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Protein

Serine/threonine-protein kinase 31

Gene

Stk31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Ser-855 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei738ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi717 – 725ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • protein phosphorylation Source: MGI
  • RNA catabolic process Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 31 (EC:2.7.11.1)
Gene namesi
Name:Stk31
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1924735 Stk31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867161 – 1018Serine/threonine-protein kinase 31Add BLAST1018

Proteomic databases

EPDiQ99MW1
MaxQBiQ99MW1
PaxDbiQ99MW1
PRIDEiQ99MW1

PTM databases

iPTMnetiQ99MW1
PhosphoSitePlusiQ99MW1

Expressioni

Tissue specificityi

Testis specific. Expressed only in male germ cells.

Gene expression databases

BgeeiENSMUSG00000023403
CleanExiMM_STK31
ExpressionAtlasiQ99MW1 baseline and differential
GenevisibleiQ99MW1 MM

Interactioni

Protein-protein interaction databases

BioGridi218727, 1 interactor
STRINGi10090.ENSMUSP00000024171

Structurei

3D structure databases

ProteinModelPortaliQ99MW1
SMRiQ99MW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 137TudorPROSITE-ProRule annotationAdd BLAST60
Domaini711 – 1018Protein kinasePROSITE-ProRule annotationAdd BLAST308

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili298 – 358Sequence analysisAdd BLAST61

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF5N Eukaryota
ENOG410XQIZ LUCA
GeneTreeiENSGT00390000007287
HOGENOMiHOG000154440
HOVERGENiHBG062739
InParanoidiQ99MW1
KOiK16316
OMAiIPKVDQF
OrthoDBiEOG091G0PO7
TreeFamiTF105335

Family and domain databases

Gene3Di2.40.50.90, 2 hits
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR035437 SNase_OB-fold_sf
IPR002999 Tudor
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00567 TUDOR, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SM00333 TUDOR, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50304 TUDOR, 1 hit

Sequencei

Sequence statusi: Complete.

Q99MW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGQRLFAGT AVAQSVSFPG LVQMDEDTHY NKVEDVVGSH VEDAVTFWAQ
60 70 80 90 100
NVSKNKDIMK IGCSLSEVCP LANSVFGNLD PKKIYGGLFS EDKCWYRCKV
110 120 130 140 150
LKTISDDKCL VRYIDYGNTE ILNRSDIVEI PPELQFSSIA KKYRLWGLQI
160 170 180 190 200
PSGQEVTQFD QGRTFLGSLI FEKEIKMRIK ATYQDGTVIA QAEYGTVDIG
210 220 230 240 250
EEVAKKGFAE KCRLTSGIDA CEAKKPDPNQ LALRSLKNPI PLWGRRSNQS
260 270 280 290 300
TFSRPKGHFN GRLTLDVKYE TSAGNHVTFP KESLAAGDFN LGSNVSLAKI
310 320 330 340 350
KQDQKLIEEN EKLKTEKEVL LENYKALELK VEQTAQELQQ EKTATMDLTK
360 370 380 390 400
HLESTLKTCV GTRLKNLAAK VELLKEIRHI NISIRFGNDL SDAMQVLDEG
410 420 430 440 450
SFTTLASLNE LEKIWAEYNV AQEKIQTCLN ENEGNILIAE RNEVQQKLFV
460 470 480 490 500
AVDVFILEVD DLPLDKRLKT LQDLATSLES VYGKAKEGTN NSEETLRKFY
510 520 530 540 550
DWQCTKREEF ASIRSETEAS LQHLVAWFQS SQKVFDLSLD EPLTSEDLIG
560 570 580 590 600
NIDEILEKTE SCVCKELELS LIEQGVIDKE IILSTYSQVL QKIHSEEKFI
610 620 630 640 650
ATLLSKYKDS VEFKKQMIDC LNKNPNVDYL LSIKKTLKGL KAQLRWKLVE
660 670 680 690 700
KSNLEESDDH DGTEIEKIKQ EITQLRNSVF QEIYHEREEY EKLNSLTQKW
710 720 730 740 750
FPELPLLYPE IGLLKYMNSG GLLTMSLERD LLDTEPMKEL SSKRPLVCSE
760 770 780 790 800
VNGQPVLLKG YSVDVDTEGR VIQRAASYHR ACGYAKEESG LLPLIFLFLC
810 820 830 840 850
KSDPVAYLMV PYYPKANLSA VQASMPLTSE EALKVMKGVA RGLHTLHSAN
860 870 880 890 900
IIHGSLHQNN VFALNREQGI VGDYDFTKSE SQRASVNAMV GGLSLLSPEL
910 920 930 940 950
KTGKPPSASS DLYAYGCLFL WLSVQNQEFE TNEDGIPKVD QFHLDDNVKS
960 970 980 990 1000
LLCSLIYFRS SMTAEQVLNA ECFLLPKGKS VPIPEKEIEC TQHSREDESK
1010
MESLDRYSEK TRNGEANP
Length:1,018
Mass (Da):115,018
Last modified:July 27, 2011 - v2
Checksum:iDFF8CC620D58B13B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti500Y → F in AAK31959 (PubMed:11279525).Curated1
Sequence conflicti500Y → F in AAI37990 (PubMed:15489334).Curated1
Sequence conflicti584S → I in AAK31959 (PubMed:11279525).Curated1
Sequence conflicti584S → I in AAI37990 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285580 mRNA Translation: AAK31959.1
AC153385 Genomic DNA No translation available.
BC137989 mRNA Translation: AAI37990.1
CCDSiCCDS39487.1
RefSeqiNP_084192.2, NM_029916.2
UniGeneiMm.128054

Genome annotation databases

EnsembliENSMUST00000024171; ENSMUSP00000024171; ENSMUSG00000023403
GeneIDi77485
KEGGimmu:77485
UCSCiuc009bws.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSTK31_MOUSE
AccessioniPrimary (citable) accession number: Q99MW1
Secondary accession number(s): B2RQM2, E9QLI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health