Q99MX1 (UBP26_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 26
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 26
Ubiquitin thioesterase 26
Ubiquitin-specific-processing protease 26

Gene names

Name:

Usp26

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	835 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome By similarity. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway By similarity.
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subunit structure	Interacts with AR By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the peptidase C19 family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Nucleus
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein deubiquitination Inferred from electronic annotation. Source: Compara ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 835	835	Ubiquitin carboxyl-terminal hydrolase 26		PRO_0000080656
Sites
	Active site	295	1	Nucleophile By similarity
	Active site	771	1	Proton acceptor By similarity
Experimental info
	Sequence conflict	746	1	L → F in AAK31949. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q99MX1 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: E66CCCE3B3042998	FASTA	835	95,452
	10 20 30 40 50 60 MEPILINAQV QMWSAKAGMS KSRNALIETC VGKREVKLIL YFSTGKIKTL QLHDNIKSVV 70 80 90 100 110 120 LQTYGEDQNY LHLTFKNNDF LFVEKLTTTD ARRLKRFLDK TSQGSIRPAR SDERCGEPST 130 140 150 160 170 180 SAQELNGSGS SCETNSECFE SPKESEMCMF RELSLLPSSS TFLHNVGLLE NQFIKRKRFF 190 200 210 220 230 240 SDLAKNEKQS NLKDSIRDFE ANLVVCISNE KGKERNVREV DISKPGFGFP FETNYPEDSG 250 260 270 280 290 300 VDVRDLNDLI TKLFSPVLLE THCIENGLEW HEYMKTYLLY PEKLWQGLPN VGNTCYINVV 310 320 330 340 350 360 LQSLCSIPLF INDLFNQGFP WIKAPKDDFN MLLMQLLVLK DIYNARFRQK LLIGITKALP 370 380 390 400 410 420 IFGEIFAVDR QNDAHEFLSL CLVQLKETFQ RVTMMWQSEN DSGDFYLLKD IFADYATINK 430 440 450 460 470 480 MPVCPVTNNF EFELLSSIFC KACGLTLFKG EPSRYLSINI PQGGKDMSIQ STLDLFFSAE 490 500 510 520 530 540 ELEHRCEKCL YNKSVSFHRF GRLPRVIIVH LKRYHFNESW VMKKDERPIL VSKYLRLSCH 550 560 570 580 590 600 CSKSTKPPPP LRPGEHVKNL DLLKPLEVLG SEILKLPFNS VRTSRSKGFE TINITSNRES 610 620 630 640 650 660 EAQSGKRVSE VLSGKVQQEN SGKGDTAHIV GSELTKETEK LKKHEEEHRP SDLDSGSIRE 670 680 690 700 710 720 AQKYQQAEKC NEGRSDKQIS LEALTQSRPK PISQEQTENL GKTTLSHTQD SSQSSQSSSD 730 740 750 760 770 780 SSKSSRCSDD LDKKAKPTRK VDPTKLNKKE DNVYRLVNII NHIGNSPNGG HYINDAFDFK 790 800 810 820 830 RQSWFTYSDL HVTRTQEDFV YRGRSSTGYV FFYMHNDIFE ELLAKETQST STSKG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An abundance of X-linked genes expressed in spermatogonia." Wang P.J., McCarrey J.R., Yang F., Page D.C. Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF285570 mRNA. Translation: AAK31949.1. AL662931 Genomic DNA. Translation: CAM18657.1. BC125454 mRNA. Translation: AAI25455.1. BC132154 mRNA. Translation: AAI32155.1.
IPI	IPI00118161.
RefSeq	NP_113565.2. NM_031388.2.
UniGene	Mm.242827.
3D structure databases
ProteinModelPortal	Q99MX1.
SMR	Q99MX1. Positions 6-103, 287-548.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000110519.
Protein family/group databases
MEROPS	C19.045.
PTM databases
PhosphoSite	Q99MX1.
Proteomic databases
PaxDb	Q99MX1.
PRIDE	Q99MX1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000069509; ENSMUSP00000069140; ENSMUSG00000055780. ENSMUST00000114869; ENSMUSP00000110519; ENSMUSG00000055780.
GeneID	83563.
KEGG	mmu:83563.
UCSC	uc009tec.1. mouse.
Organism-specific databases
CTD	83844.
MGI	MGI:1933247. Usp26.
Phylogenomic databases
eggNOG	NOG256718.
GeneTree	ENSGT00440000033542.
HOGENOM	HOG000060197.
HOVERGEN	HBG055893.
InParanoid	Q05A11.
KO	K11850.
OrthoDB	EOG49P9XV.
Gene expression databases
Bgee	Q99MX1.
CleanEx	MM_USP26.
Genevestigator	Q99MX1.
GermOnline	ENSMUSG00000055780. Mus musculus.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	350660.
SOURCE	Search...

Entry information

Entry name

UBP26_MOUSE

Accession

Primary (citable) accession number: Q99MX1
Secondary accession number(s): Q05A11

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	July 27, 2011
Last modified:	May 29, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program