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Protein

Ubiquitin carboxyl-terminal hydrolase 26

Gene

Usp26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei295NucleophilePROSITE-ProRule annotation1
Active sitei771Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPSiC19.045

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 26 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 26
Ubiquitin thioesterase 26
Ubiquitin-specific-processing protease 26
Gene namesi
Name:Usp26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1933247 Usp26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806561 – 835Ubiquitin carboxyl-terminal hydrolase 26Add BLAST835

Proteomic databases

PaxDbiQ99MX1
PRIDEiQ99MX1

PTM databases

PhosphoSitePlusiQ99MX1

Expressioni

Gene expression databases

BgeeiENSMUSG00000055780
CleanExiMM_USP26
GenevisibleiQ99MX1 MM

Interactioni

Subunit structurei

Interacts with AR.By similarity

Protein-protein interaction databases

BioGridi219948, 3 interactors
STRINGi10090.ENSMUSP00000069140

Structurei

3D structure databases

ProteinModelPortaliQ99MX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini286 – 816USPAdd BLAST531

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiKOG1868 Eukaryota
ENOG410XP8T LUCA
GeneTreeiENSGT00440000033542
HOGENOMiHOG000060197
HOVERGENiHBG055893
InParanoidiQ99MX1
KOiK11850
OMAiQNHLHLT
OrthoDBiEOG091G01DZ
TreeFamiTF323032

Family and domain databases

CDDicd13312 PH_USP37_like, 1 hit
Gene3Di2.30.29.180, 1 hit
InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR032069 USP37-like_PH
IPR038093 USP37-like_PH_sf
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF16674 UCH_N, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q99MX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPILINAQV QMWSAKAGMS KSRNALIETC VGKREVKLIL YFSTGKIKTL
60 70 80 90 100
QLHDNIKSVV LQTYGEDQNY LHLTFKNNDF LFVEKLTTTD ARRLKRFLDK
110 120 130 140 150
TSQGSIRPAR SDERCGEPST SAQELNGSGS SCETNSECFE SPKESEMCMF
160 170 180 190 200
RELSLLPSSS TFLHNVGLLE NQFIKRKRFF SDLAKNEKQS NLKDSIRDFE
210 220 230 240 250
ANLVVCISNE KGKERNVREV DISKPGFGFP FETNYPEDSG VDVRDLNDLI
260 270 280 290 300
TKLFSPVLLE THCIENGLEW HEYMKTYLLY PEKLWQGLPN VGNTCYINVV
310 320 330 340 350
LQSLCSIPLF INDLFNQGFP WIKAPKDDFN MLLMQLLVLK DIYNARFRQK
360 370 380 390 400
LLIGITKALP IFGEIFAVDR QNDAHEFLSL CLVQLKETFQ RVTMMWQSEN
410 420 430 440 450
DSGDFYLLKD IFADYATINK MPVCPVTNNF EFELLSSIFC KACGLTLFKG
460 470 480 490 500
EPSRYLSINI PQGGKDMSIQ STLDLFFSAE ELEHRCEKCL YNKSVSFHRF
510 520 530 540 550
GRLPRVIIVH LKRYHFNESW VMKKDERPIL VSKYLRLSCH CSKSTKPPPP
560 570 580 590 600
LRPGEHVKNL DLLKPLEVLG SEILKLPFNS VRTSRSKGFE TINITSNRES
610 620 630 640 650
EAQSGKRVSE VLSGKVQQEN SGKGDTAHIV GSELTKETEK LKKHEEEHRP
660 670 680 690 700
SDLDSGSIRE AQKYQQAEKC NEGRSDKQIS LEALTQSRPK PISQEQTENL
710 720 730 740 750
GKTTLSHTQD SSQSSQSSSD SSKSSRCSDD LDKKAKPTRK VDPTKLNKKE
760 770 780 790 800
DNVYRLVNII NHIGNSPNGG HYINDAFDFK RQSWFTYSDL HVTRTQEDFV
810 820 830
YRGRSSTGYV FFYMHNDIFE ELLAKETQST STSKG
Length:835
Mass (Da):95,452
Last modified:July 27, 2011 - v2
Checksum:iE66CCCE3B3042998
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti746L → F in AAK31949 (PubMed:11279525).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285570 mRNA Translation: AAK31949.1
AL662931 Genomic DNA No translation available.
BC125454 mRNA Translation: AAI25455.1
BC132154 mRNA Translation: AAI32155.1
CCDSiCCDS30122.1
RefSeqiNP_113565.2, NM_031388.2
XP_017174134.1, XM_017318645.1
UniGeneiMm.242827

Genome annotation databases

EnsembliENSMUST00000069509; ENSMUSP00000069140; ENSMUSG00000055780
ENSMUST00000114869; ENSMUSP00000110519; ENSMUSG00000055780
GeneIDi83563
KEGGimmu:83563
UCSCiuc009tec.1 mouse

Similar proteinsi

Entry informationi

Entry nameiUBP26_MOUSE
AccessioniPrimary (citable) accession number: Q99MX1
Secondary accession number(s): Q05A11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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