900
KVFSLQSKEE QEPPILQPEI EIPSFKQSLS VSPFPKKRGR PKRQMRSPVK
910 920 930 940 950
MKPPVLSVAP FVATESPSKL ESESENHRSS SDFFESEDQL QDTDDLDDSH
960 970 980 990 1000
RQSVCSMSDL EMEPDKKISK RNNGQLMKTI IRKINKMKTL KRKKLLNQIL
1010 1020 1030 1040 1050
SSSVESSNKG KVQSKLHNTV SSLAATFGSK LGQQINVSKK GTIYIGKRRG
1060 1070 1080 1090 1100
RKPKTVLNGL LSGSPASLAV LEQTAQQAAG SALGQILPPL LPSPASSSEI
1110 1120 1130 1140 1150
LPSPICSQSS GTSGGQSPVS SDAGFVEPSS VPYLHVHSRQ GSMIQTLAMK
1160 1170 1180 1190 1200
KASKGRRRLS PPTLLPNSPS HLSELTSLKE ATPSPVSESH SDETIPSDSG
1210 1220 1230 1240 1250
IGTDNNSTSD RAEKFCGQKK RRHSFEHISL IPPETSTVLN SLKEKHKHKC
1260 1270 1280 1290 1300
KRRSHDYLSY DKMKRQKRKR KKKYPQLRNR QDPDFIAELE ELISRLSEIR
1310 1320 1330 1340 1350
ITHRSHHFIP RDLLPTIFRI NFNSFYTHPS FPLDPLHYIR KPDLKKKRGR
1360 1370 1380 1390 1400
PPKMREAMAE MPFMHSLSFP LSSTGFYPSY GMPYSPSPLT AAPIGLGYYG
1410 1420 1430 1440 1450
RYPPTLYPPP PSPSFTTPLP PPSYMHAGHL LLNPTKYHKK KHKLLRQEAF
1460 1470 1480 1490 1500
LTTSRTPLLS MSTYPSVPPE MAYGWMVEHK HRHRHKHREH RSEQPQVSMD
1510 1520 1530 1540 1550
SGSSRSVLES LKRYRFGKDT VGDRYKHKEK HRCHMSCPHL SPSKNLINRE
1560 1570 1580 1590 1600
EQWVSREPSE SSSLALGLQT PLQIDCSESS PSLSLGGFTP NSEPASSDEH
1610 1620 1630 1640 1650
MNLFTSAIGS CRVSNPNSSC RKKLTDSPGL FPVQDTALNR PHRKEPLPSS
1660 1670 1680 1690 1700
ERAIQSLAGS QSASDKPSQR SSESTNCSPT RKRSSSESTS STVNGVPSRS
1710 1720 1730 1740 1750
PRLVASMDDS VDSLLQRIVH HDEQESMEKN GDASITTVSA PPSSSPGHSY
1760 1770 1780 1790 1800
SKERALGKSD SLLVPAVPND SCSNIPLLSE KSASRCSPHH IKRSVVEAMQ
1810 1820 1830 1840 1850
RQARKMCNYD KILATKKNLD HVNKILKAKK LQRQARTGNN FVKRRPGRPR
1860 1870 1880 1890 1900
KCPLQAVVSM QAFQAAQFVS PELNEGEDMS LHLSPDTVTD VIEAVVQSVN
1910 1920 1930 1940 1950
LTSEHKKGVK RKNWLLEEQT RKKQKTVPEE EEQENNKSFI ETPVEIPSPL
1960 1970 1980 1990 2000
ETPAEPSEPE NTLQPVLALI PREKKAPRPP KKKYQRAGLY SDVYKTIDPK
2010 2020 2030 2040 2050
SRLIQLKKEK LEYTPGEHEY GLFPAPIHVG KYLRQKRIDF QLPYDILWQW
2060 2070 2080 2090 2100
KHNQLYKKPD VPLYKKIRSN VYVDVKPLSG YEATTCNCKK PDDDTRKGCG
2110 2120 2130 2140 2150
DDCLNRMIFA ECSPNTCPCG EQCCNQRIQR HEWVQCLERF RAEEKGWGIR
2160 2170 2180 2190 2200
TKEPLKAGQF IIEYLGEVVS EQEFRNRMIE QYHNHSDHYC LNLDSGMVID
2210 2220 2230 2240 2250
SYRMGNEARF INHSCDPNCE MQKWSVNGVY RIGLYALKDM PAGTELTYDY
2260 2270 2280 2290 2300
NFHSFNVEKQ QLCKCGFEKC RGIIGGKSQR MNGLPSHKGS QSSSTHRKSA
2310 2320 2330 2340 2350
RAKEKRKSKH KLKKRKGHPS EEPSENINTP TRLTPQLQMK PMSNRERNFV
2360 2370 2380 2390 2400
LKHHVFLVRN WEKIHQKQEE VKHTRDIHSA SLYTRWNGLC RDDGNIKSDV
2410 2420 2430 2440 2450
FMTQFSALQT ARSVRTRRLA AAEENLEVAR AARLAQIFKE ICDGIISYRD
2460 2470 2480 2490 2500
SSQQTLAAPL LNLPPKKKNA DYYEKISDPL DLSTIEKQIL IGYYKTVEAF
2510 2520 2530 2540 2550
DADMLKVFRN AEKYYGRKSP IGRDVCRLRK AYYSARHEAS AQIDEIVGET
2560 2570 2580 2590 2600
ASEADSSETS VSEKESGHEK DDDVIRCICG LYKDEGLMIQ CDKCMVWQHC
2610 2620 2630 2640 2650
DCMGVNTDVE HYLCEQCDPR PVDREVPMIP RPHYAQPGCV YFICLLRDDL
2660 2670 2680 2690 2700
LLRQGDCVYL MRDSRRTPDG HPVRQSYRLL SHINRDKLDI FRIEKLWKNE
2710 2720 2730 2740 2750
KEERFAFGHH YFRPHETHHS PSRRFYHNEL FRVPLYEIIP LEAVVGTCCV
2760 2770 2780 2790 2800
LDLYTYCKGR PKGIKEQDVY ICDYRLDKSA HLFYKIHRNR YPVCTKPYAF
2810 2820 2830 2840 2850
DHFPKKLTPK RDFSPHYVPD NYKRNGGRSS WKSERSKPPL KDLGQEDDAL
2860 2870 2880 2890 2900
PLIEEVLASQ EQAAREVPSP EEPDQERATG DIGDAEKKPE ESSQEAQLAS
2910 2920 2930 2940 2950
TPEERRHSQR ERLNQILLNL LEKIPGKNAI DVTYLLEEGS GRKLRRRTLF

