Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q99MX1 (UBP26_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 26

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 26
Ubiquitin thioesterase 26
Ubiquitin-specific-processing protease 26
Gene names
Name:Usp26
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length835 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome By similarity. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with AR By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentNucleus
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein deubiquitination

Inferred from electronic annotation. Source: Ensembl

ubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 835835Ubiquitin carboxyl-terminal hydrolase 26
PRO_0000080656

Regions

Domain286 – 816531USP

Sites

Active site2951Nucleophile By similarity
Active site7711Proton acceptor By similarity

Experimental info

Sequence conflict7461L → F in AAK31949. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q99MX1 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: E66CCCE3B3042998

FASTA83595,452
        10         20         30         40         50         60 
MEPILINAQV QMWSAKAGMS KSRNALIETC VGKREVKLIL YFSTGKIKTL QLHDNIKSVV 

        70         80         90        100        110        120 
LQTYGEDQNY LHLTFKNNDF LFVEKLTTTD ARRLKRFLDK TSQGSIRPAR SDERCGEPST 

       130        140        150        160        170        180 
SAQELNGSGS SCETNSECFE SPKESEMCMF RELSLLPSSS TFLHNVGLLE NQFIKRKRFF 

       190        200        210        220        230        240 
SDLAKNEKQS NLKDSIRDFE ANLVVCISNE KGKERNVREV DISKPGFGFP FETNYPEDSG 

       250        260        270        280        290        300 
VDVRDLNDLI TKLFSPVLLE THCIENGLEW HEYMKTYLLY PEKLWQGLPN VGNTCYINVV 

       310        320        330        340        350        360 
LQSLCSIPLF INDLFNQGFP WIKAPKDDFN MLLMQLLVLK DIYNARFRQK LLIGITKALP 

       370        380        390        400        410        420 
IFGEIFAVDR QNDAHEFLSL CLVQLKETFQ RVTMMWQSEN DSGDFYLLKD IFADYATINK 

       430        440        450        460        470        480 
MPVCPVTNNF EFELLSSIFC KACGLTLFKG EPSRYLSINI PQGGKDMSIQ STLDLFFSAE 

       490        500        510        520        530        540 
ELEHRCEKCL YNKSVSFHRF GRLPRVIIVH LKRYHFNESW VMKKDERPIL VSKYLRLSCH 

       550        560        570        580        590        600 
CSKSTKPPPP LRPGEHVKNL DLLKPLEVLG SEILKLPFNS VRTSRSKGFE TINITSNRES 

       610        620        630        640        650        660 
EAQSGKRVSE VLSGKVQQEN SGKGDTAHIV GSELTKETEK LKKHEEEHRP SDLDSGSIRE 

       670        680        690        700        710        720 
AQKYQQAEKC NEGRSDKQIS LEALTQSRPK PISQEQTENL GKTTLSHTQD SSQSSQSSSD 

       730        740        750        760        770        780 
SSKSSRCSDD LDKKAKPTRK VDPTKLNKKE DNVYRLVNII NHIGNSPNGG HYINDAFDFK 

       790        800        810        820        830 
RQSWFTYSDL HVTRTQEDFV YRGRSSTGYV FFYMHNDIFE ELLAKETQST STSKG 

« Hide

References

« Hide 'large scale' references
[1]"An abundance of X-linked genes expressed in spermatogonia."
Wang P.J., McCarrey J.R., Yang F., Page D.C.
Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF285570 mRNA. Translation: AAK31949.1.
AL662931 Genomic DNA. Translation: CAM18657.1.
BC125454 mRNA. Translation: AAI25455.1.
BC132154 mRNA. Translation: AAI32155.1.
CCDSCCDS30122.1.
RefSeqNP_113565.2. NM_031388.2.
XP_006541622.1. XM_006541559.1.
XP_006541623.1. XM_006541560.1.
XP_006541624.1. XM_006541561.1.
UniGeneMm.242827.

3D structure databases

ProteinModelPortalQ99MX1.
SMRQ99MX1. Positions 6-103, 287-548.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000110519.

Protein family/group databases

MEROPSC19.045.

PTM databases

PhosphoSiteQ99MX1.

Proteomic databases

PaxDbQ99MX1.
PRIDEQ99MX1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000069509; ENSMUSP00000069140; ENSMUSG00000055780.
ENSMUST00000114869; ENSMUSP00000110519; ENSMUSG00000055780.
GeneID83563.
KEGGmmu:83563.
UCSCuc009tec.1. mouse.

Organism-specific databases

CTD83844.
MGIMGI:1933247. Usp26.

Phylogenomic databases

eggNOGNOG256718.
GeneTreeENSGT00440000033542.
HOGENOMHOG000060197.
HOVERGENHBG055893.
InParanoidQ05A11.
KOK11850.
OMADAYDFER.
OrthoDBEOG7HMS09.
TreeFamTF323032.

Gene expression databases

BgeeQ99MX1.
CleanExMM_USP26.
GenevestigatorQ99MX1.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio350660.
PROQ99MX1.
SOURCESearch...

Entry information

Entry nameUBP26_MOUSE
AccessionPrimary (citable) accession number: Q99MX1
Secondary accession number(s): Q05A11
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot