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Protein

Transmembrane protein adipocyte-associated 1

Gene

Tpra1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • embryonic cleavage Source: MGI
  • negative regulation of mitotic cell cycle phase transition Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein adipocyte-associated 1
Alternative name(s):
Integral membrane protein GPR175
TPRA40
Transmembrane domain protein of 40 kDa regulated in adipocytes
Gene namesi
Name:Tpra1
Synonyms:Gpr175, Tpra40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1345190. Tpra1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 65Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei120 – 140Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei189 – 209Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei262 – 282Helical; Name=7Sequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761001 – 369Transmembrane protein adipocyte-associated 1Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Glycosylationi329N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99MU1.
PRIDEiQ99MU1.

PTM databases

PhosphoSitePlusiQ99MU1.

Expressioni

Tissue specificityi

Ubiquitous, with higher levels in heart, brain, lung, liver and kidney.1 Publication

Inductioni

Induced during adipocytes differentiation and in white fat from aged and diabetics mice.1 Publication

Gene expression databases

BgeeiENSMUSG00000002871.
CleanExiMM_GPR175.
ExpressionAtlasiQ99MU1. baseline and differential.
GenevisibleiQ99MU1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063042.

Structurei

3D structure databases

ProteinModelPortaliQ99MU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0359 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4536. Eukaryota.
ENOG410XRXY. LUCA.
GeneTreeiENSGT00390000016807.
HOGENOMiHOG000112778.
HOVERGENiHBG081569.
InParanoidiQ99MU1.
OMAiMFLLWKL.
OrthoDBiEOG091G074F.
PhylomeDBiQ99MU1.
TreeFamiTF314072.

Family and domain databases

InterProiIPR018781. TPRA40.
[Graphical view]
PANTHERiPTHR15876. PTHR15876. 1 hit.
PfamiPF10160. Tmemb_40. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLQEANGS TAWPPPTASN ISEPHQCLLL LYEDIGSSRV RYWDLLLLIP
60 70 80 90 100
NVLFFIFLLW KLPLARAKIR VTSSPIFITF YILVFVVALV GIARAVVSMT
110 120 130 140 150
VSASDAATVA DKILWEITRF FLLAIELSVI ILGLAFGHLE SKSSIKRVLA
160 170 180 190 200
ITTVLSLAYS VTQGTLEILY PDSHLSAEDF NIYGHGGRQF WLVSSCFFFL
210 220 230 240 250
VYSLVVILPK TPLKERVSLP SRRSFYVYAG ILATLNLLQG LGSALLCANI
260 270 280 290 300
IVGLCCVDAT TFLYFSFFAP LIYVAFLRGF FGSEPKILFS YKCQVDEAEE
310 320 330 340 350
PDMHLPQPYA VARREGIESA GPACASAANY SSTQFDSAGV AYLDDIASMP
360
CHTGSINSTD SERWKAINA
Length:369
Mass (Da):40,578
Last modified:June 1, 2001 - v1
Checksum:iBACB74C431312443
GO

Sequence cautioni

The sequence AAD15788 differs from that shown. Reason: Frameshift at position 290.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051098 mRNA. Translation: AAD15788.1. Frameshift.
AK089317 mRNA. Translation: BAC40839.1.
AK164913 mRNA. Translation: BAE37962.1.
AK172045 mRNA. Translation: BAE42796.1.
BC010244 mRNA. Translation: AAH10244.1.
BC028977 mRNA. Translation: AAH28977.1.
AY255531 mRNA. Translation: AAO85043.1.
CCDSiCCDS39555.1.
RefSeqiNP_036036.2. NM_011906.2.
XP_006506124.1. XM_006506061.2.
XP_006506125.1. XM_006506062.2.
XP_006506126.1. XM_006506063.2.
UniGeneiMm.284480.

Genome annotation databases

EnsembliENSMUST00000055022; ENSMUSP00000063042; ENSMUSG00000002871.
ENSMUST00000203185; ENSMUSP00000145168; ENSMUSG00000002871.
ENSMUST00000204765; ENSMUSP00000145050; ENSMUSG00000002871.
GeneIDi24100.
KEGGimmu:24100.
UCSCiuc009cvy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051098 mRNA. Translation: AAD15788.1. Frameshift.
AK089317 mRNA. Translation: BAC40839.1.
AK164913 mRNA. Translation: BAE37962.1.
AK172045 mRNA. Translation: BAE42796.1.
BC010244 mRNA. Translation: AAH10244.1.
BC028977 mRNA. Translation: AAH28977.1.
AY255531 mRNA. Translation: AAO85043.1.
CCDSiCCDS39555.1.
RefSeqiNP_036036.2. NM_011906.2.
XP_006506124.1. XM_006506061.2.
XP_006506125.1. XM_006506062.2.
XP_006506126.1. XM_006506063.2.
UniGeneiMm.284480.

3D structure databases

ProteinModelPortaliQ99MU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063042.

PTM databases

PhosphoSitePlusiQ99MU1.

Proteomic databases

PaxDbiQ99MU1.
PRIDEiQ99MU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055022; ENSMUSP00000063042; ENSMUSG00000002871.
ENSMUST00000203185; ENSMUSP00000145168; ENSMUSG00000002871.
ENSMUST00000204765; ENSMUSP00000145050; ENSMUSG00000002871.
GeneIDi24100.
KEGGimmu:24100.
UCSCiuc009cvy.1. mouse.

Organism-specific databases

CTDi131601.
MGIiMGI:1345190. Tpra1.

Phylogenomic databases

eggNOGiKOG4536. Eukaryota.
ENOG410XRXY. LUCA.
GeneTreeiENSGT00390000016807.
HOGENOMiHOG000112778.
HOVERGENiHBG081569.
InParanoidiQ99MU1.
OMAiMFLLWKL.
OrthoDBiEOG091G074F.
PhylomeDBiQ99MU1.
TreeFamiTF314072.

Miscellaneous databases

PROiQ99MU1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002871.
CleanExiMM_GPR175.
ExpressionAtlasiQ99MU1. baseline and differential.
GenevisibleiQ99MU1. MM.

Family and domain databases

InterProiIPR018781. TPRA40.
[Graphical view]
PANTHERiPTHR15876. PTHR15876. 1 hit.
PfamiPF10160. Tmemb_40. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPRA1_MOUSE
AccessioniPrimary (citable) accession number: Q99MU1
Secondary accession number(s): Q80UD9
, Q8C240, Q91Z36, Q9Z112
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.