IPENSFRK
Length:2,958
Mass (Da):331,333
Last modified:July 27, 2011 - v3
Checksum:iE8CA3E7AB72BEF2B
GO

Sequence cautioni

The sequence AAK26242.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAE32182.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti331 – 3311L → M in BAC40390. (PubMed:16141072)Curated
Sequence conflicti711 – 7144RKGR → EKEE in AAK26242. 1 PublicationCurated
Sequence conflicti1073 – 10731Q → K in AAK26242. 1 PublicationCurated
Sequence conflicti1095 – 10951A → V in AAK26242. 1 PublicationCurated
Sequence conflicti1994 – 19941Y → S in AAK26242. 1 PublicationCurated
Sequence conflicti2656 – 26561D → H in AAK26242. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC127377 Genomic DNA. No translation available.
AC140468 Genomic DNA. No translation available.
AK033177 mRNA. Translation: BAC28183.2.
AK034679 mRNA. Translation: BAC28795.2.
AK088497 mRNA. Translation: BAC40390.1.
AK153783 mRNA. Translation: BAE32182.1. Different initiation.
AF247132 mRNA. Translation: AAK26242.1. Different initiation.
BC052194 mRNA. Translation: AAH52194.1.
CCDSiCCDS17487.1.
RefSeqiNP_619620.3. NM_138679.5.
XP_006501204.1. XM_006501141.1.
XP_006501205.1. XM_006501142.1.
UniGeneiMm.130752.

Genome annotation databases

EnsembliENSMUST00000090933; ENSMUSP00000088451; ENSMUSG00000028053.
ENSMUST00000186583; ENSMUSP00000140251; ENSMUSG00000028053.
GeneIDi192195.
KEGGimmu:192195.
UCSCiuc008pxi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC127377 Genomic DNA. No translation available.
AC140468 Genomic DNA. No translation available.
AK033177 mRNA. Translation: BAC28183.2 .
AK034679 mRNA. Translation: BAC28795.2 .
AK088497 mRNA. Translation: BAC40390.1 .
AK153783 mRNA. Translation: BAE32182.1 . Different initiation.
AF247132 mRNA. Translation: AAK26242.1 . Different initiation.
BC052194 mRNA. Translation: AAH52194.1 .
CCDSi CCDS17487.1.
RefSeqi NP_619620.3. NM_138679.5.
XP_006501204.1. XM_006501141.1.
XP_006501205.1. XM_006501142.1.
UniGenei Mm.130752.

3D structure databases

ProteinModelPortali Q99MY8.
SMRi Q99MY8. Positions 2064-2275, 2425-2550.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 228672. 2 interactions.

PTM databases

PhosphoSitei Q99MY8.

Proteomic databases

MaxQBi Q99MY8.
PaxDbi Q99MY8.
PRIDEi Q99MY8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090933 ; ENSMUSP00000088451 ; ENSMUSG00000028053 .
ENSMUST00000186583 ; ENSMUSP00000140251 ; ENSMUSG00000028053 .
GeneIDi 192195.
KEGGi mmu:192195.
UCSCi uc008pxi.1. mouse.

Organism-specific databases

CTDi 55870.
MGIi MGI:2183158. Ash1l.

Phylogenomic databases

eggNOGi COG2940.
GeneTreei ENSGT00760000118855.
HOVERGENi HBG080871.
InParanoidi Q99MY8.
KOi K06101.
OMAi PENSFRK.
OrthoDBi EOG7ZPNJ4.
TreeFami TF106416.

Miscellaneous databases

ChiTaRSi ASH1L. mouse.
NextBioi 371226.
PROi Q99MY8.
SOURCEi Search...

Gene expression databases

Bgeei Q99MY8.
Genevestigatori Q99MY8.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR017956. AT_hook_DNA-bd_motif.
IPR006560. AWS_dom.
IPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01426. BAH. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00628. PHD. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00384. AT_hook. 4 hits.
SM00570. AWS. 1 hit.
SM00439. BAH. 1 hit.
SM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEi PS51215. AWS. 1 hit.
PS51038. BAH. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-2005 AND 2048-2465.
    Strain: C57BL/6J and NOD.
    Tissue: Embryo, Testis and Thymus.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 88-94; 1254-1265; 1730-1752 AND 2270-2277, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  4. "A novel SWI/SNF family gene in mammals reveals a bromodomain lost in Drosophila ASH1."
    Tanaka Y.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 290-2958.
    Tissue: Thymus.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1996-2958.
    Tissue: Limb.
  6. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2307; LYS-2309 AND LYS-2313, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiASH1L_MOUSE
AccessioniPrimary (citable) accession number: Q99MY8
Secondary accession number(s): E9QNM2
, Q3U598, Q80VY5, Q8BM69, Q8BTX0, Q8BZY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3