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Q99MX1

- UBP26_MOUSE

UniProt

Q99MX1 - UBP26_MOUSE

Protein

Ubiquitin carboxyl-terminal hydrolase 26

Gene

Usp26

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei295 – 2951NucleophilePROSITE-ProRule annotation
    Active sitei771 – 7711Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. protein deubiquitination Source: Ensembl
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.045.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 26 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 26
    Ubiquitin thioesterase 26
    Ubiquitin-specific-processing protease 26
    Gene namesi
    Name:Usp26
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1933247. Usp26.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 835835Ubiquitin carboxyl-terminal hydrolase 26PRO_0000080656Add
    BLAST

    Proteomic databases

    PaxDbiQ99MX1.
    PRIDEiQ99MX1.

    PTM databases

    PhosphoSiteiQ99MX1.

    Expressioni

    Gene expression databases

    BgeeiQ99MX1.
    CleanExiMM_USP26.
    GenevestigatoriQ99MX1.

    Interactioni

    Subunit structurei

    Interacts with AR.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000110519.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99MX1.
    SMRiQ99MX1. Positions 6-103, 287-548.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini286 – 816531USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiNOG256718.
    GeneTreeiENSGT00440000033542.
    HOGENOMiHOG000060197.
    HOVERGENiHBG055893.
    InParanoidiQ05A11.
    KOiK11850.
    OMAiDAYDFER.
    OrthoDBiEOG7HMS09.
    TreeFamiTF323032.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99MX1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPILINAQV QMWSAKAGMS KSRNALIETC VGKREVKLIL YFSTGKIKTL    50
    QLHDNIKSVV LQTYGEDQNY LHLTFKNNDF LFVEKLTTTD ARRLKRFLDK 100
    TSQGSIRPAR SDERCGEPST SAQELNGSGS SCETNSECFE SPKESEMCMF 150
    RELSLLPSSS TFLHNVGLLE NQFIKRKRFF SDLAKNEKQS NLKDSIRDFE 200
    ANLVVCISNE KGKERNVREV DISKPGFGFP FETNYPEDSG VDVRDLNDLI 250
    TKLFSPVLLE THCIENGLEW HEYMKTYLLY PEKLWQGLPN VGNTCYINVV 300
    LQSLCSIPLF INDLFNQGFP WIKAPKDDFN MLLMQLLVLK DIYNARFRQK 350
    LLIGITKALP IFGEIFAVDR QNDAHEFLSL CLVQLKETFQ RVTMMWQSEN 400
    DSGDFYLLKD IFADYATINK MPVCPVTNNF EFELLSSIFC KACGLTLFKG 450
    EPSRYLSINI PQGGKDMSIQ STLDLFFSAE ELEHRCEKCL YNKSVSFHRF 500
    GRLPRVIIVH LKRYHFNESW VMKKDERPIL VSKYLRLSCH CSKSTKPPPP 550
    LRPGEHVKNL DLLKPLEVLG SEILKLPFNS VRTSRSKGFE TINITSNRES 600
    EAQSGKRVSE VLSGKVQQEN SGKGDTAHIV GSELTKETEK LKKHEEEHRP 650
    SDLDSGSIRE AQKYQQAEKC NEGRSDKQIS LEALTQSRPK PISQEQTENL 700
    GKTTLSHTQD SSQSSQSSSD SSKSSRCSDD LDKKAKPTRK VDPTKLNKKE 750
    DNVYRLVNII NHIGNSPNGG HYINDAFDFK RQSWFTYSDL HVTRTQEDFV 800
    YRGRSSTGYV FFYMHNDIFE ELLAKETQST STSKG 835
    Length:835
    Mass (Da):95,452
    Last modified:July 27, 2011 - v2
    Checksum:iE66CCCE3B3042998
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti746 – 7461L → F in AAK31949. (PubMed:11279525)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF285570 mRNA. Translation: AAK31949.1.
    AL662931 Genomic DNA. Translation: CAM18657.1.
    BC125454 mRNA. Translation: AAI25455.1.
    BC132154 mRNA. Translation: AAI32155.1.
    CCDSiCCDS30122.1.
    RefSeqiNP_113565.2. NM_031388.2.
    XP_006541622.1. XM_006541559.1.
    XP_006541623.1. XM_006541560.1.
    XP_006541624.1. XM_006541561.1.
    UniGeneiMm.242827.

    Genome annotation databases

    EnsembliENSMUST00000069509; ENSMUSP00000069140; ENSMUSG00000055780.
    ENSMUST00000114869; ENSMUSP00000110519; ENSMUSG00000055780.
    GeneIDi83563.
    KEGGimmu:83563.
    UCSCiuc009tec.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF285570 mRNA. Translation: AAK31949.1 .
    AL662931 Genomic DNA. Translation: CAM18657.1 .
    BC125454 mRNA. Translation: AAI25455.1 .
    BC132154 mRNA. Translation: AAI32155.1 .
    CCDSi CCDS30122.1.
    RefSeqi NP_113565.2. NM_031388.2.
    XP_006541622.1. XM_006541559.1.
    XP_006541623.1. XM_006541560.1.
    XP_006541624.1. XM_006541561.1.
    UniGenei Mm.242827.

    3D structure databases

    ProteinModelPortali Q99MX1.
    SMRi Q99MX1. Positions 6-103, 287-548.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000110519.

    Protein family/group databases

    MEROPSi C19.045.

    PTM databases

    PhosphoSitei Q99MX1.

    Proteomic databases

    PaxDbi Q99MX1.
    PRIDEi Q99MX1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000069509 ; ENSMUSP00000069140 ; ENSMUSG00000055780 .
    ENSMUST00000114869 ; ENSMUSP00000110519 ; ENSMUSG00000055780 .
    GeneIDi 83563.
    KEGGi mmu:83563.
    UCSCi uc009tec.1. mouse.

    Organism-specific databases

    CTDi 83844.
    MGIi MGI:1933247. Usp26.

    Phylogenomic databases

    eggNOGi NOG256718.
    GeneTreei ENSGT00440000033542.
    HOGENOMi HOG000060197.
    HOVERGENi HBG055893.
    InParanoidi Q05A11.
    KOi K11850.
    OMAi DAYDFER.
    OrthoDBi EOG7HMS09.
    TreeFami TF323032.

    Miscellaneous databases

    NextBioi 350660.
    PROi Q99MX1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99MX1.
    CleanExi MM_USP26.
    Genevestigatori Q99MX1.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An abundance of X-linked genes expressed in spermatogonia."
      Wang P.J., McCarrey J.R., Yang F., Page D.C.
      Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiUBP26_MOUSE
    AccessioniPrimary (citable) accession number: Q99MX1
    Secondary accession number(s): Q05A11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3