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Protein

G-protein coupled receptor 87

Gene

Gpr87

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 87
Gene namesi
Name:Gpr87
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1934133. Gpr87.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularSequence analysisAdd BLAST47
Transmembranei48 – 68Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini69 – 75CytoplasmicSequence analysis7
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 116ExtracellularSequence analysisAdd BLAST20
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 159CytoplasmicSequence analysisAdd BLAST22
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 208ExtracellularSequence analysisAdd BLAST28
Transmembranei209 – 229Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini230 – 256CytoplasmicSequence analysisAdd BLAST27
Transmembranei257 – 277Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini278 – 297ExtracellularSequence analysisAdd BLAST20
Transmembranei298 – 318Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini319 – 358CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695961 – 358G-protein coupled receptor 87Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Glycosylationi33N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi114 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99MT7.
PRIDEiQ99MT7.

PTM databases

PhosphoSitePlusiQ99MT7.

Expressioni

Tissue specificityi

Expressed at high levels in testis and brain and to a lesser extent placenta, ovary, prostate, and skeletal muscle but not in heart, lung, kidney, liver or intestine.1 Publication

Gene expression databases

CleanExiMM_GPR87.
ExpressionAtlasiQ99MT7. baseline and differential.
GenevisibleiQ99MT7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059272.

Structurei

3D structure databases

ProteinModelPortaliQ99MT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE7G. Eukaryota.
ENOG410YEMD. LUCA.
GeneTreeiENSGT00640000091213.
HOVERGENiHBG108228.
InParanoidiQ99MT7.
KOiK08389.
PhylomeDBiQ99MT7.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLNLTLTKL PGNELYSQAS HTANSTSEGH GKNSTLHNKF DTIILPVLYL
60 70 80 90 100
VIFVASILLN GLAVWIFFHI RNKTSFIFYL KNIVVADLIM TLTFPFRIVR
110 120 130 140 150
DAGFGPWYFE FILCRYTSVL FYANMYTSIV FLGLISVDRY LKVVKPFGDS
160 170 180 190 200
RMYSITFTKV LSVCVWVIMA ILSLPNIILT NGQPTKENIH DCMKLKSPLG
210 220 230 240 250
AKWHMAVTYV DSCLFVAVLV ILIGCYIAIS RYIHKSSRQF ISQSSRKRKH
260 270 280 290 300
NQSIRVVVAV FFTCFLPYHL CRIPFTFSNL DRLLDESAHK ILYYCKEMTL
310 320 330 340 350
FLSACNVCLD PIIYFFMCKS FSRRLFKKSN IRTRSESIRS LQSVRRSEVR

IYYDYTDV
Length:358
Mass (Da):41,414
Last modified:October 3, 2003 - v2
Checksum:i6D258E98CB3BE4B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 11MGLNLTLTKLP → MAVPNVNVSTFA (PubMed:11273702).CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295366 mRNA. Translation: AAK01866.1.
AK080394 mRNA. Translation: BAC37905.1.
CCDSiCCDS79914.1.
RefSeqiNP_001289132.1. NM_001302203.1.
UniGeneiMm.60267.

Genome annotation databases

EnsembliENSMUST00000200095; ENSMUSP00000143683; ENSMUSG00000051431.
GeneIDi84111.
KEGGimmu:84111.
UCSCiuc008pip.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295366 mRNA. Translation: AAK01866.1.
AK080394 mRNA. Translation: BAC37905.1.
CCDSiCCDS79914.1.
RefSeqiNP_001289132.1. NM_001302203.1.
UniGeneiMm.60267.

3D structure databases

ProteinModelPortaliQ99MT7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059272.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ99MT7.

Proteomic databases

PaxDbiQ99MT7.
PRIDEiQ99MT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000200095; ENSMUSP00000143683; ENSMUSG00000051431.
GeneIDi84111.
KEGGimmu:84111.
UCSCiuc008pip.2. mouse.

Organism-specific databases

CTDi53836.
MGIiMGI:1934133. Gpr87.

Phylogenomic databases

eggNOGiENOG410IE7G. Eukaryota.
ENOG410YEMD. LUCA.
GeneTreeiENSGT00640000091213.
HOVERGENiHBG108228.
InParanoidiQ99MT7.
KOiK08389.
PhylomeDBiQ99MT7.

Miscellaneous databases

PROiQ99MT7.
SOURCEiSearch...

Gene expression databases

CleanExiMM_GPR87.
ExpressionAtlasiQ99MT7. baseline and differential.
GenevisibleiQ99MT7. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR87_MOUSE
AccessioniPrimary (citable) accession number: Q99MT7
Secondary accession number(s): Q8C4Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.