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Q99MY8

- ASH1L_MOUSE

UniProt

Q99MY8 - ASH1L_MOUSE

Protein

Histone-lysine N-methyltransferase ASH1L

Gene

Ash1l

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi885 – 89713A.T hook 1Add
    BLAST
    DNA bindingi1345 – 135713A.T hook 2Add
    BLAST
    DNA bindingi1843 – 185513A.T hook 3Add
    BLAST
    Zinc fingeri2574 – 262047PHD-typeAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. DNA binding Source: InterPro
    3. histone methyltransferase activity (H3-K4 specific) Source: MGI
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histone H3-K4 methylation Source: MGI
    2. interleukin-6 production Source: MGI
    3. negative regulation of acute inflammatory response Source: MGI
    4. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
    5. negative regulation of inflammatory response Source: MGI
    6. negative regulation of MAPK cascade Source: MGI
    7. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Methyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, S-adenosyl-L-methionine, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase ASH1L (EC:2.1.1.43)
    Alternative name(s):
    ASH1-like protein
    Absent small and homeotic disks protein 1 homolog
    Gene namesi
    Name:Ash1l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:2183158. Ash1l.

    Subcellular locationi

    Nucleus By similarity. Cell junctiontight junction By similarity. Chromosome By similarity
    Note: The relevance of tight junction localization is however unclear.By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. Golgi apparatus Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell
    4. tight junction Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Chromosome, Nucleus, Tight junction

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 29582958Histone-lysine N-methyltransferase ASH1LPRO_0000259517Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei22 – 221PhosphoserineBy similarity
    Modified residuei373 – 3731N6-acetyllysineBy similarity
    Cross-linki400 – 400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki404 – 404Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Modified residuei2307 – 23071N6-acetyllysine1 Publication
    Modified residuei2309 – 23091N6-acetyllysine1 Publication
    Modified residuei2313 – 23131N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ99MY8.
    PRIDEiQ99MY8.

    PTM databases

    PhosphoSiteiQ99MY8.

    Expressioni

    Gene expression databases

    BgeeiQ99MY8.
    GenevestigatoriQ99MY8.

    Interactioni

    Protein-protein interaction databases

    BioGridi228672. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99MY8.
    SMRiQ99MY8. Positions 2064-2275, 2425-2550.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2081 – 213252AWSPROSITE-ProRule annotationAdd
    BLAST
    Domaini2135 – 2251117SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini2259 – 227517Post-SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini2452 – 252271BromoPROSITE-ProRule annotationAdd
    BLAST
    Domaini2650 – 2787138BAHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2059 – 2278220Catalytic domainBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1378 – 142245Pro-richAdd
    BLAST
    Compositional biasi1555 – 1787233Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
    Contains 3 A.T hook DNA-binding domains.Curated
    Contains 1 AWS domain.PROSITE-ProRule annotation
    Contains 1 BAH domain.PROSITE-ProRule annotation
    Contains 1 bromo domain.PROSITE-ProRule annotation
    Contains 1 PHD-type zinc finger.Curated
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri2574 – 262047PHD-typeAdd
    BLAST

    Keywords - Domaini

    Bromodomain, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG2940.
    GeneTreeiENSGT00740000114921.
    HOVERGENiHBG080871.
    InParanoidiQ99MY8.
    KOiK06101.
    OMAiPENSFRK.
    OrthoDBiEOG7ZPNJ4.
    TreeFamiTF106416.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProiIPR017956. AT_hook_DNA-bd_motif.
    IPR006560. AWS.
    IPR001025. BAH_dom.
    IPR001487. Bromodomain.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01426. BAH. 1 hit.
    PF00439. Bromodomain. 1 hit.
    PF00628. PHD. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00384. AT_hook. 4 hits.
    SM00570. AWS. 1 hit.
    SM00439. BAH. 1 hit.
    SM00297. BROMO. 1 hit.
    SM00249. PHD. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS51215. AWS. 1 hit.
    PS51038. BAH. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99MY8-1 [UniParc]FASTAAdd to Basket

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    MDPRNTAMLG LGSDSEGFSR KSPSTINPGT LASKREAEIE GATEEEDPRK     50
    RNRERGTEAG KEDGSTDAQQ QFSVKETNFS EGNLKLKIGL QAKRTKKPPK 100
    NLENYVCRPA IKTTIKHSRK ALKSGKMTDE KNEHCPSKWD SSKLFKKAGD 150
    ATAIDCQAEE SIHLHSQGES NPLSKKLSPV HSQMADYISA APSLVGSRDP 200
    DIKDRALLNG GTSVTEKLAQ LIATCPPSKS SKAKPKKLGT GTTVGLVSKD 250
    LIRKPGVGSI AGIIHKDLIK KPALSTAVGL VTKDPGKKPM FNAAVGLINK 300
    DSVKKLGTGT TAVFINKDLG KKPGAITTVG LLSKESGKKL GIGIVPGLVN 350
    KESGKKLGLG TVVGLVNKEL GKKLSSTVGL VAKDVTKKIV ASSAMGLVNK 400
    DIGKKLLNCP MAGQLGSKDA LNLKSEALLP TQEQLKASCS ANISNHDSQE 450
    LPESLKDSAT GKAFEKSVMR HSKESMLEKF SVRKEITNLE KEMFNEGTCI 500
    QQDNFSSSER GAFETSKHEK QPPVYCTSPD FQIGGASDAS TAKSPFSAVG 550
    ESNLPSSSPT VSVNPVTRSP PEASSQLVPN PLLLNSTAEQ MEEISESIGK 600
    SQFTAESTHL NVGHRSLGHS LSIECKGIDK ELNESKNTHL DIPRISSSLG 650
    KKPSLTSDSG IHAITPSVVN FTSLFSNKPF LKLGAVTAPD KHCQVAESLS 700
    SSFQSKPLKK RKGRKPRWTK VVARSTCRSP KGLDLERSEL FKNVSCSSLS 750
    NSSEPAKFMK TIGASSFVDH DFLKRRLPKL SKSSAPSLAL LTDSEKPSHK 800
    SFITHKLSSS MCVTSDLLSD IYKPKRGRPK SKEMPQLEGP PKRTLKIPAS 850
    KVFSLQSKEE QEPPILQPEI EIPSFKQSLS VSPFPKKRGR PKRQMRSPVK 900
    MKPPVLSVAP FVATESPSKL ESESENHRSS SDFFESEDQL QDTDDLDDSH 950
    RQSVCSMSDL EMEPDKKISK RNNGQLMKTI IRKINKMKTL KRKKLLNQIL 1000
    SSSVESSNKG KVQSKLHNTV SSLAATFGSK LGQQINVSKK GTIYIGKRRG 1050
    RKPKTVLNGL LSGSPASLAV LEQTAQQAAG SALGQILPPL LPSPASSSEI 1100
    LPSPICSQSS GTSGGQSPVS SDAGFVEPSS VPYLHVHSRQ GSMIQTLAMK 1150
    KASKGRRRLS PPTLLPNSPS HLSELTSLKE ATPSPVSESH SDETIPSDSG 1200
    IGTDNNSTSD RAEKFCGQKK RRHSFEHISL IPPETSTVLN SLKEKHKHKC 1250
    KRRSHDYLSY DKMKRQKRKR KKKYPQLRNR QDPDFIAELE ELISRLSEIR 1300
    ITHRSHHFIP RDLLPTIFRI NFNSFYTHPS FPLDPLHYIR KPDLKKKRGR 1350
    PPKMREAMAE MPFMHSLSFP LSSTGFYPSY GMPYSPSPLT AAPIGLGYYG 1400
    RYPPTLYPPP PSPSFTTPLP PPSYMHAGHL LLNPTKYHKK KHKLLRQEAF 1450
    LTTSRTPLLS MSTYPSVPPE MAYGWMVEHK HRHRHKHREH RSEQPQVSMD 1500
