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Protein

Serine/threonine-protein kinase 31

Gene

Stk31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei738 – 7381ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi717 – 7259ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: MGI
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  • protein phosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 31 (EC:2.7.11.1)
Gene namesi
Name:Stk31
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1924735. Stk31.

Subcellular locationi

GO - Cellular componenti

  • acrosomal vesicle Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10181018Serine/threonine-protein kinase 31PRO_0000086716Add
BLAST

Proteomic databases

EPDiQ99MW1.
PaxDbiQ99MW1.
PRIDEiQ99MW1.

PTM databases

iPTMnetiQ99MW1.
PhosphoSiteiQ99MW1.

Expressioni

Tissue specificityi

Testis specific. Expressed only in male germ cells.

Gene expression databases

BgeeiQ99MW1.
CleanExiMM_STK31.
ExpressionAtlasiQ99MW1. baseline and differential.
GenevisibleiQ99MW1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024171.

Structurei

3D structure databases

ProteinModelPortaliQ99MW1.
SMRiQ99MW1. Positions 34-208, 753-922.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 13760TudorPROSITE-ProRule annotationAdd
BLAST
Domaini711 – 1018308Protein kinasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili298 – 35861Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 Tudor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF5N. Eukaryota.
ENOG410XQIZ. LUCA.
GeneTreeiENSGT00390000007287.
HOGENOMiHOG000154440.
HOVERGENiHBG062739.
InParanoidiQ99MW1.
KOiK16316.
OMAiNRNKDIM.
OrthoDBiEOG7MPRD3.
TreeFamiTF105335.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR016071. Staphylococal_nuclease_OB-fold.
IPR002999. Tudor.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00567. TUDOR. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
SM00333. TUDOR. 1 hit.
[Graphical view]
SUPFAMiSSF50199. SSF50199. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50304. TUDOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGQRLFAGT AVAQSVSFPG LVQMDEDTHY NKVEDVVGSH VEDAVTFWAQ
60 70 80 90 100
NVSKNKDIMK IGCSLSEVCP LANSVFGNLD PKKIYGGLFS EDKCWYRCKV
110 120 130 140 150
LKTISDDKCL VRYIDYGNTE ILNRSDIVEI PPELQFSSIA KKYRLWGLQI
160 170 180 190 200
PSGQEVTQFD QGRTFLGSLI FEKEIKMRIK ATYQDGTVIA QAEYGTVDIG
210 220 230 240 250
EEVAKKGFAE KCRLTSGIDA CEAKKPDPNQ LALRSLKNPI PLWGRRSNQS
260 270 280 290 300
TFSRPKGHFN GRLTLDVKYE TSAGNHVTFP KESLAAGDFN LGSNVSLAKI
310 320 330 340 350
KQDQKLIEEN EKLKTEKEVL LENYKALELK VEQTAQELQQ EKTATMDLTK
360 370 380 390 400
HLESTLKTCV GTRLKNLAAK VELLKEIRHI NISIRFGNDL SDAMQVLDEG
410 420 430 440 450
SFTTLASLNE LEKIWAEYNV AQEKIQTCLN ENEGNILIAE RNEVQQKLFV
460 470 480 490 500
AVDVFILEVD DLPLDKRLKT LQDLATSLES VYGKAKEGTN NSEETLRKFY
510 520 530 540 550
DWQCTKREEF ASIRSETEAS LQHLVAWFQS SQKVFDLSLD EPLTSEDLIG
560 570 580 590 600
NIDEILEKTE SCVCKELELS LIEQGVIDKE IILSTYSQVL QKIHSEEKFI
610 620 630 640 650
ATLLSKYKDS VEFKKQMIDC LNKNPNVDYL LSIKKTLKGL KAQLRWKLVE
660 670 680 690 700
KSNLEESDDH DGTEIEKIKQ EITQLRNSVF QEIYHEREEY EKLNSLTQKW
710 720 730 740 750
FPELPLLYPE IGLLKYMNSG GLLTMSLERD LLDTEPMKEL SSKRPLVCSE
760 770 780 790 800
VNGQPVLLKG YSVDVDTEGR VIQRAASYHR ACGYAKEESG LLPLIFLFLC
810 820 830 840 850
KSDPVAYLMV PYYPKANLSA VQASMPLTSE EALKVMKGVA RGLHTLHSAN
860 870 880 890 900
IIHGSLHQNN VFALNREQGI VGDYDFTKSE SQRASVNAMV GGLSLLSPEL
910 920 930 940 950
KTGKPPSASS DLYAYGCLFL WLSVQNQEFE TNEDGIPKVD QFHLDDNVKS
960 970 980 990 1000
LLCSLIYFRS SMTAEQVLNA ECFLLPKGKS VPIPEKEIEC TQHSREDESK
1010
MESLDRYSEK TRNGEANP
Length:1,018
Mass (Da):115,018
Last modified:July 27, 2011 - v2
Checksum:iDFF8CC620D58B13B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti500 – 5001Y → F in AAK31959 (PubMed:11279525).Curated
Sequence conflicti500 – 5001Y → F in AAI37990 (PubMed:15489334).Curated
Sequence conflicti584 – 5841S → I in AAK31959 (PubMed:11279525).Curated
Sequence conflicti584 – 5841S → I in AAI37990 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285580 mRNA. Translation: AAK31959.1.
AC153385 Genomic DNA. No translation available.
BC137989 mRNA. Translation: AAI37990.1.
CCDSiCCDS39487.1.
RefSeqiNP_084192.2. NM_029916.2.
UniGeneiMm.128054.

