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Q99MT7

- GPR87_MOUSE

UniProt

Q99MT7 - GPR87_MOUSE

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Protein

G-protein coupled receptor 87

Gene

Gpr87

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled purinergic nucleotide receptor activity Source: InterPro

GO - Biological processi

  1. negative regulation of adenylate cyclase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 87
Gene namesi
Name:Gpr87
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1934133. Gpr87.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747ExtracellularSequence AnalysisAdd
BLAST
Transmembranei48 – 6821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini69 – 757CytoplasmicSequence Analysis
Transmembranei76 – 9621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini97 – 11620ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini138 – 15922CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei160 – 18021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini181 – 20828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini230 – 25627CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei257 – 27721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini278 – 29720ExtracellularSequence AnalysisAdd
BLAST
Transmembranei298 – 31821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini319 – 35840CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358G-protein coupled receptor 87PRO_0000069596Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi114 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ99MT7.

PTM databases

PhosphoSiteiQ99MT7.

Expressioni

Tissue specificityi

Expressed at high levels in testis and brain and to a lesser extent placenta, ovary, prostate, and skeletal muscle but not in heart, lung, kidney, liver or intestine.1 Publication

Gene expression databases

CleanExiMM_GPR87.
GenevestigatoriQ99MT7.

Structurei

3D structure databases

ProteinModelPortaliQ99MT7.
SMRiQ99MT7. Positions 38-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146234.
HOVERGENiHBG108228.
InParanoidiQ99MT7.
KOiK08389.
PhylomeDBiQ99MT7.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MT7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLNLTLTKL PGNELYSQAS HTANSTSEGH GKNSTLHNKF DTIILPVLYL
60 70 80 90 100
VIFVASILLN GLAVWIFFHI RNKTSFIFYL KNIVVADLIM TLTFPFRIVR
110 120 130 140 150
DAGFGPWYFE FILCRYTSVL FYANMYTSIV FLGLISVDRY LKVVKPFGDS
160 170 180 190 200
RMYSITFTKV LSVCVWVIMA ILSLPNIILT NGQPTKENIH DCMKLKSPLG
210 220 230 240 250
AKWHMAVTYV DSCLFVAVLV ILIGCYIAIS RYIHKSSRQF ISQSSRKRKH
260 270 280 290 300
NQSIRVVVAV FFTCFLPYHL CRIPFTFSNL DRLLDESAHK ILYYCKEMTL
310 320 330 340 350
FLSACNVCLD PIIYFFMCKS FSRRLFKKSN IRTRSESIRS LQSVRRSEVR

IYYDYTDV
Length:358
Mass (Da):41,414
Last modified:October 3, 2003 - v2
Checksum:i6D258E98CB3BE4B9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 1111MGLNLTLTKLP → MAVPNVNVSTFA(PubMed:11273702)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295366 mRNA. Translation: AAK01866.1.
AK080394 mRNA. Translation: BAC37905.1.
UniGeneiMm.60267.

Genome annotation databases

KEGGimmu:84111.
UCSCiuc008pip.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295366 mRNA. Translation: AAK01866.1 .
AK080394 mRNA. Translation: BAC37905.1 .
UniGenei Mm.60267.

3D structure databases

ProteinModelPortali Q99MT7.
SMRi Q99MT7. Positions 38-327.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 122.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q99MT7.

Proteomic databases

PRIDEi Q99MT7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

KEGGi mmu:84111.
UCSCi uc008pip.1. mouse.

Organism-specific databases

CTDi 53836.
MGIi MGI:1934133. Gpr87.

Phylogenomic databases

eggNOGi NOG146234.
HOVERGENi HBG108228.
InParanoidi Q99MT7.
KOi K08389.
PhylomeDBi Q99MT7.

Miscellaneous databases

NextBioi 350890.
PROi Q99MT7.
SOURCEi Search...

Gene expression databases

CleanExi MM_GPR87.
Genevestigatori Q99MT7.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors."
    Wittenberger T., Schaller H.C., Hellebrand S.
    J. Mol. Biol. 307:799-813(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. "The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor."
    Tabata K., Baba K., Shiraishi A., Ito M., Fujita N.
    Biochem. Biophys. Res. Commun. 363:861-866(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiGPR87_MOUSE
AccessioniPrimary (citable) accession number: Q99MT7
Secondary accession number(s): Q8C4Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: November 26, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3