    SGSSRSVLES LKRYRFGKDT VGDRYKHKEK HRCHMSCPHL SPSKNLINRE 1550
    EQWVSREPSE SSSLALGLQT PLQIDCSESS PSLSLGGFTP NSEPASSDEH 1600
    MNLFTSAIGS CRVSNPNSSC RKKLTDSPGL FPVQDTALNR PHRKEPLPSS 1650
    ERAIQSLAGS QSASDKPSQR SSESTNCSPT RKRSSSESTS STVNGVPSRS 1700
    PRLVASMDDS VDSLLQRIVH HDEQESMEKN GDASITTVSA PPSSSPGHSY 1750
    SKERALGKSD SLLVPAVPND SCSNIPLLSE KSASRCSPHH IKRSVVEAMQ 1800
    RQARKMCNYD KILATKKNLD HVNKILKAKK LQRQARTGNN FVKRRPGRPR 1850
    KCPLQAVVSM QAFQAAQFVS PELNEGEDMS LHLSPDTVTD VIEAVVQSVN 1900
    LTSEHKKGVK RKNWLLEEQT RKKQKTVPEE EEQENNKSFI ETPVEIPSPL 1950
    ETPAEPSEPE NTLQPVLALI PREKKAPRPP KKKYQRAGLY SDVYKTIDPK 2000
    SRLIQLKKEK LEYTPGEHEY GLFPAPIHVG KYLRQKRIDF QLPYDILWQW 2050
    KHNQLYKKPD VPLYKKIRSN VYVDVKPLSG YEATTCNCKK PDDDTRKGCG 2100
    DDCLNRMIFA ECSPNTCPCG EQCCNQRIQR HEWVQCLERF RAEEKGWGIR 2150
    TKEPLKAGQF IIEYLGEVVS EQEFRNRMIE QYHNHSDHYC LNLDSGMVID 2200
    SYRMGNEARF INHSCDPNCE MQKWSVNGVY RIGLYALKDM PAGTELTYDY 2250
    NFHSFNVEKQ QLCKCGFEKC RGIIGGKSQR MNGLPSHKGS QSSSTHRKSA 2300
    RAKEKRKSKH KLKKRKGHPS EEPSENINTP TRLTPQLQMK PMSNRERNFV 2350
    LKHHVFLVRN WEKIHQKQEE VKHTRDIHSA SLYTRWNGLC RDDGNIKSDV 2400
    FMTQFSALQT ARSVRTRRLA AAEENLEVAR AARLAQIFKE ICDGIISYRD 2450
    SSQQTLAAPL LNLPPKKKNA DYYEKISDPL DLSTIEKQIL IGYYKTVEAF 2500
    DADMLKVFRN AEKYYGRKSP IGRDVCRLRK AYYSARHEAS AQIDEIVGET 2550
    ASEADSSETS VSEKESGHEK DDDVIRCICG LYKDEGLMIQ CDKCMVWQHC 2600
    DCMGVNTDVE HYLCEQCDPR PVDREVPMIP RPHYAQPGCV YFICLLRDDL 2650
    LLRQGDCVYL MRDSRRTPDG HPVRQSYRLL SHINRDKLDI FRIEKLWKNE 2700
    KEERFAFGHH YFRPHETHHS PSRRFYHNEL FRVPLYEIIP LEAVVGTCCV 2750
    LDLYTYCKGR PKGIKEQDVY ICDYRLDKSA HLFYKIHRNR YPVCTKPYAF 2800
    DHFPKKLTPK RDFSPHYVPD NYKRNGGRSS WKSERSKPPL KDLGQEDDAL 2850
    PLIEEVLASQ EQAAREVPSP EEPDQERATG DIGDAEKKPE ESSQEAQLAS 2900
    TPEERRHSQR ERLNQILLNL LEKIPGKNAI DVTYLLEEGS GRKLRRRTLF 2950
    IPENSFRK 2958
    Length:2,958
    Mass (Da):331,333
    Last modified:July 27, 2011 - v3
    Checksum:iE8CA3E7AB72BEF2B
    GO

