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Protein

Transmembrane protein adipocyte-associated 1

Gene

Tpra1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • embryonic cleavage Source: MGI
  • negative regulation of mitotic cell cycle phase transition Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein adipocyte-associated 1
Alternative name(s):
Integral membrane protein GPR175
TPRA40
Transmembrane domain protein of 40 kDa regulated in adipocytes
Gene namesi
Name:Tpra1
Synonyms:Gpr175, Tpra40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1345190. Tpra1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei45 – 6521Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei73 – 9321Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei120 – 14021Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei148 – 16821Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence analysisAdd
BLAST
Transmembranei262 – 28221Helical; Name=7Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Transmembrane protein adipocyte-associated 1PRO_0000076100Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence analysis
Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ99MU1.
PaxDbiQ99MU1.
PRIDEiQ99MU1.

PTM databases

PhosphoSiteiQ99MU1.

Expressioni

Tissue specificityi

Ubiquitous, with higher levels in heart, brain, lung, liver and kidney.1 Publication

Inductioni

Induced during adipocytes differentiation and in white fat from aged and diabetics mice.1 Publication

Gene expression databases

BgeeiQ99MU1.
CleanExiMM_GPR175.
ExpressionAtlasiQ99MU1. baseline and differential.
GenevisibleiQ99MU1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063042.

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0359 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4536. Eukaryota.
ENOG410XRXY. LUCA.
GeneTreeiENSGT00390000016807.
HOGENOMiHOG000112778.
HOVERGENiHBG081569.
InParanoidiQ99MU1.
OMAiMFLLWKL.
OrthoDBiEOG74FF11.
PhylomeDBiQ99MU1.
TreeFamiTF314072.

Family and domain databases

InterProiIPR018781. TPRA40.
[Graphical view]
PANTHERiPTHR15876. PTHR15876. 1 hit.
PfamiPF10160. Tmemb_40. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLQEANGS TAWPPPTASN ISEPHQCLLL LYEDIGSSRV RYWDLLLLIP
60 70 80 90 100
NVLFFIFLLW KLPLARAKIR VTSSPIFITF YILVFVVALV GIARAVVSMT
110 120 130 140 150
VSASDAATVA DKILWEITRF FLLAIELSVI ILGLAFGHLE SKSSIKRVLA
160 170 180 190 200
ITTVLSLAYS VTQGTLEILY PDSHLSAEDF NIYGHGGRQF WLVSSCFFFL
210 220 230 240 250
VYSLVVILPK TPLKERVSLP SRRSFYVYAG ILATLNLLQG LGSALLCANI
260 270 280 290 300
IVGLCCVDAT TFLYFSFFAP LIYVAFLRGF FGSEPKILFS YKCQVDEAEE
310 320 330 340 350
PDMHLPQPYA VARREGIESA GPACASAANY SSTQFDSAGV AYLDDIASMP
360
CHTGSINSTD SERWKAINA
Length:369
Mass (Da):40,578
Last modified:June 1, 2001 - v1
Checksum:iBACB74C431312443
GO

Sequence cautioni

The sequence AAD15788.1 differs from that shown. Reason: Frameshift at position 290. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051098 mRNA. Translation: AAD15788.1. Frameshift.
AK089317 mRNA. Translation: BAC40839.1.
AK164913 mRNA. Translation: BAE37962.1.
AK172045 mRNA. Translation: BAE42796.1.
BC010244 mRNA. Translation: AAH10244.1.
BC028977 mRNA. Translation: AAH28977.1.
AY255531 mRNA. Translation: AAO85043.1.
CCDSiCCDS39555.1.
RefSeqiNP_036036.2. NM_011906.2.
XP_006506124.1. XM_006506061.2.
XP_006506125.1. XM_006506062.2.
XP_006506126.1. XM_006506063.2.
UniGeneiMm.284480.

Genome annotation databases

EnsembliENSMUST00000055022; ENSMUSP00000063042; ENSMUSG00000002871.
ENSMUST00000203185; ENSMUSP00000145168; ENSMUSG00000002871.
ENSMUST00000204765; ENSMUSP00000145050; ENSMUSG00000002871.
GeneIDi24100.
KEGGimmu:24100.
UCSCiuc009cvy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051098 mRNA. Translation: AAD15788.1. Frameshift.
AK089317 mRNA. Translation: BAC40839.1.
AK164913 mRNA. Translation: BAE37962.1.
AK172045 mRNA. Translation: BAE42796.1.
BC010244 mRNA. Translation: AAH10244.1.
BC028977 mRNA. Translation: AAH28977.1.
AY255531 mRNA. Translation: AAO85043.1.
CCDSiCCDS39555.1.
RefSeqiNP_036036.2. NM_011906.2.
XP_006506124.1. XM_006506061.2.
XP_006506125.1. XM_006506062.2.
XP_006506126.1. XM_006506063.2.
UniGeneiMm.284480.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063042.

PTM databases

PhosphoSiteiQ99MU1.

Proteomic databases

MaxQBiQ99MU1.
PaxDbiQ99MU1.
PRIDEiQ99MU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055022; ENSMUSP00000063042; ENSMUSG00000002871.
ENSMUST00000203185; ENSMUSP00000145168; ENSMUSG00000002871.
ENSMUST00000204765; ENSMUSP00000145050; ENSMUSG00000002871.
GeneIDi24100.
KEGGimmu:24100.
UCSCiuc009cvy.1. mouse.

Organism-specific databases

CTDi131601.
MGIiMGI:1345190. Tpra1.

Phylogenomic databases

eggNOGiKOG4536. Eukaryota.
ENOG410XRXY. LUCA.
GeneTreeiENSGT00390000016807.
HOGENOMiHOG000112778.
HOVERGENiHBG081569.
InParanoidiQ99MU1.
OMAiMFLLWKL.
OrthoDBiEOG74FF11.
PhylomeDBiQ99MU1.
TreeFamiTF314072.

Miscellaneous databases

NextBioi304109.
PROiQ99MU1.
SOURCEiSearch...

Gene expression databases

BgeeiQ99MU1.
CleanExiMM_GPR175.
ExpressionAtlasiQ99MU1. baseline and differential.
GenevisibleiQ99MU1. MM.

Family and domain databases

InterProiIPR018781. TPRA40.
[Graphical view]
PANTHERiPTHR15876. PTHR15876. 1 hit.
PfamiPF10160. Tmemb_40. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression of a novel seven transmembrane domain protein in epididymal fat from aged and diabetic mice."
    Yang H., Egan J.M., Rodgers B.D., Bernier M., Montrose-Rafizadeh C.
    Endocrinology 140:2859-2867(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY.
    Tissue: Adipocyte.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Lung and Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Mammary gland.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-148.

Entry informationi

Entry nameiTPRA1_MOUSE
AccessioniPrimary (citable) accession number: Q99MU1
Secondary accession number(s): Q80UD9
, Q8C240, Q91Z36, Q9Z112
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2001
Last modified: January 20, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.