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Protein

G-protein coupled receptor 87

Gene

Gpr87

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 87
Gene namesi
Name:Gpr87
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1934133. Gpr87.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularSequence analysisAdd BLAST47
Transmembranei48 – 68Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini69 – 75CytoplasmicSequence analysis7
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 116ExtracellularSequence analysisAdd BLAST20
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 159CytoplasmicSequence analysisAdd BLAST22
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 208ExtracellularSequence analysisAdd BLAST28
Transmembranei209 – 229Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini230 – 256CytoplasmicSequence analysisAdd BLAST27
Transmembranei257 – 277Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini278 – 297ExtracellularSequence analysisAdd BLAST20
Transmembranei298 – 318Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini319 – 358CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695961 – 358G-protein coupled receptor 87Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99MT7.
PRIDEiQ99MT7.

PTM databases

PhosphoSitePlusiQ99MT7.

Expressioni

Tissue specificityi

Expressed at high levels in testis and brain and to a lesser extent placenta, ovary, prostate, and skeletal muscle but not in heart, lung, kidney, liver or intestine.1 Publication

Gene expression databases

BgeeiENSMUSG00000051431.
CleanExiMM_GPR87.
ExpressionAtlasiQ99MT7. baseline and differential.
GenevisibleiQ99MT7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059272.

Structurei

3D structure databases

ProteinModelPortaliQ99MT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE7G. Eukaryota.
ENOG410YEMD. LUCA.
GeneTreeiENSGT00640000091213.
HOVERGENiHBG108228.
InParanoidiQ99MT7.
KOiK08389.
PhylomeDBiQ99MT7.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99MT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLNLTLTKL PGNELYSQAS HTANSTSEGH GKNSTLHNKF DTIILPVLYL
60 70 80 90 100
VIFVASILLN GLAVWIFFHI RNKTSFIFYL KNIVVADLIM TLTFPFRIVR
110 120 130 140 150
DAGFGPWYFE FILCRYTSVL FYANMYTSIV FLGLISVDRY LKVVKPFGDS
160 170 180 190 200
RMYSITFTKV LSVCVWVIMA ILSLPNIILT NGQPTKENIH DCMKLKSPLG
210 220 230 240 250
AKWHMAVTYV DSCLFVAVLV ILIGCYIAIS RYIHKSSRQF ISQSSRKRKH
260 270 280 290 300
NQSIRVVVAV FFTCFLPYHL CRIPFTFSNL DRLLDESAHK ILYYCKEMTL
310 320 330 340 350
FLSACNVCLD PIIYFFMCKS FSRRLFKKSN IRTRSESIRS LQSVRRSEVR

IYYDYTDV
Length:358
Mass (Da):41,414
Last modified:October 3, 2003 - v2
Checksum:i6D258E98CB3BE4B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 11MGLNLTLTKLP → MAVPNVNVSTFA (PubMed:11273702).CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295366 mRNA. Translation: AAK01866.1.
AK080394 mRNA. Translation: BAC37905.1.
CCDSiCCDS79914.1.
RefSeqiNP_001289132.1. NM_001302203.1.
UniGeneiMm.60267.

Genome annotation databases

EnsembliENSMUST00000200095; ENSMUSP00000143683; ENSMUSG00000051431.
GeneIDi84111.
KEGGimmu:84111.
UCSCiuc008pip.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiGPR87_MOUSE
AccessioniPrimary (citable) accession number: Q99MT7
Secondary accession number(s): Q8C4Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: August 30, 2017
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families