    Sequence cautioni

    The sequence AAK26242.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAE32182.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti331 – 3311L → M in BAC40390. (PubMed:16141072)Curated
    Sequence conflicti711 – 7144RKGR → EKEE in AAK26242. 1 PublicationCurated
    Sequence conflicti1073 – 10731Q → K in AAK26242. 1 PublicationCurated
    Sequence conflicti1095 – 10951A → V in AAK26242. 1 PublicationCurated
    Sequence conflicti1994 – 19941Y → S in AAK26242. 1 PublicationCurated
    Sequence conflicti2656 – 26561D → H in AAK26242. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC127377 Genomic DNA. No translation available.
    AC140468 Genomic DNA. No translation available.
    AK033177 mRNA. Translation: BAC28183.2.
    AK034679 mRNA. Translation: BAC28795.2.
    AK088497 mRNA. Translation: BAC40390.1.
    AK153783 mRNA. Translation: BAE32182.1. Different initiation.
    AF247132 mRNA. Translation: AAK26242.1. Different initiation.
    BC052194 mRNA. Translation: AAH52194.1.
    CCDSiCCDS17487.1.
    RefSeqiNP_619620.3. NM_138679.5.
    XP_006501204.1. XM_006501141.1.
    XP_006501205.1. XM_006501142.1.
    UniGeneiMm.130752.

    Genome annotation databases

    EnsembliENSMUST00000090933; ENSMUSP00000088451; ENSMUSG00000028053.
    GeneIDi192195.
    KEGGimmu:192195.
    UCSCiuc008pxi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC127377 Genomic DNA. No translation available.
    AC140468 Genomic DNA. No translation available.
    AK033177 mRNA. Translation: BAC28183.2 .
    AK034679 mRNA. Translation: BAC28795.2 .
    AK088497 mRNA. Translation: BAC40390.1 .
    AK153783 mRNA. Translation: BAE32182.1 . Different initiation.
    AF247132 mRNA. Translation: AAK26242.1 . Different initiation.
    BC052194 mRNA. Translation: AAH52194.1 .
    CCDSi CCDS17487.1.
    RefSeqi NP_619620.3. NM_138679.5.
    XP_006501204.1. XM_006501141.1.
    XP_006501205.1. XM_006501142.1.
    UniGenei Mm.130752.

    3D structure databases

    ProteinModelPortali Q99MY8.
    SMRi Q99MY8. Positions 2064-2275, 2425-2550.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 228672. 2 interactions.

    PTM databases

    PhosphoSitei Q99MY8.

    Proteomic databases

    PaxDbi Q99MY8.
    PRIDEi Q99MY8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090933 ; ENSMUSP00000088451 ; ENSMUSG00000028053 .
    GeneIDi 192195.
    KEGGi mmu:192195.
    UCSCi uc008pxi.1. mouse.

    Organism-specific databases

    CTDi 55870.
    MGIi MGI:2183158. Ash1l.

    Phylogenomic databases

    eggNOGi COG2940.
    GeneTreei ENSGT00740000114921.
    HOVERGENi HBG080871.
    InParanoidi Q99MY8.
    KOi K06101.
    OMAi PENSFRK.
    OrthoDBi EOG7ZPNJ4.
    TreeFami TF106416.

    Miscellaneous databases

    ChiTaRSi ASH1L. mouse.
    NextBioi 371226.
    PROi Q99MY8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99MY8.
    Genevestigatori Q99MY8.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProi IPR017956. AT_hook_DNA-bd_motif.
    IPR006560. AWS.
    IPR001025. BAH_dom.
    IPR001487. Bromodomain.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01426. BAH. 1 hit.
    PF00439. Bromodomain. 1 hit.
    PF00628. PHD. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00384. AT_hook. 4 hits.
    SM00570. AWS. 1 hit.
    SM00439. BAH. 1 hit.
    SM00297. BROMO. 1 hit.
    SM00249. PHD. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS51215. AWS. 1 hit.
    PS51038. BAH. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-2005 AND 2048-2465.
      Strain: C57BL/6J and NOD.
      Tissue: Embryo, Testis and Thymus.
    3. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 88-94; 1254-1265; 1730-1752 AND 2270-2277, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    4. "A novel SWI/SNF family gene in mammals reveals a bromodomain lost in Drosophila ASH1."
      Tanaka Y.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 290-2958.
      Tissue: Thymus.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1996-2958.
      Tissue: Limb.
    6. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2307; LYS-2309 AND LYS-2313, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiASH1L_MOUSE
    AccessioniPrimary (citable) accession number: Q99MY8
    Secondary accession number(s): E9QNM2
    , Q3U598, Q80VY5, Q8BM69, Q8BTX0, Q8BZY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3