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Q99MT7

- GPR87_MOUSE

UniProt

Q99MT7 - GPR87_MOUSE

Protein

G-protein coupled receptor 87

Gene

Gpr87

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (03 Oct 2003)
      Previous versions | rss
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    Functioni

    Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled purinergic nucleotide receptor activity Source: InterPro

    GO - Biological processi

    1. negative regulation of adenylate cyclase activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 87
    Gene namesi
    Name:Gpr87
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1934133. Gpr87.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358G-protein coupled receptor 87PRO_0000069596Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi114 ↔ 192PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ99MT7.

    PTM databases

    PhosphoSiteiQ99MT7.

    Expressioni

    Tissue specificityi

    Expressed at high levels in testis and brain and to a lesser extent placenta, ovary, prostate, and skeletal muscle but not in heart, lung, kidney, liver or intestine.1 Publication

    Gene expression databases

    CleanExiMM_GPR87.
    GenevestigatoriQ99MT7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99MT7.
    SMRiQ99MT7. Positions 34-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4747ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini69 – 757CytoplasmicSequence Analysis
    Topological domaini97 – 11620ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 15922CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini181 – 20828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini230 – 25627CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini278 – 29720ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini319 – 35840CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 6821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146234.
    HOVERGENiHBG108228.
    InParanoidiQ99MT7.
    KOiK08389.
    PhylomeDBiQ99MT7.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008109. P2Y13_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01735. P2Y13PRNCPTR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99MT7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLNLTLTKL PGNELYSQAS HTANSTSEGH GKNSTLHNKF DTIILPVLYL    50
    VIFVASILLN GLAVWIFFHI RNKTSFIFYL KNIVVADLIM TLTFPFRIVR 100
    DAGFGPWYFE FILCRYTSVL FYANMYTSIV FLGLISVDRY LKVVKPFGDS 150
    RMYSITFTKV LSVCVWVIMA ILSLPNIILT NGQPTKENIH DCMKLKSPLG 200
    AKWHMAVTYV DSCLFVAVLV ILIGCYIAIS RYIHKSSRQF ISQSSRKRKH 250
    NQSIRVVVAV FFTCFLPYHL CRIPFTFSNL DRLLDESAHK ILYYCKEMTL 300
    FLSACNVCLD PIIYFFMCKS FSRRLFKKSN IRTRSESIRS LQSVRRSEVR 350
    IYYDYTDV 358
    Length:358
    Mass (Da):41,414
    Last modified:October 3, 2003 - v2
    Checksum:i6D258E98CB3BE4B9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 1111MGLNLTLTKLP → MAVPNVNVSTFA(PubMed:11273702)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF295366 mRNA. Translation: AAK01866.1.
    AK080394 mRNA. Translation: BAC37905.1.
    RefSeqiNP_115775.1. NM_032399.1.
    XP_006502456.1. XM_006502393.1.
    UniGeneiMm.60267.

    Genome annotation databases

    GeneIDi84111.
    KEGGimmu:84111.
    UCSCiuc008pip.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF295366 mRNA. Translation: AAK01866.1 .
    AK080394 mRNA. Translation: BAC37905.1 .
    RefSeqi NP_115775.1. NM_032399.1.
    XP_006502456.1. XM_006502393.1.
    UniGenei Mm.60267.

    3D structure databases

    ProteinModelPortali Q99MT7.
    SMRi Q99MT7. Positions 34-328.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 122.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q99MT7.

    Proteomic databases

    PRIDEi Q99MT7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 84111.
    KEGGi mmu:84111.
    UCSCi uc008pip.1. mouse.

    Organism-specific databases

    CTDi 53836.
    MGIi MGI:1934133. Gpr87.

    Phylogenomic databases

    eggNOGi NOG146234.
    HOVERGENi HBG108228.
    InParanoidi Q99MT7.
    KOi K08389.
    PhylomeDBi Q99MT7.

    Miscellaneous databases

    NextBioi 350890.
    PROi Q99MT7.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_GPR87.
    Genevestigatori Q99MT7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008109. P2Y13_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01735. P2Y13PRNCPTR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors."
      Wittenberger T., Schaller H.C., Hellebrand S.
      J. Mol. Biol. 307:799-813(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.
    3. "The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor."
      Tabata K., Baba K., Shiraishi A., Ito M., Fujita N.
      Biochem. Biophys. Res. Commun. 363:861-866(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiGPR87_MOUSE
    AccessioniPrimary (citable) accession number: Q99MT7
    Secondary accession number(s): Q8C4Y7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: October 3, 2003
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3