Genome annotation databases

EnsembliENSMUST00000024171; ENSMUSP00000024171; ENSMUSG00000023403.
GeneIDi77485.
KEGGimmu:77485.
UCSCiuc009bws.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285580 mRNA. Translation: AAK31959.1.
AC153385 Genomic DNA. No translation available.
BC137989 mRNA. Translation: AAI37990.1.
CCDSiCCDS39487.1.
RefSeqiNP_084192.2. NM_029916.2.
UniGeneiMm.128054.

3D structure databases

ProteinModelPortaliQ99MW1.
SMRiQ99MW1. Positions 34-208, 753-922.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024171.

PTM databases

iPTMnetiQ99MW1.
PhosphoSiteiQ99MW1.

Proteomic databases

EPDiQ99MW1.
PaxDbiQ99MW1.
PRIDEiQ99MW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024171; ENSMUSP00000024171; ENSMUSG00000023403.
GeneIDi77485.
KEGGimmu:77485.
UCSCiuc009bws.2. mouse.

Organism-specific databases

CTDi56164.
MGIiMGI:1924735. Stk31.

Phylogenomic databases

eggNOGiENOG410IF5N. Eukaryota.
ENOG410XQIZ. LUCA.
GeneTreeiENSGT00390000007287.
HOGENOMiHOG000154440.
HOVERGENiHBG062739.
InParanoidiQ99MW1.
KOiK16316.
OMAiNRNKDIM.
OrthoDBiEOG7MPRD3.
TreeFamiTF105335.

Miscellaneous databases

PROiQ99MW1.
SOURCEiSearch...

Gene expression databases

BgeeiQ99MW1.
CleanExiMM_STK31.
ExpressionAtlasiQ99MW1. baseline and differential.
GenevisibleiQ99MW1. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR016071. Staphylococal_nuclease_OB-fold.
IPR002999. Tudor.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00567. TUDOR. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
SM00333. TUDOR. 1 hit.
[Graphical view]
SUPFAMiSSF50199. SSF50199. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50304. TUDOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An abundance of X-linked genes expressed in spermatogonia."
    Wang P.J., McCarrey J.R., Yang F., Page D.C.
    Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiSTK31_MOUSE
AccessioniPrimary (citable) accession number: Q99MW1
Secondary accession number(s): B2RQM2, E9QLI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Ser-855 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.