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Protein

Ubiquitin carboxyl-terminal hydrolase 26

Gene

Usp26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei295 – 2951NucleophilePROSITE-ProRule annotation
Active sitei771 – 7711Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: GO_Central
  2. ubiquitin-specific protease activity Source: GO_Central

GO - Biological processi

  1. proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
  2. protein deubiquitination Source: MGI
  3. regulation of proteasomal protein catabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.045.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 26 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 26
Ubiquitin thioesterase 26
Ubiquitin-specific-processing protease 26
Gene namesi
Name:Usp26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1933247. Usp26.

Subcellular locationi

  1. Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 835835Ubiquitin carboxyl-terminal hydrolase 26PRO_0000080656Add
BLAST

Proteomic databases

PaxDbiQ99MX1.
PRIDEiQ99MX1.

PTM databases

PhosphoSiteiQ99MX1.

Expressioni

Gene expression databases

BgeeiQ99MX1.
CleanExiMM_USP26.
GenevestigatoriQ99MX1.

Interactioni

Subunit structurei

Interacts with AR.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110519.

Structurei

3D structure databases

ProteinModelPortaliQ99MX1.
SMRiQ99MX1. Positions 6-103, 287-548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini286 – 816531USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiNOG256718.
GeneTreeiENSGT00440000033542.
HOGENOMiHOG000060197.
HOVERGENiHBG055893.
InParanoidiQ99MX1.
KOiK11850.
OMAiFETINIT.
OrthoDBiEOG7HMS09.
TreeFamiTF323032.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPILINAQV QMWSAKAGMS KSRNALIETC VGKREVKLIL YFSTGKIKTL
60 70 80 90 100
QLHDNIKSVV LQTYGEDQNY LHLTFKNNDF LFVEKLTTTD ARRLKRFLDK
110 120 130 140 150
TSQGSIRPAR SDERCGEPST SAQELNGSGS SCETNSECFE SPKESEMCMF
160 170 180 190 200
RELSLLPSSS TFLHNVGLLE NQFIKRKRFF SDLAKNEKQS NLKDSIRDFE
210 220 230 240 250
ANLVVCISNE KGKERNVREV DISKPGFGFP FETNYPEDSG VDVRDLNDLI
260 270 280 290 300
TKLFSPVLLE THCIENGLEW HEYMKTYLLY PEKLWQGLPN VGNTCYINVV
310 320 330 340 350
LQSLCSIPLF INDLFNQGFP WIKAPKDDFN MLLMQLLVLK DIYNARFRQK
360 370 380 390 400
LLIGITKALP IFGEIFAVDR QNDAHEFLSL CLVQLKETFQ RVTMMWQSEN
410 420 430 440 450
DSGDFYLLKD IFADYATINK MPVCPVTNNF EFELLSSIFC KACGLTLFKG
460 470 480 490 500
EPSRYLSINI PQGGKDMSIQ STLDLFFSAE ELEHRCEKCL YNKSVSFHRF
510 520 530 540 550
GRLPRVIIVH LKRYHFNESW VMKKDERPIL VSKYLRLSCH CSKSTKPPPP
560 570 580 590 600
LRPGEHVKNL DLLKPLEVLG SEILKLPFNS VRTSRSKGFE TINITSNRES
610 620 630 640 650
EAQSGKRVSE VLSGKVQQEN SGKGDTAHIV GSELTKETEK LKKHEEEHRP
660 670 680 690 700
SDLDSGSIRE AQKYQQAEKC NEGRSDKQIS LEALTQSRPK PISQEQTENL
710 720 730 740 750
GKTTLSHTQD SSQSSQSSSD SSKSSRCSDD LDKKAKPTRK VDPTKLNKKE
760 770 780 790 800
DNVYRLVNII NHIGNSPNGG HYINDAFDFK RQSWFTYSDL HVTRTQEDFV
810 820 830
YRGRSSTGYV FFYMHNDIFE ELLAKETQST STSKG
Length:835
Mass (Da):95,452
Last modified:July 27, 2011 - v2
Checksum:iE66CCCE3B3042998
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti746 – 7461L → F in AAK31949 (PubMed:11279525).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285570 mRNA. Translation: AAK31949.1.
AL662931 Genomic DNA. Translation: CAM18657.1.
BC125454 mRNA. Translation: AAI25455.1.
BC132154 mRNA. Translation: AAI32155.1.
CCDSiCCDS30122.1.
RefSeqiNP_113565.2. NM_031388.2.
UniGeneiMm.242827.

Genome annotation databases

EnsembliENSMUST00000069509; ENSMUSP00000069140; ENSMUSG00000055780.
ENSMUST00000114869; ENSMUSP00000110519; ENSMUSG00000055780.
GeneIDi83563.
KEGGimmu:83563.
UCSCiuc009tec.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285570 mRNA. Translation: AAK31949.1.
AL662931 Genomic DNA. Translation: CAM18657.1.
BC125454 mRNA. Translation: AAI25455.1.
BC132154 mRNA. Translation: AAI32155.1.
CCDSiCCDS30122.1.
RefSeqiNP_113565.2. NM_031388.2.
UniGeneiMm.242827.

3D structure databases

ProteinModelPortaliQ99MX1.
SMRiQ99MX1. Positions 6-103, 287-548.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110519.

Protein family/group databases

MEROPSiC19.045.

PTM databases

PhosphoSiteiQ99MX1.

Proteomic databases

PaxDbiQ99MX1.
PRIDEiQ99MX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069509; ENSMUSP00000069140; ENSMUSG00000055780.
ENSMUST00000114869; ENSMUSP00000110519; ENSMUSG00000055780.
GeneIDi83563.
KEGGimmu:83563.
UCSCiuc009tec.1. mouse.

Organism-specific databases

CTDi83844.
MGIiMGI:1933247. Usp26.

Phylogenomic databases

eggNOGiNOG256718.
GeneTreeiENSGT00440000033542.
HOGENOMiHOG000060197.
HOVERGENiHBG055893.
InParanoidiQ99MX1.
KOiK11850.
OMAiFETINIT.
OrthoDBiEOG7HMS09.
TreeFamiTF323032.

Miscellaneous databases

NextBioi350660.
PROiQ99MX1.
SOURCEiSearch...

Gene expression databases

BgeeiQ99MX1.
CleanExiMM_USP26.
GenevestigatoriQ99MX1.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An abundance of X-linked genes expressed in spermatogonia."
    Wang P.J., McCarrey J.R., Yang F., Page D.C.
    Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiUBP26_MOUSE
AccessioniPrimary (citable) accession number: Q99MX1
Secondary accession number(s): Q05A11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 27, 2011
Last modified: April 1, 2015
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.